hyperoside and Stroke

hyperoside has been researched along with Stroke* in 1 studies

Other Studies

1 other study(ies) available for hyperoside and Stroke

Article	Year
Hyperoside ameliorates cerebral ischaemic-reperfusion injury by opening the TRPV4 channel Pharmaceutical biology, 2023, Volume: 61, Issue:1 Hyperoside (Hyp), one of the active flavones from. To explore the effect of Hyp on vasodilatation in the cerebral basilar artery (CBA) of Sprague-Dawley (SD) rats suffering with ischaemic-reperfusion (IR) injury.. Sprague-Dawley rats were randomly divided into sham, model, Hyp, Hyp + channel blocker and channel blocker groups. Hyp (50 mg/kg, IC. Hyp treatment significantly ameliorated the brain damage induced by IR and evoked endothelium-dependent vasodilation rate (47.93 ± 3.09% vs. 2.99 ± 1.53%) and hyperpolarization (-8.15 ± 1.87 mV vs. -0.55 ± 0.42 mV) by increasing the expression of IP3R, PKC, transient receptor potential vanilloid channel 4 (TRPV4), IK. Although Hyp showed protective effect in ischaemic stroke, more clinical trial certification is needed due to the difference between animals and humans. Topics: Animals; Antineoplastic Agents; Brain Ischemia; Endothelial Cells; Humans; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke; TRPV Cation Channels; Vasodilation	2023

Article

Year

Hyperoside ameliorates cerebral ischaemic-reperfusion injury by opening the TRPV4 channel

Pharmaceutical biology, 2023, Volume: 61, Issue:1

Hyperoside (Hyp), one of the active flavones from. To explore the effect of Hyp on vasodilatation in the cerebral basilar artery (CBA) of Sprague-Dawley (SD) rats suffering with ischaemic-reperfusion (IR) injury.. Sprague-Dawley rats were randomly divided into sham, model, Hyp, Hyp + channel blocker and channel blocker groups. Hyp (50 mg/kg, IC. Hyp treatment significantly ameliorated the brain damage induced by IR and evoked endothelium-dependent vasodilation rate (47.93 ± 3.09% vs. 2.99 ± 1.53%) and hyperpolarization (-8.15 ± 1.87 mV vs. -0.55 ± 0.42 mV) by increasing the expression of IP3R, PKC, transient receptor potential vanilloid channel 4 (TRPV4), IK. Although Hyp showed protective effect in ischaemic stroke, more clinical trial certification is needed due to the difference between animals and humans.

Topics: Animals; Antineoplastic Agents; Brain Ischemia; Endothelial Cells; Humans; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke; TRPV Cation Channels; Vasodilation

2023