ibotenic acid has been researched along with Schizophrenia in 30 studies
Ibotenic Acid: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present work we analyzed the effect of the chronic administration of risperidone (2mg/kg over 65 days) on behavioural, morphological and molecular aspects in an experimental model of schizophrenia obtained by bilateral injection of ibotenic acid into the ventral hippocampus of new-born rats." | 7.79 | Chronic administration of risperidone in a rat model of schizophrenia: a behavioural, morphological and molecular study. ( Arji, M; Carro, J; Castellano, O; de Anchieta de Castro E Horta, J; Gómez-Nieto, R; Herrero-Turrión, MJ; López, DE; Molina, V; Riolobos, AS; Sancho, C, 2013) |
| "Clozapine is an effective atypical antipsychotic drug used to treat schizophrenia." | 7.73 | Effects of clozapine on memory function in the rat neonatal hippocampal lesion model of schizophrenia. ( Christopher, NC; Levin, ED, 2006) |
| "The lesions induced by Ibotenic acid (IA) emulate some of the symptoms associated with schizophrenia, such as impaired working memory that is predominantly organized by the medial prefrontal cortex (mPFC), or difficulties in social interactions that aremainly organized by the amygdala (AMG)." | 4.02 | Ibotenic acid induced lesions impair the modulation of dendritic spine plasticity in the prefrontal cortex and amygdala, a phenomenon that underlies working memory and social behavior. ( Flores-Soto, M; González-Burgos, I; Martín-Amaya-Barajas, FL; Martínez-Torres, NI; Vázquez-Hernández, N, 2021) |
| "In the present work we analyzed the effect of the chronic administration of risperidone (2mg/kg over 65 days) on behavioural, morphological and molecular aspects in an experimental model of schizophrenia obtained by bilateral injection of ibotenic acid into the ventral hippocampus of new-born rats." | 3.79 | Chronic administration of risperidone in a rat model of schizophrenia: a behavioural, morphological and molecular study. ( Arji, M; Carro, J; Castellano, O; de Anchieta de Castro E Horta, J; Gómez-Nieto, R; Herrero-Turrión, MJ; López, DE; Molina, V; Riolobos, AS; Sancho, C, 2013) |
| "Clozapine is an effective atypical antipsychotic drug used to treat schizophrenia." | 3.73 | Effects of clozapine on memory function in the rat neonatal hippocampal lesion model of schizophrenia. ( Christopher, NC; Levin, ED, 2006) |
| "The neonatal (PND 7) lesion of the ventral hippocampus (VH) with ibotenic acid represents a well-established experimental paradigm that recapitulates many schizophrenia-like phenomena." | 3.71 | Developmental and stress-related changes of neurotrophic factor gene expression in an animal model of schizophrenia. ( Lipska, BK; Molteni, R; Racagni, G; Riva, MA; Weinberger, DR, 2001) |
| "Postnatal lesion with ibotenic acid in the ventral hippocampus produces several behavioural effects that resemble the symptoms of schizophrenia." | 3.70 | Social memory is impaired in neonatally ibotenic acid lesioned rats. ( Becker, A; Grecksch, G, 2000) |
| "Schizophrenia is conceptualized as a neurodevelopmental disorder in which developmental alterations in immature brain systems are not clear." | 1.43 | Neonatal ventral hippocampus lesion changes nuclear restricted protein/brain (NRP/B) expression in hippocampus, cortex and striatum in developmental periods of rats. ( Chen, X; Dai, Z; Lei, Y; Ling, S; Lui, F; Tian, Y; Yang, J; Zhang, J; Zhang, Z, 2016) |
