ibotenic acid has been researched along with Nerve Degeneration in 82 studies
Ibotenic Acid: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The nifedipine response was reproduced by isradipine and by verapamil with IC50 values of 9 and 100 nM, respectively." | 1.28 | Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity. ( Memo, M; Pizzi, M; Ribola, M; Spano, P; Valerio, A, 1991) |
| "Kainic acid treatment did not alter resting mean arterial pressure or heart rate." | 1.28 | Excitotoxin-induced degeneration of rat vagal afferent neurons. ( Beart, PM; Jarrott, B; Lewis, SJ; Louis, CJ; Louis, WJ; Verberne, AJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (21.95) | 18.7374 |
| 1990's | 31 (37.80) | 18.2507 |
| 2000's | 33 (40.24) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krause, KL | 1 |
| Forster, HV | 1 |
| Kiner, T | 1 |
| Davis, SE | 1 |
| Bonis, JM | 1 |
| Qian, B | 1 |
| Pan, LG | 1 |
| Perry, T | 1 |
| Haughey, NJ | 1 |
| Mattson, MP | 1 |
| Egan, JM | 1 |
| Greig, NH | 1 |
| Todtenkopf, MS | 1 |
| Stellar, JR | 1 |
| Melloni, RH | 1 |
| Luo, J | 1 |
| Kaplitt, MG | 1 |
| Fitzsimons, HL | 1 |
| Zuzga, DS | 1 |
| Liu, Y | 1 |
| Oshinsky, ML | 1 |
| During, MJ | 1 |
| Morimoto, K | 3 |
| Murasugi, T | 1 |
| Oda, T | 2 |
| Devi, L | 1 |
| Diwakar, L | 1 |
| Raju, TR | 2 |
| Kutty, BM | 2 |
| Mesples, B | 1 |
| Plaisant, F | 1 |
| Gressens, P | 2 |
| Ishida, K | 1 |
| Shimizu, H | 1 |
| Hida, H | 1 |
| Urakawa, S | 1 |
| Ida, K | 1 |
| Nishino, H | 1 |
| Conrad, CD | 1 |
| Jackson, JL | 1 |
| Wise, LS | 1 |
| Muñoz, AM | 1 |
| Rey, P | 1 |
| Parga, J | 1 |
| Guerra, MJ | 2 |
| Labandeira-Garcia, JL | 2 |
| Hu, Y | 1 |
| Xia, Z | 1 |
| Sun, Q | 1 |
| Orsi, A | 1 |
| Rees, D | 1 |
| Jerman, TS | 1 |
| Kesner, RP | 1 |
| Lee, I | 1 |
| Berman, RF | 1 |
| Bindu, B | 1 |
| Rekha, J | 1 |
| Keller, M | 1 |
| Yang, J | 1 |
| Griesmaier, E | 1 |
| Gorna, A | 1 |
| Sarkozy, G | 1 |
| Urbanek, M | 1 |
| Simbruner, G | 1 |
| Wright, AK | 1 |
| Arbuthnott, GW | 1 |
| Di Fausto, V | 1 |
| Fiore, M | 1 |
| Tirassa, P | 1 |
| Lambiase, A | 1 |
| Aloe, L | 1 |
| Contestabile, A | 2 |
| Migani, P | 1 |
| Poli, A | 1 |
| Villani, L | 1 |
| Hansen, S | 2 |
| Köhler, C | 5 |
| Fuxe, K | 3 |
| Ogren, SO | 1 |
| Hall, H | 1 |
| Agnati, LF | 1 |
| Andersson, K | 1 |
| Schwarcz, R | 5 |
| Goldstein, M | 2 |
| Steinbusch, HV | 1 |
| Lipska, BK | 1 |
| Chrapusta, SJ | 1 |
| Egan, MF | 1 |
| Weinberger, DR | 1 |
| Panocka, I | 1 |
| Sagratella, S | 1 |
| Scotti de Carolis, A | 1 |
| Zeng, YC | 1 |
| Amenta, F | 1 |
| Lobaugh, NJ | 1 |
| Norton, D | 1 |
| Novak, K | 1 |
| Amsel, A | 1 |
| Hartley, DM | 1 |
| Kurth, MC | 1 |
| Bjerkness, L | 1 |
| Weiss, JH | 2 |
| Choi, DW | 2 |
| Scotti, AL | 2 |
| Monard, D | 1 |
| Nitsch, C | 2 |
| Inglefield, JR | 1 |
| Schwarzkopf, SB | 1 |
| Kellogg, CK | 1 |
| Shaughnessy, LW | 1 |
| Barone, S | 1 |
| Mundy, WR | 1 |
| Herr, DW | 1 |
| Tilson, HA | 1 |
| Jarrard, LE | 1 |
| Meldrum, BS | 2 |
| Saji, M | 4 |
| Blau, AD | 1 |
| Volpe, BT | 5 |
| Stefanis, L | 1 |
| Burke, RE | 1 |
| Rao, BS | 1 |
| Meti, BL | 1 |
| Endo, Y | 1 |
| Miyanishi, T | 1 |
| Ohno, K | 1 |
| DeGiorgio, LA | 3 |
| Dibinis, C | 1 |
| Milner, TA | 1 |
| DeGiorgio, N | 1 |
| Nagata, S | 1 |
| Kubo, T | 2 |
| Kaneko, I | 2 |
| Zola, SM | 1 |
| Squire, LR | 1 |
| Teng, E | 1 |
| Stefanacci, L | 1 |
| Buffalo, EA | 1 |
| Clark, RE | 1 |
| Lança, AJ | 1 |
| Adamson, KL | 1 |
| Coen, KM | 1 |
| Chow, BL | 1 |
| Corrigall, WA | 1 |
| Montero, VM | 1 |
| Lacroix, L | 1 |
| Spinelli, S | 1 |
| White, W | 1 |
| Feldon, J | 1 |
| Hagemann, G | 1 |
| Redecker, C | 1 |
| Witte, OW | 1 |
| Halim, ND | 1 |
| Swerdlow, NR | 1 |
| Caldeira, JC | 1 |
| Franci, CR | 1 |
| De Leonibus, E | 1 |
| Mele, A | 1 |
| Oliverio, A | 1 |
| Pert, A | 1 |
| White, F | 1 |
| Nicoll, JA | 1 |
| Horsburgh, K | 1 |
| Sun, W | 1 |
| Panneton, WM | 1 |
| Muñoz, A | 1 |
