hypericin has been researched along with Brain Neoplasms in 17 studies
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypericin is a potent inhibitor of glioma growth in vitro." | 9.15 | A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. ( Appley, AJ; Cabana, BE; Chen, TC; Couldwell, WT; Forsyth, PA; Hinton, DR; Spence, AM; Stillerman, CB; Surnock, AA; Tobia, AJ, 2011) |
| "In a syngeneic subcutaneous glioma mouse model we investigated the time dependent hypericin (HYP) uptake in malignant tumor tissue by microendoscopically fluorescence measurements." | 7.79 | Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model. ( Ehrhardt, A; Feigl, GC; Göbel, W; Mayer, D; Naumann, U; Noell, S; Ritz, R; Serifi, D, 2013) |
| "In five patients with a recurrence of a malignant glioma a newly developed water soluble formulation of hypericin was given intravenously (0." | 7.78 | Hypericin for visualization of high grade gliomas: first clinical experience. ( Bornemann, A; Daniels, R; Dietz, K; Feigl, GC; Mayer, D; Noell, S; Ramina, K; Ritz, R; Schmidt, V; Strauss, WS; Tatagiba, M, 2012) |
| " Hypericin (HY) exhibit high phototoxicity to malignant cells and accumulates to a higher extent in glioblastoma cells as compared to neurons." | 7.74 | Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines. ( Dietz, K; Ritz, R; Roser, F; Schenk, M; Strauss, WS; Tatagiba, M; Wein, HT, 2007) |
| "The effect of hypericin, an antiviral drug and a potent protein kinase C (PKC) inhibitor, on glioma cell invasion was investigated in vitro." | 7.69 | Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor. ( Couldwell, WT; Hinton, DR; Law, RE; Zhang, W, 1997) |
| "Malignant gliomas are diffuse infiltrative growing tumors with a poor prognosis despite treatment with a combination of surgery, radiotherapy and chemotherapy." | 5.37 | Selective enrichment of hypericin in malignant glioma: pioneering in vivo results. ( Mayer, D; Noell, S; Ritz, R; Strauss, WS; Tatagiba, MS, 2011) |
| "Three patients suffered from an anaplastic astrocytoma, WHO grade III, nine had a glioblastoma, WHO grade IV." | 5.35 | Hypericin uptake: a prognostic marker for survival in high-grade glioma. ( Bornemann, A; Dietz, K; Duffner, F; Müller, M; Ritz, R; Roser, F; Tatagiba, M, 2008) |
| "When hypericin was combined with diazepam, photocytotoxicity was increased in U-87 MG cells and primary cultures unlike U373 MG cells." | 5.33 | Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells. ( Gajdos, M; Kocanová, S; Lavicka, J; Mirossay, A; Mirossay, L; Miskovsky, P; Mojzis, J; Sarissky, M; Sulla, I, 2005) |
| "Tamoxifen and hypericin were able to greatly increase the growth-inhibitory and apoptosis-stimulatory potency of temozolomide via the downregulation of critical cell cycle-regulatory and prosurvival components." | 5.33 | Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin. ( Chen, TC; Gupta, V; Hofman, FM; Kardosh, A; Liebes, LF; Schönthal, AH; Su, YS; Wang, W, 2006) |
| "Hypericin is a potent inhibitor of glioma growth in vitro." | 5.15 | A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. ( Appley, AJ; Cabana, BE; Chen, TC; Couldwell, WT; Forsyth, PA; Hinton, DR; Spence, AM; Stillerman, CB; Surnock, AA; Tobia, AJ, 2011) |
| "In a syngeneic subcutaneous glioma mouse model we investigated the time dependent hypericin (HYP) uptake in malignant tumor tissue by microendoscopically fluorescence measurements." | 3.79 | Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model. ( Ehrhardt, A; Feigl, GC; Göbel, W; Mayer, D; Naumann, U; Noell, S; Ritz, R; Serifi, D, 2013) |
| "In five patients with a recurrence of a malignant glioma a newly developed water soluble formulation of hypericin was given intravenously (0." | 3.78 | Hypericin for visualization of high grade gliomas: first clinical experience. ( Bornemann, A; Daniels, R; Dietz, K; Feigl, GC; Mayer, D; Noell, S; Ramina, K; Ritz, R; Schmidt, V; Strauss, WS; Tatagiba, M, 2012) |
| " Hypericin (HY) exhibit high phototoxicity to malignant cells and accumulates to a higher extent in glioblastoma cells as compared to neurons." | 3.74 | Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines. ( Dietz, K; Ritz, R; Roser, F; Schenk, M; Strauss, WS; Tatagiba, M; Wein, HT, 2007) |
| "The effect of hypericin, an antiviral drug and a potent protein kinase C (PKC) inhibitor, on glioma cell invasion was investigated in vitro." | 3.69 | Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor. ( Couldwell, WT; Hinton, DR; Law, RE; Zhang, W, 1997) |
| "Malignant gliomas are diffuse infiltrative growing tumors with a poor prognosis despite treatment with a combination of surgery, radiotherapy and chemotherapy." | 1.37 | Selective enrichment of hypericin in malignant glioma: pioneering in vivo results. ( Mayer, D; Noell, S; Ritz, R; Strauss, WS; Tatagiba, MS, 2011) |
