hypochlorous acid has been researched along with Inflammation in 107 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (3.74) | 18.7374 |
| 1990's | 11 (10.28) | 18.2507 |
| 2000's | 27 (25.23) | 29.6817 |
| 2010's | 48 (44.86) | 24.3611 |
| 2020's | 17 (15.89) | 2.80 |
| Authors | Studies |
|---|---|
| Ge, Y; Hu, L; Huang, J; Li, C; Li, D; Li, Y; Lin, X; Luo, J; Man, M; Yu, H; Zhang, J | 1 |
| Kuang, G; Li, Y; Li, Z; Liang, M; Wang, H; Zhou, X | 1 |
| Nauseef, WM; Wang, G | 1 |
| Buhimschi, IA; Cater, JH; Georgiou, DK; Mañucat-Tan, NB; Ranson, M; Wyatt, AR; Zhao, G | 1 |
| Chen, Z; Gao, J; Li, H; Lv, J; Yang, M; Yuan, Z; Zeng, C | 1 |
| Cheng, D; He, L; Li, S; Liu, Y; Wang, P; Yang, K; Zhong, R | 1 |
| Baruah, M; Chang, YT; Cho, H; Kwon, HY; Samanta, A | 1 |
| Hublitz, KW; Stamatiades, EG | 1 |
| Arthur, PG; Bakker, AJ; Lea, TA; Panizza, PM; Pinniger, GJ | 1 |
| Marcinkiewicz, J; Walczewska, M | 1 |
| Chen, Y; Han, X; Ma, Y; Wang, X; Wang, Z | 1 |
| Davies, MJ; Hawkins, CL | 2 |
| Cheng, Q; Huang, J; Li, Z; Liu, Z; Wang, C; Wang, Z; Zhang, M; Zuo, M | 1 |
| Leichert, LI; Ulfig, A | 1 |
| Cassidy, CK; Guillemin, K; Ogba, OM; Perkins, A; Schirmer, T; Stansfeld, PJ; Teixeira, RD; Tudorica, DA; Zumwalt, L | 1 |
| Gilbert, JL; Kubacki, GW | 2 |
| Fernandes, E; Freitas, M; Lima, JLFC; Proença, C; Ribeiro, D; Silva, AMS; Soares, T; Tomé, SM | 1 |
| Jeong, S; Jung, Y; Kang, S; Kim, W; Lee, S; Lee, Y; Nam, J | 1 |
| Bäumer, W; Ehling, S; Fukuyama, T; Ganchingco, JR; Linder, KE; Martel, BC | 1 |
| Pitt, AR; Spickett, CM; Tveen-Jensen, K; Verrastro, I | 1 |
| Du, L; Gao, Y; Li, M; Li, X; Lin, Y; Liu, T; Tang, C; Zhang, C; Zhang, T; Zhang, X | 1 |
| Bhattacharya, P; Borah, A; Dave, KR; Kalia, K; Kaur, H; Pravalika, K; Saraf, J; Sarmah, D; Wanve, M; Yavagal, DR | 1 |
| Ford, DA; Kalogeris, TJ; Korthuis, RJ; McHowat, J; Wang, D; Wang, M; Yu, H | 1 |
| Bi, J; Feng, S; Gong, YJ; Liang, ZZ; Mao, GJ; Meng, HM; Su, L; Zhang, G; Zhang, H | 1 |
| Alhoshan, MS; El-Toni, AM; Fan, Y; Li, D; Liu, L; Wang, S; Zhang, F | 1 |
| Hu, W; Liu, Z; Mao, Z; Song, X; Wang, D | 1 |
| Bursill, C; Hawkins, CL; Macer-Wright, JL; Portman, N; Rayner, BS; Stanley, NR; Tan, JT | 1 |
| Chabielska, E; Golaszewska, A; Iwanicka, M; Leszczynska, A; Marcinczyk, N; Misztal, T; Rusak, T; Tomasiak-Lozowska, MM | 1 |
| Abdulhamid, I; Abdulridha, RM; Abu-Soud, HM; Diamond, MP; Maitra, D; Pennathur, S; Saed, GM; Shaeib, F | 1 |
| Heyes, DJ; Houee-Levin, C; Marignier, JL; Parsons, BJ; Paterson, AW; Sibanda, S | 1 |
| Albrett, AM; Chapman, AL; Dickerhof, N; Forbes, LV; Kettle, AJ; Khalilova, I; Turner, R | 1 |
| Arab, HH; Maghrabi, IA; Omar, HA; Salama, SA; Snapka, RM | 1 |
| Arnhold, J; Cherenkevich, SN; Gorudko, IV; Grigorieva, DV; Kostevich, VA; Mikhalchik, EV; Panasenko, OM; Shamova, EV; Sokolov, AV | 1 |
| Gorudko, IV; Panasenko, OM; Sokolov, AV | 1 |
| Bottle, SE; Davies, MJ; Fairfull-Smith, KE; Fu, S; Hawkins, CL; Kajer, TB; Yamada, K; Yamasaki, T | 1 |
| Hawkins, CL; Love, DT; Rayner, BS | 1 |
| Chapman, AL; Gangell, CL; Harwood, DT; Kettle, AJ; Khalilova, IS; Sly, PD; Turner, R; Winterbourn, CC | 1 |
| Dobson, CM; Gooden, CA; Kumita, JR; Mifsud, RW; Wilson, MR; Wyatt, AR | 1 |
| Chen, J; Chung, DW; Fu, X; Ling, M; López, JA; Wang, Y | 1 |
| Bochi, GV; da Silva, JE; de Almeida Vaucher, R; de Carvalho, JA; Moresco, RN; Torbitz, VD | 1 |
| Brand, D; Delikatny, EJ; Gomolin, I; Jeitner, TM; Kalogiannis, M; Palaia, T; Patrick, PA; Ragolia, L | 1 |
| Ciszek-Lenda, M; Jozefowski, S; Kozlowska, A; Marcinkiewicz, J; Surmiak, M; Walczewska, M | 1 |
| Agrawalla, BK; Chang, YT; Park, SJ; Peng, J; Sivaraman, B; Wang, L; Xu, QH; Yuan, L; Zhu, H | 1 |
| Albuquerque, KF; Bolin, AP; Marinovic, MP; Morandi, AC; Otton, R | 1 |
| Chang, SC; Delaney, JC; Essigmann, JM; Fedeles, BI; Freudenthal, BD; Li, D; Singh, V; Wilson, SH; Yau, E | 1 |
| Asahi, T; Harada, E; Hisaka, S; Kanno, T; Kato, Y; Nakamura, Y; Osawa, T; Shimoda, H; Wu, X | 1 |
| Asahi, T; Kato, Y; Nakamura, Y; Osawa, T | 1 |
