hypocrellin-b and Opportunistic-Infections

Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin B showed weak antimicrobial activities. Hypocrellin A exhibited potent antileishmanial activity, while hypocrellin B was only moderately active. These results of promising antifungal and antileishmanial activity of hypocrellin A may be useful for further structure-activity relationship and in vivo studies.

Topics: Animals; Anti-Infective Agents; Antiprotozoal Agents; Bacteria; Fungi; Leishmania donovani; Microbial Sensitivity Tests; Opportunistic Infections; Perylene; Phenol; Quinones