hyperoside and Primary-Ovarian-Insufficiency

To investigate the effect and mechanism of hyperin on the improvement of ovarian reserve of tripterygium glycosides (TG)-induced primary ovarian insufficiency (POI) in mice.. Adult female BALB/c mice were used as research subjects and were randomly assigned to the control group, POI model group and hyperin treatment group, with 40 mice in each group. TG was given at 40 mg/kg twice a day by gavage for 2 weeks to create the POI mouse model. Mice in the hyperin treatment group were given hyperin at 75 mg/(kg·d) by gavage for 4 weeks after the model was established. The body mass of the mice was weighed and the gonadal index was calculated. Ovarian histological changes were observed by HE staining, and the number of follicles at all levels was calculated. Serum estradiol (E. Compared with mice in the POI model group, the body mass and gonadal index of hyperin-treated mice increased (all. Hyperin improved ovarian reserve in TG-induced POI mice through Nrf-2/HO-1antioxidant stress response and the anti-apoptotic effect of PI3K/Akt pathways.

Topics: Animals; Female; Glycosides; Humans; Mice; Mice, Inbred BALB C; Ovarian Reserve; Phosphatidylinositol 3-Kinases; Primary Ovarian Insufficiency; Quercetin; Tripterygium