Page last updated: 2024-10-28

ibudilast and Addiction, Opioid

ibudilast has been researched along with Addiction, Opioid in 5 studies

Research Excerpts

ExcerptRelevanceReference
"Heroin craving was significantly reduced under active ibudilast vs placebo, and similar effects were observed for tobacco and cocaine craving."2.84Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence. ( Comer, SD; Johnson, KW; Jones, JD; Madera, G; Manubay, J; Metz, VE; Mogali, S; Segoshi, A; Sullivan, MA, 2017)
"Ibudilast (AV-411) is a non-selective phosphodiesterase inhibitor that is also known to suppress glial cell activation."2.44Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes. ( Hutchinson, MR; Johnson, KW; Ledeboer, A; Watkins, LR, 2007)
"Ibudilast was well tolerated; no serious adverse events occurred during the study."1.43The effects of ibudilast, a glial activation inhibitor, on opioid withdrawal symptoms in opioid-dependent volunteers. ( Comer, SD; Cooper, ZD; Glass, A; Johnson, KW; Jones, JD; Manubay, JM; Martinez, DM; Pavlicova, M; Saccone, PA; Sullivan, MA; Vosburg, SK, 2016)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Metz, VE1
Jones, JD2
Manubay, J1
Sullivan, MA2
Mogali, S1
Segoshi, A1
Madera, G1
Johnson, KW4
Comer, SD2
Cooper, ZD1
Pavlicova, M1
Glass, A1
Vosburg, SK1
Manubay, JM1
Martinez, DM1
Saccone, PA1
Hutchinson, MR2
Lewis, SS1
Coats, BD1
Skyba, DA1
Crysdale, NY1
Berkelhammer, DL1
Brzeski, A1
Northcutt, A1
Vietz, CM1
Judd, CM1
Maier, SF1
Watkins, LR2
Schwarz, JM1
Bilbo, SD1
Ledeboer, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Safety, Tolerability and Preliminary Efficacy of AV411, a Glial Activation Inhibitor, in Heroin Abusers Under Conditions of Morphine Maintenance and Withdrawal[NCT00723177]Phase 230 participants (Actual)Interventional2008-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Subjective Opioid Withdrawal Scale Score (SOWS)

Measures severity of opioid withdrawal in opioid dependent populations (0-64). Larger values indicate more severe withdrawal. (NCT00723177)
Timeframe: Measured at the end of each two-week maintenance period (i.e., Placebo, Low AV411, High AV411).

Interventionunits on a scale (Mean)
Placebo16
Low-dose AV4114
High-dose AV41124

The Effects of AV411 on the Analgesic Effects of Oxycodone.

The McGill Pain Questionnaire (Melzack, 1987) was used to assess pain experience immediately following the immersion of the hand in 4 degree Celsius water. Scores were added across all 15 items to generate a sum score, which ranged between 15 and 60. Larger scores indicate greater pain levels. (NCT00723177)
Timeframe: Measured at the end of each AV411 of the three two-week maintenance periods

Interventionunits on a scale (Mean)
Placebo40
Low-dose AV41142
High-dose AV41138

Reviews

1 review available for ibudilast and Addiction, Opioid

ArticleYear
Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes.
    Expert opinion on investigational drugs, 2007, Volume: 16, Issue:7

    Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Dru

2007

Trials

1 trial available for ibudilast and Addiction, Opioid

ArticleYear
Effects of Ibudilast on the Subjective, Reinforcing, and Analgesic Effects of Oxycodone in Recently Detoxified Adults with Opioid Dependence.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017, Volume: 42, Issue:9

    Topics: Analgesics, Opioid; Craving; Heroin; Humans; Male; Middle Aged; Morphine; Opioid-Related Disorders;

2017

Other Studies

3 other studies available for ibudilast and Addiction, Opioid

ArticleYear
The effects of ibudilast, a glial activation inhibitor, on opioid withdrawal symptoms in opioid-dependent volunteers.
    Addiction biology, 2016, Volume: 21, Issue:4

    Topics: Adult; Female; Humans; Male; Middle Aged; Opioid-Related Disorders; Phosphodiesterase Inhibitors; Py

2016
Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast).
    Brain, behavior, and immunity, 2009, Volume: 23, Issue:2

    Topics: Analgesia; Analgesics, Opioid; Animals; Anti-Bacterial Agents; Brain; Bronchodilator Agents; Dose-Re

2009
Adolescent morphine exposure affects long-term microglial function and later-life relapse liability in a model of addiction.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jan-16, Volume: 33, Issue:3

    Topics: Age Factors; Animals; Conditioning, Operant; Disease Models, Animal; Drug-Seeking Behavior; Microgli

2013