Page last updated: 2024-10-28

ibuprofen and 2019 Novel Coronavirus Disease

ibuprofen has been researched along with 2019 Novel Coronavirus Disease in 33 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

ExcerptRelevanceReference
"Insured patients with a history of osteoarthritis or back pain and receiving ibuprofen, other ns-NSAIDs, COX-2i or paracetamol between 1 November, 2019 and 31 January, 2020 (study enrolment window 1) or between 1 February, 2020 and 31 October, 2020 (study enrolment window 2)."9.41Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study. ( Argyriou, G; Brash, JT; Driessen, S; Prieto-Alhambra, D; Reich, C; Seager, S; Turkmen, C; Varrassi, G; Xie, J, 2023)
"Insured patients with a history of osteoarthritis or back pain and receiving ibuprofen, other ns-NSAIDs, COX-2i or paracetamol between 1 November, 2019 and 31 January, 2020 (study enrolment window 1) or between 1 February, 2020 and 31 October, 2020 (study enrolment window 2)."5.41Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study. ( Argyriou, G; Brash, JT; Driessen, S; Prieto-Alhambra, D; Reich, C; Seager, S; Turkmen, C; Varrassi, G; Xie, J, 2023)
" One hundred and seventy-nine (44%) patients had fever, with 32% using paracetamol and 22% using ibuprofen, for symptom-relief."3.96Ibuprofen use and clinical outcomes in COVID-19 patients. ( Bar-Haim, A; Kozer, E; Rinott, E; Shapira, Y; Youngster, I, 2020)
" Globally, the pharmacologic treatment of pain in pediatric patients is limited largely to nonopioid analgesics, and dosing must account for differences in age, weight, metabolism, and risk of adverse effects."3.01Common Selfcare Indications of Pain Medications in Children. ( Bell, J; Kachroo, P; Mossali, VM; Siddiqui, K; Zempsky, W, 2023)
"At the start of the coronavirus disease 2019 (COVID-19) pandemic (March 2020), there was speculation that non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, used to manage some of the symptoms of COVID-19, could increase the susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and negatively impact clinical outcomes."3.01Ibuprofen, other NSAIDs and COVID-19: a narrative review. ( Charlesworth, B; Laughey, W; Lodhi, I; Pennick, G; Sandhu, S; Sanni, O; Smart, L, 2023)
"non-ibuprofen patients were 16."1.56Association Between Prescribed Ibuprofen and Severe COVID-19 Infection: A Nationwide Register-Based Cohort Study. ( Andersen, MP; Bang, CN; Butt, JH; Fosbøl, E; Gerds, TA; Gislason, G; Kragholm, K; Køber, L; Pallisgaard, J; Phelps, M; Schou, M; Torp-Pedersen, C; Østergaard, L, 2020)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's33 (100.00)2.80