| Barbisan, F; Bochi, GV; da Cruz, IB; de Campos, LP; Fernandes, NF; Gomes, P; Moresco, RN; Moretto, MB; Sangoi, MB; Torbitz, VD | 1 |
| Cheng, D; Maghzal, GJ; Stocker, R; Talib, J | 1 |
| Hardy, M; Kalyanaraman, B; Podsiadły, R; Zielonka, J; Zielonka, M | 1 |
| Altomare, A; Clerici, M; Colombo, G; Dalle-Donne, I; Garavaglia, ML; Giustarini, D; Milzani, A; Portinaro, N; Rossi, R; Rusconi, F | 1 |
| Dennis, JM; Kim, HB; McMahon, A; Szuchman-Sapir, A; Wang, XS; Witting, PK | 1 |
| Schiller, J; Schröter, J | 1 |
| Chiu, RK; Godschalk, RW; Güngör, N; Haenen, GR; Knaapen, AM; Munnia, A; Peluso, M; van Schooten, FJ | 1 |
| Lu, Z; Szép, S; Xu, Y | 1 |
| Abdulhamid, I; Abu-Soud, HM; Byun, J; Diamond, MP; Maitra, D; Pennathur, S; Saed, GM; Sliskovic, I | 1 |
| Assinger, A; Babeluk, R; Koller, E; Koller, F; Schmid, W; Volf, I; Zellner, M | 1 |
| Catapano, AL; Pirillo, A; Uboldi, P | 1 |
| Batteux, F; Kavian, N; Servettaz, A | 1 |
| Abu-Soud, HM; Diamond, MP; Maitra, D; Moura, AA; Pennathur, S; Saed, GM; Souza, CE | 1 |
| Aratani, Y; Miura, N; Ohno, N; Suzuki, K | 1 |
| Adam, M; Baldus, S; Klinke, A; Nussbaum, C; Sperandio, M | 1 |
| Gusev, AA; Gusev, SA; Kostevich, VA; Lobach, AS; Melnikova, VI; Sokolov, AV; Vakhrusheva, TV; Vlasova, II | 1 |
| Chapman, AL; Chen, B; Jameson, GN; Kettle, AJ; Khalilova, I; Mocatta, TJ; Paumann-Page, ME; Seidel, A; Shiva, S; Winterbourn, CC | 1 |
| Halliwell, B; Hooper, DC; Koprowski, H; Scott, GS; Whiteman, M | 1 |
| Hsu, FF; Lakshmi, VM; Zenser, TV | 1 |
| Byun, J; Heinecke, JW; Henderson, JP; Takeshita, J | 1 |
| Ames, BN; Blount, BC; Jiang, Q | 1 |
| Bergt, C; d'Avignon, A; Fu, X; Heinecke, JW; Huq, NP; Kao, JL; Kassim, SY; Mecham, RP; Parks, WC | 1 |
| Konat, GW; Krasowska, A | 1 |
| Harris, HE; Westman, E | 1 |
| Kawai, Y; Kondo, H; Miyoshi, N; Morinaga, H; Nakamura, Y; Osawa, T; Uchida, K | 1 |
| Arnhold, J; Gey, C; Glander, HJ; Grunewald, S; Lessig, J; Paasch, U; Schiller, J; Süss, R | 1 |
| Belaaouaj, A; Fu, X; Heinecke, JW; Shao, B; Verlinde, CL | 1 |
| Bobryshev, YV; Cai, H; Gaus, K; Geczy, CL; Lord, RS; McCormick, MM; Rahimi, F; Zreiqat, H | 1 |
| Mueller, S | 1 |
| Rabelink, TJ; van Zonneveld, AJ | 1 |
| Demling, N; Frank, S; Hammer, A; Malle, E; Marsche, G; Sattler, W; Schmidt, K; Semlitsch, M; Waeg, G; Weigle, B; Windischhofer, W | 1 |
| Ippolito, S; Mani, AR; Moore, KP; Moreno, JC; Visser, TJ | 1 |
| Harwood, DT; Kettle, AJ; Meotti, FC; Missau, FC; Pizzolatti, MG; Senthilmohan, R | 1 |
| Benson, R; Dever, GJ; Kennedy, S; Spickett, CM; Wainwright, CL | 1 |
| Spencer, JP; Whiteman, M | 1 |
| Balbi, A; Bevilacqua, M; Dallegri, F; Dapino, P; Ottonello, L; Scirocco, MC | 1 |
| Ciofani, G; Consoli, A; Cuccurullo, F; De Gioia, S; Di Ilio, C; Lapenna, D; Mezzetti, A | 1 |
| Kettle, AJ | 1 |
| Anderson, MM; Hazen, SL; Heinecke, JW; Hsu, FF | 1 |
| Crowley, JR; Hazen, SL; Heinecke, JW; Mueller, DM | 1 |
| d'Avignon, A; Hazen, SL; Heinecke, JW; Hsu, FF | 1 |
| Alewood, P; Geczy, CL; Harrison, CA; Iismaa, SE; Raftery, MJ; Thliveris, S; Walsh, J | 1 |
| Anderson, MM; Crowley, JR; Heinecke, JW; Requena, JR; Thorpe, SR | 1 |
| Kettle, AJ; Senthilmohan, R; van Dalen, CJ; Winterbourn, CC | 1 |
| Chapman, AL; Kettle, AJ; Senthilmohan, R; Winterbourn, CC | 1 |
| Kettle, AJ; Rothwell, LA; Vile, GF | 1 |
| Byun, J; Heinecke, JW; Henderson, JP; McCormick, ML; Mueller, DM; Williams, MV | 1 |
| Himmelfarb, J; McMonagle, E | 1 |
| Hayashi, K; Hosoe, H; Kaise, T; Ohmori, K | 1 |
| Nauseef, WM | 1 |
| Gröne, HJ; Malle, E; Sattler, W; Thiery, J; Wäg, G | 1 |
| Halliwell, B; Hoult, JR; Payá, M | 1 |
| Ballestrero, A; Dallegri, F; Ferrando, F; Ottonello, L; Patrone, F; Sacchetti, C | 1 |
| Be, RM; Gaginella, TS; Granger, DN; Grisham, MB; Tamai, H; von Ritter, C | 1 |
| Weiss, SJ | 1 |
| Ballestrero, A; Dallegri, F; Frumento, G; Patrone, F | 1 |
| Blake, DR; Halliwell, B; Hoult, JR | 1 |
| Collins-Lech, C; Severns, C; Sohnle, PG | 1 |
17 review(s) available for hypochlorous acid and Inflammation
| Article | Year |
|---|---|
Neutrophil dysfunction in the pathogenesis of cystic fibrosis.
