hypericin has been researched along with Dermatitis, Contact, Phototoxic in 9 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Therefore, we preloaded microplates with hypericin, Foscan, PVP-hypericin, or aluminum (III) phthalocyanine tetrasulfonate chloride (AlPCS4) for 24 hours and measured the PS distribution after addition of A431 human carcinoma cells: following another 24 hours up to 68% of hypericin were detected in the cell fraction." | 3.79 | Photosensitizer adhered to cell culture microplates induces phototoxicity in carcinoma cells. ( Kiesslich, T; Krammer, B; Plaetzer, K; Ziegler, V, 2013) |
| "Severe cutaneous phototoxicity was observed in 11 of 23 (48% [95% CI, 27% to 69%]) evaluable patients, and dose escalation could not be completed." | 2.69 | Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258. ( Crumpacker, C; Forcht, J; Gulick, RM; Holden-Wiltse, J; Hussey, S; Liebes, L; McAuliffe, V; Meehan, P; Stein, DS; Valentine, FT, 1999) |
| " John's wort have recorded an incidence of adverse events (AE) among those treated of between 1 and 3%." | 2.41 | Incidence and clinical relevance of the interactions and side effects of Hypericum preparations. ( Schulz, V, 2001) |
| "Hypericin is a naturally occurring photosensitizer, whose presence in plants has been responsible for cutaneous phototoxicity in grazing animals." | 1.29 | Hypericin-induced phototoxicity in cultured fibroblasts and swine erythrocytes. ( Kegode, R; Osweller, GD; Wolford, ST; Yu, H; Zhao, W, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ziegler, V | 1 |
| Kiesslich, T | 1 |
| Krammer, B | 1 |
| Plaetzer, K | 1 |
| Onoue, S | 1 |
| Seto, Y | 1 |
| Ochi, M | 1 |
| Inoue, R | 1 |
| Ito, H | 1 |
| Hatano, T | 1 |
| Yamada, S | 1 |
| Solár, P | 1 |
| Cavarga, I | 1 |
| Hofmanová, J | 1 |
| Cekanová-Figurová, M | 1 |
| Miskovský, P | 1 |
| Brezáni, P | 1 |
| Hrcková, G | 1 |
| Kozubík, A | 1 |
| Fedorocko, P | 1 |
| Boiy, A | 1 |
| Roelandts, R | 1 |
| van den Oord, J | 1 |
| de Witte, PA | 1 |
| Yu, H | 1 |
| Wolford, ST | 1 |
| Kegode, R | 1 |
| Zhao, W | 1 |
| Osweller, GD | 1 |
| Gulick, RM | 1 |
| McAuliffe, V | 1 |
| Holden-Wiltse, J | 1 |
| Crumpacker, C | 1 |
| Liebes, L | 1 |
| Stein, DS | 1 |
| Meehan, P | 1 |
| Hussey, S | 1 |
| Forcht, J | 1 |
| Valentine, FT | 1 |
| Schulz, V | 1 |
| Chen, B | 1 |
| Xu, Y | 1 |
| Roskams, T | 1 |
| Delaey, E | 1 |
| Agostinis, P | 1 |
| Vandenheede, JR | 1 |
| de Witte, P | 1 |
| Cotterill, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Dose Escalation Study of Synthetic Hypericin in HIV-Infected Patients With Less Than 300 CD4 Lymphocytes[NCT00000645] | Phase 1 | 32 participants | Interventional | Completed | |||
| A Pharmacologically Guided Phase I/II Study of Daily Orally Administered Synthetic Hypericin in HIV-Infected Subjects[NCT00000792] | Phase 1 | 24 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hypericin and Dermatitis, Contact, Phototoxic
| Article | Year |
|---|---|
Incidence and clinical relevance of the interactions and side effects of Hypericum preparations.
Topics: Anthracenes; Antidepressive Agents; Clinical Trials as Topic; Contraindications; Dermatitis, Phototo | 2001 |
1 trial available for hypericin and Dermatitis, Contact, Phototoxic
| Article | Year |
|---|---|
Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258.
Topics: Administration, Oral; Adult; Anthracenes; Anti-HIV Agents; CD4 Lymphocyte Count; Dermatitis, Phototo | 1999 |
Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258.
Topics: Administration, Oral; Adult; Anthracenes; Anti-HIV Agents; CD4 Lymphocyte Count; Dermatitis, Phototo | 1999 |
Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258.
Topics: Administration, Oral; Adult; Anthracenes; Anti-HIV Agents; CD4 Lymphocyte Count; Dermatitis, Phototo | 1999 |
Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258.
Topics: Administration, Oral; Adult; Anthracenes; Anti-HIV Agents; CD4 Lymphocyte Count; Dermatitis, Phototo | 1999 |
7 other studies available for hypericin and Dermatitis, Contact, Phototoxic
| Article | Year |
|---|---|
Photosensitizer adhered to cell culture microplates induces phototoxicity in carcinoma cells.
Topics: Anthracenes; Carcinoma; Cell Adhesion; Cell Culture Techniques; Cell Line, Tumor; Cell Membrane; Cul | 2013 |
In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts.
Topics: Anthracenes; Antidepressive Agents; Biological Products; Dermatitis, Phototoxic; DNA Damage; Enzyme | 2011 |
Effect of acetazolamide on hypericin photocytotoxicity.
Topics: Acetazolamide; Anthracenes; Antineoplastic Agents; Carbonic Anhydrase Inhibitors; Cell Division; Cel | 2002 |
Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin.
Topics: Administration, Topical; Aminolevulinic Acid; Animals; Anthracenes; Dermatitis, Phototoxic; Female; | 2008 |
Hypericin-induced phototoxicity in cultured fibroblasts and swine erythrocytes.
Topics: 3T3 Cells; Animals; Anthracenes; Dermatitis, Phototoxic; Erythrocytes; Fibroblasts; In Vitro Techniq | 1996 |
Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model.
Topics: Animals; Anthracenes; Antineoplastic Agents; Dermatitis, Phototoxic; Disease Models, Animal; Female; | 2001 |
Severe phototoxic reaction to laser treatment in a patient taking St John's Wort.
Topics: Anthracenes; Antidepressive Agents; Dermatitis, Phototoxic; Face; Female; Humans; Hypericum; Keratos | 2001 |