Authors

AuthorsStudies
Wong, J1
Sharma, S1
Yao, JV1
Aggarwal, A1
Grigg, L1
de Bruin, N1
Schneider, AK1
Reus, P1
Talmon, S1
Ciesek, S1
Bojkova, D1
Cinatl, J1
Lodhi, I2
Charlesworth, B3
Sinclair, S1
Pennick, G3
Laughey, WF1
Gribbon, P1
Kannt, A1
Schiffmann, S1
Schneider, T1
Mauermann, E1
Ilgenstein, B1
Jaquiery, C1
Ruppen, W1
Abdool-Ghany, AA1
Sahwell, PJ1
Klaus, J1
Gidley, ML1
Sinigalliano, CD1
Solo-Gabriele, HM1
Xie, J1
Brash, JT1
Turkmen, C1
Driessen, S1
Varrassi, G1
Argyriou, G1
Seager, S1
Reich, C1
Prieto-Alhambra, D1
Kasprzyk-Hordern, B1
Sims, N1
Farkas, K1
Jagadeesan, K1
Proctor, K1
Wade, MJ1
Jones, DL1
Karami, S1
Asonye, C1
Pinnow, E1
Pratt, V1
McCulley, L1
Dwumfour, N1
Zhou, EH1
Zempsky, W1
Bell, J1
Mossali, VM1
Kachroo, P1
Siddiqui, K1
Marcianò, G1
Muraca, L1
Rania, V1
Gallelli, L1
Apata, J1
Pennap, DD1
Mosholder, AD1
Laughey, W1
Smart, L2
Sanni, O1
Sandhu, S1
Sodhi, M1
Etminan, M1
MaassenVanDenBrink, A1
de Vries, T1
Danser, AHJ1
Vanegas Ramirez, A1
Efe, D1
Fischer, M1
Zolk, O1
Hafner, S1
Schmidt, CQ1
Arjomandi Rad, A1
Vardanyan, R1
Tas, NR1
Veljkovic, V4
Vergara-Alert, J4
Segalés, J4
Paessler, S4
Cui, S1
Chen, S1
Ke, L1
Dhillon, P1
Breuer, M1
Hirst, N1
Martins-Filho, PR1
do Nascimento-Júnior, EM1
Santos, VS1
Moore, N1
Carleton, B1
Blin, P1
Bosco-Levy, P1
Droz, C1
Rinott, E1
Kozer, E1
Shapira, Y1
Bar-Haim, A1
Youngster, I1
Fawkes, N1
Goggin, P1
Rainsford, KD1
Shah, N1
Vaja, R1
Chan, JSK1
Ferreira, P1
Harky, A1
Rogers, LJ1
Gashaw, HH1
Kirkby, NS1
Mitchell, JA1
Vosu, J1
Britton, P1
Howard-Jones, A1
Isaacs, D1
Kesson, A1
Khatami, A1
Marais, B1
Nayda, C1
Outhred, A1
Kelleni, MT1
Kragholm, K1
Gerds, TA1
Fosbøl, E1
Andersen, MP1
Phelps, M1
Butt, JH1
Østergaard, L1
Bang, CN1
Pallisgaard, J1
Gislason, G1
Schou, M1
Køber, L1
Torp-Pedersen, C1
Quaglietta, L1
Martinelli, M1
Staiano, A1
Toom, S1
Wolf, B1
Avula, A1
Peeke, S1
Becker, K1
Valenzuela, R1
Pedrosa, MA1
Garrido-Gil, P1
Labandeira, CM1
Navarro, G1
Franco, R1
Rodriguez-Perez, AI1
Labandeira-Garcia, JL1
Poutoglidou, F1
Saitis, A1
Kouvelas, D1
Salva, O1
Alasino, R1
Giller, C1
Borello, J1
Doresky, A1
Karayan, G1
Beltramo, D1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Extended Compassionate Use Program (UCA) With Inhalational Ibuprofen in Patients With Acute Respiratory Pathology, Mediated by COVID-19.[NCT04382768]40 participants (Anticipated)Interventional2020-05-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for ibuprofen and 2019 Novel Coronavirus Disease

ArticleYear
Risk of COVID-19 Diagnosis and Hospitalisation in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study.
    Drugs, 2023, Volume: 83, Issue:3

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Cohort Studies; COVID-19; COVID-1

2023
Common Selfcare Indications of Pain Medications in Children.
    Paediatric drugs, 2023, Volume: 25, Issue:3

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; COVID-19; Fever; Humans; Ibuprofen; Pain

2023
Ibuprofen in the Management of Viral Infections: The Lesson of COVID-19 for Its Use in a Clinical Setting.
    Journal of clinical pharmacology, 2023, Volume: 63, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; COVID-19; Humans; Ibuprofen; Inflammation; Pain

2023
Ibuprofen, other NSAIDs and COVID-19: a narrative review.
    Inflammopharmacology, 2023, Volume: 31, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; COVID-19; COVID-19 Vaccines; Humans; Ibuprofen; SARS-CoV-2

2023
COVID-19 pandemic and therapy with ibuprofen or renin-angiotensin system blockers: no need for interruptions or changes in ongoing chronic treatments.
    Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:7

