ibotenic acid has been researched along with Parkinsonian Disorders in 8 studies
Ibotenic Acid: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.
Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Following postoperative recovery, we recorded sleep for 6h, induced anesthesia 24h later using ketamine/diazepam or pentobarbital, and repeated sleep recordings sessions 48h and 6days later." | 3.81 | Impact of anesthetic regimen on the respiratory pattern, EEG microstructure and sleep in the rat model of cholinergic Parkinson's disease neuropathology. ( Ciric, J; Kalauzi, A; Lazic, K; Petrovic, J; Saponjic, J, 2015) |
| "The severity of the abnormal involuntary movements induced by L-DOPA correlated with the basal firing parameters of LC neuronal activity." | 1.37 | The locus coeruleus is directly implicated in L-DOPA-induced dyskinesia in parkinsonian rats: an electrophysiological and behavioural study. ( Aristieta, A; Cenci, MA; Miguelez, C; Ugedo, L, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumbhare, D | 1 |
| Holloway, KL | 1 |
| Baron, MS | 1 |
| Gut, NK | 1 |
| Winn, P | 1 |
| Lazic, K | 1 |
| Petrovic, J | 1 |
| Ciric, J | 1 |
| Kalauzi, A | 1 |
| Saponjic, J | 1 |
| Miguelez, C | 1 |
| Aristieta, A | 1 |
| Cenci, MA | 1 |
| Ugedo, L | 1 |
| Hou, C | 1 |
| Xue, L | 1 |
| Feng, J | 1 |
| Zhang, L | 1 |
| Wang, Y | 1 |
| Chen, L | 1 |
| Wang, T | 1 |
| Zhang, QJ | 1 |
| Liu, J | 1 |
| Luo, J | 1 |
| Kaplitt, MG | 1 |
| Fitzsimons, HL | 1 |
| Zuzga, DS | 1 |
| Liu, Y | 1 |
| Oshinsky, ML | 1 |
| During, MJ | 1 |
| Bacci, JJ | 1 |
| Kachidian, P | 1 |
| Kerkerian-Le Goff, L | 1 |
| Salin, P | 1 |
| Wright, AK | 1 |
| Arbuthnott, GW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I Study of Subthalamic GAD Gene Transfer in Medically Refractory Parkinson's Disease Patients[NCT00195143] | Phase 1 | 12 participants | Interventional | 2003-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for ibotenic acid and Parkinsonian Disorders
| Article | Year |
|---|---|
Parkinsonism and dystonia are differentially induced by modulation of different territories in the basal ganglia.
Topics: Action Potentials; Animals; Dystonia; Electric Stimulation; Female; Globus Pallidus; Ibotenic Acid; | 2017 |
Deep brain stimulation of different pedunculopontine targets in a novel rodent model of parkinsonism.
Topics: Animals; Cell Survival; Cholinergic Neurons; Deep Brain Stimulation; Disease Models, Animal; Dopamin | 2015 |
Impact of anesthetic regimen on the respiratory pattern, EEG microstructure and sleep in the rat model of cholinergic Parkinson's disease neuropathology.
Topics: Adjuvants, Anesthesia; Anesthesia; Anesthetics; Animals; Brain; Diazepam; Electrocorticography; Elec | 2015 |
The locus coeruleus is directly implicated in L-DOPA-induced dyskinesia in parkinsonian rats: an electrophysiological and behavioural study.
Topics: Amphetamine; Animals; Behavior, Animal; Dyskinesias; Electrophysiology; Female; Ibotenic Acid; Levod | 2011 |
Unilateral lesion of the nigrostriatal pathway decreases the response of GABA interneurons in the dorsal raphe nucleus to 5-HT(1A) receptor stimulation in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Cell Count; Corpus Striatum; Dop | 2012 |
Subthalamic GAD gene therapy in a Parkinson's disease rat model.
Topics: Animals; Dependovirus; Disease Models, Animal; Dopamine; Electric Stimulation; Electrophysiology; ga | 2002 |
Intralaminar thalamic nuclei lesions: widespread impact on dopamine denervation-mediated cellular defects in the rat basal ganglia.
Topics: Adrenergic Agents; Animals; Autoradiography; Basal Ganglia; Carrier Proteins; Dopamine; Female; Gene | 2004 |
The influence of the subthalamic nucleus upon the damage to the dopamine system following lesions of globus pallidus in rats.
Topics: Animals; Cell Death; Cell Survival; Denervation; Dopamine; Globus Pallidus; Ibotenic Acid; Male; Ner | 2007 |