hypericin has been researched along with Melanoma in 9 studies
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Photodynamic-induced cytotoxicity by hypericin (HYP) was studied on three human melanoma cell lines: one pigmented cell line (G361) and two amelanotic cell lines (M18 and M6)." | 7.69 | Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells. ( Favier, A; Hadjur, C; Jardon, P; Parat, MO; Richard, MJ, 1996) |
| "Hypericin was taken up by all melanoma cells and partially co-localized to the endoplasmic reticulum, mitochondria, lysosomes and melanosomes, but not the nucleus." | 5.40 | St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death. ( Davids, LM; Kleemann, B; Lang, D; Loos, B; Scriba, TJ, 2014) |
| "Melanoma is the main cause of death in skin cancers." | 5.38 | Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death. ( Davids, LM; Sharma, KV, 2012) |
| " This would result in toxic melanin precursors (of an indolic and phenolic nature) leaking into the cytoplasm which in turn leads to cell death." | 5.35 | Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells. ( Davids, LM; Kacerovská, D; Kidson, SH; Kleemann, B; Pizinger, K, 2008) |
| "Photodynamic-induced cytotoxicity by hypericin (HYP) was studied on three human melanoma cell lines: one pigmented cell line (G361) and two amelanotic cell lines (M18 and M6)." | 3.69 | Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells. ( Favier, A; Hadjur, C; Jardon, P; Parat, MO; Richard, MJ, 1996) |
| "Hypericin was taken up by all melanoma cells and partially co-localized to the endoplasmic reticulum, mitochondria, lysosomes and melanosomes, but not the nucleus." | 1.40 | St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death. ( Davids, LM; Kleemann, B; Lang, D; Loos, B; Scriba, TJ, 2014) |
| "Melanoma is the main cause of death in skin cancers." | 1.38 | Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death. ( Davids, LM; Sharma, KV, 2012) |
| " This would result in toxic melanin precursors (of an indolic and phenolic nature) leaking into the cytoplasm which in turn leads to cell death." | 1.35 | Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells. ( Davids, LM; Kacerovská, D; Kidson, SH; Kleemann, B; Pizinger, K, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Naidoo, C | 1 |
| Kruger, CA | 1 |
| Abrahamse, H | 1 |
| Biteghe, FAN | 1 |
| Padayachee, E | 1 |
| Davids, LM | 7 |
| Chalomie, NET | 1 |
| Ndong, JC | 1 |
| Barth, S | 1 |
| Kleemann, B | 3 |
| Loos, B | 1 |
| Scriba, TJ | 1 |
| Lang, D | 1 |
| Biteghe, FN | 1 |
| Cooper, S | 1 |
| Kidson, SH | 2 |
| Sharma, KV | 2 |
| Bowers, N | 1 |
| Kacerovská, D | 1 |
| Pizinger, K | 1 |
| Hadjur, C | 1 |
| Richard, MJ | 1 |
| Parat, MO | 1 |
| Jardon, P | 1 |
| Favier, A | 1 |
1 review available for hypericin and Melanoma
| Article | Year |
|---|---|
Simultaneous Photodiagnosis and Photodynamic Treatment of Metastatic Melanoma.
Topics: Aminolevulinic Acid; Anthracenes; Biopsy, Fine-Needle; Drug Carriers; Early Diagnosis; Humans; Indol | 2019 |
8 other studies available for hypericin and Melanoma
| Article | Year |
|---|---|
Desensitization of metastatic melanoma cells to therapeutic treatment through repeated exposure to dacarbazine.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Bi | 2020 |
St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death.
Topics: Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Size; Drug Screening A | 2014 |
A combination of photodynamic therapy and chemotherapy displays a differential cytotoxic effect on human metastatic melanoma cells.
Topics: Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Dacarbazine; Humans; Melanoma; Neoplasm Metast | 2017 |
Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy.
Topics: Anthracenes; Autophagy; Cell Death; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Huma | 2009 |
Photodynamic therapy-induced killing is enhanced in depigmented metastatic melanoma cells.
Topics: Anthracenes; Cell Line, Tumor; Cell Survival; Humans; Melanoma; Monophenol Monooxygenase; Perylene; | 2011 |
Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death.
Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Humans; Melanins; Melanoma; Perylene; Photochemotherapy; P | 2012 |
Hypericin phototoxicity induces different modes of cell death in melanoma and human skin cells.
Topics: Anthracenes; Apoptosis; Caspase 3; Caspase 7; Cell Death; Cell Line, Tumor; Cell Survival; Humans; I | 2008 |
Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells.
Topics: Anthracenes; Humans; Lipid Peroxidation; Melanoma; Perylene; Photochemotherapy; Radiation-Sensitizin | 1996 |