Topics: Chlorides; Cystic Fibrosis; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Leukocyte Disorders; Neutrophils; Peroxidase | 2022 |
Neutrophils as Sentinel Cells of the Immune System: A Role of the MPO-halide-system in Innate and Adaptive Immunity.
Topics: Adaptive Immunity; Humans; Hypochlorous Acid; Immunity, Innate; Inflammation; Inflammation Mediators; Neutrophils; Peroxidase | 2020 |
The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease.
Topics: Animals; Arthritis; Atherosclerosis; Enzyme Inhibitors; Humans; Hypochlorous Acid; Inflammation; Kidney Diseases; Lung Diseases; Neoplasms; Neurodegenerative Diseases; Peroxidase | 2020 |
The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens.
Topics: Animals; Bacteria; Bacterial Infections; Bacterial Physiological Phenomena; Bromates; Extracellular Traps; Host-Pathogen Interactions; Humans; Hypochlorous Acid; Inflammation; Neutrophils; Phagocytosis; Thiocyanates | 2021 |
Role of myeloperoxidase and oxidant formation in the extracellular environment in inflammation-induced tissue damage.
Topics: Humans; Hypochlorous Acid; Inflammation; Oxidants; Oxidation-Reduction; Peroxidase | 2021 |
Myeloperoxidase and Neurological Disorder: A Crosstalk.
Topics: Animals; Humans; Hypochlorous Acid; Inflammation; Nervous System Diseases; Neutrophils; Oxidative Stress; Peroxidase | 2018 |
Measuring chlorine bleach in biology and medicine.
Topics: Animals; Humans; Hypochlorous Acid; Inflammation; Neutrophils; Peroxidase | 2014 |
Hypochlorous acid as a precursor of free radicals in living systems.
Topics: Animals; Free Radicals; Humans; Hypochlorous Acid; Inflammation; Oxidation-Reduction | 2013 |
Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells.
Topics: Animals; Bromates; Calcium; Endothelial Cells; Epithelial Cells; Erythrocytes; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Intracellular Signaling Peptides and Proteins; Oxidants; Oxidative Stress; Peroxidase; Signal Transduction; Thiocyanates | 2014 |
Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins.
Topics: Chlorohydrins; Fatty Acids; Gas Chromatography-Mass Spectrometry; Halogenation; Humans; Hypochlorous Acid; Inflammation; Peroxidase; Phospholipids; Reactive Oxygen Species | 2016 |
New insights on chemically induced animal models of systemic sclerosis.
Topics: Animals; Autoimmunity; Bleomycin; Disease Models, Animal; Fibrosis; Humans; Hypochlorous Acid; Inflammation; Mice; Reactive Oxygen Species; Scleroderma, Systemic | 2011 |
[Role of neutrophil-derived reactive oxygen species in host defense and inflammation].
Topics: Animals; Chemokine CXCL2; Disease Susceptibility; Humans; Hypochlorous Acid; Inflammation; Lung; Lung Diseases, Fungal; Metabolism, Inborn Errors; NADPH Oxidases; Neutrophil Activation; Neutrophils; Peroxidase; Phagocytes; Reactive Oxygen Species; Zymosan | 2012 |
Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular disease.
Topics: Cardiovascular Diseases; Humans; Hypochlorous Acid; Infections; Inflammation; Leukocytes; Neutrophils; Peroxidase | 2013 |
Manifestations of oxidant stress in uremia.
Topics: Biomarkers; Blood Proteins; C-Reactive Protein; Cardiovascular Diseases; Dose-Response Relationship, Drug; Elapid Venoms; Humans; Hypochlorous Acid; Inflammation; Kidney Failure, Chronic; Macrophage Activation; N-Formylmethionine Leucyl-Phenylalanine; Oxidation-Reduction; Oxidative Stress; Peroxidase; Phagocytes; Phagocytosis; Renal Dialysis; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate; Uremia | 2001 |
Contributions of myeloperoxidase to proinflammatory events: more than an antimicrobial system.
Topics: Animals; Anti-Infective Agents; Arteriosclerosis; Central Nervous System Diseases; Humans; Hypochlorous Acid; Inflammation; Peroxidase | 2001 |
Tissue destruction by neutrophils.
Topics: Animals; Humans; Hypochlorous Acid; Inflammation; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxygen | 1989 |
Oxidants, inflammation, and anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Humans; Hydrogen Peroxide; Hydroxides; Hypochlorous Acid; Inflammation; Oxygen; Superoxides | 1988 |
90 other study(ies) available for hypochlorous acid and Inflammation
| Article | Year |
|---|---|
Deficiency of vitamin D receptor in keratinocytes augments dermal fibrosis and inflammation in a mouse model of HOCl-induced scleroderma.
Topics: Animals; Collagen; Dermis; Disease Models, Animal; Fibrosis; Hypochlorous Acid; Inflammation; Keratinocytes; Mice, Inbred C57BL; Mice, Knockout; Receptors, Calcitriol; Skin Diseases; Up-Regulation | 2022 |
Hypochlorous Acid Can Be the Novel Option for the Meibomian Gland Dysfunction Dry Eye through Ultrasonic Atomization.
Topics: Adult; Asian People; Dry Eye Syndromes; Female; Humans; Hypochlorous Acid; Inflammation; Male; Meibomian Gland Dysfunction; Tears; Ultrasonics | 2022 |
A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Female; Humans; Hypochlorous Acid; Inflammation; Intracellular Signaling Peptides and Proteins; Molecular Chaperones; Placenta; Plasminogen Activator Inhibitor 2; Pre-Eclampsia; Pregnancy; Serine Proteinase Inhibitors | 2022 |
A Hydroxytricyanopyrrole-Based Fluorescent Probe for Sensitive and Selective Detection of Hypochlorous Acid.
Topics: Fluorescent Dyes; Humans; Hypochlorous Acid; Inflammation; Optical Imaging | 2022 |
A mitochondrial-targeted near-infrared fluorescent probe for visualizing the fluctuation of hypochlorite acid in idiopathic pulmonary fibrosis mice.
Topics: Animals; Fluorescent Dyes; Hypochlorous Acid; Idiopathic Pulmonary Fibrosis; Inflammation; Mice; Microscopy, Fluorescence | 2023 |
A Photoinduced Electron Transfer-Based Hypochlorite-Specific Fluorescent Probe for Selective Imaging of Proinflammatory M1 in a Rheumatoid Arthritis Model.
Topics: Animals; Arthritis, Rheumatoid; Electrons; Fluorescent Dyes; Hypochlorous Acid; Inflammation; Mice | 2023 |
Elucidating Immune Monitoring of Tissue-Resident Macrophages by Intravital Microscopy.
