ibotenic acid has been researched along with Seizures in 29 studies
Ibotenic Acid: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intraperitoneal pentylenetetrazole injection did not induce any seizure activity in the control rats, although it elicited seizures of variable severity in the polymicrogyria rats." | 3.81 | Increased expression of GAP43 in interneurons in a rat model of experimental polymicrogyria. ( Matsui, K; Takano, T, 2015) |
| "To elucidate the possible roles of the caudate-putamen (CP) on the development of amygdala (AM) kindling and AM-kindled seizures, the bilateral CP were destroyed by intra-CP injection of ibotenic acid (0." | 3.71 | The effect of the destruction of the caudate-putamen on the development of amygdaloid kindling and kindled seizures. ( Hoshino, S; Mori, N; Niwa, S; Osonoe, K; Osonoe, M; Suzuki, K; Yamada, Y, 2002) |
| "The excitatory amino acid antagonists, NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline) and GYKI 52466 (1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine) that act on non-NMDA receptors, provide potent anticonvulsant protection against AMPA [RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)-induced seizures in Swiss mice and against sound-induced seizures in seizure-susceptible DBA/2 mice." | 3.68 | The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice. ( Chapman, AG; Meldrum, BS; Smith, SE, 1991) |
| "Bilateral inferior olive lesions, produced by systemic administration of the neurotoxin 3-acetylpyridine (3AP) produce a proconvulsant state specific for strychnine-induced seizures and myoclonus." | 3.68 | The effects of inferior olive lesion on strychnine seizure. ( Anderson, MC; Chung, EY; Van Woert, MH, 1990) |
| "The degenerative lesions of bilateral substantia nigra (SN) were made by means of microinjections of ibotenic acid (IBO) solutions and influences upon kainic acid (KA)-induced seizures were studied." | 3.67 | Ibotenic acid-induced nigral lesion and limbic seizure in cats. ( Kaijima, M; Tanaka, S; Tanaka, T; Yonemasu, Y, 1989) |
| "Generalised tonic-clonic seizures, generated by abnormal neuronal hyper-activity, cause a significant and long-lasting increase in the nociceptive threshold." | 1.48 | Neurotoxic lesions of the pedunculopontine tegmental nucleus impair the elaboration of postictal antinociception. ( Almada, RC; Bazaglia-de-Sousa, G; Biagioni, AF; Coimbra, NC; de Oliveira, R; de Oliveira, RC; Dos Anjos-Garcia, T; Falconi-Sobrinho, LL; Khan, AU, 2018) |
| "Chemical lesions did not affect convulsions in response to pentylenetetrazole, which blocks GABA(A) receptor-mediated transmission." | 1.37 | Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in mice. ( Buck, KJ; Chen, G; Kozell, LB, 2011) |
| "One week after kainate-induced seizure CaSR was found in the injured CA3 region of the hippocampus and very interestingly it was found up-regulated in the neurons of CA1-CA2 and dentate gyrus." | 1.35 | Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain. ( Barresi, V; Belluardo, N; Condorelli, DF; Mudò, G; Trovato-Salinaro, A, 2009) |
| "Thiorphan effects were mimicked by substance P (SP) and, in a less potent manner, by neurokinin A." | 1.33 | Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice. ( Dournaud, P; Fontaine, RH; Gressens, P; Lebas, F; Lelièvre, V; Leroux, P; Medja, F; Ouimet, T; Rougeot, C; Saria, A, 2006) |
| "Kainic acid-induced seizure activity in adult rats produces an impairment of long-term potentiation induction in hippocampal slices." | 1.28 | Effect of seizure activity and calpain inhibitor I on LTP in juvenile hippocampal slices. ( Baudry, M; Fitzpatrick, JS; Shahi, K, 1992) |
| ", allowing for better dosage control." | 1.28 | 4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action. ( Arnold, MB; Elzey, T; Leander, JD; Lodge, D; Ornstein, PL; Paschal, JW; Schoepp, DD, 1991) |
| "Seizures were subsided but interictal discharges were observed at the injected site of the amygdala." | 1.28 | [Limbic seizure and ibotenic acid-induced lesions of substantia innominata in cats]. ( Kunimoto, M; Tanaka, T; Yonemasu, Y, 1989) |
