hypericin has been researched along with Sensitivity and Specificity in 27 studies
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the optimum dosage and instillation time for water-soluble polyvinylpyrrolidone (PVP)-hypericin for photodynamic diagnosis of bladder cancer and to monitor its use in regard to patient safety." | 9.20 | A phase IIA dose-finding study of PVP-hypericin fluorescence cystoscopy for detection of nonmuscle-invasive bladder cancer. ( Abrahamsberg, C; Gschwend, JE; Horn, T; Russ, D; Straub, M, 2015) |
| "In a syngeneic subcutaneous glioma mouse model we investigated the time dependent hypericin (HYP) uptake in malignant tumor tissue by microendoscopically fluorescence measurements." | 7.79 | Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model. ( Ehrhardt, A; Feigl, GC; Göbel, W; Mayer, D; Naumann, U; Noell, S; Ritz, R; Serifi, D, 2013) |
| "In five patients with a recurrence of a malignant glioma a newly developed water soluble formulation of hypericin was given intravenously (0." | 7.78 | Hypericin for visualization of high grade gliomas: first clinical experience. ( Bornemann, A; Daniels, R; Dietz, K; Feigl, GC; Mayer, D; Noell, S; Ramina, K; Ritz, R; Schmidt, V; Strauss, WS; Tatagiba, M, 2012) |
| "In this study we have evaluated the use of hypericin ex vivo urine fluorescence cytology as a non-invasive method for detecting early bladder cancers." | 7.72 | Novel photodynamic diagnosis of bladder cancer: ex vivo fluorescence cytology using hypericin. ( Bhuvaneswari, R; Cheng, C; Lau, W; Manivasager, V; Olivo, M; Soo, KC; Tan, PH; Wei, Z, 2003) |
| "We determined the sensitivity and specificity of detecting flat bladder carcinoma in situ through fluorescent detection after intravesical hypericin instillations." | 7.70 | Fluorescence detection of flat bladder carcinoma in situ after intravesical instillation of hypericin. ( Baert, L; D'Hallewin, MA; De Witte, PA; Merlevede, W; Waelkens, E, 2000) |
| "To determine the optimum dosage and instillation time for water-soluble polyvinylpyrrolidone (PVP)-hypericin for photodynamic diagnosis of bladder cancer and to monitor its use in regard to patient safety." | 5.20 | A phase IIA dose-finding study of PVP-hypericin fluorescence cystoscopy for detection of nonmuscle-invasive bladder cancer. ( Abrahamsberg, C; Gschwend, JE; Horn, T; Russ, D; Straub, M, 2015) |
| "In a syngeneic subcutaneous glioma mouse model we investigated the time dependent hypericin (HYP) uptake in malignant tumor tissue by microendoscopically fluorescence measurements." | 3.79 | Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model. ( Ehrhardt, A; Feigl, GC; Göbel, W; Mayer, D; Naumann, U; Noell, S; Ritz, R; Serifi, D, 2013) |
| "In five patients with a recurrence of a malignant glioma a newly developed water soluble formulation of hypericin was given intravenously (0." | 3.78 | Hypericin for visualization of high grade gliomas: first clinical experience. ( Bornemann, A; Daniels, R; Dietz, K; Feigl, GC; Mayer, D; Noell, S; Ramina, K; Ritz, R; Schmidt, V; Strauss, WS; Tatagiba, M, 2012) |
| "In this study we have evaluated the use of hypericin ex vivo urine fluorescence cytology as a non-invasive method for detecting early bladder cancers." | 3.72 | Novel photodynamic diagnosis of bladder cancer: ex vivo fluorescence cytology using hypericin. ( Bhuvaneswari, R; Cheng, C; Lau, W; Manivasager, V; Olivo, M; Soo, KC; Tan, PH; Wei, Z, 2003) |
