Page last updated: 2024-10-21

ibotenic acid and Huntington Disease

ibotenic acid has been researched along with Huntington Disease in 18 studies

Ibotenic Acid: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.

Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Research Excerpts

ExcerptRelevanceReference
"Bilateral ibotenic acid lesions of the anteromedial neostriatum produce neuropathological and behavioral changes in rats that are characterized by locomotor hyperactivity and severe maze learning impairments, which can be viewed as analogous to changes seen in Huntington disease."3.67Graft-induced behavioral recovery in an animal model of Huntington disease. ( Björklund, A; Dunnett, SB; Isacson, O, 1986)
"Huntington's disease is a dominantly inherited, progressive neurodegenerative disorder causing marked pathology in the basal ganglia."1.28Excitatory amino acid binding sites in the caudate nucleus and frontal cortex of Huntington's disease. ( Dure, LS; Penney, JB; Young, AB, 1991)
"The apomorphine test was highly reproducible and individual animals responded with a similar set and incidence of dyskinesia in successive tests."1.28A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon. ( Hantraye, P; Isacson, O; Maziere, M; Riche, D, 1990)
"Huntington's disease is accompanied by severe neuronal death in the striatum, but despite this cell loss, there is a marked increase in the striatal concentration of somatostatin-like immunoreactivity (SLI)."1.27Excitotoxin lesions do not mimic the alteration of somatostatin in Huntington's disease. ( Beal, MF; Burd, GD; Landis, DM; Marshall, PE; Martin, JB, 1985)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19906 (33.33)18.7374
1990's10 (55.56)18.2507
2000's2 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mazurová, Y1
Osterreicher, J1
Valousková, V1
Schwarcz, R1
Köhler, C1
Kremer, B1
Tallaksen-Greene, SJ1
Albin, RL1
Stefanis, L1
Burke, RE1
Sjöborg, M1
Pietz, K1
Ahgren, A1
Yamada, N1
Lindvall, O1
Funa, K1
Odin, P1
Muñoz, A1
Lopez, A1
Caruncho, HJ1
Guerra, MJ1
Labandeira-García, JL1
Cotton, P1
Schumacher, JM1
Hantraye, P3
Brownell, AL1
Riche, D3
Madras, BK1
Davenport, PD1
Maziere, M3
Elmaleh, DR1
Brownell, GL1
Isacson, O7
Dure, LS1
Young, AB1
Penney, JB1
Beal, MF2
Ferrante, RJ1
Swartz, KJ1
Kowall, NW1
Sirinathsinghji, DJ1
Wisden, W1
Northrop, A1
Hunt, SP1
Dunnett, SB2
Morris, BJ1
Sofroniew, MV1
Dawbarn, D2
Brundin, P3
Gage, FH2
Emson, PC2
Björklund, A4
Marshall, PE1
Burd, GD1
Landis, DM1
Martin, JB1
Rossor, MN1
Rehfeld, JF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
NMDA-Receptor Blockade in Huntington's Chorea[NCT00001930]Phase 225 participants Interventional1999-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

18 other studies available for ibotenic acid and Huntington Disease

ArticleYear
[An animal model of Huntington's disease: the development of histopathological changes within the neurotoxic lesions of the striatum in long-term surviving rats].
    Acta medica (Hradec Kralove). Supplementum, 2002, Volume: 45, Issue:2

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Huntington Disease; Ibotenic Acid; Kainic Acid; Ne

2002
Differential vulnerability of central neurons of the rat to quinolinic acid.
    Neuroscience letters, 1983, Jul-15, Volume: 38, Issue:1

    Topics: Animals; Brain; Corpus Striatum; Diencephalon; Epilepsy, Temporal Lobe; Hippocampus; Huntington Dise

1983
AMPA and NMDA binding sites in the hypothalamic lateral tuberal nucleus: implications for Huntington's disease.
    Neurology, 1993, Volume: 43, Issue:8

    Topics: Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Glutamates; Glutamic Acid; Humans; H