| "Ibotenate-induced seizures and lesions and their specific blockade by a selective antagonist may constitute valuable experimental paradigms for the investigation of seizure disorders." | 1.27 | The effects of intrahippocampal ibotenic acid and their blockade by (-) 2-amino-7-phosphonoheptanoic acid: morphological and electroencephalographical analysis. ( Aldinio, C; French, ED; Schwarcz, R, 1983) |
| "The development of kindled seizures elicited through electrical stimulation of the rat olfactory bulb (OB) was examined under two conditions which decrease cholinergic neurotransmission." | 1.27 | Atropine slows olfactory bulb kindling while diminished cholinergic innervation does not. ( Berman, RF; Lupica, CR, 1988) |
| "Seizures were associated with a significant reduction in the levels of norepinephrine and with increases in the levels of 5-hydroxyindoleacetic acid in the cortex and hippocampal formation and increases in the levels of gamma-aminobutyric acid in the hippocampal formation." | 1.26 | Excitatory amino acid analogues: neurotoxicity and seizures. ( Coyle, JT; Zaczek, R, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (37.93) | 18.7374 |
| 1990's | 10 (34.48) | 18.2507 |
| 2000's | 5 (17.24) | 29.6817 |
| 2010's | 3 (10.34) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Oliveira, RC | 1 |
| de Oliveira, R | 1 |
| Falconi-Sobrinho, LL | 1 |
| Biagioni, AF | 1 |
| Almada, RC | 1 |
| Dos Anjos-Garcia, T | 1 |
| Bazaglia-de-Sousa, G | 1 |
| Khan, AU | 1 |
| Coimbra, NC | 1 |
| Takano, T | 1 |
| Matsui, K | 1 |
| François, J | 1 |
| Ferrandon, A | 1 |
| Koning, E | 1 |
| Angst, MJ | 1 |
| Sandner, G | 1 |
| Nehlig, A | 1 |
| Mudò, G | 1 |
| Trovato-Salinaro, A | 1 |
| Barresi, V | 1 |
| Belluardo, N | 1 |
| Condorelli, DF | 1 |
| Chen, G | 1 |
| Kozell, LB | 1 |
| Buck, KJ | 1 |
| Yamada, Y | 1 |
| Mori, N | 1 |
| Suzuki, K | 1 |
| Osonoe, K | 1 |
| Osonoe, M | 1 |
| Hoshino, S | 1 |
| Niwa, S | 1 |
| Medja, F | 1 |
| Lelièvre, V | 1 |
| Fontaine, RH | 1 |
| Lebas, F | 1 |
| Leroux, P | 1 |
| Ouimet, T | 1 |
| Saria, A | 1 |
| Rougeot, C | 1 |
| Dournaud, P | 1 |
| Gressens, P | 1 |
| Aldinio, C | 1 |
| French, ED | 1 |
| Schwarcz, R | 1 |
| Guldin, WO | 1 |
| Markowitsch, HJ | 1 |
| Zaczek, R | 1 |
| Coyle, JT | 1 |
| Laudrup, P | 1 |
| Klitgaard, H | 1 |
| Shukla, VK | 1 |
| Lemaire, S | 1 |
| Fischer, S | 1 |
| Wolf, G | 1 |
| Keilhoff, G | 1 |
| Hass, P | 1 |
| Beason-Held, LL | 1 |
| Rosene, DL | 1 |
| Killiany, RJ | 1 |
| Moss, MB | 1 |
| Schwabe, K | 1 |
| Ebert, U | 1 |
| Löscher, W | 1 |
| Akiyama, K | 1 |
| Daigen, A | 1 |
| Yamada, N | 1 |
| Itoh, T | 1 |
| Kohira, I | 1 |
| Ujike, H | 1 |
| Otsuki, S | 1 |
| McDonald, JW | 1 |
| Trescher, WH | 1 |
| Johnston, MV | 1 |
| Fitzpatrick, JS | 1 |
| Shahi, K | 1 |
| Baudry, M | 1 |
| Chapman, AG | 1 |
| Smith, SE | 1 |
| Meldrum, BS | 1 |
| Ornstein, PL | 1 |
| Schoepp, DD | 1 |
| Arnold, MB | 1 |
| Leander, JD | 1 |
| Lodge, D | 1 |
| Paschal, JW | 1 |
| Elzey, T | 1 |
| Anderson, MC | 1 |
| Chung, EY | 1 |
| Van Woert, MH | 1 |
| Kondo, S | 1 |
| Tanaka, S | 2 |
| Tanaka, T | 4 |
| Yonemasu, Y | 4 |
| Hori, T | 1 |
| Kaijima, M | 1 |
| Kunimoto, M | 1 |
| Frandsen, A | 1 |
| Belhage, B | 1 |
| Schousboe, A | 1 |
| Lupica, CR | 1 |
| Berman, RF | 1 |
| Watanabe, K | 1 |
| Murphy, DE | 1 |
| Boast, CA | 1 |
| Nitsch, C | 1 |
| Hubauer, H | 1 |
29 other studies available for ibotenic acid and Seizures
| Article | Year |
|---|---|
Neurotoxic lesions of the pedunculopontine tegmental nucleus impair the elaboration of postictal antinociception.
Topics: Analgesia; Animals; Ibotenic Acid; Male; Microinjections; Pain Measurement; Pedunculopontine Tegment | 2018 |
Increased expression of GAP43 in interneurons in a rat model of experimental polymicrogyria.
Topics: Animals; Animals, Newborn; Brain; Disease Models, Animal; Female; GAP-43 Protein; Ibotenic Acid; Int | 2015 |
Selective reorganization of GABAergic transmission in neonatal ventral hippocampal-lesioned rats.