| "To determine the use of hypericin instillation for the fluorescent detection of papillary bladder cancer and carcinoma in situ." | 3.71 | Hypericin-based fluorescence diagnosis of bladder carcinoma. ( Baert, L; D'Hallewin, MA; De Witte, PA; Kamuhabwa, AR; Roskams, T, 2002) |
| "We determined the sensitivity and specificity of detecting flat bladder carcinoma in situ through fluorescent detection after intravesical hypericin instillations." | 3.70 | Fluorescence detection of flat bladder carcinoma in situ after intravesical instillation of hypericin. ( Baert, L; D'Hallewin, MA; De Witte, PA; Merlevede, W; Waelkens, E, 2000) |
| "In flat bladder cancer and carcinoma in situ, and in multifocal papillary cancer, some smaller lesions may be overlooked at cystoscopy." | 2.44 | Recent developments in fluorescence cystoscopy: do novel agents bring a benefit? ( Marberger, M; Schmidbauer, J, 2007) |
| "Hypericin (HY) has been found to be superior to 5-aminolevulinic acid (5-ALA) and its ester derivative hexaminolevulinate (HA) as a fluorescence diagnostic agent, hence its development for delivery in vitro and in vivo, is the subject of this review." | 2.43 | Delivery of hypericin for photodynamic applications. ( Heng, PW; Olivo, M; Saw, CL; Soo, KC, 2006) |
| "Hypericin (HYP) was employed as the efficient fluorophore." | 1.40 | Effect of glutathione on peroxyoxalate chemiluminescence of hypericin as the fluorophore. ( Abedirad, SM; Kazemi, SY, 2014) |
| "The high mortality rate in bladder cancer can be reduced by early treatment following pre-cancerous screening." | 1.34 | Fluorescence detection of bladder cancer using urine cytology. ( Chin, WW; Fu, CY; Lau, WK; Ng, BK; Olivo, M; Razul, SG; Tan, PH, 2007) |
| "Hypericin was introduced intravesically for 2 h before cystoscopy." | 1.33 | Is photodynamic diagnosis using hypericin better than white-light cystoscopy for detecting superficial bladder carcinoma? ( Cheng, CW; Lau, WK; Olivo, M; Sim, HG; Tan, PH, 2005) |
| "Hypericin was determined using an RP C18 (3 microns) column 8." | 1.29 | High-performance liquid chromatographic determination of the biologically active principle hypericin in phytotherapeutic vegetable extracts and alcoholic beverages. ( Currò, P; Lanuzza, F; Micali, G, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (14.81) | 18.2507 |
| 2000's | 16 (59.26) | 29.6817 |
| 2010's | 7 (25.93) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Müller, K | 1 |
| Prinz, H | 1 |
| Gawlik, I | 1 |
| Ziereis, K | 1 |
| Huang, HS | 1 |
| Zeliou, K | 1 |
| Kontaxis, NI | 1 |
| Margianni, E | 1 |
| Petrou, C | 1 |
| Lamari, FN | 1 |
| Kazemi, SY | 1 |
| Abedirad, SM | 1 |
| Noell, S | 2 |
| Feigl, GC | 2 |
| Serifi, D | 1 |
| Mayer, D | 2 |
| Naumann, U | 1 |
| Göbel, W | 1 |
| Ehrhardt, A | 1 |
| Ritz, R | 2 |
| Penjweini, R | 1 |
| Loew, HG | 1 |
| Breit, P | 1 |
| Kratky, KW | 1 |
| Larisch, P | 1 |
| Verwanger, T | 1 |
| Linecker, M | 1 |
| Krammer, B | 1 |
| Straub, M | 1 |
| Russ, D | 1 |
| Horn, T | 1 |
| Gschwend, JE | 1 |
| Abrahamsberg, C | 1 |
| Daniels, R | 1 |
| Schmidt, V | 1 |