| Lopez, A | 1 |
| Caruncho, HJ | 1 |
| Eid, T | 1 |
| Du, F | 1 |
| Glickstein, SB | 1 |
| Ilch, CP | 1 |
| Reis, DJ | 3 |
| Golanov, EV | 1 |
| Ciani, E | 1 |
| Baldinotti, I | 1 |
| Gerlai, RT | 1 |
| McNamara, A | 1 |
| Williams, S | 1 |
| Phillips, HS | 1 |
| Attardi, B | 1 |
| Shimizu, Y | 1 |
| Ogata, M | 1 |
| Hökfelt, T | 1 |
| Jonsson, G | 1 |
| Terenius, L | 1 |
| Zawia, N | 1 |
| Arendash, GW | 1 |
| Wecker, L | 1 |
| Lindefors, N | 1 |
| Boatell, ML | 1 |
| Mahy, N | 1 |
| Persson, H | 1 |
| Koh, JY | 1 |
| Palmer, E | 1 |
| Lin, A | 1 |
| Cotman, CW | 1 |
| Bakker, MH | 1 |
| Foster, AC | 2 |
| Stewart, GR | 1 |
| Olney, JW | 1 |
| Pathikonda, M | 1 |
| Snider, WD | 1 |
| Pizzi, M | 1 |
| Ribola, M | 1 |
| Valerio, A | 1 |
| Memo, M | 1 |
| Spano, P | 1 |
| Buchanan, SL | 1 |
| Erselius, RT | 2 |
| Wree, A | 2 |
| Moncada, C | 1 |
| Arvin, B | 1 |
| Le Peillet, E | 1 |
| Schoepp, DD | 2 |
| Ornstein, PL | 2 |
| Salhoff, CR | 2 |
| Leander, JD | 1 |
| Koh, J | 1 |
| Baimbridge, KG | 1 |
| Hajós, F | 1 |
| Kálmán, M | 1 |
| Zilles, K | 1 |
| Schleicher, A | 1 |
| Sótonyi, P | 1 |
| Lewis, SJ | 1 |
| Verberne, AJ | 1 |
| Louis, CJ | 1 |
| Jarrott, B | 1 |
| Beart, PM | 1 |
| Louis, WJ | 1 |
| Coffey, PJ | 1 |
| Perry, VH | 1 |
| Rawlins, JN | 1 |
| Hillman, CC | 1 |
| Pedata, F | 1 |
| Di Patre, PL | 1 |
| Giovannini, MG | 1 |
| Pazzagli, M | 1 |
| Pepeu, G | 1 |
| Morgan, IG | 1 |
| Benavides, J | 1 |
| Fage, D | 1 |
| Carter, C | 1 |
| Scatton, B | 1 |
| Gill, R | 1 |
| Woodruff, GN | 1 |
| Katz, IR | 1 |
| Iacovitti, L | 1 |
| Isacson, O | 1 |
| Fischer, W | 1 |
| Wictorin, K | 1 |
| Dawbarn, D | 1 |
| Björklund, A | 1 |
| Watanabe, K | 1 |
| Tanaka, T | 1 |
| Yonemasu, Y | 1 |
| Carpenter, P | 1 |
| Sefton, AJ | 1 |
| Dreher, B | 1 |
| Lim, WL | 1 |
| Jellestad, FK | 1 |
| Bakke, HK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of GLP-1 on Glucose Uptake in the CNS and Heart in Healthy Subjects During Normoglycaemia Assessed by Positron Emission Tomografi[NCT00256256] | 10 participants (Actual) | Interventional | 2005-11-30 | Completed | |||
| Phase I Study of Subthalamic GAD Gene Transfer in Medically Refractory Parkinson's Disease Patients[NCT00195143] | Phase 1 | 12 participants | Interventional | 2003-08-31 | Completed | ||
| The Relationship Between Neuropsychological Testing and MRI, PET and Blood Biomarkers in Neurodegenerative Disease (COBRE - Project 1): AIM 2[NCT03702816] | Phase 2 | 24 participants (Actual) | Interventional | 2018-12-13 | Terminated (stopped due to GE180 has limited Blood - brain barrier permeation, reducing its utility in neuroinflammation. COVID19 created supply chain issues, impacting enrollment.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Cingulate SUVR- GE180 binding potential in the cingulate ROI, as a marker of cingulate neuroinflammation. Cingulate neuroinflammation would be expected to relate to cingulate AD pathology, and given known cingulate lobe role in executive system function, is hypothesized to relate to measures of executive function in particular, with greater cingulate GE180 relating to poorer cognitive function. (NCT03702816)
Timeframe: Baseline (Single scan)
| Intervention | SUVR (Mean) |
|---|---|
| Control | 0.9994 |
| Mild Cognitive Impairment | 1.0387 |
| Alzheimer's Disease | 1.0554 |
| Parkinson's Disease | 0.9893 |
DRS- The Dementia Rating Scale is a comprehensive, but relatively brief assessment of overall cognitive functioning. The measure consists of items testing memory, attention, executive skills, and visuospatial skill, for a total of 144 points. A score of less than 124 is indicative of dementia level cognitive functioning. A higher score indicates a better outcome. (NCT03702816)
Timeframe: Baseline (Pre-scan)
| Intervention | score on a scale (Mean) |
|---|---|
| Control | 139.2 |
| Mild Cognitive Impairment | 130.4 |
| Alzheimer's Disease | 120.3 |
