hypericin has been researched along with Disease Models, Animal in 36 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We determined whether sodium cholate (NaCh) could act as a solubilizing agent for the necrosis avid iodine-123-labeled hypericin ((123)I-Hyp) and investigated biodistribution and targetability of this formulation in rabbits with acute myocardial infarction (AMI)." | 7.81 | Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction. ( Cona, MM; Feng, Y; Li, Y; Ni, Y; Oyen, R; Verbruggen, A; Zhang, J, 2015) |
| "Hypericin (Hyp) is newly recognized as a necrosis avid agent, but its poor solubility imposes a great hindrance in clinical application." | 7.80 | Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis. ( Cona, MM; Fang, Z; Gao, M; Ji, Y; Jiang, C; Jiang, X; Li, Y; Liu, W; Ni, Y; Sun, Z; Wang, J; Wang, Q; Wang, X; Yao, N; Yin, Z; Zhan, Y; Zhang, J, 2014) |
| "In a syngeneic subcutaneous glioma mouse model we investigated the time dependent hypericin (HYP) uptake in malignant tumor tissue by microendoscopically fluorescence measurements." | 7.79 | Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model. ( Ehrhardt, A; Feigl, GC; Göbel, W; Mayer, D; Naumann, U; Noell, S; Ritz, R; Serifi, D, 2013) |
| "Histomorphological changes in murine fibrosarcoma after photodynamic therapy (PDT) based on the natural photosensitizer hypericin were evaluated." | 7.74 | Histomorphological changes in murine fibrosarcoma after hypericin-based photodynamic therapy. ( Bobrov, N; Brezáni, P; Cavarga, I; Fedorocko, P; Longauer, F; Mirossay, L; Miskovský, P; Rybárová, S; Stubna, J, 2007) |
| "Mono-[(123)I]iodohypericin ([(123)I]MIH) has been reported to have high avidity for necrosis." | 7.74 | Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT. ( Bormans, G; Feng, Y; Fonge, H; Mortelmans, L; Ni, Y; Nuyts, J; Verbruggen, A; Vunckx, K; Wang, H, 2008) |
| "Gavage administration of hypericin or SJW significantly inhibited the degree of retinal neovascularization, but did not affect the area of retinal vasoobliteration in a mouse model of OIR." | 7.74 | Hypericin inhibits pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy. ( Higuchi, A; Jo, N; Matsumura, M; Yamada, E; Yamada, H, 2008) |
| "Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and constitutes a major risk factor for progression to cirrhosis, liver failure and hepatocellular carcinoma (HCC)." | 5.56 | Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo. ( Bai, M; Bao, Y; Huang, Y; Li, Y; Liang, C; Liu, L; Song, Z; Sun, L; Wang, S; Yang, H; Yi, J; Yu, C, 2020) |
| "In conclusion, NTRT improved the anticancer efficacy of VDT in rabbits with VX2 tumors." | 5.42 | Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models. ( Chen, F; Dai, X; Li, Y; Ni, Y; Shao, H; Sun, Z; Xu, K; Zhang, J, 2015) |
| "Hypericin was radiolabeled with I using iodogen as oxidant, and (99m)Tc-Sestamibi was prepared from a commercial kit and radioactive sodium pertechnetate." | 5.39 | Comparative study of iodine-123-labeled hypericin and (99m)Tc-labeled hexakis [2-methoxy isobutyl isonitrile] in a rabbit model of myocardial infarction. ( Chen, F; Cona, MM; Feng, Y; Gheysens, O; Li, Y; Ni, Y; Nuyts, J; Oyen, R; Rezaei, A; Van Slambrouck, K; Verbruggen, A; Vunckx, K; Zhou, L, 2013) |
