hypericin has been researched along with Glioblastoma in 10 studies
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hypericin (HY) exhibit high phototoxicity to malignant cells and accumulates to a higher extent in glioblastoma cells as compared to neurons." | 7.74 | Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines. ( Dietz, K; Ritz, R; Roser, F; Schenk, M; Strauss, WS; Tatagiba, M; Wein, HT, 2007) |
| "The naturally occurring photosensitizer, hypericin, with its high quantum yield of singlet oxygen photogeneration was studied for its ability to differentiate between glioblastoma cells and fetal rat neurons using fluorescence microscopy." | 7.73 | Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro. ( Dietz, K; Kuci, S; Müller, M; Ritz, R; Roser, F; Tatagiba, M; Weller, M, 2005) |
| "Three patients suffered from an anaplastic astrocytoma, WHO grade III, nine had a glioblastoma, WHO grade IV." | 5.35 | Hypericin uptake: a prognostic marker for survival in high-grade glioma. ( Bornemann, A; Dietz, K; Duffner, F; Müller, M; Ritz, R; Roser, F; Tatagiba, M, 2008) |
| "When hypericin was combined with diazepam, photocytotoxicity was increased in U-87 MG cells and primary cultures unlike U373 MG cells." | 5.33 | Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells. ( Gajdos, M; Kocanová, S; Lavicka, J; Mirossay, A; Mirossay, L; Miskovsky, P; Mojzis, J; Sarissky, M; Sulla, I, 2005) |
| "Tamoxifen and hypericin were able to greatly increase the growth-inhibitory and apoptosis-stimulatory potency of temozolomide via the downregulation of critical cell cycle-regulatory and prosurvival components." | 5.33 | Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin. ( Chen, TC; Gupta, V; Hofman, FM; Kardosh, A; Liebes, LF; Schönthal, AH; Su, YS; Wang, W, 2006) |
| "Hypericin was concentrated in the perinucleolar cytoplasmic area mainly on one side of the nucleus--the region rich in endoplasmic reticulum and Golgi." | 5.31 | Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines. ( Hjortland, GO; Iani, V; Ma, LW; Moan, J; Steen, HB; Uzdensky, AB, 2001) |
| " Hypericin (HY) exhibit high phototoxicity to malignant cells and accumulates to a higher extent in glioblastoma cells as compared to neurons." | 3.74 | Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines. ( Dietz, K; Ritz, R; Roser, F; Schenk, M; Strauss, WS; Tatagiba, M; Wein, HT, 2007) |
| "The naturally occurring photosensitizer, hypericin, with its high quantum yield of singlet oxygen photogeneration was studied for its ability to differentiate between glioblastoma cells and fetal rat neurons using fluorescence microscopy." | 3.73 | Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro. ( Dietz, K; Kuci, S; Müller, M; Ritz, R; Roser, F; Tatagiba, M; Weller, M, 2005) |
| "Three patients suffered from an anaplastic astrocytoma, WHO grade III, nine had a glioblastoma, WHO grade IV." | 1.35 | Hypericin uptake: a prognostic marker for survival in high-grade glioma. ( Bornemann, A; Dietz, K; Duffner, F; Müller, M; Ritz, R; Roser, F; Tatagiba, M, 2008) |
| "When hypericin was combined with diazepam, photocytotoxicity was increased in U-87 MG cells and primary cultures unlike U373 MG cells." | 1.33 | Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells. ( Gajdos, M; Kocanová, S; Lavicka, J; Mirossay, A; Mirossay, L; Miskovsky, P; Mojzis, J; Sarissky, M; Sulla, I, 2005) |
| "Tamoxifen and hypericin were able to greatly increase the growth-inhibitory and apoptosis-stimulatory potency of temozolomide via the downregulation of critical cell cycle-regulatory and prosurvival components." | 1.33 | Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin. ( Chen, TC; Gupta, V; Hofman, FM; Kardosh, A; Liebes, LF; Schönthal, AH; Su, YS; Wang, W, 2006) |
| "Hypericin was concentrated in the perinucleolar cytoplasmic area mainly on one side of the nucleus--the region rich in endoplasmic reticulum and Golgi." | 1.31 | Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines. ( Hjortland, GO; Iani, V; Ma, LW; Moan, J; Steen, HB; Uzdensky, AB, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghiasvand, S | 1 |
| Javidi, MA | 1 |
| Mohammadian, A | 1 |
| Mousavi, SA | 1 |
| Shahriari, F | 1 |
| Alavian, F | 1 |
| Keksel, N | 1 |
| Bussmann, H | 1 |
| Unger, M | 1 |
| Drewe, J | 1 |
| Boonen, G | 1 |
| Häberlein, H | 1 |
| Franken, S | 1 |
| Dror, N | 1 |
| Mandel, M | 1 |
| Lavie, G | 1 |
| Chen, TC | 2 |
| Su, S | 1 |
| Fry, D | 1 |
| Liebes, L | 1 |
| Sarissky, M | 1 |
| Lavicka, J | 1 |
| Kocanová, S | 1 |
| Sulla, I | 1 |
| Mirossay, A | 1 |
| Miskovsky, P | 1 |
| Gajdos, M | 1 |
| Mojzis, J | 1 |
| Mirossay, L | 1 |
| Ritz, R | 3 |
| Müller, M | 2 |
| Weller, M | 1 |
| Dietz, K | 3 |
| Kuci, S | 1 |
| Roser, F | 3 |
| Tatagiba, M | 3 |
| Gupta, V | 1 |
| Su, YS | 1 |
| Wang, W | 1 |
| Kardosh, A | 1 |
| Liebes, LF | 1 |
| Hofman, FM | 1 |
| Schönthal, AH | 1 |
| Wein, HT | 1 |
| Schenk, M | 1 |
| Strauss, WS | 1 |
| Duffner, F | 1 |
| Bornemann, A | 1 |
| Uzdensky, AB | 1 |
| Ma, LW | 1 |
| Iani, V | 1 |
| Hjortland, GO | 1 |
| Steen, HB | 1 |
| Moan, J | 1 |
10 other studies available for hypericin and Glioblastoma
| Article | Year |
|---|---|
Transcriptome analysis evinces anti-neoplastic mechanisms of hypericin: A study on U87 glioblastoma cell line.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Gene Expressio | 2021 |
St John's wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Membrane; Glioblastoma; Hydrocortisone; Hypericum; Memb | 2019 |
Unique anti-glioblastoma activities of hypericin are at the crossroad of biochemical and epigenetic events and culminate in tumor cell differentiation.
Topics: Anthracenes; Cell Cycle; Cell Differentiation; Cell Line, Tumor; DNA Methylation; Epigenesis, Geneti | 2013 |
Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apop | 2003 |
Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells.
Topics: Adult; Aged; Anthracenes; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Diazepam; Drug Interact | 2005 |
Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro.
Topics: Animals; Animals, Newborn; Anthracenes; Astrocytes; Cell Line, Tumor; Cells, Cultured; Fluorescence; | 2005 |
Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin.
Topics: Animals; Anthracenes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combi | 2006 |
Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Glioblastoma; Glioma; Humans; Light; | 2007 |
Hypericin uptake: a prognostic marker for survival in high-grade glioma.
Topics: Adult; Aged; Anthracenes; Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Diseas | 2008 |
Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines.
Topics: Adenocarcinoma; Anthracenes; Carcinoma in Situ; Colonic Neoplasms; Female; Glioblastoma; Humans; Per | 2001 |