| Parkinson's Disease | 139.3 |
The executive function composite score is comprised from data from two gold-standard clinical measures of set-shifting and inhibition (Trail Making Test, part B; Delis Kaplan Executive Functioning Scale Color Word Inhibition, inhibition score). The raw score for each individual assessment is corrected for age based on published normative data for each test. These adjusted scores (T scores and/or scaled scores) are converted to z-scores, then the two z-scores are averaged together to create the composite score. A higher value is indicative of better executive function, a lower value is indicative of worse executive function. A z-score of 0 represents the sample mean. Composite Z-scores do not have direct clinical relevance. (NCT03702816)
Timeframe: Baseline (Pre-scan)
| Intervention | z score (Mean) |
|---|---|
| Control | 0.572 |
| Mild Cognitive Impairment | -0.011 |
| Alzheimer's Disease | -1.361 |
| Parkinson's Disease | 0.029 |
Frontal SUVR- GE180 binding potential in the frontal cortical ROI, as a marker of frontal neuroinflammation. Frontal neuroinflammation would be expected to relate to frontal lobe AD pathology, and given known frontal lobe role in executive system function, is hypothesized to relate to measures of executive function in particular, and also to memory and language dysfunction, as these have executive components. Greater frontal lobe GE180 is expected to relate to poorer cognitive function. (NCT03702816)
Timeframe: Baseline (Single scan)
| Intervention | SUVR (Mean) |
|---|---|
| Control | 0.8893 |
| Mild Cognitive Impairment | 0.9436 |
| Alzheimer's Disease | 0.8855 |
| Parkinson's Disease | 0.8850 |
The language composite score is comprised from data from two gold-standard clinical measures of confrontation naming and semantic fluency (Boston Naming Test; Animal Naming Test). The raw score for the Animal Naming Test is converted directly to a z-score based on published normative data. The Boston Naming Test is corrected for age based on published normative data, resulting in a scaled score, which is then converted to a z-score. Then the two z-scores are averaged together to create the composite score. A higher value is indicative of better language function, a lower value is indicative of worse language function. A z-score of 0 represents the sample mean. Composite Z-scores do not have direct clinical relevance. (NCT03702816)
Timeframe: Baseline (Pre-scan)
| Intervention | z score (Mean) |
|---|---|
| Control | 0.584 |
| Mild Cognitive Impairment | -0.234 |
| Alzheimer's Disease | -0.7272 |
| Parkinson's Disease | 0.541 |
The memory composite score is comprised from data from two gold-standard clinical measures of verbal and nonverbal memory (Rey Auditory Verbal Learning Test, delayed recall score; Brief Visuospatial Memory Test, Revised, delayed recall score). The raw score for each individual assessment is corrected for age based on published normative data for each test. These adjusted scores (T scores and/or scaled scores) are converted to z-scores, then the two z-scores are averaged together to create the composite score. A higher value is indicative of better memory function, a lower value is indicative of worse memory function. A z-score of 0 represents the sample mean. Composite Z-scores do not have direct clinical relevance. (NCT03702816)
Timeframe: Baseline (Pre-scan)
| Intervention | z score (Mean) |
|---|---|
| Control | 0.367 |
| Mild Cognitive Impairment | -0.675 |
| Alzheimer's Disease | -2.483 |
| Parkinson's Disease | -0.404 |
MoCA -The Montreal Cognitive Assessment is a brief screening tool, originally designed to detect patients with MCI in a memory disorders clinic [10]. Standard administration consists of 12 individual tasks grouped into seven cognitive domains (visuospatial/executive, naming; attention, language, abstraction, memory, and orientation). Task performance is summed generating both domain and a total score. An education correction of one point is added to the total score for individuals with 12 years of education or less. Scores range from 0-30, with a score of 26 or less indicating cognitive impairment. (NCT03702816)