| "Tamoxifen and hypericin were able to greatly increase the growth-inhibitory and apoptosis-stimulatory potency of temozolomide via the downregulation of critical cell cycle-regulatory and prosurvival components." | 5.33 | Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin. ( Chen, TC; Gupta, V; Hofman, FM; Kardosh, A; Liebes, LF; Schönthal, AH; Su, YS; Wang, W, 2006) |
| "Clinical data indicate that hydroalcoholic extracts of Hypericum perforatum might be as valuable as conventional antidepressants in mild-to-moderate depression, with fewer side effects." | 4.82 | The antidepressant mechanism of Hypericum perforatum. ( Gobbi, M; Mennini, T, 2004) |
| "Photodynamic therapy with hypericin (HY-PDT) and hyperforin (HP) could be treatment modalities for colorectal cancer (CRC), but evidence of their effect on angiogenic factors in CRC is missing." | 3.91 | Novel Insights into the Effect of Hyperforin and Photodynamic Therapy with Hypericin on Chosen Angiogenic Factors in Colorectal Micro-Tumors Created on Chorioallantoic Membrane. ( Babinčák, M; Buríková, M; Fedoročko, P; Jendželovská, Z; Jendželovský, R; Košuth, J; Majerník, M; Ševc, J; Tonelli Gombalová, Z, 2019) |
| "We determined whether sodium cholate (NaCh) could act as a solubilizing agent for the necrosis avid iodine-123-labeled hypericin ((123)I-Hyp) and investigated biodistribution and targetability of this formulation in rabbits with acute myocardial infarction (AMI)." | 3.81 | Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction. ( Cona, MM; Feng, Y; Li, Y; Ni, Y; Oyen, R; Verbruggen, A; Zhang, J, 2015) |
| " Hypericin (HY) is the main components in SJW extracts, which is used to treat fatigue, weakness, and mild depression." | 3.81 | LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model. ( Chen, C; Chen, F; Lu, YN; Zhai, XJ; Zhu, CR, 2015) |
| "Hypericin (Hyp) is newly recognized as a necrosis avid agent, but its poor solubility imposes a great hindrance in clinical application." | 3.80 | Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis. ( Cona, MM; Fang, Z; Gao, M; Ji, Y; Jiang, C; Jiang, X; Li, Y; Liu, W; Ni, Y; Sun, Z; Wang, J; Wang, Q; Wang, X; Yao, N; Yin, Z; Zhan, Y; Zhang, J, 2014) |
| "Thirty severe combined immunodeficiency (SCID) mice bearing bilateral radiation-induced fibrosarcoma-1 (RIF-1) subcutaneously were divided into group A of SMSDTTS with sequential intravenous injections of combretastatin A4 phosphate (CA4P) and (131)I-iodohypericin ((131)I-Hyp) at a 24 h interval; group B of single targeting control with CA4P and vehicle of (131)I-Hyp; and group C of vehicle control (10 mice per group)." | 3.79 | Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts. ( Chen, F; Cona, MM; de Witte, P; Feng, Y; Li, J; Ni, Y; Nuyts, J; Oyen, R; Verbruggen, A; Yu, J; Zhang, G; Zhang, J; Zhou, L, 2013) |
| "In a syngeneic subcutaneous glioma mouse model we investigated the time dependent hypericin (HYP) uptake in malignant tumor tissue by microendoscopically fluorescence measurements." | 3.79 | Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model. ( Ehrhardt, A; Feigl, GC; Göbel, W; Mayer, D; Naumann, U; Noell, S; Ritz, R; Serifi, D, 2013) |
| " In the present study, the efficacy of topical hypericin-PDT was evaluated using a mouse model for actinic keratosis." | 3.77 | Photodynamic therapy using topically applied hypericin: comparative effect with methyl-aminolevulinic acid on UV induced skin tumours. ( Boiy, A; de Witte, PA; Roelandts, R, 2011) |
