ibuprofen and Abdominal Pain studies

Abdominal Pain: Sensation of discomfort, distress, or agony in the abdominal region.

Research Excerpts

Excerpt	Relevance	Reference
"Postprocedural pain scores and the number of patients who had increased abdominal pain after the procedure were significantly lower in the IV ibuprofen group."	9.34	IV Ibuprofen for Prevention of Post-ERCP Pancreatitis in Children: A Randomized Placebo-controlled Feasibility Study. ( Barth, BA; Gurram, B; Huang, R; Troendle, DM, 2020)
" Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine."	6.55	Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017)
"Postprocedural pain scores and the number of patients who had increased abdominal pain after the procedure were significantly lower in the IV ibuprofen group."	5.34	IV Ibuprofen for Prevention of Post-ERCP Pancreatitis in Children: A Randomized Placebo-controlled Feasibility Study. ( Barth, BA; Gurram, B; Huang, R; Troendle, DM, 2020)
"He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated."	5.34	Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007)
"Over a 6-month period, two patients presented to a community hospital emergency department with perforated gastric ulcers as the result of recreational misuse of over-the-counter ibuprofen-codeine preparations."	3.74	Nurofen Plus misuse: an emerging cause of perforated gastric ulcer. ( Dutch, MJ, 2008)
"Ibuprofen is a peripherally acting nonsteroidal anti-inflammatory drug indicated fo ranalgesia, antipyresis, and various arthritic conditions."	2.70	Onset of analgesia for liquigel ibuprofen 400 mg, acetaminophen 1000 mg, ketoprofen 25 mg, and placebo in the treatment of postoperative dental pain. ( Cooper, S; Doyle, G; Jayawardena, S; Marrero, I; Olson, NZ; Otero, AM; Sunshine, A; Tirado, S, 2001)
" A positive dose-response was seen for both active drugs with meclofenamate 100 mg and ibuprofen 400 mg exhibiting the greatest efficacy for pain relief, pain reduction, time to remedication, and overall evaluation."	2.67	Single dose and multidose analgesic study of ibuprofen and meclofenamate sodium after third molar surgery. ( Bergman, S; Betts, N; Cooper, S; Gaston, G; Henry, E; Hersh, EV; Lamp, C; MacAfee, K; Quinn, P; Wedell, D, 1993)
" Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine."	2.55	Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017)
"He had an upper respiratory tract infection in which a vaso-occlusive crisis was precipitated."	1.34	Tramadol infusion for the pain management in sickle cell disease: a case report. ( Aydinok, Y; Balkan, C; Erhan, E; Inal, MT; Yegul, I, 2007)
"Pretreatment with ibuprofen or acetaminophen appears to decrease the occurrence of adverse events from pamidronate therapy."	1.32	Effectiveness of pretreatment in decreasing adverse events associated with pamidronate in children and adolescents. ( Bates, CM; Batisky, DL; Hayes, JR; Mahan, JD; Nahata, MC; Robinson, RE, 2004)
"Although migraine is the main chronic headache in childhood and adolescence, it remains extensively misdiagnosed."	1.31	[Migraine, misunderstood pathology in children]. ( Annequin, D; Dumas, C; Tourniaire, B, 2000)

Research

Studies (18)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

24-h Post-ERCP Pain Score

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (16.67)	18.2507
2000's	9 (50.00)	29.6817
2010's	5 (27.78)	24.3611
2020's	1 (5.56)	2.80

Authors	Studies
Troendle, DM	1
Gurram, B	1
Huang, R	1
Barth, BA	1
Lipton, RB	1
Diener, HC	1
Robbins, MS	1
Garas, SY	1
Patel, K	1
Yehiyan, A	1
Barman, S	1
Varia, H	1
Pettit, S	1
Sivayogajeyam, S	1
Christensen, KD	1
Lalazar, G	1
Doviner, V	1
Ben-Chetrit, E	1
Coolsen, M	1
Leedham, SJ	1
Guy, RJ	1
Garg, R	1
Zahra, F	1
Chandra, JA	1
Vatsal, P	1
Goldstein, JL	1
Zhao, SZ	1
Burke, TA	1
Palmer, R	1
von Allmen, H	1
Henderson, SC	1
Robinson, RE	1
Nahata, MC	1
Hayes, JR	1
Batisky, DL	1
Bates, CM	1
Mahan, JD	1
Sangha, S	1
Soto, JA	1
Becker, JM	1
Farraye, FA	1
Erhan, E	1
Inal, MT	1
Aydinok, Y	1
Balkan, C	1
Yegul, I	1
Dutch, MJ	1
Wattad, A	1
Feehan, T	1
Shepard, FM	1
Youngberg, G	1
Hersh, EV	1
Cooper, S	2
Betts, N	1
Wedell, D	1
MacAfee, K	1
Quinn, P	1
Lamp, C	1
Gaston, G	1
Bergman, S	1
Henry, E	1
Box, SA	1
Lee, MR	1
Annequin, D	1
Tourniaire, B	1
Dumas, C	1
Olivencia, G	1
Olson, NZ	1
Otero, AM	1
Marrero, I	1
Tirado, S	1
Doyle, G	1
Jayawardena, S	1
Sunshine, A	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
IV Ibuprofen for the Prevention of Post-ERCP Pancreatitis[NCT02241512]	Phase 2	69 participants (Actual)	Interventional	2014-09-30	Terminated (stopped due to lack of funding)
Acute Headache Treatment in Pregnancy: Improvement in Pain Scores With Occipital Nerve Block vs PO Acetaminophen With Caffeine A Randomized Controlled Trial[NCT03951649]	Phase 4	62 participants (Actual)	Interventional	2020-02-10	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Pain score recorded 24-hrs after the ERCP was performed as recorded on a 10-point Likert pain scale (0= lowest value, no pain, 10=highest value, severe pain) (NCT02241512)
Timeframe: pre-procedural, 24 hours