Topics: Acoustic Stimulation; Action Potentials; Animals; Animals, Newborn; Apomorphine; Calbindin 2; Calbin | 2009 |
Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain.
Topics: Animals; Brain; Brain Injuries; Cell Count; Ibotenic Acid; Immunohistochemistry; In Situ Hybridizati | 2009 |
Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in mice.
Topics: Animals; Barbiturates; Ethanol; Excitatory Amino Acid Agonists; Ibotenic Acid; Male; Mice; Pentobarb | 2011 |
The effect of the destruction of the caudate-putamen on the development of amygdaloid kindling and kindled seizures.
Topics: Amygdala; Animals; Caudate Nucleus; Ibotenic Acid; Kindling, Neurologic; Male; Putamen; Rats; Rats, | 2002 |
Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice.
Topics: Animals; Animals, Newborn; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Cerebral Palsy; | 2006 |
The effects of intrahippocampal ibotenic acid and their blockade by (-) 2-amino-7-phosphonoheptanoic acid: morphological and electroencephalographical analysis.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Behavior, Animal; Dose-Response Relationship, Dru | 1983 |
Epidural kainate, but not ibotenate, produces lesions in local and distant regions of the brain. A comparison of the intracerebral actions of kainic acid and ibotenic acid.
Topics: Animals; Brain; Brain Mapping; Cerebral Cortex; Dose-Response Relationship, Drug; Hippocampus; Ibote | 1982 |
Excitatory amino acid analogues: neurotoxicity and seizures.
Topics: Amino Acids; Animals; Choline O-Acetyltransferase; Corpus Striatum; Electroencephalography; Glutamat | 1982 |
Metabotropic and ionotropic excitatory amino acid receptor agonists induce different behavioral effects in mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cycloleucine; D | 1993 |
Norbinaltorphimine protection against N-methyl-D-aspartic acid-induced convulsions and mortality.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicu | 1993 |
Mg2+ antagonizes alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-induced brain damage and convulsions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Diseases; Ibotenic Acid; Ma | 1993 |
Hippocampal formation lesions produce memory impairment in the rhesus monkey.
Topics: Animals; Brain Mapping; Color Perception; Hippocampus; Ibotenic Acid; Learning; Macaca mulatta; Male | 1999 |
Bilateral lesions of the central but not anterior or posterior parts of the piriform cortex retard amygdala kindling in rats.
Topics: Amygdala; Animals; Epilepsy, Temporal Lobe; Female; Ibotenic Acid; Kindling, Neurologic; Neural Path | 2000 |
Long-lasting enhancement of metabotropic excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/pyriform cortex of deep prepiriform cortical kindled rats.
Topics: Amygdala; Animals; Cerebral Cortex; Cycloleucine; Electric Stimulation; Hydrolysis; Ibotenic Acid; I | 1992 |
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1992 |
Effect of seizure activity and calpain inhibitor I on LTP in juvenile hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Glycoproteins; Hip | 1992 |
The anticonvulsant effect of the non-NMDA antagonists, NBQX and GYKI 52466, in mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiet | 1991 |
4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Ibotenic Acid; I | 1991 |
The effects of inferior olive lesion on strychnine seizure.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Dizocilpine Male | 1990 |
[Influence of destruction of bilateral hippocampus upon amygdaloid kindling in rats].
Topics: Amygdala; Animals; Hippocampus; Ibotenic Acid; Kindling, Neurologic; Male; Rats; Rats, Inbred Strain | 1989 |
Ibotenic acid-induced nigral lesion and limbic seizure in cats.
Topics: Animals; Brain Diseases; Cats; Electroencephalography; Female; Ibotenic Acid; Kainic Acid; Limbic Sy | 1989 |
[Limbic seizure and ibotenic acid-induced lesions of substantia innominata in cats].
Topics: Amygdala; Animals; Basal Ganglia; Cats; Cholinergic Fibers; Ibotenic Acid; Kainic Acid; Limbic Syste | 1989 |
Differences between seizure-prone and non-seizure-prone mice with regard to glutamate and GABA receptor binding in the hippocampus and other regions of the brain.
Topics: Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Cerebral | 1987 |
Atropine slows olfactory bulb kindling while diminished cholinergic innervation does not.
Topics: Acetylcholinesterase; Animals; Atropine; Brain; Choline O-Acetyltransferase; Electric Stimulation; E | 1988 |
[Ibotenic acid-induced limbic seizures and neuronal degeneration].
Topics: Amygdala; Animals; Cats; Electroencephalography; Hippocampus; Ibotenic Acid; Injections; Limbic Syst | 1987 |
Searching for models of Alzheimer's disease: a comparison of four amnestic treatments in two behavioral tasks.
Topics: Acetylcholine; Age Factors; Alzheimer Disease; Animals; Avoidance Learning; Behavior, Animal; Discri | 1985 |
Distant blood-brain barrier opening in subfields of the rat hippocampus after intrastriatal injections of kainic acid but not ibotenic acid.
Topics: Animals; Blood-Brain Barrier; Corpus Striatum; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Oxazol | 1986 |