| "Histomorphological changes in murine fibrosarcoma after photodynamic therapy (PDT) based on the natural photosensitizer hypericin were evaluated." | 3.74 | Histomorphological changes in murine fibrosarcoma after hypericin-based photodynamic therapy. ( Bobrov, N; Brezáni, P; Cavarga, I; Fedorocko, P; Longauer, F; Mirossay, L; Miskovský, P; Rybárová, S; Stubna, J, 2007) |
| "Seven mice bearing intrahepatic radiation-induced fibrosarcoma-1 tumors were intravenously injected with hypericin 1 hour before (n = 3) or 24 hours after (n = 4) intratumoral ethanol injection." | 3.74 | Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model. ( Chen, F; de Witte, PA; Ni, Y; Van de Putte, M; Wang, H, 2008) |
| "Mono-[(123)I]iodohypericin ([(123)I]MIH) has been reported to have high avidity for necrosis." | 3.74 | Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT. ( Bormans, G; Feng, Y; Fonge, H; Mortelmans, L; Ni, Y; Nuyts, J; Verbruggen, A; Vunckx, K; Wang, H, 2008) |
| "Gavage administration of hypericin or SJW significantly inhibited the degree of retinal neovascularization, but did not affect the area of retinal vasoobliteration in a mouse model of OIR." | 3.74 | Hypericin inhibits pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy. ( Higuchi, A; Jo, N; Matsumura, M; Yamada, E; Yamada, H, 2008) |
| " HYP-LCPS induced a significant reduction in the number of CFU/ml in the mice; thus this formulation indicated it is as effective as a commercial dosage form." | 1.62 | In vivo study of hypericin-loaded poloxamer-based mucoadhesive in situ gelling liquid crystalline precursor system in a mice model of vulvovaginal candidiasis. ( Araújo, VHS; Bauab, TM; Calixto, GMF; Chorilli, M; de Araújo, PR; Oshiro-Junior, JA; Rodero, CF; Sato, MR, 2021) |
| "Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and constitutes a major risk factor for progression to cirrhosis, liver failure and hepatocellular carcinoma (HCC)." | 1.56 | Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo. ( Bai, M; Bao, Y; Huang, Y; Li, Y; Liang, C; Liu, L; Song, Z; Sun, L; Wang, S; Yang, H; Yi, J; Yu, C, 2020) |
| " Their biodistribution and pharmacokinetic properties were determined in rat models of induced necrosis." | 1.43 | Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones. ( Feng, Y; Gao, M; Huang, D; Jiang, C; Ni, Y; Shao, H; Sun, Z; Wang, X; Yang, S; Yin, Z; Zhang, D; Zhang, J, 2016) |
| "In conclusion, NTRT improved the anticancer efficacy of VDT in rabbits with VX2 tumors." | 1.42 | Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models. ( Chen, F; Dai, X; Li, Y; Ni, Y; Shao, H; Sun, Z; Xu, K; Zhang, J, 2015) |
| "Hypericin was radiolabeled with I using iodogen as oxidant, and (99m)Tc-Sestamibi was prepared from a commercial kit and radioactive sodium pertechnetate." | 1.39 | Comparative study of iodine-123-labeled hypericin and (99m)Tc-labeled hexakis [2-methoxy isobutyl isonitrile] in a rabbit model of myocardial infarction. ( Chen, F; Cona, MM; Feng, Y; Gheysens, O; Li, Y; Ni, Y; Nuyts, J; Oyen, R; Rezaei, A; Van Slambrouck, K; Verbruggen, A; Vunckx, K; Zhou, L, 2013) |
| "Hypericin (HY) is a naturally-occurring, potent photosensitizer." | 1.39 | Antibiotic-free nanotherapeutics: hypericin nanoparticles thereof for improved in vitro and in vivo antimicrobial photodynamic therapy and wound healing. ( Asem, H; El-Gowelli, H; Kandil, S; Nafee, N; Youssef, A, 2013) |
