hypericum and Postoperative-Complications

This multicenter study aimed to evaluate the effects of St. John's wort oil and virgin olive oil on the postoperative complications and compare this with chlorhexidine gluconate plus benzydamine hydrochloride mouthwash after the removal of impacted third molar.. A total of 90 patients in need of impacted third molar surgery were included in this study. All included patients were randomly divided into 3 groups. The patients in group 1 received St. John's wort oil; the patients in group 2 received virgin olive oil, and those in group 3 received mouthwash containing chlorhexidine gluconate plus benzydamine hydrochloride. The self-reported pain and difficulty during jaw function, trismus, facial swelling, number of analgesics used during first postoperative week, and postoperative periodontal condition including plaque accumulation, bleeding on probing, and periodontal pocket depth were compared between the groups.. No significant differences were found regarding the study variables.. The data of the present study supports that the use of essential oils provides efficient alternative to the gold standard chlorhexidine gluconate mouthwash in reducing postoperative complications and improving healing process without adverse effects after surgical removal of impacted third molars.. The use of essential oils showed similar results as the chlorhexidine gluconate mouthwash regarding swelling, mouth opening, pain, need for rescue medication, infectious complications (i.e., alveolar osteitis), and periodontal healing. Therefore, essential oils can be an alternative to routine mouthwashes to ensure oral hygiene after impacted third molar surgery.

Topics: Double-Blind Method; Humans; Hypericum; Molar, Third; Olive Oil; Postoperative Complications; Tooth, Impacted

The aim of this study was to determine the effects of Hypericum perforatum on cesarean wound healing and hypertrophic scar.. This was a randomized, double-blind clinical trial study.. The study was conducted in Samen-Ol-Aemmeh (Pbuh) Hospital in Mashhad, Iran.. The subjects included 144 women with surgical childbirth who had eligible criteria.. The participants were randomly assigned to three groups. The treatment and placebo groups applied H. perforatum or placebo ointment 3 times a day for 16 days based on consecutive coded ointments. The control group remained without any intervention postoperatively.. Wound healing was assessed on the 10th day postcesarean using the REEDA scale (REEDA stands for redness, edema, ecchymosis, discharge, and approximation), which had criteria including redness, edema, ecchymosis, discharge, and approximation. On the 40th day, the degree of scarring was assessed using the Vancouver scar scale including pigmentation, height, pliability, and vascularity. The subjects were also asked some questions about pain by using the Visual Analogue Scale and pruritus of scar.. The mean age of all the study subjects was 23.50 +/- 4.03 and mean parity was 1.23 +/- 0.48. There were significant differences in wound healing on the 10th day (p < 0.005) and scar formation on the 40th day postpartum (p < 0.0001) between treatment group with placebo and control groups. However, the placebo group had no differences in wound healing (p = 0.93) and scar formation (p = 0.11) with the control group. In addition, significantly lower pain and pruritus were reported by the treatment group compared with the placebo and control groups on the 40th day postpartum.. Topical application of H. perforatum is safe and can facilitate cesarean wound healing and minimize formation of scar and its pain and pruritus.

Topics: Administration, Topical; Adult; Cesarean Section; Cicatrix; Double-Blind Method; Female; Humans; Hypericum; Ointments; Pain, Postoperative; Parity; Phytotherapy; Plant Extracts; Postoperative Complications; Pregnancy; Pruritus; Wound Healing; Young Adult

The purpose of this study was to identify the possible effects of Hypericum Perforatum (HP) on the prevention of experimentally induced myringosclerosis (MS).. Twenty eight Wistar Albino rats were used and they were divided into four groups. Tympanic membranes of all animals were perforated and then group I had no treatment as a control group, group II had treated with olive oil only, group III had treated with HP orally and group IV had treated with HP topically.. Groups I and II showed extensive myringosclerosis in contrast to those of Groups III and IV which had significantly less changes (p<0.05). The inflammation and fibrosis in the lamina propria of the tympanic membranes of Groups I and II were found to be significantly more pronounced (p<0.05). The tympanic membranes were found to be significantly thinner in Groups III and IV when compared with Groups I and II (p<0.05).. The results of the present study suggested that oral or topical administration of HP extract after myringotomy suppressed the inflammation and fibroblastic activity in the lamina propria of the myringotomized TMs of the rats. Further clinical studies with larger population using HP and other antioxidants will be essential to provide further evidence for use of antioxidant therapy in patients with myringotomy and ventilation tube insertion for otitis media with effusion.