Topics: Animals; Hypochlorous Acid; Inflammation; Intravital Microscopy; Macrophages; Mice; Monitoring, Immunologic | 2024 |
Hypochlorous acid exposure impairs skeletal muscle function and Ca
Topics: Animals; Disease Models, Animal; Hypochlorous Acid; Inflammation; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Peroxidase | 2023 |
Enhancement of the Aggregation-Induced Emission by Hydrogen Bond for Visualizing Hypochlorous Acid in an Inflammation Model and a Hepatocellular Carcinoma Model.
Topics: Animals; Carcinoma, Hepatocellular; Disease Models, Animal; Female; Fluorescent Dyes; HeLa Cells; Humans; Hydrogen Bonding; Hypochlorous Acid; Inflammation; Lipopolysaccharides; Liver Neoplasms; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Optical Imaging; RAW 264.7 Cells | 2020 |
Monitoring Neuroinflammation with an HOCl-Activatable and Blood-Brain Barrier Permeable Upconversion Nanoprobe.
Topics: Animals; Blood-Brain Barrier; Hypochlorous Acid; Inflammation; Ischemic Stroke; Male; Mice; Molecular Probes; Nanoparticles; Optical Imaging; Permeability | 2020 |
A Bacterial Inflammation Sensor Regulates c-di-GMP Signaling, Adhesion, and Biofilm Formation.
Topics: Bacteria; Bacterial Adhesion; Biofilms; Cyclic GMP; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genome, Bacterial; Hypochlorous Acid; Inflammation; Signal Transduction | 2021 |
The effect of hypochlorous acid on the tribocorrosion of CoCrMo/Ti-6Al-4V bearing couples.
Topics: Alloys; Bone and Bones; Corrosion; Hip Prosthesis; Hypochlorous Acid; Inflammation; Oxidation-Reduction; Powders; Prostheses and Implants; Prosthesis Design; Surface Properties; Titanium; Vitallium | 2021 |
Chlorinated Flavonoids Modulate the Inflammatory Process in Human Blood.
Topics: Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Flavonoids; Humans; Hydrocarbons, Chlorinated; Hypochlorous Acid; Inflammation; Inflammation Mediators; Interleukin-8; Structure-Activity Relationship | 2017 |
Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid.
Topics: Animals; Anti-Inflammatory Agents; Colonic Neoplasms; HCT116 Cells; Heme Oxygenase-1; Humans; Hypochlorous Acid; Inflammation; Inflammatory Bowel Diseases; Kelch-Like ECH-Associated Protein 1; Male; Mesalamine; NF-E2-Related Factor 2; Oxidation-Reduction; Protein Binding; Rats; Rats, Sprague-Dawley | 2017 |
Hypochlorous acid is antipruritic and anti-inflammatory in a mouse model of atopic dermatitis.
Topics: Animals; Anti-Inflammatory Agents; Antigens, Dermatophagoides; Antipruritics; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Female; Hypochlorous Acid; Inflammation; Mice; Mice, Inbred BALB C | 2018 |
The effect of HOCl-induced modifications on phosphatase and tensin homologue (PTEN) structure and function.
Topics: Humans; Hypochlorous Acid; Inflammation; Oxidants; Oxidation-Reduction; Protein Conformation; PTEN Phosphohydrolase | 2018 |
Bioluminescent probe for detecting endogenous hypochlorite in living mice.
Topics: Animals; Cell Line, Tumor; Firefly Luciferin; Humans; Hypochlorous Acid; Inflammation; Luciferases; Luminescent Agents; Male; Mice; Zymosan | 2018 |
Chlorinated Lipids Elicit Inflammatory Responses in vitro and in vivo.
Topics: Aldehydes; Animals; Blood Platelets; Cell Adhesion; Cell Line; Endothelial Cells; Humans; Hypochlorous Acid; Inflammation; Male; Neutrophils; Peroxidase; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sepsis; Shock, Hemorrhagic | 2019 |
The effect of the inflammatory species hypochlorous acid on the corrosion and surface damage of Ti-6Al-4V and CoCrMo alloys.
Topics: Alloys; Biocompatible Materials; Corrosion; Humans; Hypochlorous Acid; Inflammation; Materials Testing; Prostheses and Implants; Surface Properties; Titanium; Vitallium | 2018 |
A near-infrared fluorescent probe based on photostable Si-rhodamine for imaging hypochlorous acid during lysosome-involved inflammatory response.
Topics: Animals; Escherichia coli; Fluorescence; Fluorescent Dyes; HeLa Cells; Humans; Hypochlorous Acid; Inflammation; Limit of Detection; Luminescent Measurements; Lysosomes; Mice; Mice, Nude; Microscopy, Fluorescence; RAW 264.7 Cells; Rhodamines | 2019 |
In Vivo High-resolution Ratiometric Fluorescence Imaging of Inflammation Using NIR-II Nanoprobes with 1550 nm Emission.
Topics: Biosensing Techniques; Fluorescent Dyes; Humans; Hypochlorous Acid; Inflammation; Lanthanoid Series Elements; Nanoparticles; Optical Imaging; Photons; Spectroscopy, Near-Infrared | 2019 |
A highly specific and ultrasensitive probe for the imaging of inflammation-induced endogenous hypochlorous acid.
Topics: Animals; Fluorescence; Fluorescent Dyes; HeLa Cells; Humans; Hydrogen-Ion Concentration; Hypochlorous Acid; Inflammation; Light; Limit of Detection; Lipopolysaccharides; Mice, Nude; Microscopy, Fluorescence; Rats | 2019 |
A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation.
Topics: Animals; Cells, Cultured; Halogenation; Hypochlorous Acid; Inflammation; Macrophages; Mice; Nucleosides | 2019 |
The myeloperoxidase product, hypochlorous acid, reduces thrombus formation under flow and attenuates clot retraction and fibrinolysis in human blood.
Topics: Blood Coagulation; Blood Platelets; Clot Retraction; Factor XIII; Fibrin; Fibrinogen; Fibrinolysis; Hemostasis; Humans; Hypochlorous Acid; Inflammation; Peroxidase; Thrombin; Thrombosis | 2019 |
Myeloperoxidase acts as a source of free iron during steady-state catalysis by a feedback inhibitory pathway.
Topics: Catalysis; Chlorides; Feedback, Physiological; Ferrozine; Free Radicals; Heme; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Iron; Kinetics; Metabolic Networks and Pathways; Oxidation-Reduction; Peroxidase | 2013 |
One-electron oxidation and reduction of glycosaminoglycan chloramides: a kinetic study.
Topics: Electron Spin Resonance Spectroscopy; Electrons; Extracellular Matrix; Glycosaminoglycans; Heparin; Hyaluronic Acid; Hydroxyl Radical; Hypochlorous Acid; Inflammation; Kinetics; Oxidation-Reduction; Pulse Radiolysis | 2013 |
Nicotine mediates hypochlorous acid-induced nuclear protein damage in mammalian cells.