| "The high recurrence and lethality of ovarian cancer at advanced stages is problematic, especially due to the development of numerous micrometastases scattered throughout the abdominal cavity." | 1.35 | Benefits of nanoencapsulation for the hypercin-mediated photodetection of ovarian micrometastases. ( Delie, F; Gurny, R; Lange, N; Zeisser-Labouèbe, M, 2009) |
| "Tamoxifen and hypericin were able to greatly increase the growth-inhibitory and apoptosis-stimulatory potency of temozolomide via the downregulation of critical cell cycle-regulatory and prosurvival components." | 1.33 | Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin. ( Chen, TC; Gupta, V; Hofman, FM; Kardosh, A; Liebes, LF; Schönthal, AH; Su, YS; Wang, W, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (5.56) | 18.2507 |
| 2000's | 15 (41.67) | 29.6817 |
| 2010's | 15 (41.67) | 24.3611 |
| 2020's | 4 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Lei, C | 1 |
| Li, N | 1 |
| Chen, J | 1 |
| Wang, Q | 2 |
| Liang, C | 1 |
| Li, Y | 6 |
| Bai, M | 1 |
| Huang, Y | 1 |
| Yang, H | 1 |
| Liu, L | 1 |
| Wang, S | 1 |
| Yu, C | 1 |
| Song, Z | 1 |
| Bao, Y | 1 |
| Yi, J | 1 |
| Sun, L | 1 |
| de Araújo, PR | 1 |
| Calixto, GMF | 1 |
| Araújo, VHS | 1 |
| Sato, MR | 1 |
| Rodero, CF | 1 |
| Oshiro-Junior, JA | 1 |
| Bauab, TM | 1 |
| Chorilli, M | 1 |
| Macedo, PD | 1 |
| Corbi, ST | 1 |
| de Oliveira, GJPL | 1 |
| Perussi, JR | 1 |
| Ribeiro, AO | 1 |
| Marcantonio, RAC | 1 |
| Majerník, M | 1 |
| Jendželovský, R | 1 |
| Babinčák, M | 1 |
| Košuth, J | 1 |
| Ševc, J | 1 |
| Tonelli Gombalová, Z | 1 |
| Jendželovská, Z | 1 |
| Buríková, M | 1 |
| Fedoročko, P | 2 |
| Li, J | 1 |
| Cona, MM | 4 |
| Chen, F | 5 |
| Feng, Y | 5 |
| Zhou, L | 2 |
| Zhang, G | 1 |
| Nuyts, J | 3 |
| de Witte, P | 2 |
| Zhang, J | 5 |
| Yu, J | 1 |
| Oyen, R | 3 |
| Verbruggen, A | 4 |
| Ni, Y | 9 |
| Vunckx, K | 2 |
| Van Slambrouck, K | 1 |
| Rezaei, A | 1 |
| Gheysens, O | 1 |
| Nafee, N | 1 |
| Youssef, A | 1 |
| El-Gowelli, H | 1 |
| Asem, H | 1 |
| Kandil, S | 1 |
| Noell, S | 1 |
| Feigl, GC | 1 |
| Serifi, D | 1 |
| Mayer, D | 1 |
| Naumann, U | 1 |
| Göbel, W | 1 |
| Ehrhardt, A | 1 |
| Ritz, R | 1 |
| Ji, Y | 1 |
| Zhan, Y | 1 |
| Jiang, C | 2 |
| Jiang, X | 1 |
| Gao, M | 2 |
| Liu, W | 1 |
| Wang, J | 1 |
| Yao, N | 1 |
| Wang, X | 2 |
| Fang, Z | 1 |
| Yin, Z | 2 |
| Sun, Z | 3 |
| Ouyang, Z | 1 |
| Zhai, Z | 1 |
| Li, H | 1 |
| Liu, X | 1 |
| Qu, X | 1 |
| Li, X | 1 |
| Fan, Q | 1 |
| Tang, T | 1 |
| Qin, A | 1 |
| Dai, K | 1 |
| Zhai, XJ | 1 |
| Chen, C | 1 |
| Zhu, CR | 1 |
| Lu, YN | 1 |
| Shao, H | 2 |
| Dai, X | 1 |
| Xu, K | 1 |
| Zhang, D | 1 |
| Yang, S | 1 |
| Huang, D | 1 |
| Zeisser-Labouèbe, M | 1 |
| Delie, F | 1 |
| Gurny, R | 1 |
| Lange, N | 1 |
| Wang, D | 1 |
| Bai, J | 1 |
| Sun, F | 1 |
| Yang, D | 1 |
| Galeotti, N | 1 |
| Vivoli, E | 1 |
| Bilia, AR | 1 |
| Bergonzi, MC | 1 |
| Bartolini, A | 1 |
| Ghelardini, C | 1 |
| Boiy, A | 1 |
| Roelandts, R | 1 |
| de Witte, PA | 5 |
| Chen, B | 4 |
| Roskams, T | 3 |
| Ahmed, B | 1 |
| Landuyt, W | 1 |
| Gaspar, R | 1 |
| Mennini, T | 1 |
| Gobbi, M | 1 |
| Blank, M | 2 |
| Lavie, G | 2 |
| Mandel, M | 2 |
| Hazan, S | 2 |
| Orenstein, A | 1 |
| Meruelo, D | 2 |
| Keisari, Y | 1 |
| Barliya, T | 1 |
| Grunbaum, A | 1 |
| Solomon, A | 1 |
| Gupta, V | 1 |
| Su, YS | 1 |
| Wang, W | 1 |
| Kardosh, A | 1 |
| Liebes, LF | 1 |
| Hofman, FM | 1 |
| Schönthal, AH | 1 |
| Chen, TC | 1 |
| Bobrov, N | 1 |
| Cavarga, I | 1 |