Timeframe: Baseline (Pre-scan)
| Intervention | score on a scale (Mean) |
|---|---|
| Control | 26.0 |
| Mild Cognitive Impairment | 23.4 |
| Alzheimer's Disease | 18.3 |
| Parkinson's Disease | 27.5 |
Parietal SUVR - GE180 binding potential in the parietal cortical ROI, as a marker of parietal neuroinflammation. Parietal neuroinflammation would be expected to relate to parietal lobe AD pathology, and given known parietal lobe role in visual and executive system function, is hypothesized to relate to measures of visuospatial and executive skills in particular, with greater parietal lobe GE180 relating to poorer cognitive function. (NCT03702816)
Timeframe: Baseline (Single scan)
| Intervention | SUVR (Mean) |
|---|---|
| Control | 0.8701 |
| Mild Cognitive Impairment | 0.9241 |
| Alzheimer's Disease | 0.8847 |
| Parkinson's Disease | 0.8562 |
The speed composite score is comprised from data from two gold-standard clinical measures of speeded attention and psychomotor speed (Trail Making Test, part A; Symbol Digit Modalities Test, oral version). The raw score for the Symbol Digit Modalities Test, oral version is converted directly to a z-score based on published normative data. The Trail making Test, part A is corrected for age based on published normative data, resulting in a T-score, which is then converted to a z-score. Then the two z-scores are averaged together to create the composite score. A higher value is indicative of better speed function, a lower value is indicative of worse speed function. A z-score of 0 represents the sample mean. Composite Z-scores do not have direct clinical relevance. (NCT03702816)
Timeframe: Baseline (Pre-scan)
| Intervention | z score (Mean) |
|---|---|
| Control | 0.285 |
| Mild Cognitive Impairment | -0.013 |
| Alzheimer's Disease | -1.585 |
| Parkinson's Disease | -0.731 |
Temporal SUVR-- GE180 binding potential in the temporal cortical ROI, as a marker of temporal neuroinflammation. Temporal neuroinflammation would be expected to relate to temporal lobe AD pathology, and given known temporal lobe role in memory and language system function, is hypothesized to relate to measures of memory in particular, with greater temporal lobe GE180 relating to poorer memory and language function. (NCT03702816)
Timeframe: Baseline (Single scan)
| Intervention | SUVR (Mean) |
|---|---|
| Control | 0.9127 |
| Mild Cognitive Impairment | 0.9779 |
| Alzheimer's Disease | 0.9146 |
| Parkinson's Disease | 0.8899 |
Whole Brain GE180- GE180 binding potential in the whole brain, as a marker of global neuroinflammation. Global neuroinflammation would be expected to relate to more widespread pathology on average, and is hypothesized to relate to global measures of cognition, including the MoCA and DRS, with greater whole brain GE180 relating to poorer cognitive function overall. (NCT03702816)
Timeframe: Baseline (Single scan)
| Intervention | SUVR (Mean) |
|---|---|
| Control | 0.9179 |
| Mild Cognitive Impairment | 0.9711 |
| Alzheimer's Disease | 0.9351 |
| Parkinson's Disease | 0.9051 |
1 review available for ibotenic acid and Nerve Degeneration
| Article | Year |
|---|---|
Recent advances in the use of selective neuron-destroying agents for neurobiological research.
Topics: Animals; Aziridines; Choline; Colchicine; Folic Acid; Glutamates; Glutamic Acid; Ibotenic Acid; Kain | 1984 |
81 other studies available for ibotenic acid and Nerve Degeneration
| Article | Year |
|---|---|
Normal breathing pattern and arterial blood gases in awake and sleeping goats after near total destruction of the presumed pre-Botzinger complex and the surrounding region.