1993
Transneuronal degeneration in substantia nigra pars reticulata following striatal excitotoxic injury in adult rat: time-course, distribution, and morphology of cell death.
    Neuroscience, 1996, Volume: 74, Issue:4

    Topics: Animals; Cell Death; Excitatory Amino Acid Agonists; Globus Pallidus; Huntington Disease; Ibotenic A

1996
Expression of platelet-derived growth factor after intrastriatal ibotenic acid injury.
    Experimental brain research, 1998, Volume: 119, Issue:2

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Hunting

1998
Long-term cortical atrophy after excitotoxic striatal lesion: effects of intrastriatal fetal-striatum grafts and implications for Huntington disease.
    Journal of neuropathology and experimental neurology, 2001, Volume: 60, Issue:8

    Topics: Animals; Atrophy; Brain Diseases; Cerebral Cortex; Corpus Striatum; Female; Fetal Tissue Transplanta

2001
Neuroscientists begin to piece together more parts of Huntington's disease puzzle.
    JAMA, 1992, Dec-16, Volume: 268, Issue:23

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biomarkers; Brain Chemistry; Dise

1992
A primate model of Huntington's disease: functional neural transplantation and CT-guided stereotactic procedures.
    Cell transplantation, 1992, Volume: 1, Issue:4

    Topics: Animals; Apomorphine; Brain Tissue Transplantation; Carbon Radioisotopes; Caudate Nucleus; Cocaine;

1992
Excitatory amino acid binding sites in the caudate nucleus and frontal cortex of Huntington's disease.
    Annals of neurology, 1991, Volume: 30, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Bind

1991
Chronic quinolinic acid lesions in rats closely resemble Huntington's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1991, Volume: 11, Issue:6

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atrophy; Biogenic Amines; Cerebra

1991
Cellular localisation of neurotransmitter mRNAs in striatal grafts.
    Progress in brain research, 1990, Volume: 82

    Topics: Animals; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; DNA, Antisense; Feta

1990
A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon.
    Experimental neurology, 1990, Volume: 108, Issue:2

    Topics: Animals; Apomorphine; Behavior, Animal; Brain Diseases; Caudate Nucleus; Disease Models, Animal; Dys

1990
Apomorphine-induced dyskinesias after excitotoxic caudate-putamen lesions and the effects of neural transplantation in non-human primates.
    Progress in brain research, 1990, Volume: 82

    Topics: Animals; Apomorphine; Brain Tissue Transplantation; Caudate Nucleus; Corpus Striatum; Disease Models

1990
Neural grafting in a rat model of Huntington's disease: striosomal-like organization of striatal grafts as revealed by acetylcholinesterase histochemistry, immunocytochemistry and receptor autoradiography.
    Neuroscience, 1987, Volume: 22, Issue:2

    Topics: Acetylcholinesterase; Animals; Autoradiography; Corpus Striatum; Histocytochemistry; Huntington Dise

1987
Excitotoxin lesions do not mimic the alteration of somatostatin in Huntington's disease.
    Brain research, 1985, Dec-30, Volume: 361, Issue:1-2

    Topics: Animals; Brain; Corpus Striatum; Disease Models, Animal; Enkephalin, Leucine; Humans; Huntington Dis

1985
Neural grafting in a rat model of Huntington's disease: progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting.
    Neuroscience, 1985, Volume: 16, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Choline O-Acetyltransferase; Corpus Striatum; Disease Model

1985
Graft-induced behavioral recovery in an animal model of Huntington disease.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:8

    Topics: Animals; Attention; Behavior, Animal; Cognition; Corpus Striatum; Disease Models, Animal; Globus Pal

1986
Cholecystokinin content in the basal ganglia in Huntington's disease. The expression of cholecystokinin immunoreactivity in striatal grafts to ibotenic acid-lesioned rat striatum.
    Annals of the New York Academy of Sciences, 1985, Volume: 448

    Topics: Animals; Basal Ganglia; Brain Chemistry; Cell Survival; Cholecystokinin; Corpus Striatum; Disease Mo

1985