| Longauer, F | 1 |
| Rybárová, S | 1 |
| Brezáni, P | 1 |
| Miskovský, P | 1 |
| Mirossay, L | 1 |
| Stubna, J | 1 |
| Savikin, K | 1 |
| Dobrić, S | 1 |
| Tadić, V | 1 |
| Zdunić, G | 1 |
| Butterweck, V | 1 |
| Schmidt, M | 1 |
| Van de Putte, M | 1 |
| Wang, H | 2 |
| Fonge, H | 1 |
| Mortelmans, L | 1 |
| Bormans, G | 1 |
| Higuchi, A | 1 |
| Yamada, H | 1 |
| Yamada, E | 1 |
| Jo, N | 1 |
| Matsumura, M | 1 |
| Kako, MD | 1 |
| al-Sultan, II | 1 |
| Saleem, AN | 1 |
| Tahara, YR | 1 |
| Sakamoto, TR | 1 |
| Oshima, YR | 1 |
| Ishibashi, TR | 1 |
| Inomata, HR | 1 |
| Murata, TR | 1 |
| Hinton, DR | 1 |
| Ryan, SJ | 1 |
| Xu, Y | 1 |
| Delaey, E | 1 |
| Agostinis, P | 1 |
| Vandenheede, JR | 1 |
2 reviews available for hypericin and Disease Models, Animal
| Article | Year |
|---|---|
The antidepressant mechanism of Hypericum perforatum.
Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Hypericum; Neur | 2004 |
St. John's wort: role of active compounds for its mechanism of action and efficacy.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Cells, Cultured; Clinical Tr | 2007 |
34 other studies available for hypericin and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Methyltransferases; Mice; Nerve | 2023 |
Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo.
Topics: AMP-Activated Protein Kinases; Animals; Anthracenes; Apoptosis; Cell Differentiation; Cell Survival; | 2020 |
In vivo study of hypericin-loaded poloxamer-based mucoadhesive in situ gelling liquid crystalline precursor system in a mice model of vulvovaginal candidiasis.
Topics: Adhesives; Animals; Anthracenes; Antifungal Agents; Candida albicans; Candidiasis, Vulvovaginal; Chr | 2021 |
Hypericin-glucamine antimicrobial photodynamic therapy in the progression of experimentally induced periodontal disease in rats.
Topics: Animals; Anthracenes; Disease Models, Animal; Disease Progression; Male; Maxilla; Molar; Periodontal | 2019 |
Novel Insights into the Effect of Hyperforin and Photodynamic Therapy with Hypericin on Chosen Angiogenic Factors in Colorectal Micro-Tumors Created on Chorioallantoic Membrane.
Topics: Angiogenesis Inducing Agents; Animals; Anthracenes; Biomarkers; Cell Line, Tumor; Chick Embryo; Chor | 2019 |
Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts.
Topics: Administration, Intravenous; Animals; Anthracenes; Antineoplastic Agents; Disease Models, Animal; Fi | 2013 |
Comparative study of iodine-123-labeled hypericin and (99m)Tc-labeled hexakis [2-methoxy isobutyl isonitrile] in a rabbit model of myocardial infarction.
Topics: Animals; Anthracenes; Autoradiography; Coronary Circulation; Coronary Vessels; Disease Models, Anima | 2013 |
Antibiotic-free nanotherapeutics: hypericin nanoparticles thereof for improved in vitro and in vivo antimicrobial photodynamic therapy and wound healing.
Topics: Animals; Anthracenes; Biofilms; Chemistry, Pharmaceutical; Disease Models, Animal; Female; Inflammat | 2013 |
Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model.
Topics: Animals; Anthracenes; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Endoscopy; Glioma; | 2013 |
Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis.
Topics: Animals; Anthracenes; Disease Models, Animal; Iodine Radioisotopes; Liver; Magnetic Resonance Imagin | 2014 |
Sodium cholate, a solubilizing agent for the necrosis avid radioiodinated hypericin in rabbits with acute myocardial infarction.
