i(3)so3-galactosylceramide and Hepatitis--Chronic

i(3)so3-galactosylceramide has been researched along with Hepatitis--Chronic* in 3 studies

Other Studies

3 other study(ies) available for i(3)so3-galactosylceramide and Hepatitis--Chronic

ArticleYear
Autoimmune hepatitis.
    Internal medicine (Tokyo, Japan), 1993, Volume: 32, Issue:12

    Topics: Adrenal Cortex Hormones; Antibodies, Antinuclear; Autoantibodies; Autoimmune Diseases; Biomarkers; Diagnosis, Differential; Hepatitis C; Hepatitis, Chronic; Humans; Sulfoglycosphingolipids

1993
Antibodies against sulphatide in sera from patients with autoimmune rheumatic diseases.
    Clinical and experimental immunology, 1992, Volume: 87, Issue:3

    We tested sera of patients with various autoimmune rheumatic diseases for the presence of antibodies against sulphatide (an acidic glycosphingolipid), identified as a target antigen for antibodies against the liver cell membrane. Thirty-five percent (7/20) of patients with lupus in the active stage possessed anti-sulphatide antibodies, whereas 10% (2/20) of those in the inactive stage and 20% (4/20) of those in the stationary stage possessed such antibodies. Moreover, 10% (3/29) of patients with other autoimmune rheumatic diseases also possessed anti-sulphatide antibodies. The level of anti-sulphatide antibodies was significantly correlated with the levels of anti-double-stranded (ds) DNA antibodies (r = 0.634, P less than 0.001) and dextran sulphate-binding IgG (r = 0.407, P less than 0.001). The serum levels of antibodies against sulphatide were correlated with a history of seizures or psychosis in patients with autoimmune rheumatic diseases. Gels coupled with polyanionic dextran sulphate, monoanionic sulphanilic acid and DNA were shown effectively to adsorb anti-sulphatide antibodies in the sera of patients with active systemic lupus erythematosus (SLE) and autoimmune chronic active hepatitis (AI-CAH). These results suggest that the observed reactivity with sulphatide is due to the presence of antibodies capable of reacting with various anionic molecules in the sera of patients with autoimmune rheumatic diseases as well as those with AI-CAH.

    Topics: Adsorption; Antibodies, Antinuclear; Autoimmune Diseases; Cardiolipins; Chromatography, Gel; Dextran Sulfate; Enzyme-Linked Immunosorbent Assay; Heparitin Sulfate; Hepatitis, Chronic; Humans; Immunoglobulin G; Rheumatic Diseases; Sulfoglycosphingolipids

1992
Hepatocyte plasma membrane glycosphingolipid reactive with sera from patients with autoimmune chronic active hepatitis: its identification as sulfatide.
    Hepatology (Baltimore, Md.), 1990, Volume: 12, Issue:4 Pt 1

    Sera from patients with autoimmune chronic active hepatitis were found to contain IgG-class antibody to the acidic glycosphingolipid fraction from rabbit hepatocyte plasma membrane by solid-phase enzyme-linked immunosorbent assay. Using serum positive for the antibody as a probe, we isolated the target antigen by Iatrobeads column chromatography. Analysis by thin-layer chromatography and negative ion fast atom-bombardment mass spectrometry revealed that the antigen was sulfatide. The presence of antisulfatide antibody was also confirmed by immunoblotting. The reactivity of the serum with sulfatide was diminished by preincubation of the serum with galactosylceramide-6-sulfate and sulfatide, indicating that the antibody reacted with sulfated galactosylceramide regardless of the position of the sulfate residue. The antibody was found in 92.3%, 42.9%, 15.8%, 14.2%, 0% and 0%, respectively, of patients with autoimmune chronic active hepatitis, primary biliary cirrhosis, cirrhosis, systemic lupus erythematosus, chronic active hepatitis and chronic persistent hepatitis. Thus antisulfatide antibody was characteristic of autoimmune-type chronic liver diseases. Antisulfatide antibody was absorbed by rabbit hepatocyte plasma membrane. Preincubation of sera with sulfatide immobilized on Sepharose decreased their reactivities with not only sulfatide but also rabbit plasma membrane and rat hepatocytes. Therefore sulfatide may be a target antigen of the antibody to hepatocyte surface membrane.

    Topics: Antigens, Surface; Autoantibodies; Autoantigens; Autoimmune Diseases; Chromatography, Thin Layer; Enzyme-Linked Immunosorbent Assay; Glycosphingolipids; Hepatitis, Chronic; Humans; Liver; Membrane Lipids; Sulfoglycosphingolipids

1990
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