Topics: Acetylcysteine; Antioxidants; Ascorbic Acid; Cell Line; Cell Proliferation; Chromans; Glutathione; Humans; Hypochlorous Acid; Inflammation; Kidney; Lung; Neutrophils; Nicotine; Oxidation-Reduction; Proliferating Cell Nuclear Antigen | 2014 |
Hypohalous acid-modified human serum albumin induces neutrophil NADPH oxidase activation, degranulation, and shape change.
Topics: Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; NADPH Oxidases; Neutrophil Activation; Neutrophils; Oxidants; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases; Serum Albumin | 2014 |
Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides.
Topics: Animals; Antioxidants; Cyclic N-Oxides; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Neutrophil Activation; Neutrophils; Peroxidase; Superoxide Dismutase; Superoxides | 2014 |
Oxidation contributes to low glutathione in the airways of children with cystic fibrosis.
Topics: Antioxidants; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Case-Control Studies; Child; Child, Preschool; Cystic Fibrosis; Glutathione; Humans; Hypochlorous Acid; Inflammation; Lung; Mass Spectrometry; Neutrophils; Oxidative Stress; Oxygen; Peroxidase; Radiography, Thoracic; Respiratory System; Retrospective Studies; Sulfones; Tomography, X-Ray Computed | 2014 |
Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin.
Topics: alpha-Macroglobulins; Animals; Cell Line; Cell Line, Tumor; Cell Survival; Humans; Hydrophobic and Hydrophilic Interactions; Hypochlorous Acid; Immunity, Innate; Inflammation; Mice; Molecular Chaperones; Oxidants; Oxygen; Protein Conformation; Protein Denaturation; Protein Folding; Protein Processing, Post-Translational; Surface Properties; Thermodynamics | 2014 |
Hypochlorous acid generated by neutrophils inactivates ADAMTS13: an oxidative mechanism for regulating ADAMTS13 proteolytic activity during inflammation.
Topics: ADAM Proteins; ADAMTS13 Protein; Chromatography, Liquid; Fibrinolysin; Gene Expression Regulation, Enzymologic; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Leukocyte Elastase; Mass Spectrometry; Methionine; Neutrophils; Oxidants; Oxygen; Peroxidase; Protein Structure, Tertiary; Thrombosis; von Willebrand Factor | 2015 |
In vitro oxidation of fibrinogen promotes functional alterations and formation of advanced oxidation protein products, an inflammation mediator.
Topics: Advanced Oxidation Protein Products; Fibrinogen; Humans; Hypochlorous Acid; Inflammation; Inflammation Mediators; Oxidation-Reduction; Oxidative Stress | 2015 |
Inflaming the diseased brain: a role for tainted melanins.
Topics: Animals; Apoptosis; Brain; Brain Chemistry; Cell Line, Tumor; Dopamine; Halogenation; Humans; Hypochlorous Acid; Immunohistochemistry; Inflammation; Male; Melanins; Mice, Inbred C57BL; Microscopy, Electron; Phagocytes; Phagocytosis; Spectrophotometry; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2015 |
Impact of Taurine on Innate and Adaptive Immunity as the Result of HOCl Neutralization.
Topics: Adaptive Immunity; Albumins; alpha 1-Antitrypsin; Animals; Antibody Formation; Hypochlorous Acid; Immunity, Innate; Inflammation; Mice; Mice, Inbred CBA; Ovalbumin; Oxidation-Reduction; Protein Processing, Post-Translational; Taurine | 2015 |
Development of targetable two-photon fluorescent probes to image hypochlorous Acid in mitochondria and lysosome in live cell and inflamed mouse model.
Topics: Animals; Cell Survival; Disease Models, Animal; Fluorescent Dyes; HeLa Cells; Humans; Hypochlorous Acid; Inflammation; Lipopolysaccharides; Lysosomes; Macrophages; Mice; Mitochondria; Molecular Structure; Photons; Spectrometry, Fluorescence | 2015 |
Green tea polyphenol extract in vivo attenuates inflammatory features of neutrophils from obese rats.
Topics: Animals; Antioxidants; Catalase; CD11b Antigen; Glucosephosphate Dehydrogenase; Hexokinase; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Interleukin-1beta; Interleukin-6; Male; Neutrophils; Obesity; Peroxidase; Phagocytosis; Plant Extracts; Polyphenols; Rats; Rats, Wistar; RNA, Messenger; Superoxides; Tea; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2016 |
Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer.
Topics: Biomarkers, Tumor; Carcinogenesis; Chromatography, High Pressure Liquid; Cytosine; DNA Mutational Analysis; Humans; Hypochlorous Acid; Inflammation; Inflammatory Bowel Diseases; Models, Molecular; Mutagenesis; Mutagens; Mutation; Neoplasms; Oligonucleotides; Peroxidase; Sequence Analysis, DNA | 2015 |
A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation.
Topics: Agaricales; Animals; Anti-Inflammatory Agents; Ascorbic Acid; Bromates; Deoxyguanosine; DNA; Ergothioneine; Glutathione; Halogenation; Hypochlorous Acid; Inflammation; Male; Mice; Mice, Hairless; Peroxidase; Ultraviolet Rays | 2016 |
Specific role of taurine in the 8-brominated-2'-deoxyguanosine formation.
Topics: Animals; Bromates; Chromatography, High Pressure Liquid; Deoxyguanosine; Halogenation; Humans; Hypochlorous Acid; In Vitro Techniques; Inflammation; Peroxidase; Tandem Mass Spectrometry; Taurine | 2015 |
In Vitro Oxidation of Collagen Promotes the Formation of Advanced Oxidation Protein Products and the Activation of Human Neutrophils.
Topics: Advanced Oxidation Protein Products; alpha-Tocopherol; Apoptosis; Cell Survival; Cells, Cultured; Collagen; Humans; Hypochlorous Acid; Inflammation; Neutrophil Activation; Neutrophils; Nitric Oxide; Oxidation-Reduction; Superoxides | 2016 |
Detailed protocol to assess in vivo and ex vivo myeloperoxidase activity in mouse models of vascular inflammation and disease using hydroethidine.
Topics: Animals; Biomarkers; Chromatography, Liquid; Disease Models, Animal; Halogenation; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Mice; Oxidation-Reduction; Peroxidase; Phenanthridines; Tandem Mass Spectrometry; Tyrosine; Vascular Diseases | 2016 |
On the use of peroxy-caged luciferin (PCL-1) probe for bioluminescent detection of inflammatory oxidants in vitro and in vivo - Identification of reaction intermediates and oxidant-specific minor products.
