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hypericin and Fibrosarcoma

hypericin has been researched along with Fibrosarcoma in 11 studies

Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
"Histomorphological changes in murine fibrosarcoma after photodynamic therapy (PDT) based on the natural photosensitizer hypericin were evaluated."7.74Histomorphological changes in murine fibrosarcoma after hypericin-based photodynamic therapy. ( Bobrov, N; Brezáni, P; Cavarga, I; Fedorocko, P; Longauer, F; Mirossay, L; Miskovský, P; Rybárová, S; Stubna, J, 2007)
"Hypericin, a potent necrosis avid agent, features a peculiar affinity for necrotic tissue."7.74Exploration of the mechanism underlying the tumor necrosis avidity of hypericin. ( De Witte, PA; Ni, Y; Van de Putte, M, 2008)
"To study the effect of co-injecting unlabelled hypericin (Hyp) on biodistribution, necrosis uptake and tumour retention of iodine-123 or iodine-131 labelled hypericin ((123/131)I-Hyp), a necrosis avid agent for an anticancer radiotherapy."3.80Targetability and biodistribution of radioiodinated hypericin: comparison between microdosing and carrier-added preparations. ( Chen, F; Cona, MM; Feng, Y; Li, J; Ni, Y; Oyen, R; Verbruggen, A; Witte, Pd, 2014)
"Thirty severe combined immunodeficiency (SCID) mice bearing bilateral radiation-induced fibrosarcoma-1 (RIF-1) subcutaneously were divided into group A of SMSDTTS with sequential intravenous injections of combretastatin A4 phosphate (CA4P) and (131)I-iodohypericin ((131)I-Hyp) at a 24 h interval; group B of single targeting control with CA4P and vehicle of (131)I-Hyp; and group C of vehicle control (10 mice per group)."3.79Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts. ( Chen, F; Cona, MM; de Witte, P; Feng, Y; Li, J; Ni, Y; Nuyts, J; Oyen, R; Verbruggen, A; Yu, J; Zhang, G; Zhang, J; Zhou, L, 2013)
"Histomorphological changes in murine fibrosarcoma after photodynamic therapy (PDT) based on the natural photosensitizer hypericin were evaluated."3.74Histomorphological changes in murine fibrosarcoma after hypericin-based photodynamic therapy. ( Bobrov, N; Brezáni, P; Cavarga, I; Fedorocko, P; Longauer, F; Mirossay, L; Miskovský, P; Rybárová, S; Stubna, J, 2007)
"Seven mice bearing intrahepatic radiation-induced fibrosarcoma-1 tumors were intravenously injected with hypericin 1 hour before (n = 3) or 24 hours after (n = 4) intratumoral ethanol injection."3.74Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model. ( Chen, F; de Witte, PA; Ni, Y; Van de Putte, M; Wang, H, 2008)
"Hypericin, a potent necrosis avid agent, features a peculiar affinity for necrotic tissue."3.74Exploration of the mechanism underlying the tumor necrosis avidity of hypericin. ( De Witte, PA; Ni, Y; Van de Putte, M, 2008)
" 33% fractionated dose), but the fractionated schedule of hypericin dosing was found to be more efficient than the single dose, measured by survival assay (p < 0."1.33Photoinduced antitumour effect of hypericin can be enhanced by fractionated dosing. ( Bobrov, N; Brezáni, P; Cavarga, I; Fedorocko, P; Longauer, F; Mirossay, L; Miskovský, P; Rybárova, S; Stubna, J, 2005)
"Hypericin is a natural photosensitizer produced in plants of the genus Hypericum."1.31Synergistic effect of photodynamic therapy with hypericin in combination with hyperthermia on loss of clonogenicity of RIF-1 cells. ( Agostinis, P; Chen, B; De Witte, PA; Xu, Y, 2001)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (72.73)29.6817
2010's3 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, J3
Cona, MM3
Chen, F3
Feng, Y2
Zhou, L1
Zhang, G1
Nuyts, J1
de Witte, P1
Zhang, J1
Yu, J1
Oyen, R2
Verbruggen, A3
Ni, Y6
Witte, Pd1
Van de Putte, M3
Marysael, T1
Fonge, H1
Roskams, T3
Bormans, G1
de Witte, PA6
Chen, B3
Ahmed, B1
Landuyt, W1
Gaspar, R1
Cavarga, I3
Brezáni, P3
Fedorocko, P3
Miskovský, P3
Bobrov, N2
Longauer, F2
Rybárova, S2
Mirossay, L2
Stubna, J2
Wang, H1
Xu, Y2
Agostinis, P2
Cekanová-Figurová, M1
Solár, P1

Other Studies

11 other studies available for hypericin and Fibrosarcoma

ArticleYear
Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts.
    Theranostics, 2013, Volume: 3, Issue:2

    Topics: Administration, Intravenous; Animals; Anthracenes; Antineoplastic Agents; Disease Models, Animal; Fi

2013
Targetability and biodistribution of radioiodinated hypericin: comparison between microdosing and carrier-added preparations.
    Anti-cancer agents in medicinal chemistry, 2014, Volume: 14, Issue:6

    Topics: Animals; Anthracenes; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Carriers; Fi

2014
Radiolabeled iodohypericin as tumor necrosis avid tracer: diagnostic and therapeutic potential.
    International journal of cancer, 2012, Jul-15, Volume: 131, Issue:2

    Topics: Animals; Anthracenes; Autoradiography; Female; Fibrosarcoma; Fluorodeoxyglucose F18; Mice; Mice, Inb

2012
Potentiation of photodynamic therapy with hypericin by mitomycin C in the radiation-induced fibrosarcoma-1 mouse tumor model.
    Photochemistry and photobiology, 2003, Volume: 78, Issue:3

    Topics: Animals; Anthracenes; Disease Models, Animal; Drug Synergism; Female; Fibrosarcoma; Mice; Mitomycin;

2003
Photoinduced antitumour effect of hypericin can be enhanced by fractionated dosing.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2005, Volume: 12, Issue:9

    Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Drug Administration Sched

2005
Histomorphological changes in murine fibrosarcoma after hypericin-based photodynamic therapy.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2007, Volume: 14, Issue:2-3

    Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Disease Models, Animal; F

2007
Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model.
    Academic radiology, 2008, Volume: 15, Issue:1

    Topics: Analysis of Variance; Animals; Anthracenes; Antineoplastic Agents; Disease Models, Animal; Ethanol;

2008
Exploration of the mechanism underlying the tumor necrosis avidity of hypericin.
    Oncology reports, 2008, Volume: 19, Issue:4

    Topics: Animals; Anthracenes; Carbocyanines; Female; Fibrosarcoma; Lipoproteins; Mice; Mice, Inbred C3H; Nec

2008
Synergistic effect of photodynamic therapy with hypericin in combination with hyperthermia on loss of clonogenicity of RIF-1 cells.
    International journal of oncology, 2001, Volume: 18, Issue:6

    Topics: Animals; Anthracenes; Apoptosis; Blotting, Western; Cell Death; Combined Modality Therapy; Drug Syne

2001
Photodynamic therapy of murine fibrosarcoma with topical and systemic administration of hypericin.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2001, Volume: 8, Issue:5

    Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Fibrosarcoma; Light; Male; Mice; Mice, Inbr

2001
Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model.
    International journal of cancer, 2002, Mar-10, Volume: 98, Issue:2

    Topics: Animals; Anthracenes; Apoptosis; Blood Vessels; Cell Nucleus; Cell Survival; DNA Fragmentation; Dose

2002