ibotenic acid has been researched along with Acute Confusional Senile Dementia in 47 studies
Ibotenic Acid: A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was aimed to explore the effects of ICS II on cognitive dysfunction and apoptotic response induced by excitatory neurotoxin ibotenic acid (IBO) injection in rats." | 3.88 | Icariside II ameliorates ibotenic acid-induced cognitive impairment and apoptotic response via modulation of MAPK pathway in rats. ( Deng, Y; Gao, J; Gong, Q; He, L; Zeng, L, 2018) |
| "To observe the effect of Bushen Yizhi Recipe (BYD) on somatostatin-like (SS-like) immuno-reactivity and SS mRNA expressed-positive neurons in Alzheimer disease (AD) model rats induced by D-galactose intraperitoneal and ibotenic acid (IBO) intracerebral injection." | 3.70 | [Effects of bushen yizhi recipe on somatostatin-like immunopositive and somatostatin messenger ribonucleic acid expressed-positive neurons in Alzheimer's disease model rats]. ( Hu, J; Liang, W; Wang, Q, 2000) |
| "Animal models of Alzheimer's Disease (AD) are designed to duplicate a subset of selected neuropathological, biochemical and behavioral changes that are associated with AD." | 2.38 | A primate model of Alzheimer's disease. ( Wenk, GL, 1993) |
| "Icariin is a flavonoid component of a traditional Chinese medicine reported to possess a broad spectrum of pharmacological effects." | 1.43 | Icariin, a major constituent from Epimedium brevicornum, attenuates ibotenic acid-induced excitotoxicity in rat hippocampus. ( Deng, Y; Gong, Q; Jin, F; Li, F; Shi, J; Zong, N, 2016) |
| "The spatial learning and memory of Alzheimer's disease (AD) rats in STL-bFGF-NP group were significantly improved compared with AD model group, and were also better than other preparations." | 1.40 | Intranasal nanoparticles of basic fibroblast growth factor for brain delivery to treat Alzheimer's disease. ( Chen, J; Feng, C; Jiang, X; Liu, Q; Pang, Z; Shao, X; Zhang, C; Zhang, Q, 2014) |
| "The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain." | 1.40 | Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease. ( Brundin, P; George, S; Gouras, GK; Graff, C; Grueninger, F; Petit, GH; Rönnbäck, A; Winblad, B, 2014) |
| "For the in vivo study, an Alzheimer's disease (AD) model with severe damage to the hippocampal tissue was constructed by injecting the hippocampi of rats with aggregated Aβ1-40, followed 48 h later by an injection of ibotenate [an agonist for N-methyl-d-aspartate (NMDA) receptor]." | 1.40 | SUN11602 has basic fibroblast growth factor-like activity and attenuates neuronal damage and cognitive deficits in a rat model of Alzheimer's disease induced by amyloid β and excitatory amino acids. ( Inoue, T; Murayama, N; Narii, N; Noshita, T; Ogino, R; Oka, T; Takemoto, N; Toba, T; Ueno, N; Yoshida, S, 2014) |
| "Memory deficits as the first symptom of Alzheimer's disease can be explained by the initial lesion of the entorhinal-hippocampal connection." | 1.29 | Plasticity and neurotransmitter receptor changes in Alzheimer's disease and experimental cortical infarcts. ( Kraemer, M; Qü, M; Schleicher, A; Schroeter, M; Witte, OW; Zilles, K, 1995) |