Increased Pain Score

Intervention	score on a Likert pain scale (Mean)
Ibuprofen	1.1
Placebo	3.1

Number of patients with increased pain scores after the procedure (NCT02241512)
Timeframe: pre-procedural, 24 hours

Post-ERCP Bleeding

Intervention	Participants (Count of Participants)
Ibuprofen	1
Placebo	11

Number of patients who develop post-ERCP bleeding (NCT02241512)
Timeframe: 2 weeks

Post-ERCP Pancreatitis

Intervention	Participants (Count of Participants)
Ibuprofen	2
Placebo	0

Number of patients who develop post-ERCP pancreatitis (NCT02241512)
Timeframe: 2 weeks

Duration of Headache Free Period at 7 Days

Number of Participants With Development of Hypertensive Disease of Pregnancy Within 28 Days

Number of Participants With Development of Hypertensive Disease of Pregnancy Within 7 Days

Number of Participants With Injection Site Complication (Infection, Hematoma, and Ecchymosis)

Number of Participants With Need for Admission for Treatment of Headache

Number of Participants With Need for Crossover Treatment

Number of Participants With Need for Neurology Consult

Number of Participants With Need for Representation for Treatment of Headache With 28 Days

Intervention	Participants (Count of Participants)
Ibuprofen	2
Placebo	5

Intervention	days (Median)
Occipital Nerve Block	6
Oral Acetaminophen/Caffeine Group	1

Intervention	Participants (Count of Participants)
Occipital Nerve Block	9
Oral Acetaminophen/Caffeine Group	4

Intervention	Participants (Count of Participants)
Occipital Nerve Block	7
Oral Acetaminophen/Caffeine Group	2

Intervention	Participants (Count of Participants)
Occipital Nerve Block	0
Oral Acetaminophen/Caffeine Group	2

Intervention	Participants (Count of Participants)
Occipital Nerve Block	0
Oral Acetaminophen/Caffeine Group	0

Intervention	Participants (Count of Participants)
Occipital Nerve Block	9
Oral Acetaminophen/Caffeine Group	14

Intervention	Participants (Count of Participants)
Occipital Nerve Block	4
Oral Acetaminophen/Caffeine Group	2

Emergency department for treatment of headache since treatment asked at 28 day follow up (NCT03951649)
Timeframe: 28 days

Number of Participants With Need for Second Line Treatment

Number of Participants With Response to Occipital Nerve Block in Pregnancy

Intervention	Participants (Count of Participants)
Occipital Nerve Block	5
Oral Acetaminophen/Caffeine Group	1

Intervention	Participants (Count of Participants)
Occipital Nerve Block	5
Oral Acetaminophen/Caffeine Group	5

Based on guidelines from the International Headache Society the primary outcome is the portion of women who experience resolution of headache or improvement of headache to mild range (VRS ≤ 3) at 2 hours following treatment with Occipital nerve block as compared to acetaminophen/caffeine cocktail. (NCT03951649)
Timeframe: 60-300 min

Response to Cross Over Treatment at 60 Min

Intervention	Participants (Count of Participants)
Occipital Nerve Block	20
Oral Acetaminophen/Caffeine Group	16

"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 60 min

Response to Second Line Treatment at 60 Min

Intervention	score on a scale (Median)
Occipital Nerve Block	6
Oral Acetaminophen/Caffeine Group	3

