i(3)so3-galactosylceramide and Polyps

Topics: Aging; Cerebroside-Sulfatase; Endometrial Neoplasms; Endometrium; Female; Humans; Polyps; Progesterone; Sulfoglycosphingolipids

To assess if arylsulfatase A activity (ASA) and sulfatide (SL) concentration in the human endometrium can be predictive of the development of endometrial polyps over the years, since ASA activity reflects the endometrial sensitivity to hormones.. ASA activity and SL concentration were determined by biochemical procedures on endometrial samples collected between 1990 and 1994 in non-menopausal women. These women underwent a new endometrial sampling following the clinical indication some years after the first endometrial sampling. The histological assessment of the second endometrial specimens found four patients with normal endometrial pattern and 10 patients with one or more endometrial polyps. ASA activity/years elapsed and SL concentration/years elapsed were compared using two tailed Mann-Whitney test for unpaired data between patients with normal pattern and patients with endometrial polyps.. Median ASA activities were 2.62 (normal pattern) versus 1.85 (endometrial polyps) nmol hydrolized substrate/min. Median activity/years elapsed is higher in patients with second endometrial sample presenting normal pattern (p=0.006) and median SL concentration/years elapsed does not differ significantly among groups, even if median SL concentration seems to be higher in patients who subsequently developed polyps (1031 µg/g of fresh tissue versus 341,5 µg/g of fresh tissue).. ASA activity can predict the onset of endometrial polyps over the years.

Topics: Adult; Cerebroside-Sulfatase; Endometrium; Female; Humans; Middle Aged; Polyps; Predictive Value of Tests; Prognosis; Retrospective Studies; Sulfoglycosphingolipids; Time Factors; Uterine Diseases

Polypoid masses metachromatic sulfatides have been found at autopsy in the gallbladder of patients with metachromatic leucodystrophy. In a 10-year-old girl with this disease oral cholecystrography demonstrated a filling defect, which was felt to represent a polyp. In the proper clinical setting, sulfatide cholecystosis should be considered in the differential diagnosis of polypoid lesions of the gallbladder.

Topics: Autopsy; Child; Female; Gallbladder Neoplasms; Humans; Leukodystrophy, Metachromatic; Polyps; Radiography; Sulfoglycosphingolipids