Topics: Animals; Anthracenes; Autoradiography; Disease Models, Animal; Gamma Cameras; Heart; Iodine Radioiso | 2015 |
Hypericin suppresses osteoclast formation and wear particle-induced osteolysis via modulating ERK signalling pathway.
Topics: Animals; Anthracenes; Bone Density Conservation Agents; Cell Line, Transformed; Cell Survival; Cell | 2014 |
LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model.
Topics: Amino Acids; Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; Chromatography, Liquid; | 2015 |
Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models.
Topics: Animals; Anthracenes; Autoradiography; Disease Models, Animal; Iodine Radioisotopes; Necrosis; Neopl | 2015 |
Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones.
Topics: Animals; Anthracenes; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; Drug Design; | 2016 |
Benefits of nanoencapsulation for the hypercin-mediated photodetection of ovarian micrometastases.
Topics: Animals; Anthracenes; Disease Models, Animal; Drug Delivery Systems; Endoscopy; Female; Fluorescence | 2009 |
Chemical constituents and antidepressant activity of the new species Hypericum enshiense occurring in China.
Topics: Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; China; Depression; Disease Models, An | 2010 |
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Anthracenes; Chromatography, High Pressure Liq | 2010 |
Photodynamic therapy using topically applied hypericin: comparative effect with methyl-aminolevulinic acid on UV induced skin tumours.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Anthracenes; Antineoplastic Agents; Disease M | 2011 |
Antivascular tumor eradication by hypericin-mediated photodynamic therapy.
Topics: Animals; Anthracenes; Blood Vessels; Disease Models, Animal; Female; Laser Therapy; Mice; Mice, Inbr | 2002 |
Potentiation of photodynamic therapy with hypericin by mitomycin C in the radiation-induced fibrosarcoma-1 mouse tumor model.
Topics: Animals; Anthracenes; Disease Models, Animal; Drug Synergism; Female; Fibrosarcoma; Mice; Mitomycin; | 2003 |
Antimetastatic activity of the photodynamic agent hypericin in the dark.
Topics: Animals; Anthracenes; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous Cell; Disease Mod | 2004 |
Anti-angiogenic activities of hypericin in vivo: potential for ophthalmologic applications.
Topics: Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Animals; Anthracenes; Cornea; Corneal Neovasc | 2005 |
Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin.
Topics: Animals; Anthracenes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combi | 2006 |
Histomorphological changes in murine fibrosarcoma after hypericin-based photodynamic therapy.
Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Disease Models, Animal; F | 2007 |
Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H. barbatum Jacq., H. hirsutum L., H. richeri Vill. and H. androsaemum L. in rats.
Topics: Animals; Anthracenes; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, | 2007 |
Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model.
Topics: Analysis of Variance; Animals; Anthracenes; Antineoplastic Agents; Disease Models, Animal; Ethanol; | 2008 |
Non-invasive detection and quantification of acute myocardial infarction in rabbits using mono-[123I]iodohypericin microSPECT.
Topics: Animals; Anthracenes; Disease Models, Animal; Drug Evaluation, Preclinical; Heart; Iodine Radioisoto | 2008 |
Hypericin inhibits pathological retinal neovascularization in a mouse model of oxygen-induced retinopathy.
Topics: Angiogenesis Inhibitors; Animals; Anthracenes; Disease Models, Animal; Enzyme Activation; Extracellu | 2008 |
Studies of sheep experimentally poisoned with Hypericum perforatum.
Topics: Animals; Anthracenes; Disease Models, Animal; Enzymes; Hemodynamics; Perylene; Plant Poisoning; Plan | 1993 |
The antidepressant hypericin inhibits progression of experimental proliferative vitreoretinopathy.
Topics: Animals; Anthracenes; Antidepressive Agents; Conjunctiva; Disease Models, Animal; Disease Progressio | 1999 |
Photodynamic therapy efficacy and tissue distribution of hypericin in a mouse P388 lymphoma tumor model.
Topics: Animals; Anthracenes; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Dru | 2000 |
Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model.
Topics: Animals; Anthracenes; Antineoplastic Agents; Dermatitis, Phototoxic; Disease Models, Animal; Female; | 2001 |