hyperoside and Brain-Ischemia

hyperoside has been researched along with Brain-Ischemia* in 2 studies

Other Studies

2 other study(ies) available for hyperoside and Brain-Ischemia

Article	Year
Hyperoside ameliorates cerebral ischaemic-reperfusion injury by opening the TRPV4 channel Pharmaceutical biology, 2023, Volume: 61, Issue:1 Hyperoside (Hyp), one of the active flavones from. To explore the effect of Hyp on vasodilatation in the cerebral basilar artery (CBA) of Sprague-Dawley (SD) rats suffering with ischaemic-reperfusion (IR) injury.. Sprague-Dawley rats were randomly divided into sham, model, Hyp, Hyp + channel blocker and channel blocker groups. Hyp (50 mg/kg, IC. Hyp treatment significantly ameliorated the brain damage induced by IR and evoked endothelium-dependent vasodilation rate (47.93 ± 3.09% vs. 2.99 ± 1.53%) and hyperpolarization (-8.15 ± 1.87 mV vs. -0.55 ± 0.42 mV) by increasing the expression of IP3R, PKC, transient receptor potential vanilloid channel 4 (TRPV4), IK. Although Hyp showed protective effect in ischaemic stroke, more clinical trial certification is needed due to the difference between animals and humans. Topics: Animals; Antineoplastic Agents; Brain Ischemia; Endothelial Cells; Humans; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke; TRPV Cation Channels; Vasodilation	2023
[Protective effect of hyperin against cerebral ischemia-reperfusion injury]. Yao xue xue bao = Acta pharmaceutica Sinica, 1998, Volume: 33, Issue:1 The protective effect of hyperin (Hyp) against cerebral ischemia-reperfusion injury was studied. On the cerebral ischemia-reperfusion model in mice, Hyp (50, 100 mg.kg-1, i.p.) was shown to markedly and dose-dependently inhibit the decrease of lactate dehydrogenase (LDH) in cerebrum and improve the learning and memory impairment on the step down test. On the four-vessel occlusion model in rats, Hyp(50 and 100 mg.kg-1, i.p.) significantly reduced the decreases of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD) and LDH activities in the cerebrum. Hyp was also shown to inhibit the increase of nitric oxide (NO) and malondialdehyde (MDA) contents in the cerebrum and promote the recovery of EEG activities. These results suggest that Hyp has protective effect against cerebral ischemia-reperfusion injury via attenuating free radical and NO. Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Female; L-Lactate Dehydrogenase; Male; Malondialdehyde; Mice; Nitric Oxide; Quercetin; Rats; Rats, Sprague-Dawley; Reperfusion Injury	1998

Article

Year

Hyperoside ameliorates cerebral ischaemic-reperfusion injury by opening the TRPV4 channel

Pharmaceutical biology, 2023, Volume: 61, Issue:1

Hyperoside (Hyp), one of the active flavones from. To explore the effect of Hyp on vasodilatation in the cerebral basilar artery (CBA) of Sprague-Dawley (SD) rats suffering with ischaemic-reperfusion (IR) injury.. Sprague-Dawley rats were randomly divided into sham, model, Hyp, Hyp + channel blocker and channel blocker groups. Hyp (50 mg/kg, IC. Hyp treatment significantly ameliorated the brain damage induced by IR and evoked endothelium-dependent vasodilation rate (47.93 ± 3.09% vs. 2.99 ± 1.53%) and hyperpolarization (-8.15 ± 1.87 mV vs. -0.55 ± 0.42 mV) by increasing the expression of IP3R, PKC, transient receptor potential vanilloid channel 4 (TRPV4), IK. Although Hyp showed protective effect in ischaemic stroke, more clinical trial certification is needed due to the difference between animals and humans.

Topics: Animals; Antineoplastic Agents; Brain Ischemia; Endothelial Cells; Humans; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke; TRPV Cation Channels; Vasodilation

2023

[Protective effect of hyperin against cerebral ischemia-reperfusion injury].

Yao xue xue bao = Acta pharmaceutica Sinica, 1998, Volume: 33, Issue:1

The protective effect of hyperin (Hyp) against cerebral ischemia-reperfusion injury was studied. On the cerebral ischemia-reperfusion model in mice, Hyp (50, 100 mg.kg-1, i.p.) was shown to markedly and dose-dependently inhibit the decrease of lactate dehydrogenase (LDH) in cerebrum and improve the learning and memory impairment on the step down test. On the four-vessel occlusion model in rats, Hyp(50 and 100 mg.kg-1, i.p.) significantly reduced the decreases of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD) and LDH activities in the cerebrum. Hyp was also shown to inhibit the increase of nitric oxide (NO) and malondialdehyde (MDA) contents in the cerebrum and promote the recovery of EEG activities. These results suggest that Hyp has protective effect against cerebral ischemia-reperfusion injury via attenuating free radical and NO.

Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Female; L-Lactate Dehydrogenase; Male; Malondialdehyde; Mice; Nitric Oxide; Quercetin; Rats; Rats, Sprague-Dawley; Reperfusion Injury

1998