| "Ibotenic acid was injected bilaterally into MDTN in rats." | 1.32 | Effects of a mediodorsal thalamus lesion on prefrontal inhibitory circuitry: implications for schizophrenia. ( Lewis, DA; Volk, DW, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 4 (13.33) | 18.2507 |
| 2000's | 16 (53.33) | 29.6817 |
| 2010's | 8 (26.67) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Martínez-Torres, NI | 1 |
| Vázquez-Hernández, N | 1 |
| Martín-Amaya-Barajas, FL | 1 |
| Flores-Soto, M | 1 |
| González-Burgos, I | 1 |
| Magdaleno-Madrigal, VM | 1 |
| Contreras-Murillo, G | 1 |
| Camacho-Abrego, I | 1 |
| Negrete-Díaz, JV | 1 |
| Valdés-Cruz, A | 1 |
| Fernández-Mas, R | 1 |
| Almazán-Alvarado, S | 1 |
| Flores, G | 1 |
| Placek, K | 1 |
| Dippel, WC | 1 |
| Jones, S | 1 |
| Brady, AM | 1 |
| Cabungcal, JH | 1 |
| Counotte, DS | 1 |
| Lewis, E | 1 |
| Tejeda, HA | 1 |
| Piantadosi, P | 1 |
| Pollock, C | 1 |
| Calhoon, GG | 1 |
| Sullivan, E | 1 |
| Presgraves, E | 1 |
| Kil, J | 1 |
| Hong, LE | 1 |
| Cuenod, M | 1 |
| Do, KQ | 1 |
| O'Donnell, P | 2 |
| Tian, Y | 1 |
| Yang, J | 1 |
| Lei, Y | 1 |
| Zhang, Z | 1 |
| Dai, Z | 1 |
| Chen, X | 1 |
| Lui, F | 1 |
| Zhang, J | 1 |
| Ling, S | 1 |
| Alexander, KS | 1 |
| Brooks, JM | 1 |
| Sarter, M | 1 |
| Bruno, JP | 1 |
| Wolf, R | 1 |
| Matzke, K | 1 |
| Paelchen, K | 1 |
| Dobrowolny, H | 1 |
| Bogerts, B | 1 |
| Schwegler, H | 1 |
| Lee, H | 1 |
| Dvorak, D | 1 |
| Kao, HY | 1 |
| Duffy, ÁM | 1 |
| Scharfman, HE | 1 |
| Fenton, AA | 1 |
| Chen, XS | 1 |
| Zhang, C | 1 |
| Xu, YF | 1 |
| Zhang, MD | 1 |
| Lou, FY | 1 |
| Chen, C | 1 |
| Tang, J | 1 |
| Castellano, O | 1 |
| Arji, M | 1 |
| Sancho, C | 1 |
| Carro, J | 1 |
| Riolobos, AS | 1 |
| Molina, V | 1 |
| Gómez-Nieto, R | 1 |
| de Anchieta de Castro E Horta, J | 1 |
| Herrero-Turrión, MJ | 1 |
| López, DE | 1 |
| Goto, Y | 1 |
| Ashe, PC | 1 |
| Chlan-Fourney, J | 1 |
| Juorio, AV | 1 |
| Li, XM | 1 |
| Volk, DW | 1 |
| Lewis, DA | 1 |
| Lipska, BK | 3 |
| Lerman, DN | 1 |
| Khaing, ZZ | 1 |
| Weickert, CS | 1 |
| Weinberger, DR | 3 |
| Van den Buuse, M | 1 |
| Garner, B | 1 |
| Koch, M | 2 |
| Schwabe, K | 1 |
| Levin, ED | 2 |
| Christopher, NC | 1 |
| Marquis, JP | 1 |
| Goulet, S | 1 |
| Doré, FY | 1 |
| Ahnaou, A | 1 |
| Nayak, S | 1 |
| Heylen, A | 1 |
| Ashton, D | 1 |
| Drinkenburg, WH | 1 |
| Jonsson, G | 1 |
| Freed, WJ | 1 |
| Dillon-Carter, O | 1 |
| Kleinman, JE | 1 |
| Jaskiw, GE | 1 |
| Chambers, RA | 1 |
| Moore, J | 1 |
| McEvoy, JP | 1 |
| Becker, A | 1 |
| Grecksch, G | 1 |
| Lacroix, L | 1 |
| Spinelli, S | 1 |
| White, W | 1 |
| Feldon, J | 1 |
| Stine, CD | 1 |
| Lu, W | 1 |
| Wolf, ME | 1 |
| Kato, K | 1 |
| Shishido, T | 1 |
| Ono, M | 1 |
| Shishido, K | 1 |
| Kobayashi, M | 1 |
| Niwa, S | 1 |
| Molteni, R | 1 |
| Racagni, G | 1 |
| Riva, MA | 1 |
| Le Pen, G | 1 |
| Gaudet, L | 1 |
| Mortas, P | 1 |
| Mory, R | 1 |
| Moreau, JL | 1 |
| Kurumaji, A | 1 |
| Ishimaru, M | 1 |
| Toru, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of N-acetylcysteine on Psychosis-like Symptoms and a Neurophysiological Biomarker of the Clinical High Risk for Schizophrenia[NCT05142735] | 90 participants (Anticipated) | Interventional | 2023-01-13 | Recruiting | |||