Topics: Adaptation, Physiological; Animals; Blood Pressure; Carbon Dioxide; Excitatory Amino Acid Agonists; | 2009 |
Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.
Topics: Animals; Basal Ganglia; Cell Death; Cell Survival; Cells, Cultured; Choline O-Acetyltransferase; Cyc | 2002 |
Neither ibotenic acid nor volkensin lesions of the nucleus accumbens shell affect the expression of cocaine sensitization.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine; Drug Administration Schedule; Excitatory Amin | 2002 |
Subthalamic GAD gene therapy in a Parkinson's disease rat model.
Topics: Animals; Dependovirus; Disease Models, Animal; Dopamine; Electric Stimulation; Electrophysiology; ga | 2002 |
Acute neuroinflammation exacerbates excitotoxicity in rat hippocampus in vivo.
Topics: Acute Disease; Animals; Excitatory Amino Acid Agonists; Hippocampus; Ibotenic Acid; Inflammation; Li | 2002 |
Selective neurodegeneration of hippocampus and entorhinal cortex correlates with spatial learning impairments in rats with bilateral ibotenate lesions of ventral subiculum.
Topics: Animals; Cell Count; Cell Survival; Entorhinal Cortex; Excitatory Amino Acid Agonists; Female; Hippo | 2003 |
Effects of interleukin-10 on neonatal excitotoxic brain lesions in mice.
Topics: Animals; Animals, Newborn; Cell Death; Cerebral Cortex; Cerebral Palsy; Drug Interactions; Encephali | 2003 |
Argyrophilic dark neurons represent various states of neuronal damage in brain insults: some come to die and others survive.
Topics: Animals; Brain; Brain Diseases; Brain Injuries; Caspase 3; Caspases; Cell Death; Cytoskeleton; Dendr | 2004 |
Chronic stress enhances ibotenic acid-induced damage selectively within the hippocampal CA3 region of male, but not female rats.
Topics: Acute Disease; Animals; Chronic Disease; Female; Hippocampus; Ibotenic Acid; Male; Nerve Degeneratio | 2004 |
Glial overexpression of heme oxygenase-1: a histochemical marker for early stages of striatal damage.
Topics: 5,7-Dihydroxytryptamine; Afferent Pathways; Animals; Astrocytes; Basal Ganglia Diseases; Biomarkers; | 2005 |
A new approach to the pharmacological regulation of memory: Sarsasapogenin improves memory by elevating the low muscarinic acetylcholine receptor density in brains of memory-deficit rat models.
Topics: Acetylcholinesterase; Age Factors; Amyloid beta-Peptides; Animals; Autoradiography; Brain; Disease M | 2005 |
Patterns of hippocampal cell loss based on subregional lesions of the hippocampus.
Topics: Animals; Cell Count; Colchicine; Dentate Gyrus; Entorhinal Cortex; Excitatory Amino Acid Agonists; F | 2005 |
Post insult enriched housing improves the 8-arm radial maze performance but not the Morris water maze task in ventral subicular lesioned rats.
Topics: Animals; Behavior, Animal; Environment Design; Excitatory Amino Acid Agonists; Hippocampus; Housing, | 2005 |
Erythropoietin is neuroprotective against NMDA-receptor-mediated excitotoxic brain injury in newborn mice.
Topics: Animals; Animals, Newborn; Brain; Cytoprotection; Disease Models, Animal; Drug Administration Schedu | 2006 |
The influence of the subthalamic nucleus upon the damage to the dopamine system following lesions of globus pallidus in rats.
Topics: Animals; Cell Death; Cell Survival; Denervation; Dopamine; Globus Pallidus; Ibotenic Acid; Male; Ner | 2007 |
Eye drop NGF administration promotes the recovery of chemically injured cholinergic neurons of adult mouse forebrain.
Topics: Acetylcholine; Animals; Basal Nucleus of Meynert; Cerebral Cortex; Choline O-Acetyltransferase; Chol | 2007 |
The importance of the peripeduncular nucleus in the neuroendocrine control of sexual behavior and milk ejection in the rat.
Topics: Animals; Body Weight; Dopamine; Female; Hydroxydopamines; Ibotenic Acid; Lactation; Male; Milk Eject | 1984 |
Effects of chronic treatment with l-sulpiride and haloperidol on central monoaminergic mechanisms.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Behavior, Animal; Biogenic Amines; Brain; Haloperidol; Hy | 1980 |
Evidence against an exclusive role of glutamate in kainic acid neurotoxicity.