| Bornemann, A | 1 |
| Ramina, K | 1 |
| Dietz, K | 1 |
| Strauss, WS | 1 |
| Tatagiba, M | 1 |
| D'Hallewin, MA | 3 |
| Bezdetnaya, L | 1 |
| Guillemin, F | 1 |
| Piperopoulos, G | 1 |
| Kiehne, A | 1 |
| Ingendoh, A | 1 |
| Zeller, KP | 1 |
| Olivo, M | 4 |
| Lau, W | 1 |
| Manivasager, V | 1 |
| Bhuvaneswari, R | 1 |
| Wei, Z | 1 |
| Soo, KC | 2 |
| Cheng, C | 1 |
| Tan, PH | 3 |
| Piovan, A | 1 |
| Filippini, R | 1 |
| Borsarini, A | 1 |
| Caniato, R | 1 |
| Riedel, KD | 1 |
| Rieger, K | 1 |
| Martin-Facklam, M | 1 |
| Mikus, G | 1 |
| Haefeli, WE | 1 |
| Burhenne, J | 1 |
| Sim, HG | 1 |
| Lau, WK | 2 |
| Cheng, CW | 1 |
| Gioti, EM | 1 |
| Skalkos, DC | 1 |
| Fiamegos, YC | 1 |
| Stalikas, CD | 1 |
| Saw, CL | 1 |
| Heng, PW | 1 |
| Chandrasekera, DH | 1 |
| Welham, KJ | 1 |
| Ashton, D | 1 |
| Middleton, R | 1 |
| Heinrich, M | 1 |
| Fu, CY | 1 |
| Ng, BK | 1 |
| Razul, SG | 1 |
| Chin, WW | 1 |
| Schmidbauer, J | 1 |
| Marberger, M | 1 |
| Micali, G | 1 |
| Lanuzza, F | 1 |
| Currò, P | 1 |
| Chi, JD | 1 |
| Franklin, M | 1 |
| De Witte, PA | 2 |
| Waelkens, E | 1 |
| Merlevede, W | 1 |
| Baert, L | 2 |
| Draves, AH | 1 |
| Walker, SE | 1 |
| Bauer, S | 1 |
| Störmer, E | 1 |
| Graubaum, HJ | 1 |
| Roots, I | 1 |
| Pytel, A | 1 |
| Schmeller, N | 1 |
| Kamuhabwa, AR | 1 |
| Roskams, T | 1 |
| Liebes, L | 1 |
| Mazur, Y | 1 |
| Freeman, D | 1 |
| Lavie, D | 1 |
| Lavie, G | 1 |
| Kudler, N | 1 |
| Mendoza, S | 1 |
| Levin, B | 1 |
| Hochster, H | 1 |
| Meruelo, D | 1 |
3 reviews available for hypericin and Sensitivity and Specificity
| Article | Year |
|---|---|
Fluorescence detection of bladder cancer: a review.
Topics: Administration, Intravesical; Aminolevulinic Acid; Anthracenes; Carcinoma in Situ; Cystoscopy; Dihem | 2002 |
Delivery of hypericin for photodynamic applications.
Topics: Animals; Anthracenes; Fluorescent Dyes; Humans; Perylene; Photochemotherapy; Photosensitizing Agents | 2006 |
Recent developments in fluorescence cystoscopy: do novel agents bring a benefit?
Topics: Aminolevulinic Acid; Anthracenes; Carcinoma in Situ; Cystoscopy; Fluorescence; Fluorescent Dyes; Hum | 2007 |
1 trial available for hypericin and Sensitivity and Specificity
| Article | Year |
|---|---|
A phase IIA dose-finding study of PVP-hypericin fluorescence cystoscopy for detection of nonmuscle-invasive bladder cancer.
Topics: Adult; Aged; Aged, 80 and over; Anthracenes; Cystoscopy; Dose-Response Relationship, Drug; Female; F | 2015 |
23 other studies available for hypericin and Sensitivity and Specificity
| Article | Year |
|---|---|
Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity.
Topics: Administration, Topical; Animals; Anthralin; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non | 1997 |
Optimized and Validated HPLC Analysis of St. John's Wort Extract and Final Products by Simultaneous Determination of Major Ingredients.
Topics: Anthracenes; Chlorogenic Acid; Chromatography, High Pressure Liquid; Drug Stability; Hypericum; Line | 2017 |
Effect of glutathione on peroxyoxalate chemiluminescence of hypericin as the fluorophore.
Topics: Anthracenes; Fluorescent Dyes; Glutathione; Kinetics; Luminescence; Luminescent Measurements; Models | 2014 |
Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model.