| "Ibotenic acid was injected into the nucleus basalis magnocellularis region of rat brain in order to study whether an elevation of lipase activities was associated with the degeneration of cholinergic neurons in this potential animal model of Alzheimer's disease." | 1.28 | Stimulation of mono- and diacylglycerol lipase activities in ibotenate-induced lesions of nucleus basalis magnocellularis. ( Farooqui, AA; Horrocks, LA; Wallace, LJ, 1991) |
| "Pentobarbital treatment reduced 2-DG accumulation in all brain areas examined and these reductions were not influenced by the nBM lesions." | 1.27 | Deoxyglucose uptake and choline acetyltransferase activity in cerebral cortex following lesions of the nucleus basalis magnocellularis. ( Fibiger, HC; Lamarca, MV, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (10.64) | 18.7374 |
| 1990's | 18 (38.30) | 18.2507 |
| 2000's | 11 (23.40) | 29.6817 |
| 2010's | 11 (23.40) | 24.3611 |
| 2020's | 2 (4.26) | 2.80 |
| Authors | Studies |
|---|---|
| Rezk, S | 2 |
| Lashen, S | 2 |
| El-Adl, M | 1 |
| Elshopakey, GE | 1 |
| Elghareeb, MM | 1 |
| Hendam, BM | 1 |
| Caceci, T | 1 |
| Cenciarelli, C | 2 |
| Marei, HE | 2 |
| Doulah, A | 1 |
| Mahmoodi, G | 1 |
| Pourmahdi Borujeni, M | 1 |
| He, L | 1 |
| Deng, Y | 2 |
| Gao, J | 1 |
| Zeng, L | 1 |
| Gong, Q | 2 |
| Zhang, J | 1 |
| Li, P | 1 |
| Wang, Y | 2 |
| Liu, J | 1 |
| Zhang, Z | 1 |
| Cheng, W | 1 |
| Zhang, C | 1 |
| Chen, J | 1 |
| Feng, C | 1 |
| Shao, X | 1 |
| Liu, Q | 1 |
| Zhang, Q | 1 |
| Pang, Z | 1 |
| Jiang, X | 1 |
| George, S | 1 |
| Rönnbäck, A | 1 |
| Gouras, GK | 1 |
| Petit, GH | 1 |
| Grueninger, F | 1 |
| Winblad, B | 1 |
| Graff, C | 1 |
| Brundin, P | 1 |
| Farag, A | 1 |
| Althani, A | 1 |
| Afifi, N | 1 |
| Abd-Elmaksoud, A | 1 |
| Pallini, R | 1 |
| Casalbore, P | 1 |
| Ogino, R | 1 |
| Murayama, N | 1 |
| Noshita, T | 1 |
| Takemoto, N | 1 |
| Toba, T | 1 |
| Oka, T | 1 |
| Narii, N | 1 |
| Yoshida, S | 1 |
| Ueno, N | 1 |
| Inoue, T | 1 |
| Arunsundar, M | 1 |
| Shanmugarajan, TS | 1 |
| Ravichandran, V | 1 |
| Zong, N | 1 |
| Li, F | 1 |
| Shi, J | 1 |
| Jin, F | 1 |
| Hosseini, N | 1 |
| Alaei, H | 1 |
| Reisi, P | 1 |
| Radahmadi, M | 1 |
| Kadish, I | 1 |
| van Groen, T | 1 |
| Zhao, Z | 1 |
| Zhao, S | 1 |
| Xu, N | 1 |
| Yu, C | 1 |
| Guan, S | 1 |
| Liu, X | 1 |
| Huang, L | 1 |
| Liao, W | 1 |
| Jia, W | 1 |
| Malek, M | 1 |
| Zahedi Asl, S | 1 |
| Sarkaki, A | 1 |
| Farbood, Y | 1 |
| Doulah, AH | 1 |
| Ahmed, T | 1 |
| Gilani, AH | 1 |
| Babar, E | 1 |
| Melik, E | 1 |
| Ozgünen, T | 1 |
| Kaya, M | 1 |
| Polat, S | 1 |
| Kubo, T | 2 |
| Nishimura, S | 1 |
| Kumagae, Y | 1 |
| Kaneko, I | 2 |
| Ahmed, MM | 1 |
| Hoshino, H | 1 |
| Chikuma, T | 1 |
| Yamada, M | 1 |
| Kato, T | 1 |
| Zhong, Z | 1 |
| Qu, Z | 1 |
| Wang, N | 1 |
| Wang, J | 1 |
| Xie, Z | 1 |
| Zhang, F | 1 |
| Zhang, W | 1 |
| Lu, Z | 1 |
| Zhong, ZG | 1 |
| Qu, ZQ | 1 |
| Wang, NP | 1 |
| Zhang, FF | 1 |
| Zhang, WY | 1 |
| Lu, UP | 1 |
| Hruska, Z | 1 |
| Dohanich, GP | 1 |
| Lamarca, MV | 1 |
| Fibiger, HC | 1 |
| London, ED | 1 |
| McKinney, M | 1 |
| Dam, M | 1 |
| Ellis, A | 1 |
| Coyle, JT | 2 |
| Krogsgaard-Larsen, P | 2 |
| Wahl, P | 1 |
| Schousboe, A | 1 |
| Madsen, U | 1 |
| Hansen, JJ | 2 |
| Vickers, JC | 1 |
| Huntley, GW | 1 |
| Edwards, AM | 1 |
| Moran, T | 1 |
| Rogers, SW | 1 |
| Heinemann, SF | 1 |
| Morrison, JH | 1 |
| Zilles, K | 1 |
| Qü, M | 1 |
| Schleicher, A | 1 |
| Schroeter, M | 1 |