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammato

2020
COVID-19 breakthroughs: separating fact from fiction.
    The FEBS journal, 2020, Volume: 287, Issue:17

    Topics: Adult; Aged; Child; COVID-19; Evidence-Based Medicine; Female; Fomites; Humans; Ibuprofen; Male; Nic

2020
A narrative review of the potential pharmacological influence and safety of ibuprofen on coronavirus disease 19 (COVID-19), ACE2, and the immune system: a dichotomy of expectation and reality.
    Inflammopharmacology, 2020, Volume: 28, Issue:5

    Topics: Angiotensin-Converting Enzyme 2; Anti-Inflammatory Agents, Non-Steroidal; Coronavirus Infections; CO

2020
The COVID-19 ibuprofen controversy: A systematic review of NSAIDs in adult acute lower respiratory tract infections.
    British journal of clinical pharmacology, 2021, Volume: 87, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; COVID-19; COVID-19 Drug Treatment;

2021
Serious infectious events and ibuprofen administration in pediatrics: a narrative review in the era of COVID-19 pandemic.
    Italian journal of pediatrics, 2021, Jan-29, Volume: 47, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Communicable Diseases; COVID-19; COVID-19 Drug Treat

2021

Trials

2 trials available for ibuprofen and 2019 Novel Coronavirus Disease

ArticleYear
Analgesic benefit of metamizole and ibuprofen vs. either medication alone: a randomized clinical trial.
    Minerva anestesiologica, 2022, Volume: 88, Issue:6

    Topics: Analgesics; COVID-19; Cross-Over Studies; Dipyrone; Double-Blind Method; Humans; Ibuprofen; Pain, Po

2022
Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects.
    Platelets, 2022, Apr-03, Volume: 33, Issue:3

    Topics: Adult; Blood Platelets; COVID-19; COVID-19 Drug Treatment; Enoxaparin; Female; Humans; Ibuprofen; Ma

2022

Other Studies

22 other studies available for ibuprofen and 2019 Novel Coronavirus Disease

ArticleYear
COVID-19 mRNA vaccine (Comirnaty)-induced myocarditis.
    The Medical journal of Australia, 2022, 02-21, Volume: 216, Issue:3

    Topics: Bisoprolol; BNT162 Vaccine; COVID-19; Drug Therapy, Combination; Electrocardiography; Heart; Humans;

2022
Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection.
    International journal of molecular sciences, 2022, Jan-19, Volume: 23, Issue:3

    Topics: Acetaminophen; Angiotensin-Converting Enzyme 2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ca

2022
Fecal indicator bacteria levels at a marine beach before, during, and after the COVID-19 shutdown period and associations with decomposing seaweed and human presence.
    The Science of the total environment, 2022, Dec-10, Volume: 851, Issue:Pt 2

    Topics: Acetaminophen; Animals; Bacteria; Bathing Beaches; Caffeine; COVID-19; Dogs; Enterococcus; Environme

2022
Wastewater-based epidemiology for comprehensive community health diagnostics in a national surveillance study: Mining biochemical markers in wastewater.
    Journal of hazardous materials, 2023, 05-15, Volume: 450

    Topics: Biomarkers; COVID-19; COVID-19 Testing; Humans; Ibuprofen; Public Health; SARS-CoV-2; Wastewater; Wa

2023
Trends in pediatric nonprescription analgesic/antipyretic exposures during the COVID-19 pandemic.
    Clinical toxicology (Philadelphia, Pa.), 2023, Volume: 61, Issue:3

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Antipyretics; Aspirin; Child; Child, Preschool;

2023
The use of analgesics for intentional self-poisoning: Trends in U.S. poison center data.
    Journal of psychiatric research, 2023, Volume: 163

    Topics: Acetaminophen; Adolescent; Adult; Analgesics; Aspirin; Child; COVID-19; Female; Humans; Ibuprofen; M

