ibotenic acid has been researched along with Huntington Disease in 18 studies
Ibotenic Acid: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bilateral ibotenic acid lesions of the anteromedial neostriatum produce neuropathological and behavioral changes in rats that are characterized by locomotor hyperactivity and severe maze learning impairments, which can be viewed as analogous to changes seen in Huntington disease." | 3.67 | Graft-induced behavioral recovery in an animal model of Huntington disease. ( Björklund, A; Dunnett, SB; Isacson, O, 1986) |
| "Huntington's disease is a dominantly inherited, progressive neurodegenerative disorder causing marked pathology in the basal ganglia." | 1.28 | Excitatory amino acid binding sites in the caudate nucleus and frontal cortex of Huntington's disease. ( Dure, LS; Penney, JB; Young, AB, 1991) |
| "The apomorphine test was highly reproducible and individual animals responded with a similar set and incidence of dyskinesia in successive tests." | 1.28 | A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon. ( Hantraye, P; Isacson, O; Maziere, M; Riche, D, 1990) |
| "Huntington's disease is accompanied by severe neuronal death in the striatum, but despite this cell loss, there is a marked increase in the striatal concentration of somatostatin-like immunoreactivity (SLI)." | 1.27 | Excitotoxin lesions do not mimic the alteration of somatostatin in Huntington's disease. ( Beal, MF; Burd, GD; Landis, DM; Marshall, PE; Martin, JB, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (33.33) | 18.7374 |
| 1990's | 10 (55.56) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mazurová, Y | 1 |
| Osterreicher, J | 1 |
| Valousková, V | 1 |
| Schwarcz, R | 1 |
| Köhler, C | 1 |
| Kremer, B | 1 |
| Tallaksen-Greene, SJ | 1 |
| Albin, RL | 1 |
| Stefanis, L | 1 |
| Burke, RE | 1 |
| Sjöborg, M | 1 |
| Pietz, K | 1 |
| Ahgren, A | 1 |
| Yamada, N | 1 |
| Lindvall, O | 1 |
| Funa, K | 1 |
| Odin, P | 1 |
| Muñoz, A | 1 |
| Lopez, A | 1 |
| Caruncho, HJ | 1 |
| Guerra, MJ | 1 |
| Labandeira-García, JL | 1 |
| Cotton, P | 1 |
| Schumacher, JM | 1 |
| Hantraye, P | 3 |
| Brownell, AL | 1 |
| Riche, D | 3 |
| Madras, BK | 1 |
| Davenport, PD | 1 |
| Maziere, M | 3 |
| Elmaleh, DR | 1 |
| Brownell, GL | 1 |
| Isacson, O | 7 |
| Dure, LS | 1 |
| Young, AB | 1 |
| Penney, JB | 1 |
| Beal, MF | 2 |
| Ferrante, RJ | 1 |
| Swartz, KJ | 1 |
| Kowall, NW | 1 |
| Sirinathsinghji, DJ | 1 |
| Wisden, W | 1 |
| Northrop, A | 1 |
| Hunt, SP | 1 |
| Dunnett, SB | 2 |
| Morris, BJ | 1 |
| Sofroniew, MV | 1 |
| Dawbarn, D | 2 |
| Brundin, P | 3 |
| Gage, FH | 2 |
| Emson, PC | 2 |
| Björklund, A | 4 |
| Marshall, PE | 1 |
| Burd, GD | 1 |
| Landis, DM | 1 |
| Martin, JB | 1 |
| Rossor, MN | 1 |
| Rehfeld, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NMDA-Receptor Blockade in Huntington's Chorea[NCT00001930] | Phase 2 | 25 participants | Interventional | 1999-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 other studies available for ibotenic acid and Huntington Disease
| Article | Year |
|---|---|
[An animal model of Huntington's disease: the development of histopathological changes within the neurotoxic lesions of the striatum in long-term surviving rats].
Topics: Animals; Corpus Striatum; Disease Models, Animal; Huntington Disease; Ibotenic Acid; Kainic Acid; Ne | 2002 |
Differential vulnerability of central neurons of the rat to quinolinic acid.
Topics: Animals; Brain; Corpus Striatum; Diencephalon; Epilepsy, Temporal Lobe; Hippocampus; Huntington Dise | 1983 |
AMPA and NMDA binding sites in the hypothalamic lateral tuberal nucleus: implications for Huntington's disease.
Topics: Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Glutamates; Glutamic Acid; Humans; H | 1993 |
Transneuronal degeneration in substantia nigra pars reticulata following striatal excitotoxic injury in adult rat: time-course, distribution, and morphology of cell death.
Topics: Animals; Cell Death; Excitatory Amino Acid Agonists; Globus Pallidus; Huntington Disease; Ibotenic A | 1996 |
Expression of platelet-derived growth factor after intrastriatal ibotenic acid injury.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Hunting | 1998 |
Long-term cortical atrophy after excitotoxic striatal lesion: effects of intrastriatal fetal-striatum grafts and implications for Huntington disease.
Topics: Animals; Atrophy; Brain Diseases; Cerebral Cortex; Corpus Striatum; Female; Fetal Tissue Transplanta | 2001 |
Neuroscientists begin to piece together more parts of Huntington's disease puzzle.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Brain Chemistry; Dise | 1992 |
A primate model of Huntington's disease: functional neural transplantation and CT-guided stereotactic procedures.
Topics: Animals; Apomorphine; Brain Tissue Transplantation; Carbon Radioisotopes; Caudate Nucleus; Cocaine; | 1992 |
Excitatory amino acid binding sites in the caudate nucleus and frontal cortex of Huntington's disease.
Topics: Adolescent; Adult; Age Factors; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Bind | 1991 |
Chronic quinolinic acid lesions in rats closely resemble Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atrophy; Biogenic Amines; Cerebra | 1991 |
Cellular localisation of neurotransmitter mRNAs in striatal grafts.
Topics: Animals; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; DNA, Antisense; Feta | 1990 |
A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon.
Topics: Animals; Apomorphine; Behavior, Animal; Brain Diseases; Caudate Nucleus; Disease Models, Animal; Dys | 1990 |
Apomorphine-induced dyskinesias after excitotoxic caudate-putamen lesions and the effects of neural transplantation in non-human primates.
Topics: Animals; Apomorphine; Brain Tissue Transplantation; Caudate Nucleus; Corpus Striatum; Disease Models | 1990 |
Neural grafting in a rat model of Huntington's disease: striosomal-like organization of striatal grafts as revealed by acetylcholinesterase histochemistry, immunocytochemistry and receptor autoradiography.
Topics: Acetylcholinesterase; Animals; Autoradiography; Corpus Striatum; Histocytochemistry; Huntington Dise | 1987 |
Excitotoxin lesions do not mimic the alteration of somatostatin in Huntington's disease.
Topics: Animals; Brain; Corpus Striatum; Disease Models, Animal; Enkephalin, Leucine; Humans; Huntington Dis | 1985 |
Neural grafting in a rat model of Huntington's disease: progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Choline O-Acetyltransferase; Corpus Striatum; Disease Model | 1985 |
Graft-induced behavioral recovery in an animal model of Huntington disease.
Topics: Animals; Attention; Behavior, Animal; Cognition; Corpus Striatum; Disease Models, Animal; Globus Pal | 1986 |
Cholecystokinin content in the basal ganglia in Huntington's disease. The expression of cholecystokinin immunoreactivity in striatal grafts to ibotenic acid-lesioned rat striatum.
Topics: Animals; Basal Ganglia; Brain Chemistry; Cell Survival; Cholecystokinin; Corpus Striatum; Disease Mo | 1985 |