| Kraemer, M | 1 |
| Witte, OW | 1 |
| Boatell, ML | 1 |
| Bendahan, G | 1 |
| Mahy, N | 1 |
| Ukai, M | 1 |
| Kobayashi, T | 1 |
| Kameyama, T | 1 |
| Wenk, GL | 2 |
| Bhattacharya, SK | 1 |
| Kumar, A | 1 |
| Le Mestric, C | 1 |
| Chavoix, C | 1 |
| Chapon, F | 1 |
| Mézenge, F | 1 |
| Epelbaum, J | 1 |
| Baron, JC | 1 |
| Nag, S | 1 |
| Tang, F | 1 |
| Sedman, AJ | 1 |
| Bockbrader, H | 1 |
| Schwarz, RD | 1 |
| Morimoto, K | 1 |
| Hu, J | 1 |
| Wang, Q | 1 |
| Liang, W | 1 |
| Xu, XH | 1 |
| Pan, YP | 1 |
| Wang, XL | 1 |
| Arendt, T | 1 |
| Brückner, MK | 1 |
| Lange, M | 1 |
| Bigl, V | 1 |
| Farooqui, AA | 1 |
| Wallace, LJ | 1 |
| Horrocks, LA | 1 |
| Dewar, D | 3 |
| Chalmers, DT | 3 |
| Graham, DI | 3 |
| McCulloch, J | 3 |
| Haroutunian, V | 1 |
| Santucci, AC | 1 |
| Davis, KL | 1 |
| Shand, A | 1 |
| Brooks, DN | 1 |
| Thal, LJ | 1 |
| Mandel, RJ | 1 |
| Terry, RD | 1 |
| Buzsaki, G | 1 |
| Gage, FH | 1 |
| Hohmann, GF | 1 |
| Lowenstein, P | 1 |
| Brown, ME | 1 |
| Murphy, DE | 1 |
| Boast, CA | 1 |
| Fine, A | 1 |
| Dunnett, SB | 1 |
| Björklund, A | 1 |
| Iversen, SD | 1 |
3 reviews available for ibotenic acid and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Excitatory amino acid research in Alzheimer's disease: enhancement and blockade of receptor functions.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Humans; Iboten | 1993 |
A primate model of Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Attention; Brain; Cholinergic Fibers; Disease Models, Ani | 1993 |
Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design.
Topics: Alzheimer Disease; Animals; Drug Design; Humans; Ibotenic Acid; Receptors, AMPA; Receptors, Glutamat | 1992 |
1 trial available for ibotenic acid and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Preclinical and phase 1 clinical characterization of CI-979/RU35926, a novel muscarinic agonist for the treatment of Alzheimer's disease.
Topics: Adolescent; Adult; Alzheimer Disease; Animals; Behavior, Animal; Body Temperature; Brain; Cerebrovas | 1995 |
43 other studies available for ibotenic acid and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Effects of Rosemary Oil (Rosmarinus officinalis) supplementation on the fate of the transplanted human olfactory bulb neural stem cells against ibotenic acid-induced neurotoxicity (Alzheimer model) in rat.
Topics: Alzheimer Disease; Animals; Antioxidants; Dietary Supplements; Humans; Ibotenic Acid; Maze Learning; | 2022 |
Evaluation of the pre-treatment effect of Centella asiatica medicinal plants on long-term potentiation (LTP) in rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Basal Nucleus of Meynert; Disease Models, Animal; Hippocampus; Ibotenic | 2020 |
Icariside II ameliorates ibotenic acid-induced cognitive impairment and apoptotic response via modulation of MAPK pathway in rats.
Topics: Alzheimer Disease; Animals; Apoptosis; Calbindins; Caspase 3; Cognitive Dysfunction; Down-Regulation | 2018 |
Ameliorative effects of a combination of baicalin, jasminoidin and cholic acid on ibotenic acid-induced dementia model in rats.
Topics: Alzheimer Disease; Animals; Cholic Acid; Dementia; Disease Models, Animal; Drug Combinations; Drugs, | 2013 |
Intranasal nanoparticles of basic fibroblast growth factor for brain delivery to treat Alzheimer's disease.
