Page last updated: 2024-10-28

hypericin and Melanoma

hypericin has been researched along with Melanoma in 9 studies

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"Photodynamic-induced cytotoxicity by hypericin (HYP) was studied on three human melanoma cell lines: one pigmented cell line (G361) and two amelanotic cell lines (M18 and M6)."7.69Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells. ( Favier, A; Hadjur, C; Jardon, P; Parat, MO; Richard, MJ, 1996)
"Hypericin was taken up by all melanoma cells and partially co-localized to the endoplasmic reticulum, mitochondria, lysosomes and melanosomes, but not the nucleus."5.40St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death. ( Davids, LM; Kleemann, B; Lang, D; Loos, B; Scriba, TJ, 2014)
"Melanoma is the main cause of death in skin cancers."5.38Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death. ( Davids, LM; Sharma, KV, 2012)
" This would result in toxic melanin precursors (of an indolic and phenolic nature) leaking into the cytoplasm which in turn leads to cell death."5.35Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells. ( Davids, LM; Kacerovská, D; Kidson, SH; Kleemann, B; Pizinger, K, 2008)
"Photodynamic-induced cytotoxicity by hypericin (HYP) was studied on three human melanoma cell lines: one pigmented cell line (G361) and two amelanotic cell lines (M18 and M6)."3.69Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells. ( Favier, A; Hadjur, C; Jardon, P; Parat, MO; Richard, MJ, 1996)
"Hypericin was taken up by all melanoma cells and partially co-localized to the endoplasmic reticulum, mitochondria, lysosomes and melanosomes, but not the nucleus."1.40St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death. ( Davids, LM; Kleemann, B; Lang, D; Loos, B; Scriba, TJ, 2014)
"Melanoma is the main cause of death in skin cancers."1.38Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death. ( Davids, LM; Sharma, KV, 2012)
" This would result in toxic melanin precursors (of an indolic and phenolic nature) leaking into the cytoplasm which in turn leads to cell death."1.35Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells. ( Davids, LM; Kacerovská, D; Kidson, SH; Kleemann, B; Pizinger, K, 2008)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's2 (22.22)29.6817
2010's5 (55.56)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Naidoo, C1
Kruger, CA1
Abrahamse, H1
Biteghe, FAN1
Padayachee, E1
Davids, LM7
Chalomie, NET1
Ndong, JC1
Barth, S1
Kleemann, B3
Loos, B1
Scriba, TJ1
Lang, D1
Biteghe, FN1
Cooper, S1
Kidson, SH2
Sharma, KV2
Bowers, N1
Kacerovská, D1
Pizinger, K1
Hadjur, C1
Richard, MJ1
Parat, MO1
Jardon, P1
Favier, A1

Reviews

1 review available for hypericin and Melanoma

ArticleYear
Simultaneous Photodiagnosis and Photodynamic Treatment of Metastatic Melanoma.
    Molecules (Basel, Switzerland), 2019, Aug-29, Volume: 24, Issue:17

    Topics: Aminolevulinic Acid; Anthracenes; Biopsy, Fine-Needle; Drug Carriers; Early Diagnosis; Humans; Indol

2019

Other Studies

8 other studies available for hypericin and Melanoma

ArticleYear
Desensitization of metastatic melanoma cells to therapeutic treatment through repeated exposure to dacarbazine.
    Journal of photochemistry and photobiology. B, Biology, 2020, Volume: 211

    Topics: Anthracenes; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Bi

2020
St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Size; Drug Screening A

2014
A combination of photodynamic therapy and chemotherapy displays a differential cytotoxic effect on human metastatic melanoma cells.
    Journal of photochemistry and photobiology. B, Biology, 2017, Volume: 166

    Topics: Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Dacarbazine; Humans; Melanoma; Neoplasm Metast

2017
Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy.
    Cell biology international, 2009, Volume: 33, Issue:10

    Topics: Anthracenes; Autophagy; Cell Death; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Huma

2009
Photodynamic therapy-induced killing is enhanced in depigmented metastatic melanoma cells.
    Cell biology international, 2011, Volume: 35, Issue:9

    Topics: Anthracenes; Cell Line, Tumor; Cell Survival; Humans; Melanoma; Monophenol Monooxygenase; Perylene;

2011
Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death.
    Photodiagnosis and photodynamic therapy, 2012, Volume: 9, Issue:2

    Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Humans; Melanins; Melanoma; Perylene; Photochemotherapy; P

2012
Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells.
    Journal of photochemistry and photobiology. B, Biology, 2008, May-29, Volume: 91, Issue:2-3

    Topics: Anthracenes; Apoptosis; Caspase 3; Caspase 7; Cell Death; Cell Line, Tumor; Cell Survival; Humans; I

2008
Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells.
    Photochemistry and photobiology, 1996, Volume: 64, Issue:2

    Topics: Anthracenes; Humans; Lipid Peroxidation; Melanoma; Perylene; Photochemotherapy; Radiation-Sensitizin

1996