Topics: Animals; Choline O-Acetyltransferase; Glutamates; Granulocytes; Hippocampus; Ibotenic Acid; Kainic A | 1980 |
Effects of ibotenic acid-induced neuronal degeneration in the medial preoptic area and the lateral hypothalamic area on sexual behavior in the male rat.
Topics: Animals; Hypothalamus; Ibotenic Acid; Male; Nerve Degeneration; Oxazoles; Preoptic Area; Rats; Rats, | 1982 |
Neonatal excitotoxic ventral hippocampal damage alters dopamine response to mild repeated stress and to chronic haloperidol.
Topics: Animals; Corpus Striatum; Dopamine; Female; Frontal Lobe; Haloperidol; Handling, Psychological; Hipp | 1995 |
Microanatomical and electrophysiological changes of the rat dentate gyrus caused by lesions of the nucleus basalis magnocellularis.
Topics: Animals; Cerebellar Nuclei; Choline O-Acetyltransferase; Electrophysiology; Hippocampus; Ibotenic Ac | 1995 |
Age and dose-related effects of hippocampal ibotenic acid on lesion size, mortality, and nonspatial working memory in infant rats.
Topics: Age Factors; Animals; Animals, Newborn; Brain Mapping; Dominance, Cerebral; Dose-Response Relationsh | 1995 |
Glutamate receptor-induced 45Ca2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim | 1993 |
Re-expression of glia-derived nexin/protease nexin 1 depends on mode of lesion-induction or terminal degeneration: observations after excitotoxin or 6-hydroxydopamine lesions of rat substantia nigra.
Topics: Amyloid beta-Protein Precursor; Animals; Carrier Proteins; Glial Fibrillary Acidic Protein; Ibotenic | 1994 |
Alterations in behavioral responses to stressors following excitotoxin lesions of dorsomedial hypothalamic regions.
Topics: Acoustic Stimulation; Animals; Anxiety; Behavior, Animal; Dorsomedial Hypothalamic Nucleus; Explorat | 1994 |
Comparison of intracranial infusions of colchicine and ibotenic acid as models of neurodegeneration in the basal forebrain.
Topics: Animals; Avoidance Learning; Basal Ganglia; Brain Chemistry; Catecholamines; Choline O-Acetyltransfe | 1994 |
Selective excitotoxic pathology in the rat hippocampus.
Topics: Animals; Brain; Brain Damage, Chronic; Cell Death; Hippocampus; Ibotenic Acid; Kainic Acid; Male; N- | 1993 |
Prevention of transneuronal degeneration of neurons in the substantia nigra reticulata by ablation of the subthalamic nucleus.
Topics: Animals; Caudate Nucleus; Globus Pallidus; Ibotenic Acid; Male; Nerve Degeneration; Neurons; Rats; R | 1996 |
Transneuronal degeneration in substantia nigra pars reticulata following striatal excitotoxic injury in adult rat: time-course, distribution, and morphology of cell death.
Topics: Animals; Cell Death; Excitatory Amino Acid Agonists; Globus Pallidus; Huntington Disease; Ibotenic A | 1996 |
Loss of hippocampal CA1 neurons and learning impairment in subicular lesioned rats.
Topics: Animals; Axons; Cell Count; Conditioning, Operant; Electroshock; Excitatory Amino Acid Antagonists; | 1997 |
Behavioral correlates of transneuronal degeneration of substantia nigra reticulata neurons are reversed by ablation of the subthalamic nucleus.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Functional Laterality; Gene Expression Re | 1997 |
Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury.
Topics: Animals; Apoptosis; Cell Count; Corpus Striatum; Excitatory Amino Acid Agonists; Ibotenic Acid; Male | 1998 |
Dizocilpine maleate, MK-801, but not 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline, NBQX, prevents transneuronal degeneration of nigral neurons after neurotoxic striatal-pallidal lesion.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Evaluation, Pr | 1999 |
[Amyloidogenic peptides such as beta-amyloid, amylin and calcitonin strongly enhance the susceptibility of rat hippocampal neurons to excitatory amino acids in vivo].
Topics: Amyloid; Amyloid beta-Peptides; Animals; Calcitonin; Cells, Cultured; Excitatory Amino Acid Agonists | 1998 |
Impaired recognition memory in monkeys after damage limited to the hippocampal region.
Topics: Animals; Behavior, Animal; Brain Ischemia; Excitatory Amino Acid Agonists; Hippocampus; Ibotenic Aci | 2000 |
The pedunculopontine tegmental nucleus and the role of cholinergic neurons in nicotine self-administration in the rat: a correlative neuroanatomical and behavioral study.
Topics: Acetylcholine; Animals; Aziridines; Behavior, Animal; Choline; Cholinergic Fibers; Denervation; Dihy | 2000 |
Attentional activation of the visual thalamic reticular nucleus depends on 'top-down' inputs from the primary visual cortex via corticogeniculate pathways.