Topics: Administration, Intranasal; Alzheimer Disease; Animals; Area Under Curve; Blood-Brain Barrier; Brain | 2014 |
Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brai | 2014 |
Human olfactory bulb neural stem cells expressing hNGF restore cognitive deficit in Alzheimer's disease rat model.
Topics: Alzheimer Disease; Animals; Astrocytes; Cell Differentiation; Cell Line; Cell Proliferation; Cell- a | 2015 |
SUN11602 has basic fibroblast growth factor-like activity and attenuates neuronal damage and cognitive deficits in a rat model of Alzheimer's disease induced by amyloid β and excitatory amino acids.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzamides; Cognition; Disease Models, Animal; Fe | 2014 |
3,4-dihydroxyphenylethanol attenuates spatio-cognitive deficits in an Alzheimer's disease mouse model: modulation of the molecular signals in neuronal survival-apoptotic programs.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Cognition Disorders; Di | 2015 |
Icariin, a major constituent from Epimedium brevicornum, attenuates ibotenic acid-induced excitotoxicity in rat hippocampus.
Topics: Administration, Oral; Alzheimer Disease; Animals; Apoptosis; Calbindins; Drugs, Chinese Herbal; Epim | 2016 |
The effects of NBM- lesion on synaptic plasticity in rats.
Topics: Alzheimer Disease; Analysis of Variance; Animals; Basal Nucleus of Meynert; Dentate Gyrus; Disease M | 2017 |
Lesion-induced hippocampal plasticity in transgenic Alzheimer's disease mouse models: influences of age, genotype, and estrogen.
Topics: Acetylcholinesterase; Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disea | 2009 |
Lovastatin improves neurological outcome after nucleus basalis magnocellularis lesion in rats.
Topics: Acetylcholine; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Binding, Competitive; Cerebral | 2010 |
The effect of intra-hippocampal injection of growth hormone on spatial learning and memory in animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Excitatory Amino Acid Agonists; Growth Hormone; | 2009 |
A comparative study of curcuminoids to measure their effect on inflammatory and apoptotic gene expression in an Aβ plus ibotenic acid-infused rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosi | 2011 |
Effects of excitotoxic median raphe lesions on scopolamine-induced working memory deficits in inhibitory avoidance.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Behavior, Animal; Excitatory Amino Acid Agonists; Ib | 2002 |
In vivo conversion of racemized beta-amyloid ([D-Ser 26]A beta 1-40) to truncated and toxic fragments ([D-Ser 26]A beta 25-35/40) and fragment presence in the brains of Alzheimer's patients.
Topics: Aged; Aging; Alzheimer Disease; Amino Acid Isomerases; Amyloid beta-Peptides; Animals; Astrocytes; B | 2002 |
Effect of memantine on the levels of glial cells, neuropeptides, and peptide-degrading enzymes in rat brain regions of ibotenic acid-treated alzheimer's disease model.
Topics: Alzheimer Disease; Animals; Blotting, Western; Brain; Disease Models, Animal; Dopamine Agents; Elect | 2004 |
[Protective effects of Panax notoginseng saponins against pathological lesion of cholinergic neuron in rat model with Alzheimer' s disease].
Topics: Alzheimer Disease; Animals; Choline O-Acetyltransferase; Cholinergic Fibers; Disease Models, Animal; | 2005 |
[Effects of the Panax notoginseng saponins on the level of synaptophysin protein in brain in rat model with lesion of Meynert].
Topics: Alzheimer Disease; Animals; Basal Nucleus of Meynert; Brain; Galactose; Ginsenosides; Ibotenic Acid; | 2005 |
The effects of chronic estradiol treatment on working memory deficits induced by combined infusion of beta-amyloid (1-42) and ibotenic acid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Disease Models, Animal; Est | 2007 |
Deoxyglucose uptake and choline acetyltransferase activity in cerebral cortex following lesions of the nucleus basalis magnocellularis.
Topics: Alzheimer Disease; Animals; Basal Ganglia; Brain Diseases; Cerebral Cortex; Choline O-Acetyltransfer | 1984 |
Decreased cortical glucose utilization after ibotenate lesion of the rat ventromedial globus pallidus.