Topics: Animals; Cell Line; Firefly Luciferin; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Luminescent Measurements; Macrophages; Mice; Molecular Probes; Oxidation-Reduction; Peroxynitrous Acid; Spin Trapping | 2016 |
Thiol oxidation and di-tyrosine formation in human plasma proteins induced by inflammatory concentrations of hypochlorous acid.
Topics: Apolipoprotein A-I; Biomarkers; Blood Proteins; Blood Specimen Collection; Complement C3; Fibrinogen; Humans; Hypochlorous Acid; Inflammation; Mass Spectrometry; Oxidation-Reduction; Oxidative Stress; Peroxidase; Protein Aggregates; Sulfhydryl Compounds; Tyrosine | 2017 |
Neutrophils recruited to the myocardium after acute experimental myocardial infarct generate hypochlorous acid that oxidizes cardiac myoglobin.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Heart; Heart Failure; Heart Ventricles; Hypochlorous Acid; Immunohistochemistry; Inflammation; Male; Myocardial Infarction; Myocardium; Myoglobin; Neutrophils; Oxygen; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfoxides; Tandem Mass Spectrometry | 2016 |
Genotoxic effects of neutrophils and hypochlorous acid.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma; Animals; Cells, Cultured; Colony-Forming Units Assay; Deoxyguanosine; DNA Adducts; DNA Breaks, Single-Stranded; DNA Damage; Humans; Hypochlorous Acid; Hypoxanthine Phosphoribosyltransferase; Inflammation; Lipid Peroxidation; Lipopolysaccharides; Lung; Lung Neoplasms; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Mutation; Neutrophils; Oxidants; Peroxidase; Purine Nucleosides | 2010 |
The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases.
Topics: Analysis of Variance; Antioxidants; Cell Line; Cell Survival; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Lactoperoxidase; Lung; Peroxidase; Thiocyanates | 2009 |
Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid.
Topics: Antioxidants; Cardiovascular Diseases; Carotenoids; Chromatography, High Pressure Liquid; Free Radical Scavengers; Hypochlorous Acid; In Vitro Techniques; Inflammation; Lycopene; Mass Spectrometry; Oxidation-Reduction; Solanum lycopersicum | 2010 |
Specific binding of hypochlorite-oxidized HDL to platelet CD36 triggers proinflammatory and procoagulant effects.
Topics: Binding, Competitive; Blood Coagulation; Blood Platelets; Calcium Signaling; CD36 Antigens; CD40 Ligand; Flow Cytometry; Humans; Hypochlorous Acid; Inflammation; Inflammation Mediators; Lipoproteins, HDL; Male; Oxidants; Oxidation-Reduction; P-Selectin; Phosphatidylserines; Platelet Aggregation; Platelet Function Tests; Protein Binding; Reactive Oxygen Species; Time Factors | 2010 |
Dual effect of hypochlorite in the modification of high density lipoproteins.
Topics: Animals; Cell Line; Cholesterol; Hypochlorous Acid; Inflammation; Lipoproteins, HDL; Lipoproteins, HDL3; Macrophages; Mice | 2010 |
Hypochlorous acid-induced heme degradation from lactoperoxidase as a novel mechanism of free iron release and tissue injury in inflammatory diseases.
Topics: Animals; Biocatalysis; Cattle; Chromatography, High Pressure Liquid; Fluorescence; Heme; Hypochlorous Acid; Inflammation; Iron; Kinetics; Lactoperoxidase; Models, Biological; Organ Specificity; Protein Structure, Quaternary; Spectrum Analysis; Thiocyanates | 2011 |
PEGylated single-walled carbon nanotubes activate neutrophils to increase production of hypochlorous acid, the oxidant capable of degrading nanotubes.
Topics: Animals; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Injections, Intraperitoneal; Macrophages; Male; Mice; Mice, Inbred CBA; Nanotubes, Carbon; Neutrophil Activation; Neutrophils; Oxidants; Peritoneal Cavity; Peroxidase; Polyethylene Glycols; Sodium Hypochlorite | 2012 |
Ceruloplasmin is an endogenous inhibitor of myeloperoxidase.
Topics: Animals; Ascorbic Acid; Ceruloplasmin; Enzyme Inhibitors; Humans; Hypochlorous Acid; Inflammation; Mice; Mice, Knockout; Oxidation-Reduction; Peroxidase; Protein Binding | 2013 |
Inhibition of hypochlorous acid-induced cellular toxicity by nitrite.
Topics: Adenosine Triphosphate; Cell Line; Cell Survival; Chondrocytes; Glutathione; Humans; Hypochlorous Acid; Inflammation; L-Lactate Dehydrogenase; Nitrates; Nitric Oxide; Nitrites | 2002 |
Transformation and activation of benzidine by oxidants of the inflammatory response.
Topics: Animals; Benzidines; Benzoates; Biotransformation; Cattle; DNA; Glutathione; Hydrogen Peroxide; Hypochlorous Acid; Imidazoles; Inflammation; Mass Spectrometry; Oxidants; Oxidation-Reduction; Reactive Nitrogen Species; Reactive Oxygen Species | 2003 |
Phagocytes produce 5-chlorouracil and 5-bromouracil, two mutagenic products of myeloperoxidase, in human inflammatory tissue.
Topics: Bromouracil; Gas Chromatography-Mass Spectrometry; HL-60 Cells; Humans; Hydrogen-Ion Concentration; Hypochlorous Acid; Inflammation; Mutagenesis; Neutrophils; Peroxidase; Phagocytes; Uracil | 2003 |
5-Chlorouracil, a marker of DNA damage from hypochlorous acid during inflammation. A gas chromatography-mass spectrometry assay.
Topics: Alkaline Phosphatase; Animals; Biomarkers; Carrageenan; Cell Line; Chlorine; DNA; DNA Damage; Dose-Response Relationship, Drug; Electrons; Gas Chromatography-Mass Spectrometry; Hydrogen Peroxide; Hydrolysis; Hypochlorous Acid; Inflammation; Mice; Models, Chemical; Neutrophils; Nucleosides; Oxygen; Rats; Single-Strand Specific DNA and RNA Endonucleases; Thymidine Phosphorylase; Time Factors; Uracil | 2003 |
Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation.
Topics: Amino Acid Motifs; Catalytic Domain; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Deuterium; Glycine; Hydrogen; Hypochlorous Acid; Inflammation; Kinetics; Magnetic Resonance Spectroscopy; Mass Spectrometry; Matrix Metalloproteinase 7; Models, Chemical; Models, Molecular; Oxygen; Peptide Library; Peptides; Phagocytes; Spectrometry, Mass, Electrospray Ionization; Temperature; Tryptophan; Ultraviolet Rays | 2004 |
Vulnerability of brain tissue to inflammatory oxidant, hypochlorous acid.