Topics: Action Potentials; Animals; Attention; Denervation; Excitatory Amino Acid Agonists; Functional Later | 2000 |
The effects of ibotenic acid lesions of the medial and lateral prefrontal cortex on latent inhibition, prepulse inhibition and amphetamine-induced hyperlocomotion.
Topics: Amphetamine; Animals; Denervation; Disease Models, Animal; Dopamine; Hyperkinesis; Ibotenic Acid; Ma | 2000 |
Intact functional inhibition in the surround of experimentally induced focal cortical dysplasias in rats.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Electrophysiology; Epilepsy; Exc | 2000 |
Distributed neurodegenerative changes 2-28 days after ventral hippocampal excitotoxic lesions in rats.
Topics: Animals; Cerebral Cortex; Dopamine; Efferent Pathways; Excitatory Amino Acid Agonists; Hippocampus; | 2000 |
Prolactin and corticosterone secretion in response to acute stress after paraventricular nucleus lesion by ibotenic acid.
Topics: Acute Disease; Animals; Corticosterone; Denervation; Hypothalamo-Hypophyseal System; Ibotenic Acid; | 2000 |
Locomotor activity induced by the non-competitive N-methyl-D-aspartate antagonist, MK-801: role of nucleus accumbens efferent pathways.
Topics: Animals; Denervation; Dizocilpine Maleate; Dose-Response Relationship, Drug; Efferent Pathways; Exci | 2001 |
Alterations in ApoE and ApoJ in relation to degeneration and regeneration in a mouse model of entorhinal cortex lesion.
Topics: Animals; Apolipoproteins E; Clusterin; Dentate Gyrus; Disease Models, Animal; Entorhinal Cortex; Fun | 2001 |
Negative chronotropism of the heart is inhibited with lesions of the caudal medulla in the rat.
Topics: Animals; Denervation; Excitatory Amino Acid Agonists; Heart Rate; Ibotenic Acid; Medulla Oblongata; | 2001 |
Drastic neuronal loss in vivo by beta-amyloid racemized at Ser(26) residue: conversion of non-toxic [D-Ser(26)]beta-amyloid 1-40 to toxic and proteinase-resistant fragments.
Topics: Alzheimer Disease; Amino Acid Isomerases; Amino Acid Sequence; Aminopeptidases; Amyloid beta-Peptide | 2001 |
Long-term cortical atrophy after excitotoxic striatal lesion: effects of intrastriatal fetal-striatum grafts and implications for Huntington disease.
Topics: Animals; Atrophy; Brain Diseases; Cerebral Cortex; Corpus Striatum; Female; Fetal Tissue Transplanta | 2001 |
Ibotenate injections into the pre- and parasubiculum provide partial protection against kainate-induced epileptic damage in layer III of rat entorhinal cortex.
Topics: Animals; Convulsants; Disease Models, Animal; Entorhinal Cortex; Epilepsy; Epilepsy, Temporal Lobe; | 2001 |
Stimulation of the subthalamic vasodilator area and fastigial nucleus independently protects the brain against focal ischemia.
Topics: Animals; Brain Ischemia; Cerebellar Nuclei; Cerebrovascular Circulation; Denervation; Electric Stimu | 2001 |
Sustained, long-lasting inhibition of nitric oxide synthase aggravates the neural damage in some models of excitotoxic brain injury.
Topics: Animals; Basal Nucleus of Meynert; Brain; Brain Injuries; Calcium Channel Blockers; Choline O-Acetyl | 2001 |
Hippocampal dysfunction and behavioral deficit in the water maze in mice: an unresolved issue?
Topics: Animals; Behavior, Animal; Brain Injuries; Disease Models, Animal; Excitatory Amino Acid Agonists; F | 2002 |
17 beta-estradiol treatment retards excitotoxic delayed degeneration in substantia nigra reticulata neurons.
Topics: Animals; Cell Count; Cell Death; Corpus Striatum; Disease Models, Animal; Estradiol; Female; Functio | 2002 |
Ibotenic acid-induced neuronal degeneration: a morphological and neurochemical study.
Topics: Animals; Brain; Choline O-Acetyltransferase; Corpus Striatum; Dopamine; Enkephalins; Fluorescent Ant | 1979 |
Hippocampal lesions indicate differences between the excitotoxic properties of acidic amono acids.
Topics: Animals; Glutamates; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Nerve Degeneration; Neural Pathw | 1979 |
Ibotenic acid-induced calcium deposits in rat substantia nigra. Ultrastructure of their time-dependent formation.
Topics: Animals; Brain Diseases; Calcinosis; Ibotenic Acid; Male; Microscopy, Electron; Nerve Degeneration; | 1992 |
Basal forebrain cholinergic neurons in aged rat brain are more susceptible to ibotenate-induced degeneration than neurons in young adult brain.