Response to Treatment Within 2 Hours

Article	Year
Caffeine in the management of patients with headache. The journal of headache and pain, 2017, Oct-24, Volume: 18, Issue:1 Topics: Abdominal Pain; Acetaminophen; Adult; Analgesics; Aspirin; Caffeine; Central Nervous System Stimulan	2017
Primary epiploic appendagitis: an underappreciated diagnosis. A case series and review of the literature. Digestive diseases and sciences, 2004, Volume: 49, Issue:2 Topics: Abdominal Pain; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Colon; Female; Humans; I	2004

Article	Year
IV Ibuprofen for Prevention of Post-ERCP Pancreatitis in Children: A Randomized Placebo-controlled Feasibility Study. Journal of pediatric gastroenterology and nutrition, 2020, Volume: 70, Issue:1 Topics: Abdominal Pain; Administration, Intravenous; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Ch	2020
A comparative study of injection placentrex and conventional therapy in treatment of pelvic inflammatory disease. Journal of the Indian Medical Association, 2008, Volume: 106, Issue:7 Topics: Abdominal Pain; Adnexal Diseases; Adult; Alkylating Agents; Anti-Bacterial Agents; Anti-Infective Ag	2008
Single dose and multidose analgesic study of ibuprofen and meclofenamate sodium after third molar surgery. Oral surgery, oral medicine, and oral pathology, 1993, Volume: 76, Issue:6 Topics: Abdominal Pain; Adolescent; Adult; Analysis of Variance; Chi-Square Distribution; Diarrhea; Dose-Res	1993
Onset of analgesia for liquigel ibuprofen 400 mg, acetaminophen 1000 mg, ketoprofen 25 mg, and placebo in the treatment of postoperative dental pain. Journal of clinical pharmacology, 2001, Volume: 41, Issue:11 Topics: Abdominal Pain; Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory	2001

Article	Year
Short-course high-dose ibuprofen causing both early and delayed jejunal perforations in a non-smoking man. BMJ case reports, 2017, Dec-22, Volume: 2017 Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Humans; Ibuprofen; Intestinal Pe	2017
[Videocapsule endoscopy used for diagnosis of Henoch-Schönlein purpura with gastrointestinal complications]. Ugeskrift for laeger, 2013, Sep-16, Volume: 175, Issue:38 Topics: Abdominal Pain; Analgesics, Non-Narcotic; Capsule Endoscopy; Glucocorticoids; Humans; Ibuprofen; IgA	2013
Clinical problem-solving. Unfolding the diagnosis. The New England journal of medicine, 2014, Apr-03, Volume: 370, Issue:14 Topics: Abdominal Pain; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cytomegalovirus Infections; Gastriti	2014
Non-steroidal anti-inflammatory drug-induced diaphragm disease: an uncommon cause of small bowel obstruction. Annals of the Royal College of Surgeons of England, 2016, Volume: 98, Issue:8 Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Diaphragm; Humans; Ibupr	2016
Incidence of outpatient physician claims for upper gastrointestinal symptoms among new users of celecoxib, ibuprofen, and naproxen in an insured population in the United States. The American journal of gastroenterology, 2003, Volume: 98, Issue:12 Topics: Abdominal Pain; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhi	2003
Effectiveness of pretreatment in decreasing adverse events associated with pamidronate in children and adolescents. Pharmacotherapy, 2004, Volume: 24, Issue:2 Topics: Abdominal Pain; Acetaminophen; Adolescent; Child; Child, Preschool; Diphosphonates; Female; Hospital	2004
Tramadol infusion for the pain management in sickle cell disease: a case report. Paediatric anaesthesia, 2007, Volume: 17, Issue:1 Topics: Abdominal Pain; Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anemia, Sickle Cell; Ch	2007
Nurofen Plus misuse: an emerging cause of perforated gastric ulcer. The Medical journal of Australia, 2008, Jan-07, Volume: 188, Issue:1 Topics: Abdominal Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Drug Co	2008
A unique complication of nonsteroidal anti-inflammatory drug use. Pediatrics, 1994, Volume: 93, Issue:4 Topics: Abdominal Pain; Acute Kidney Injury; Adolescent; Female; Humans; Ibuprofen; Nephritis, Interstitial	1994
A systemic reaction following exposure to a pyrethroid insecticide. Human & experimental toxicology, 1996, Volume: 15, Issue:5 Topics: Abdominal Pain; Agricultural Workers' Diseases; Analgesics, Opioid; Animals; Anti-Allergic Agents; A	1996
[Migraine, misunderstood pathology in children]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2000, Volume: 7, Issue:9 Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; Child; Child Welfare; Diagnosis, Differenti	2000
Life-threatening illness in a nontransfusable patient: a health care challenge. Nephrology nursing journal : journal of the American Nephrology Nurses' Association, 2000, Volume: 27, Issue:2 Topics: Abdominal Pain; Adult; Analgesics, Non-Narcotic; Anemia, Iron-Deficiency; Appendicitis; Epoetin Alfa	2000

ibuprofen and Abdominal Pain