| Differences in Voxel-based Morphometry of Different Brain Structures in Patients With Mood Disorder Bipolar Mania in Comparison to Morphometry of Nrmal Controls[NCT03181698] | 45 participants (Actual) | Observational | 2017-09-22 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ibotenic acid and Schizophrenia
| Article | Year |
|---|---|
Neurodevelopmental animal models of schizophrenia: effects on prepulse inhibition.
Topics: Amygdala; Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Ibotenic Aci | 2003 |
Chemical neurotoxins as denervation tools in neurobiology.
Topics: 5,6-Dihydroxytryptamine; 5,7-Dihydroxytryptamine; Animals; Benzylamines; Brain; Catecholamines; Dene | 1980 |
28 other studies available for ibotenic acid and Schizophrenia
| Article | Year |
|---|---|
Ibotenic acid induced lesions impair the modulation of dendritic spine plasticity in the prefrontal cortex and amygdala, a phenomenon that underlies working memory and social behavior.
Topics: Amygdala; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Dendritic Spines; Disease Mo | 2021 |
Short-term deep brain stimulation of the thalamic reticular nucleus modifies aberrant oscillatory activity in a neurodevelopment model of schizophrenia.
Topics: Animals; Brain Waves; Deep Brain Stimulation; Disease Models, Animal; Electrocorticography; Female; | 2017 |
Impairments in set-shifting but not reversal learning in the neonatal ventral hippocampal lesion model of schizophrenia: further evidence for medial prefrontal deficits.
Topics: Animals; Attention; Disease Models, Animal; Hippocampus; Ibotenic Acid; Maze Learning; Prefrontal Co | 2013 |
Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia.
Topics: Acetylcysteine; Animals; Animals, Newborn; Antioxidants; Disease Models, Animal; Dopamine Agonists; | 2014 |
Neonatal ventral hippocampus lesion changes nuclear restricted protein/brain (NRP/B) expression in hippocampus, cortex and striatum in developmental periods of rats.
Topics: Animals; Animals, Newborn; Blotting, Western; Cerebral Cortex; Corpus Striatum; Disease Models, Anim | 2016 |
Disruption of mesolimbic regulation of prefrontal cholinergic transmission in an animal model of schizophrenia and normalization by chronic clozapine treatment.
Topics: Acetylcholine; Aging; Amphetamine; Animals; Animals, Newborn; Clozapine; Disease Models, Animal; Hip | 2009 |
Reduction of Prepulse Inhibition (PPI) after neonatal excitotoxic lesion of the ventral thalamus in pubertal and adult rats.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Antipsychotic Agents; Clozapine; Disease Models, Anim | 2010 |
Early cognitive experience prevents adult deficits in a neurodevelopmental schizophrenia model.
Topics: Animals; Animals, Newborn; Avoidance Learning; Brain Waves; Cell Count; Cognition Disorders; Cogniti | 2012 |
Neonatal ventral hippocampal lesion as a valid model of schizophrenia: evidence from sensory gating study.
Topics: Animals; Animals, Newborn; Central Nervous System; Evoked Potentials, Auditory; Hippocampus; Iboteni | 2012 |
Chronic administration of risperidone in a rat model of schizophrenia: a behavioural, morphological and molecular study.