Topics: Acetylcholinesterase; Aging; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Ibotenic Acid; M | 1992 |
Widespread neuronal degeneration after ibotenic acid lesioning of cholinergic neurons in the nucleus basalis revealed by in situ hybridization.
Topics: Animals; Autoradiography; Choline O-Acetyltransferase; gamma-Aminobutyric Acid; Glutamate Decarboxyl | 1992 |
A metabotropic glutamate receptor agonist does not mediate neuronal degeneration in cortical culture.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; | 1991 |
An investigation of the mechanisms of delayed neurodegeneration caused by direct injection of quinolinate into the rat striatum in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Convulsants; Corpus Striatum; Dialysis; Diaz | 1991 |
Excitotoxicity in the embryonic chick spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amin | 1991 |
Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Differential and reversal Pavlovian conditioning in rabbits with mediodorsal thalamic lesions: assessment of heart rate and eyeblink responses.
Topics: Animals; Blinking; Conditioning, Classical; Electroshock; Extinction, Psychological; Female; Heart R | 1991 |
Ultrastructure of axons in stereotaxically placed ibotenic acid-induced lesions of the hippocampus in the adult rat. Evidence for demyelination and degeneration of dispersed axons of passage.
Topics: Animals; Axons; Demyelinating Diseases; Hippocampus; Ibotenic Acid; Male; Microscopy, Electron; Nerv | 1991 |
Differential vulnerability of neurons toward local injection of ibotenic acid in the hippocampus of the adult rat. An electron microscopic study.
Topics: Animals; Hippocampus; Ibotenic Acid; Male; Microscopy, Electron; Nerve Degeneration; Neurons; Pyrami | 1991 |
Non-NMDA antagonists protect against kainate more than AMPA toxicity in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepi | 1991 |
Neuroprotectant effects of LY274614, a structurally novel systemically active competitive NMDA receptor antagonist.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competi | 1991 |
Cortical neurons containing somatostatin- or parvalbumin-like immunoreactivity are atypically vulnerable to excitotoxic injury in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Survival; Cel | 1990 |
Remote astrocytic response as demonstrated by glial fibrillary acidic protein immunohistochemistry in the visual cortex of dorsal lateral geniculate nucleus lesioned rats.
Topics: Afferent Pathways; Animals; Astrocytes; Cell Division; Female; Geniculate Bodies; Glial Fibrillary A | 1990 |
Excitotoxin-induced degeneration of rat vagal afferent neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Dose-Response Rel | 1990 |
An investigation into the early stages of the inflammatory response following ibotenic acid-induced neuronal degeneration.
Topics: Animals; Blood-Brain Barrier; Encephalitis; Gliosis; Ibotenic Acid; Macrophage Activation; Nerve Deg | 1990 |
CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Dibenzocyc | 1989 |
Cholinergic and noradrenergic denervations decrease labelled purine release from electrically stimulated rat cortical slices.
Topics: Adenosine; Adrenergic Fibers; Animals; Basal Ganglia; Cerebral Cortex; Choline O-Acetyltransferase; | 1989 |
AMPA is a powerful neurotoxin in the chicken retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chickens; Choline | 1987 |
Peripheral type benzodiazepine binding sites are a sensitive indirect index of neuronal damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Binding Sites; Cho | 1987 |
Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Aspartic Acid; Brain; | 1988 |
Cells proliferating in vitro to local brain injury are primarily of hematic origin and differ from those associated with anterograde degeneration.
Topics: Animals; Antibodies, Monoclonal; Antigens, Surface; Brain Injuries; Caudate Nucleus; Cell Division; | 1988 |
Astroglial response in the excitotoxically lesioned neostriatum and its projection areas in the rat.
Topics: Animals; Astrocytes; Caudate Nucleus; Cerebral Cortex; Female; Glial Fibrillary Acidic Protein; Glob | 1987 |
[Ibotenic acid-induced limbic seizures and neuronal degeneration].
Topics: Amygdala; Animals; Cats; Electroencephalography; Hippocampus; Ibotenic Acid; Injections; Limbic Syst | 1987 |
Role of target tissue in regulating the development of retinal ganglion cells in the albino rat: effects of kainate lesions in the superior colliculus.
Topics: Aging; Animals; Cell Count; Horseradish Peroxidase; Ibotenic Acid; Kainic Acid; Microinjections; Ner | 1986 |
Delayed transneuronal death of substantia nigra neurons prevented by gamma-aminobutyric acid agonist.
Topics: Animals; Cell Survival; gamma-Aminobutyric Acid; Ibotenic Acid; Male; Muscimol; Nerve Degeneration; | 1987 |
Passive avoidance after ibotenic acid and radio frequency lesions in the rat amygdala.
Topics: Amygdala; Animals; Arousal; Avoidance Learning; Brain Mapping; Corticosterone; Electroshock; Iboteni | 1985 |