Topics: Administration, Oral; Administration, Topical; Animals; Fibrosis; Hypericum; Inflammation; Male; Models, Animal; Mucous Membrane; Myringosclerosis; Plant Extracts; Postoperative Complications; Rats, Wistar; Tympanic Membrane

To evaluate the efficacy of a plant-derived wound dressing, a mixture of hypericum oil (Hypericum perforatum) and neem oil (Azadirachta indica), in scalp wounds with exposed bone.. A retrospective review was conducted of all patients presenting with scalp wounds with exposed bone following the excision of skin tumours and treated with a plant-derived wound dressings (1 Primary Wound Dressing; Phytoceuticals AG), from January to July 2011. Time to healing, wound size, area of exposed bone, ease of handling, pain and complications were evaluated.. Nine consecutive patients were analysed retrospectively. The patients' mean age was 81.2 ± 8.5 years (63-90 years), with a mean wound size of 13.2 ± 6.8cm(2) (0.4-22.6cm(2)) and 6.8 ± 6.5cm(2) (0.3-20.7cm(2)) of exposed bone. The time to complete healing by secondary intention was 4-20 weeks. A rapid induction of granulation tissue was observed, which covered the entire exposed bone surface in six out of nine cases (67%) after 4 weeks, and showed a reduction in the mean area of exposed bone of 95%. Dressing change was easy and without pain and there were no complications.. This retrospective, non-controlled analysis suggests that ONE is a very simple to use, safe and potentially effective therapy for the treatment of scalp wounds with exposed bone.. There were no external sources of funding for this study. The authors have no conflict of interest to declare.

Topics: Aged; Aged, 80 and over; Azadirachta; Drug Therapy, Combination; Female; Head and Neck Neoplasms; Humans; Hypericum; Middle Aged; Phytotherapy; Plant Oils; Postoperative Complications; Scalp; Skin Neoplasms; Skull; Wounds, Nonpenetrating

We describe an alcohol and cocaine abusing female patient who developed a first manic episode in the context of a corticosteroid prescription. The differential diagnoses are discussed on the basis of the available literature on secondary manias.

Topics: Adenoma, Pleomorphic; Adult; Alcohol Drinking; Bipolar Disorder; Cocaine; Diagnosis, Differential; Drug Interactions; Facial Paralysis; Female; Humans; Hypericum; Parotid Neoplasms; Postoperative Complications; Prednisone

Potential patients in the developed world are increasingly turning to treatment with herbs. One of the most popular herbs taken for depression is St John's Wort, which contains the potential photosensitizer hypericin. 'Hypericism' is a term used to describe a state of skin sensitivity to visible light in animals following ingestion of hypericin-containing plants and feed. A patient who developed a severe phototoxic reaction to laser light at 532 nm and also an exaggerated and unexpectedly severe response to pulsed dye laser light at 585 nm is described. It subsequently transpired that the patient was taking St John's Wort at the time of laser treatment.

Topics: Anthracenes; Antidepressive Agents; Dermatitis, Phototoxic; Face; Female; Humans; Hypericum; Keratosis; Laser Therapy; Leg; Middle Aged; Perylene; Phytotherapy; Plant Preparations; Plastic Surgery Procedures; Postoperative Complications; Radiation-Sensitizing Agents

We describe the case of a patient who developed depression following bilateral orchidectomy for cryptorchidism. He was treated with a conventional selective serotonin reuptake inhibitor antidepressant, but continued to take St John's wort (hypericum) against medical advice. He subsequently developed a manic episode. We discuss postulated modes of action of St John's wort and the possible aetiological importance of testosterone replacement and abnormal gonadotrophin levels in this case.

Topics: Administration, Oral; Adult; Antidepressive Agents; Arousal; Bipolar Disorder; Cryptorchidism; Depressive Disorder; Humans; Hypericum; Male; Orchiectomy; Plants, Medicinal; Postoperative Complications; Sertraline; Testosterone