hypericin has been researched along with Depression in 14 studies
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using the keywords [St John's Wort OR Hypericum perforatum OR hypericin OR hyperforin OR johanniskraut OR] AND [depression OR antidepressant OR SSRI], a preliminary search (without language restriction) on the PubMed, Ovid, Clinical Trials Register of the Cochrane Collaboration Depression, Anxiety and Neurosis Group, Cochrane Field for Complementary Medicine, China National Knowledge Infrastructure and WanFang database yielded 5428 papers between 1-Jan-1960 and 1-May-2016." | 8.95 | Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. ( Ho, CY; Ng, QX; Venkatanarayanan, N, 2017) |
| "Using the keywords [St John's Wort OR Hypericum perforatum OR hypericin OR hyperforin OR johanniskraut OR] AND [depression OR antidepressant OR SSRI], a preliminary search (without language restriction) on the PubMed, Ovid, Clinical Trials Register of the Cochrane Collaboration Depression, Anxiety and Neurosis Group, Cochrane Field for Complementary Medicine, China National Knowledge Infrastructure and WanFang database yielded 5428 papers between 1-Jan-1960 and 1-May-2016." | 4.95 | Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis. ( Ho, CY; Ng, QX; Venkatanarayanan, N, 2017) |
| "Hypericum perforatum (St John's Wort [SJW]) counts among the most favourite herbal drugs, and is the only herbal alternative to classic synthetic antidepressants in the therapy of mild to moderate depression." | 4.83 | Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. ( Schubert-Zsilavecz, M; Wurglics, M, 2006) |
| "Clinical data indicate that hydroalcoholic extracts of Hypericum perforatum might be as valuable as conventional antidepressants in mild-to-moderate depression, with fewer side effects." | 4.82 | The antidepressant mechanism of Hypericum perforatum. ( Gobbi, M; Mennini, T, 2004) |
| " Hypericin (HY) is the main components in SJW extracts, which is used to treat fatigue, weakness, and mild depression." | 3.81 | LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model. ( Chen, C; Chen, F; Lu, YN; Zhai, XJ; Zhu, CR, 2015) |
| " However, mounting evidence suggests one component, hypericin, may be associated with cataractogenesis." | 3.75 | The association between self-reported cataracts and St. John's Wort. ( Booth, JN; McGwin, G, 2009) |
| "Studies of St." | 2.43 | St. John's wort. ( Lawvere, S; Mahoney, MC, 2005) |
| "As hypericin has been found to bind to LDL one may assume that it can act as antioxidant of LDL lipid oxidation, a property which is of prophylactic/therapeutic interest regarding atherogenesis as LDL oxidation may play a pivotal role in the onset of atherosclerosis." | 1.34 | The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug? ( Exner, M; Gmeiner, BM; Hermann, M; Kapiotis, S; Laggner, H; Mühl, A; Schreier, S, 2007) |
| "John's wort supplement for treatment of depression." | 1.32 | Clinic at the health food store? Employee recommendations and product analysis. ( Abourashed, EA; Glisson, JK; Hufford, CD; Khan, I; Ogletree, R; Rogers, HE, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Lei, C | 1 |
| Li, N | 1 |
| Chen, J | 1 |
| Wang, Q | 1 |
| Russo, E | 1 |
| Scicchitano, F | 1 |
| Whalley, BJ | 1 |
| Mazzitello, C | 1 |
| Ciriaco, M | 1 |
| Esposito, S | 1 |
| Patanè, M | 1 |
| Upton, R | 1 |
| Pugliese, M | 1 |
| Chimirri, S | 1 |
| Mammì, M | 1 |
| Palleria, C | 1 |
| De Sarro, G | 1 |
| Zhai, XJ | 1 |
| Chen, F | 1 |
| Chen, C | 1 |
| Zhu, CR | 1 |
| Lu, YN | 1 |
| Ng, QX | 1 |
| Venkatanarayanan, N | 1 |
| Ho, CY | 1 |
| Wang, D | 1 |
| Bai, J | 1 |
| Sun, F | 1 |
| Yang, D | 1 |
| Booth, JN | 1 |
| McGwin, G | 1 |
| Glisson, JK | 1 |
| Rogers, HE | 1 |
| Abourashed, EA | 1 |
| Ogletree, R | 1 |
| Hufford, CD | 1 |
| Khan, I | 1 |
| WENZEL, E | 1 |
| Mennini, T | 1 |
| Gobbi, M | 1 |
| Capasso, R | 1 |
| Borrelli, F | 1 |
| Capasso, F | 1 |
| Mascolo, N | 1 |
| Izzo, AA | 1 |
| Lawvere, S | 1 |
| Mahoney, MC | 1 |
| Wurglics, M | 1 |
| Schubert-Zsilavecz, M | 1 |
| Laggner, H | 1 |
| Schreier, S | 1 |
| Hermann, M | 1 |
| Exner, M | 1 |
| Mühl, A | 1 |
| Gmeiner, BM | 1 |
| Kapiotis, S | 1 |
5 reviews available for hypericin and Depression
| Article | Year |
|---|---|
Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions.
Topics: Anthracenes; Antidepressive Agents; Antiviral Agents; Depression; Herb-Drug Interactions; Humans; Hy | 2014 |
Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis.
Topics: Anthracenes; Antidepressive Agents; Depression; Humans; Hypericum; Perylene; Phloroglucinol; Phytoth | 2017 |
The antidepressant mechanism of Hypericum perforatum.
Topics: Animals; Anthracenes; Bridged Bicyclo Compounds; Depression; Disease Models, Animal; Hypericum; Neur | 2004 |
St. John's wort.
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Humans; Hypericum; Peryle | 2005 |
Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients.
Topics: Animals; Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Clinical Trials as Topic; De | 2006 |
9 other studies available for hypericin and Depression
| Article | Year |
|---|---|
Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Methyltransferases; Mice; Nerve | 2023 |
LC-MS/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model.
Topics: Amino Acids; Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; Chromatography, Liquid; | 2015 |
Chemical constituents and antidepressant activity of the new species Hypericum enshiense occurring in China.
Topics: Animals; Anthracenes; Antidepressive Agents; Behavior, Animal; China; Depression; Disease Models, An | 2010 |
The association between self-reported cataracts and St. John's Wort.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anthracenes; Cataract; Depression; Female; Humans; Hype | 2009 |
Clinic at the health food store? Employee recommendations and product analysis.
Topics: Anthracenes; Chromatography, High Pressure Liquid; Consumer Product Safety; Depression; Drug Labelin | 2003 |
[On the therapy of depressive states with hypericin (Preliminary results with the experimental preparation Hyp. No 1)].
Topics: Anthracenes; Depression; Depressive Disorder; Perylene; Tranquilizing Agents | 1959 |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridge | 2004 |
The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug?
Topics: Anthracenes; Antidepressive Agents; Antioxidants; Atherosclerosis; Bridged Bicyclo Compounds; Cells, | 2007 |
[Therapy of mild to medium degree depression].
Topics: Anthracenes; Antidepressive Agents; Bridged Bicyclo Compounds; Depression; Depressive Disorder; Huma | 1998 |