Topics: Alzheimer Disease; Animals; Autoradiography; Brain Diseases; Cerebral Cortex; Globus Pallidus; Gluco | 1984 |
Quantitative localization of AMPA/kainate and kainate glutamate receptor subunit immunoreactivity in neurochemically identified subpopulations of neurons in the prefrontal cortex of the macaque monkey.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Animals; Antibodies; Bi | 1993 |
Plasticity and neurotransmitter receptor changes in Alzheimer's disease and experimental cortical infarcts.
Topics: Alzheimer Disease; Animals; Autoradiography; Brain Diseases; Cerebral Cortex; Cerebral Infarction; D | 1995 |
Time-related cortical amino acid changes after basal forebrain lesion: a microdialysis study.
Topics: Alzheimer Disease; Amino Acids; Animals; Brain Diseases; Cerebral Cortex; Chromatography, High Press | 1995 |
Dynorphin A-(1-13) attenuates basal forebrain-lesion-induced amnesia in rats.
Topics: Alzheimer Disease; Amnesia; Animals; Avoidance Learning; Cognition; Disease Models, Animal; Dynorphi | 1993 |
Effect of Trasina, an ayurvedic herbal formulation, on experimental models of Alzheimer's disease and central cholinergic markers in rats.
Topics: Acetylcholine; Alzheimer Disease; Animals; Binding Sites; Choline O-Acetyltransferase; Cholinergic A | 1997 |
Effects of damage to the basal forebrain on brain glucose utilization: a reevaluation using positron emission tomography in baboons with extensive unilateral excitotoxic lesion.
Topics: Alzheimer Disease; Animals; Excitatory Amino Acid Agonists; Glucose; Ibotenic Acid; Male; Papio; Pro | 1998 |
Cholinergic lesions of the rat brain by ibotenic acid and 192 IgG-saporin: effects on somatostatin, substance P and neuropeptide Y levels in the cerebral cortex and the hippocampus.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Behavior, Animal; Brain Chemistry; Cerebral Cort | 1998 |
Drastic neuronal loss in vivo by beta-amyloid racemized at Ser(26) residue: conversion of non-toxic [D-Ser(26)]beta-amyloid 1-40 to toxic and proteinase-resistant fragments.
Topics: Alzheimer Disease; Amino Acid Isomerases; Amino Acid Sequence; Aminopeptidases; Amyloid beta-Peptide | 2001 |
[Effects of bushen yizhi recipe on somatostatin-like immunopositive and somatostatin messenger ribonucleic acid expressed-positive neurons in Alzheimer's disease model rats].
Topics: Alzheimer Disease; Animals; Brain; Drugs, Chinese Herbal; Female; Galactose; Ibotenic Acid; Neurons; | 2000 |
mRNA expression alterations of inward rectifier potassium channels in rat brain with cholinergic impairment.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Cerebral | 2002 |
Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development--a study of molecular forms.
Topics: Acetylcholinesterase; Adult; Afferent Pathways; Aged; Alzheimer Disease; Animals; Brain; Butyrylchol | 1992 |
Stimulation of mono- and diacylglycerol lipase activities in ibotenate-induced lesions of nucleus basalis magnocellularis.
Topics: Alzheimer Disease; Animals; Basal Ganglia; Brain; Cell Membrane; Disease Models, Animal; Functional | 1991 |
Glutamate metabotropic and AMPA binding sites are reduced in Alzheimer's disease: an autoradiographic study of the hippocampus.
Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease | 1991 |
Implications of multiple transmitter system lesions for cholinomimetic therapy in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Avoidance Learning; Cerebral Cortex; Choline O-Ace | 1990 |
Selective reduction of quisqualate (AMPA) receptors in Alzheimer cerebellum.
Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease | 1990 |
Differential alterations of cortical glutamatergic binding sites in senile dementia of the Alzheimer type.
Topics: Aged; Aged, 80 and over; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease | 1990 |
Nucleus basalis lesions fail to induce senile plaques in the rat.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Basal Ganglia; Choline O-Acetyltransferase; Diseas | 1990 |
Age-related recurrence of basal forebrain lesion-induced cholinergic deficits.
Topics: Age Factors; Aging; Alzheimer Disease; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Cholin | 1987 |
Searching for models of Alzheimer's disease: a comparison of four amnestic treatments in two behavioral tasks.
Topics: Acetylcholine; Age Factors; Alzheimer Disease; Animals; Avoidance Learning; Behavior, Animal; Discri | 1985 |
Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Avoidance Learning; Cholinergic Fibers; Disease Mo | 1985 |