hypericum has been researched along with Crigler-Najjar-Syndrome* in 1 studies
1 other study(ies) available for hypericum and Crigler-Najjar-Syndrome
| Article | Year |
|---|---|
Reduction of hyperbilirubinemia with hypericum extract (St. John's Wort) in a patient with Crigler-Najjar syndrome type II.
Crigler-Najjar syndrome (CN) type II is a congenital disease with unconjugated hyperbilirubinemia due to a deficiency of uridine 5'-diphospho-glucuronosyltransferase 1A1. Since the currently proposed treatment with phenobarbital is associated with adverse reactions, we investigated the effect of hypericum extract.. Repetitive determination of total serum bilirubin in a female with CN type II before, during and after daily treatment with 900 mg hypericum extract on two occasions for 8 weeks. Confirmation of the enzyme-inducing effect of hypericum using the cytochrome P450 3A4 probe drug i.v. midazolam.. Hypericum reduced midazolam exposure by 42% and the total serum bilirubin concentration by 30 to 35%.. Hypericum extract is a potential alternative to phenobarbital in patients with CN type II. Topics: Adult; Area Under Curve; Bilirubin; Crigler-Najjar Syndrome; Cytochrome P-450 CYP3A; Enzyme Induction; Female; GABA Modulators; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Hypericum; Midazolam; Phenobarbital; Plant Extracts; Pregnane X Receptor; Receptors, Steroid; Young Adult | 2016 |