hypophyllanthin and Leukemia-P388

hypophyllanthin has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for hypophyllanthin and Leukemia-P388

Article	Year
1H- and 13C-nmr assignments of phyllanthin and hypophyllanthin: lignans that enhance cytotoxic responses with cultured multidrug-resistant cells. Journal of natural products, 1993, Volume: 56, Issue:2 Complete 1H-nmr data and unambiguous assignments of the 13C-nmr spectra of phyllanthin [1] and hypophyllanthin [2] were obtained through extensive nmr studies, including homonuclear COSY, homonuclear decoupling, APT, HETCOR, nOe difference, selective INEPT, and COLOC experiments. The absolute configuration of hypophyllanthin [2] was determined by cd. Neither of these lignans demonstrated significant cytotoxic activity when evaluated with a battery of cultured mammalian cells, but both were found to enhance the cytotoxic response mediated by vinblastine with multidrug-resistant KB cells. In addition, 1 was found to displace the binding of vinblastine with membrane vesicles derived from this cell line, suggesting an interaction with the P-glycoprotein. Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Membrane; Cell Survival; Drug Resistance; Drug Synergism; Glycoproteins; Humans; KB Cells; Leukemia P388; Lignans; Lignin; Magnetic Resonance Spectroscopy; Tumor Cells, Cultured; Vinblastine	1993

Article

Year

1H- and 13C-nmr assignments of phyllanthin and hypophyllanthin: lignans that enhance cytotoxic responses with cultured multidrug-resistant cells.

Journal of natural products, 1993, Volume: 56, Issue:2

Complete 1H-nmr data and unambiguous assignments of the 13C-nmr spectra of phyllanthin [1] and hypophyllanthin [2] were obtained through extensive nmr studies, including homonuclear COSY, homonuclear decoupling, APT, HETCOR, nOe difference, selective INEPT, and COLOC experiments. The absolute configuration of hypophyllanthin [2] was determined by cd. Neither of these lignans demonstrated significant cytotoxic activity when evaluated with a battery of cultured mammalian cells, but both were found to enhance the cytotoxic response mediated by vinblastine with multidrug-resistant KB cells. In addition, 1 was found to displace the binding of vinblastine with membrane vesicles derived from this cell line, suggesting an interaction with the P-glycoprotein.

Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Membrane; Cell Survival; Drug Resistance; Drug Synergism; Glycoproteins; Humans; KB Cells; Leukemia P388; Lignans; Lignin; Magnetic Resonance Spectroscopy; Tumor Cells, Cultured; Vinblastine

1993