Topics: Animals; Antioxidants; Brain; Dose-Response Relationship, Drug; Female; Hypochlorous Acid; Inflammation; Oxidants; Protein Biosynthesis; Rats; Rats, Sprague-Dawley | 2004 |
Alteration of an autoantigen by chlorination, a process occurring during inflammation, can overcome adaptive immune tolerance.
Topics: Adjuvants, Immunologic; Animals; Autoantigens; Chlorine; Electrophoresis, Polyacrylamide Gel; Hydrogen Peroxide; Hypochlorous Acid; Immune Tolerance; Inflammation; Oxidants; Peroxidase; Rats; Serum Albumin | 2004 |
Endogenous formation of novel halogenated 2'-deoxycytidine. Hypohalous acid-mediated DNA modification at the site of inflammation.
Topics: Animals; Antibodies, Monoclonal; Bromates; Chloramines; Chlorine; Chromatography, High Pressure Liquid; Chromatography, Liquid; Deoxycytidine; DNA; DNA Damage; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; HL-60 Cells; Humans; Hypochlorous Acid; Immunohistochemistry; Inflammation; Leukocytes; Lipopolysaccharides; Liver; Lung; Mass Spectrometry; Mice; Mice, Inbred C57BL; Models, Chemical; Oligonucleotides; Oxidants; Oxygen; Peroxidase; Phagocytosis; Reactive Oxygen Species; Sodium Hypochlorite; Time Factors | 2004 |
Hypochlorous acid-induced stress on human spermatozoa. A model for inflammation in the male genital tract.
Topics: Cell Membrane; Flow Cytometry; Humans; Hypochlorous Acid; Infertility, Male; Inflammation; Lysophosphatidylcholines; Male; Models, Biological; Oxidants; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spermatozoa; Stress, Physiological | 2005 |
Methionine sulfoxide and proteolytic cleavage contribute to the inactivation of cathepsin G by hypochlorous acid: an oxidative mechanism for regulation of serine proteinases by myeloperoxidase.
Topics: Animals; Catalytic Domain; Cathepsin G; Cathepsins; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Mass Spectrometry; Methionine; Mice; Models, Chemical; Models, Molecular; Neutrophils; Oxidants; Oxygen; Peptides; Peroxidase; Protein Binding; Serine Endopeptidases; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2005 |
S100A8 and S100A9 in human arterial wall. Implications for atherogenesis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Aorta; Apolipoproteins E; Arteries; Atherosclerosis; Blotting, Western; Calcium; Calgranulin A; Calgranulin B; Carotid Arteries; Cell Adhesion; Cell Movement; Cholesterol; Cross-Linking Reagents; Cytosol; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Foam Cells; Humans; Hypochlorous Acid; Immunohistochemistry; In Situ Hybridization; Inflammation; Lipids; Macrophages; Male; Microscopy, Electron; Microscopy, Electron, Transmission; Middle Aged; Monocytes; Neutrophils; Oxidants; Oxygen; Phenotype; Phospholipids; Phosphorylation; Recombinant Proteins; RNA, Messenger | 2005 |
Iron regulatory protein 1 as a sensor of reactive oxygen species.
Topics: Anemia; Chronic Disease; Doxorubicin; Homeostasis; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Iron; Iron Regulatory Protein 1; Oxidative Stress; Reactive Oxygen Species; Response Elements; Signal Transduction; Superoxides | 2005 |
Coupling eNOS uncoupling to the innate immune response.
Topics: Animals; Endothelium, Vascular; Hypochlorous Acid; Immunity, Innate; Inflammation; Mice; NADPH Oxidases; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Signal Transduction | 2006 |
Hypochlorite-modified albumin colocalizes with RAGE in the artery wall and promotes MCP-1 expression via the RAGE-Erk1/2 MAP-kinase pathway.
Topics: Albumins; Arteries; Cell Line; Chemokine CCL2; Gene Expression Regulation; Humans; Hypochlorous Acid; Inflammation; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Peroxidase; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Signal Transduction | 2007 |
The metabolism and dechlorination of chlorotyrosine in vivo.
Topics: Albumins; Animals; Catalysis; Chlorine; Gas Chromatography-Mass Spectrometry; Hypochlorous Acid; Inflammation; Male; Monocytes; Mutation; Peroxidase; Proteins; Rats; Rats, Sprague-Dawley; Tyrosine | 2007 |
Myricitrin as a substrate and inhibitor of myeloperoxidase: implications for the pharmacological effects of flavonoids.
Topics: Apoptosis; Chromatography, High Pressure Liquid; Enzyme Activation; Flavonoids; Free Radicals; Glutathione; Humans; Hypochlorous Acid; In Vitro Techniques; Inflammation; Neutrophils; Oxidation-Reduction; Peroxidase; Structure-Activity Relationship; Substrate Specificity | 2008 |
Phospholipid chlorohydrin induces leukocyte adhesion to ApoE-/- mouse arteries via upregulation of P-selectin.
Topics: Animals; Anticholesteremic Agents; Apolipoproteins E; Arteries; Atherosclerosis; Cell Adhesion; Chlorohydrins; Hypochlorous Acid; Inflammation; Intercellular Adhesion Molecule-1; Leukocytes; Lipoproteins, LDL; Mice; Mice, Knockout; Nitrates; P-Selectin; Phosphatidylcholines; Phospholipids; Pravastatin; Reactive Oxygen Species; Up-Regulation | 2008 |
Loss of 3-chlorotyrosine by inflammatory oxidants: implications for the use of 3-chlorotyrosine as a bio-marker in vivo.
Topics: Animals; Biomarkers; HL-60 Cells; Humans; Hypochlorous Acid; Inflammation; Macrophage Activation; Macrophages; Mice; Neutrophils; Nitrites; Oxidants; Peroxidase; Peroxynitrous Acid; Reactive Oxygen Species; Tyrosine | 2008 |
Sulphonamides as anti-inflammatory agents: old drugs for new therapeutic strategies in neutrophilic inflammation?
Topics: alpha 1-Antitrypsin; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Dapsone; Humans; Hypochlorous Acid; Inflammation; Leukocyte Elastase; Male; Neutrophil Activation; Neutrophils; Pancreatic Elastase; Sulfapyridine; Sulfonamides | 1995 |
Hypochlorous acid-induced zinc release from thiolate bonds: a potential protective mechanism towards biomolecules oxidant damage during inflammation.
Topics: alpha-Linolenic Acid; Animals; Antioxidants; Deoxyribose; Dimercaprol; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Iron; Organometallic Compounds; Oxidants; Zinc | 1994 |
Neutrophils convert tyrosyl residues in albumin to chlorotyrosine.
