ibotenic acid has been researched along with Cerebral Palsy in 11 studies
Ibotenic Acid: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.
Cerebral Palsy: A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thiorphan effects were mimicked by substance P (SP) and, in a less potent manner, by neurokinin A." | 1.33 | Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice. ( Dournaud, P; Fontaine, RH; Gressens, P; Lebas, F; Lelièvre, V; Leroux, P; Medja, F; Ouimet, T; Rougeot, C; Saria, A, 2006) |
| "Periventricular leukomalacia is one of the main causes of cerebral palsy." | 1.31 | Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge. ( Bac, P; Evrard, P; Gressens, P; Husson, I; Mesplès, B; Vamecq, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 8 (72.73) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Titomanlio, L | 1 |
| Bouslama, M | 1 |
| Le Verche, V | 1 |
| Dalous, J | 1 |
| Kaindl, AM | 1 |
| Tsenkina, Y | 1 |
| Lacaud, A | 1 |
| Peineau, S | 1 |
| El Ghouzzi, V | 1 |
| Lelièvre, V | 3 |
| Gressens, P | 10 |
| Sokolowska, P | 1 |
| Passemard, S | 1 |
| Mok, A | 1 |
| Schwendimann, L | 2 |
| Gozes, I | 1 |
| Mesples, B | 3 |
| Plaisant, F | 2 |
| Dommergues, MA | 2 |
| Verney, C | 1 |
| Sfaello, I | 1 |
| Baud, O | 1 |
| Arzimanoglou, A | 1 |
| Medja, F | 1 |
| Fontaine, RH | 1 |
| Lebas, F | 1 |
| Leroux, P | 1 |
| Ouimet, T | 1 |
| Saria, A | 1 |
| Rougeot, C | 1 |
| Dournaud, P | 1 |
| Favrais, G | 1 |
| Chen, A | 1 |
| Dimambro, N | 1 |
| Clowry, GJ | 1 |
| Lamboley, G | 1 |
| Evrard, P | 3 |
| Patkai, J | 1 |
| Fromont, G | 1 |
| Thornton, EM | 1 |
| Renauld, JC | 1 |
| Husson, I | 1 |
| Bac, P | 1 |
| Vamecq, J | 1 |
11 other studies available for ibotenic acid and Cerebral Palsy
| Article | Year |
|---|---|
Implanted neurosphere-derived precursors promote recovery after neonatal excitotoxic brain injury.
Topics: Animals; Animals, Newborn; Brain Injuries; Brain Tissue Transplantation; Cell Differentiation; Cell | 2011 |
Neuroprotective effects of NAP against excitotoxic brain damage in the newborn mice: implications for cerebral palsy.
Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Brain Injuries; Cerebral Palsy; Disease Mod | 2011 |
Effects of interleukin-10 on neonatal excitotoxic brain lesions in mice.
Topics: Animals; Animals, Newborn; Cell Death; Cerebral Cortex; Cerebral Palsy; Drug Interactions; Encephali | 2003 |
Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Antirheumatic Agents; Brain; Brain Injuries; Cell | 2003 |
Topiramate prevents excitotoxic damage in the newborn rodent brain.
Topics: Alanine; Animals; Animals, Newborn; Brain; Cerebral Palsy; Disease Models, Animal; Dose-Response Rel | 2005 |
Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice.
Topics: Animals; Animals, Newborn; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Cerebral Palsy; | 2006 |
Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain lesions in newborn mice.
Topics: Animals; Animals, Newborn; Brain; Cerebral Palsy; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinop | 2007 |
A comparison of behavioural and histological outcomes of periventricular injection of ibotenic acid in neonatal rats at postnatal days 5 and 7.
Topics: Animals; Animals, Newborn; Atrophy; Brain; Cerebral Cortex; Cerebral Palsy; Corpus Callosum; Disease | 2008 |
[Prenatal inhibition of intestinal vasoactive peptide and cerebral excitatory lesions in the newborn mouse].
Topics: Animals; Animals, Newborn; Cerebral Palsy; Disease Models, Animal; Drug Evaluation, Preclinical; Emb | 1999 |
Deleterious effects of IL-9-activated mast cells and neuroprotection by antihistamine drugs in the developing mouse brain.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cerebral Palsy; Cromolyn Sodium; Disease Models, | 2001 |
Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge.
Topics: Animals; Animals, Newborn; Antioxidants; Cell Death; Cerebral Palsy; Cystine; Denervation; Disease M | 2002 |