2023
EMA advice on the use of NSAIDs for Covid-19.
    Drug and therapeutics bulletin, 2020, Volume: 58, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19

2020
Safety of Ibuprofen in Patients With COVID-19: Causal or Confounded?
    Chest, 2020, Volume: 158, Issue:1

    Topics: Acetaminophen; Antipyretics; Betacoronavirus; Coronavirus Infections; COVID-19; Humans; Ibuprofen; P

2020
Headache medication and the COVID-19 pandemic.
    The journal of headache and pain, 2020, Apr-25, Volume: 21, Issue:1

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inh

2020
Drug-induced vasculitis in a patient with COVID-19.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2020, Volume: 34, Issue:8

    Topics: Anti-Bacterial Agents; Betacoronavirus; Coronavirus Infections; COVID-19; Female; Humans; Ibuprofen;

2020
Ibuprofen and thromboembolism in SARS-COV2.
    Journal of thrombosis and haemostasis : JTH, 2020, Volume: 18, Issue:9

    Topics: COVID-19; Humans; Ibuprofen; RNA, Viral; SARS-CoV-2; Thromboembolism

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target.
    F1000Research, 2020, Volume: 9

    Topics: Actins; Angiotensin-Converting Enzyme 2; Betacoronavirus; China; Computer Simulation; Coronavirus In

2020
Reply to "Ibuprofen and thromboembolism in SARS-COV2".
    Journal of thrombosis and haemostasis : JTH, 2020, Volume: 18, Issue:9

    Topics: COVID-19; Humans; Ibuprofen; Pandemics; SARS-CoV-2; Thromboembolism

2020
No current evidence supporting risk of using Ibuprofen in patients with COVID-19.
    International journal of clinical practice, 2020, Volume: 74, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Betacoronavirus; Coronavirus Infections; COVID-19; Diabetes

2020
Does Ibuprofen Worsen COVID-19?
    Drug safety, 2020, Volume: 43, Issue:7

    Topics: Acute Disease; Angiotensin-Converting Enzyme 2; Anti-Inflammatory Agents, Non-Steroidal; Betacoronav

2020
Ibuprofen use and clinical outcomes in COVID-19 patients.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2020, Volume: 26, Issue:9

    Topics: Acetaminophen; Adult; Antipyretics; COVID-19; COVID-19 Drug Treatment; Female; Fever; Humans; Ibupro

2020
Is the risk of ibuprofen or other non-steroidal anti-inflammatory drugs increased in COVID-19?
    Journal of paediatrics and child health, 2020, Volume: 56, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Coronavirus Infections; COVID-19; COVID-19 Drug Trea

2020
ACEIs, ARBs, ibuprofen originally linked to COVID-19: the other side of the mirror.
    Inflammopharmacology, 2020, Volume: 28, Issue:6

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents

2020
Association Between Prescribed Ibuprofen and Severe COVID-19 Infection: A Nationwide Register-Based Cohort Study.
    Clinical and translational science, 2020, Volume: 13, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Cohort Studies; COVID-19; Drug Prescriptions; Female; Humans; Ibupro

2020
Familial thrombocytopenia flare-up following the first dose of mRNA-1273 Covid-19 vaccine.
    American journal of hematology, 2021, 05-01, Volume: 96, Issue:5

    Topics: 2019-nCoV Vaccine mRNA-1273; Adult; Analgesics, Non-Narcotic; Chronic Disease; COVID-19; COVID-19 Va

2021
Interactions between ibuprofen, ACE2, renin-angiotensin system, and spike protein in the lung. Implications for COVID-19.
    Clinical and translational medicine, 2021, Volume: 11, Issue:4

    Topics: Angiotensin-Converting Enzyme 2; Animals; COVID-19; Disease Models, Animal; Humans; Ibuprofen; Lung;

2021
Ibuprofen and COVID-19 disease: separating the myths from facts.
    Expert review of respiratory medicine, 2021, Volume: 15, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; COVID-19; Cytokines; Humans; Ibuprofen; SARS-CoV-2

2021