i(3)so3-galactosylceramide has been researched along with Brain-Injuries* in 2 studies
2 other study(ies) available for i(3)so3-galactosylceramide and Brain-Injuries
| Article | Year |
|---|---|
Impact of inhaled nitric oxide on the sulfatide profile of neonatal rat brain studied by TOF-SIMS imaging.
Despite advances in neonatal intensive care leading to an increased survival rate in preterm infants, brain lesions and subsequent neurological handicaps following preterm birth remain a critical issue. To prevent brain injury and/or enhance repair, one of the most promising therapies investigated in preclinical models is inhaled nitric oxide (iNO). We have assessed the effect of this therapy on brain lipid content in air- and iNO-exposed rat pups by mass spectrometry imaging using a time-of-flight secondary ion mass spectrometry (TOF-SIMS) method. This technique was used to map the variations in lipid composition of the rat brain and, particularly, of the white matter. Triplicate analysis showed a significant increase of sulfatides (25%-50%) in the white matter on Day 10 of life in iNO-exposed animals from Day 0-7 of life. These robust, repeatable and semi-quantitative data demonstrate a potent effect of iNO at the molecular level. Topics: Administration, Inhalation; Animals; Brain Injuries; Brain Mapping; Mass Spectrometry; Neuroprotective Agents; Nitric Oxide; Rats; Rats, Sprague-Dawley; Sulfoglycosphingolipids; White Matter | 2014 |
The fatty acid composition of sphingomyelin from adult human cerebral white matter and changes in childhood, senium and unspecific brain damage.
A micromethod for the investigation of the fatty acid composition of sphingomyelin in presented. In the cerebral white matter of 17 normal adult brains, analyzed for reference, the predominant fatty acids are C 18:0 and C 24:1. Our results are in agreement with those of other authors. Short chained fatty acids are relatively increased in young children; this shift is typical of "immature" myelin. Similar changes are described here in old persons and cases of non-specific brain damage associated with demyelination (autolysis, chronic uremia, juvenile chorea). Sphingomyelin fatty acid composition can be considered a sensitive measure of both disturbed myelination and demyelination. Topics: Adolescent; Adult; Age Factors; Aged; Brain Chemistry; Brain Injuries; Cerebrosides; Chemical Phenomena; Chemistry; Child, Preschool; Fatty Acids; Female; Humans; Huntington Disease; Infant; Male; Middle Aged; Sphingomyelins; Sulfoglycosphingolipids; Uremia | 1977 |