Topics: Animals; Anthracenes; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Endoscopy; Glioma; | 2013 |
Optimizing the antitumor selectivity of PVP-Hypericin re A549 cancer cells and HLF normal cells through pulsed blue light.
Topics: Aminolevulinic Acid; Anthracenes; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Color; Dose-Re | 2013 |
The interrelation between a pro-inflammatory milieu and fluorescence diagnosis or photodynamic therapy of human skin cell lines.
Topics: Anthracenes; Cell Line; Cell Survival; Cytokines; Dermatitis; Dose-Response Relationship, Drug; Huma | 2014 |
Hypericin for visualization of high grade gliomas: first clinical experience.
Topics: Aged; Anthracenes; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Injections, Intravenous; M | 2012 |
[Methyl-D3]2hypericin as internal standard for quantification in human plasma.
Topics: Anthracenes; Deuterium; Humans; Molecular Structure; Perylene; Reference Standards; Sensitivity and | 2003 |
Novel photodynamic diagnosis of bladder cancer: ex vivo fluorescence cytology using hypericin.
Topics: Anthracenes; Carcinoma, Transitional Cell; Diagnostic Imaging; Fluorescence; Humans; Microscopy, Con | 2003 |
Flow injection analysis mass spectrometry, a tool to investigate the problems in the quantitative analysis of hypericin using reversed-phase high-performance liquid chromatography.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Flow Injection Analysis; Mass Spectrometry; Peryl | 2004 |
Simultaneous determination of hypericin and hyperforin in human plasma with liquid chromatography-tandem mass spectrometry.
Topics: Aged; Anthracenes; Bridged Bicyclo Compounds; Calibration; Chromatography, High Pressure Liquid; Fem | 2004 |
Is photodynamic diagnosis using hypericin better than white-light cystoscopy for detecting superficial bladder carcinoma?
Topics: Aged; Aged, 80 and over; Anthracenes; Cystoscopy; Early Diagnosis; Female; Humans; Male; Middle Aged | 2005 |
Single-drop liquid-phase microextraction for the determination of hypericin, pseudohypericin and hyperforin in biological fluids by high performance liquid chromatography.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentra | 2005 |
Quantitative analysis of the major constituents of St John's wort with HPLC-ESI-MS.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Hypericum; Perylene; P | 2005 |
Fluorescence detection of bladder cancer using urine cytology.
Topics: Anthracenes; Automation; Humans; Image Processing, Computer-Assisted; Microscopy, Confocal; Microsco | 2007 |
High-performance liquid chromatographic determination of the biologically active principle hypericin in phytotherapeutic vegetable extracts and alcoholic beverages.
Topics: Alcoholic Beverages; Anthracenes; Antiviral Agents; Chromatography, High Pressure Liquid; Perylene; | 1996 |
Determination of hypericin in plasma by high-performance liquid chromatography.
Topics: Anthracenes; Antidepressive Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Male; | 1999 |
Fluorescence detection of flat bladder carcinoma in situ after intravesical instillation of hypericin.
Topics: Administration, Intravesical; Anthracenes; Carcinoma in Situ; Carcinoma, Transitional Cell; Fluoresc | 2000 |
Determination of hypericin and pseudohypericin in pharmaceutical preparations by liquid chromatography with fluorescence detection.
Topics: Anthracenes; Chromatography, Liquid; Perylene; Pharmaceutical Preparations; Sensitivity and Specific | 2000 |
Determination of hyperforin, hypericin, and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection.
Topics: Anthracenes; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Humans; Perylene; Phlo | 2001 |
New aspect of photodynamic diagnosis of bladder tumors: fluorescence cytology.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Anthracenes; Carcinoma in Situ; Cystitis; Cytophotomet | 2002 |
Hypericin-based fluorescence diagnosis of bladder carcinoma.
Topics: Anthracenes; Carcinoma in Situ; Carcinoma, Papillary; Cystoscopy; Humans; Microscopy, Fluorescence; | 2002 |
A method for the quantitation of hypericin, an antiviral agent, in biological fluids by high-performance liquid chromatography.
Topics: Animals; Anthracenes; Antiviral Agents; Body Fluids; Chromatography, High Pressure Liquid; Mice; Mic | 1991 |