Topics: Amino Acid Sequence; Humans; Hypochlorous Acid; In Vitro Techniques; Inflammation; Molecular Sequence Data; Neutrophils; Oligopeptides; Peroxidase; Serum Albumin; Tyrosine | 1996 |
Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated
Topics: Acetaldehyde; Acrolein; Aldehydes; Amino Acids; Catalase; Chlorides; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Heme; Humans; Hydrogen Peroxide; Hydroxy Acids; Hypochlorous Acid; Inflammation; Lysine; Mass Spectrometry; Molecular Structure; Neutrophil Activation; Neutrophils; Oxidation-Reduction; Peroxidase; Serine; Threonine | 1997 |
Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attomole sensitivity: a sensitive and specific marker for myeloperoxidase-catalyzed chlorination at sites of inflammation.
Topics: Analysis of Variance; Aorta; Arteriosclerosis; Biomarkers; Calibration; Carbon; Carbon Isotopes; Catalysis; Chlorine; Female; Gas Chromatography-Mass Spectrometry; Humans; Hypochlorous Acid; Inflammation; Lipoproteins, LDL; Male; Peroxidase; Sensitivity and Specificity; Tyrosine | 1997 |
Human neutrophils employ myeloperoxidase to convert alpha-amino acids to a battery of reactive aldehydes: a pathway for aldehyde generation at sites of inflammation.
Topics: Aldehydes; Amino Acids; Catalysis; Chlorides; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Neutrophil Activation; Neutrophils; Oxidation-Reduction; Peroxidase | 1998 |
Oxidation regulates the inflammatory properties of the murine S100 protein S100A8.
Topics: Animals; Antigens, Differentiation; Bronchoalveolar Lavage Fluid; Calcium-Binding Proteins; Calgranulin A; Chemotactic Factors; Cysteine; Dimerization; Disulfides; HL-60 Cells; Humans; Hypochlorous Acid; Inflammation; Leukocytes; Mass Spectrometry; Mice; Mutation; Oxidants; Peroxidase; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1999 |
The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation.
Topics: Aldehydes; Catalase; Cations; Cells, Cultured; Chelating Agents; Glycosylation; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Lysine; Maillard Reaction; Neutrophils; Oxidation-Reduction; Peroxidase; Protein Processing, Post-Translational; Ribonuclease, Pancreatic; Serine; Sodium Azide | 1999 |
Nitrite as a substrate and inhibitor of myeloperoxidase. Implications for nitration and hypochlorous acid production at sites of inflammation.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Neutrophils; Nitrites; Oxidation-Reduction; Peroxidase; Spectrophotometry, Atomic; Spectrophotometry, Ultraviolet; Tyrosine | 2000 |
Comparison of mono- and dichlorinated tyrosines with carbonyls for detection of hypochlorous acid modified proteins.
Topics: Animals; Antibodies; Antibody Specificity; Bromates; Carbonic Acid; Cattle; Chlorine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epitopes; Hypochlorous Acid; Inflammation; Mass Spectrometry; Oxidants; Oxidative Stress; Serum Albumin; Tyrosine | 2000 |
Initiation of rapid, P53-dependent growth arrest in cultured human skin fibroblasts by reactive chlorine species.
Topics: Cell Division; Cell Survival; Cells, Cultured; Chloramines; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA; Dose-Response Relationship, Drug; Fibroblasts; Glycine; Humans; Hypochlorous Acid; Inflammation; Inflammation Mediators; Skin; Taurine; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53 | 2000 |
Production of brominating intermediates by myeloperoxidase. A transhalogenation pathway for generating mutagenic nucleobases during inflammation.
Topics: Bromine; Bromouracil; Deoxycytidine; DNA Damage; Humans; Hydrogen Peroxide; Hypochlorous Acid; Inflammation; Mutagens; Neutrophils; Oxidation-Reduction; Peroxidase; Uracil | 2001 |
Protective effect of erdosteine against hypochlorous acid-induced acute lung injury and lipopolysaccharide-induced neutrophilic lung inflammation in mice.
Topics: Administration, Oral; Animals; Bronchitis; Bronchoalveolar Lavage Fluid; Chronic Disease; Disease Models, Animal; Expectorants; Hypochlorous Acid; Inflammation; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred BALB C; Reactive Oxygen Species; Thioglycolates; Thiophenes; Tumor Necrosis Factor-alpha | 2000 |
Hypochlorite-modified (lipo)proteins are present in rabbit lesions in response to dietary cholesterol.
Topics: Animals; Arteriosclerosis; Cholesterol, Dietary; Diet, Atherogenic; Disease Models, Animal; Humans; Hyperlipidemias; Hypochlorous Acid; Inflammation; Lipoproteins; Monocytes; Oxidants; Peroxidase; Proteins; Rabbits | 2001 |
Interactions of a series of coumarins with reactive oxygen species. Scavenging of superoxide, hypochlorous acid and hydroxyl radicals.
Topics: Animals; Coumarins; Female; Free Radical Scavengers; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Hypochlorous Acid; Inflammation; Lipid Peroxidation; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Superoxides; Xanthine Oxidase | 1992 |
Inactivation of neutrophil-derived hypochlorous acid by nimesulide: a potential mechanism for the tissue protection during inflammation.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Hydrogen Peroxide; Hypochlorous Acid; In Vitro Techniques; Inflammation; Male; Neutrophils; Oxygen Consumption; Peroxidase; Sulfonamides; Superoxides | 1990 |
Effects of neutrophil-derived oxidants on intestinal permeability, electrolyte transport, and epithelial cell viability.
Topics: Animals; Body Water; Cell Membrane Permeability; Chloramines; Edetic Acid; Electrolytes; Epithelium; Hydrogen Peroxide; Hypochlorous Acid; Ileum; Inflammation; Intestinal Mucosa; Male; Neutrophils; Oxidation-Reduction; Rats; Rats, Inbred Strains; Taurine | 1990 |
Augmentation of neutrophil-mediated erythrocyte lysis by cells derived in vitro from human monocytes.
Topics: Cells, Cultured; Cytotoxicity, Immunologic; Erythrocytes; Free Radicals; Glucose Oxidase; Hemolysis; Humans; Hypochlorous Acid; Immunity, Cellular; In Vitro Techniques; Inflammation; Monocytes; Neutrophils; Oxygen; Peroxidase | 1987 |
Effect of temperature on production of hypochlorous acid by stimulated human neutrophils.
Topics: Cell Survival; Horseradish Peroxidase; Humans; Hydrogen Peroxide; Hypochlorous Acid; In Vitro Techniques; Inflammation; Neutrophils; Peroxidase; Phagocytosis; Superoxides; Taurine; Temperature | 1986 |