Topics: Age Factors; Animals; Animals, Newborn; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; | 2013 |
Delayed mesolimbic system alteration in a developmental animal model of schizophrenia.
Topics: Administration, Oral; Age Factors; Animals; Animals, Newborn; Corpus Striatum; Disease Models, Anima | 2002 |
Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus.
Topics: Animals; Animals, Newborn; Brain Injuries; Brain-Derived Neurotrophic Factor; Excitatory Amino Acid | 2002 |
Effects of a mediodorsal thalamus lesion on prefrontal inhibitory circuitry: implications for schizophrenia.
Topics: Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamate Decarboxylase; Ibotenic A | 2003 |
Gene expression in dopamine and GABA systems in an animal model of schizophrenia: effects of antipsychotic drugs.
Topics: Animals; Animals, Newborn; Antipsychotic Agents; Brain; Clozapine; Dopamine; Enkephalins; gamma-Amin | 2003 |
Role of the medial prefrontal cortex in N-methyl-D-aspartate receptor antagonist induced sensorimotor gating deficit in rats.
Topics: Animals; Apomorphine; Denervation; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Ant | 2004 |
Effects of clozapine on memory function in the rat neonatal hippocampal lesion model of schizophrenia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antipsychotic Agents; Clozapine; Disease Models, An | 2006 |
Neonatal lesions of the ventral hippocampus in rats lead to prefrontal cognitive deficits at two maturational stages.
Topics: Aging; Animals; Animals, Newborn; Avoidance Learning; Cognition Disorders; Denervation; Disease Mode | 2006 |
Sleep and EEG profile in neonatal hippocampal lesion model of schizophrenia.
Topics: Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Electroencephalography; Electromyogr | 2007 |
Properties of [3H]AMPA binding in postmortem human brain from psychotic subjects and controls: increases in caudate nucleus associated with suicide.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Brain; Cadaver; Caudate Nucleus; Female; F | 1993 |
Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: a potential animal model of schizophrenia.
Topics: Animals; Animals, Newborn; Dextroamphetamine; Disease Models, Animal; Female; Haloperidol; Hippocamp | 1993 |
Cognitive effects of neonatal hippocampal lesions in a rat model of schizophrenia.
Topics: Amphetamine; Animals; Behavior, Animal; Brain Diseases; Central Nervous System Stimulants; Disease M | 1996 |
Social memory is impaired in neonatally ibotenic acid lesioned rats.
Topics: Animals; Animals, Newborn; Brain Mapping; Disease Models, Animal; Excitatory Amino Acid Antagonists; | 2000 |
The effects of ibotenic acid lesions of the medial and lateral prefrontal cortex on latent inhibition, prepulse inhibition and amphetamine-induced hyperlocomotion.
Topics: Amphetamine; Animals; Denervation; Disease Models, Animal; Dopamine; Hyperkinesis; Ibotenic Acid; Ma | 2000 |
Expression of AMPA receptor flip and flop mRNAs in the nucleus accumbens and prefrontal cortex after neonatal ventral hippocampal lesions.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Disease Models, Animal; Excitatory Amino Acids; | 2001 |
Glycine reduces novelty- and methamphetamine-induced locomotor activity in neonatal ventral hippocampal damaged rats.
Topics: Animals; Disease Models, Animal; Glycine; Hippocampus; Hyperkinesis; Ibotenic Acid; Methamphetamine; | 2001 |
Developmental and stress-related changes of neurotrophic factor gene expression in an animal model of schizophrenia.
Topics: Animals; Brain Chemistry; Brain-Derived Neurotrophic Factor; Denervation; Disease Models, Animal; Ex | 2001 |
Deficits in reward sensitivity in a neurodevelopmental rat model of schizophrenia.
Topics: Age Factors; Animals; Animals, Newborn; Conditioning, Psychological; Disease Models, Animal; Female; | 2002 |
Alpha-[3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding to human cerebral cortical membranes: minimal changes in postmortem brains of chronic schizophrenics.
Topics: 4-Chloromercuribenzenesulfonate; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Ac | 1992 |