| "Three patients suffered from an anaplastic astrocytoma, WHO grade III, nine had a glioblastoma, WHO grade IV." | 1.35 | Hypericin uptake: a prognostic marker for survival in high-grade glioma. ( Bornemann, A; Dietz, K; Duffner, F; Müller, M; Ritz, R; Roser, F; Tatagiba, M, 2008) |
| "When hypericin was combined with diazepam, photocytotoxicity was increased in U-87 MG cells and primary cultures unlike U373 MG cells." | 1.33 | Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells. ( Gajdos, M; Kocanová, S; Lavicka, J; Mirossay, A; Mirossay, L; Miskovsky, P; Mojzis, J; Sarissky, M; Sulla, I, 2005) |
| "Tamoxifen and hypericin were able to greatly increase the growth-inhibitory and apoptosis-stimulatory potency of temozolomide via the downregulation of critical cell cycle-regulatory and prosurvival components." | 1.33 | Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin. ( Chen, TC; Gupta, V; Hofman, FM; Kardosh, A; Liebes, LF; Schönthal, AH; Su, YS; Wang, W, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Bassler, MC | 1 |
| Rammler, T | 1 |
| Wackenhut, F | 1 |
| Zur Oven-Krockhaus, S | 1 |
| Secic, I | 1 |
| Ritz, R | 6 |
| Meixner, AJ | 1 |
| Brecht, M | 1 |
| Chong, K | 1 |
| Ku, T | 1 |
| Saw, PE | 1 |
| Jon, S | 1 |
| Park, JH | 1 |
| Choi, C | 1 |
| Noell, S | 3 |
| Feigl, GC | 2 |
| Serifi, D | 1 |
| Mayer, D | 3 |
| Naumann, U | 1 |
| Göbel, W | 1 |
| Ehrhardt, A | 1 |
| Garg, AD | 1 |
| Vandenberk, L | 1 |
| Koks, C | 1 |
| Verschuere, T | 1 |
| Boon, L | 1 |
| Van Gool, SW | 1 |
| Agostinis, P | 1 |
| Misuth, M | 1 |
| Joniova, J | 1 |
| Horvath, D | 1 |
| Dzurova, L | 1 |
| Nichtova, Z | 1 |
| Novotova, M | 1 |
| Miskovsky, P | 2 |
| Stroffekova, K | 1 |
| Huntosova, V | 1 |
| Shibata, Y | 1 |
| Strauss, WS | 3 |
| Tatagiba, MS | 1 |
| Couldwell, WT | 4 |
| Surnock, AA | 2 |
| Tobia, AJ | 1 |
| Cabana, BE | 1 |
| Stillerman, CB | 1 |
| Forsyth, PA | 1 |
| Appley, AJ | 1 |
| Spence, AM | 1 |
| Hinton, DR | 4 |
| Chen, TC | 3 |
| Daniels, R | 1 |
| Schmidt, V | 1 |
| Bornemann, A | 2 |
| Ramina, K | 1 |
| Dietz, K | 3 |
| Tatagiba, M | 3 |
| Su, S | 1 |
| Fry, D | 1 |
| Liebes, L | 1 |
| Sarissky, M | 1 |
| Lavicka, J | 1 |
| Kocanová, S | 1 |
| Sulla, I | 1 |
| Mirossay, A | 1 |
| Gajdos, M | 1 |
| Mojzis, J | 1 |
| Mirossay, L | 1 |
| Gupta, V | 1 |
| Su, YS | 1 |
| Wang, W | 1 |
| Kardosh, A | 1 |
| Liebes, LF | 1 |
| Hofman, FM | 1 |
| Schönthal, AH | 1 |
| Wein, HT | 1 |
| Schenk, M | 1 |
| Roser, F | 2 |
| Müller, M | 1 |
| Duffner, F | 1 |
| Gopalakrishna, R | 1 |
| He, S | 1 |
| Weiss, MH | 1 |
| Law, RE | 3 |
| Apuzzo, ML | 1 |
| Zhang, W | 2 |
1 trial available for hypericin and Brain Neoplasms
| Article | Year |
|---|---|
A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anthracenes; Antineoplastic Agents; Brain Neoplasms; | 2011 |
16 other studies available for hypericin and Brain Neoplasms
| Article | Year |
|---|---|
Accumulation and penetration behavior of hypericin in glioma tumor spheroids studied by fluorescence microscopy and confocal fluorescence lifetime imaging microscopy.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Glioma; Humans; Microscopy, Fluorescence; Perylene; | 2022 |
Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Humans; Light; Micelles; Mitochondria | 2013 |
Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model.
Topics: Animals; Anthracenes; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Endoscopy; Glioma; | 2013 |
Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma.
Topics: Adaptive Immunity; Animals; Anthracenes; Apoptosis; Brain Neoplasms; Cancer Vaccines; CD8-Positive T | 2016 |
The flashlights on a distinct role of protein kinase C δ: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells.
Topics: Algorithms; Anthracenes; Apoptosis; Brain Neoplasms; Catalytic Domain; Cell Line, Tumor; Glioma; Hum | 2017 |
Comment on "Hypericin uptake: a prognostic marker for survival in high-grade glioma".
Topics: Anthracenes; Brain Neoplasms; Glioma; Humans; Perylene | 2009 |
Selective enrichment of hypericin in malignant glioma: pioneering in vivo results.
Topics: Animals; Anthracenes; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Glioma; Male; Neopla | 2011 |
Hypericin for visualization of high grade gliomas: first clinical experience.
Topics: Aged; Anthracenes; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Injections, Intravenous; M | 2012 |
Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apop | 2003 |
Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells.
Topics: Adult; Aged; Anthracenes; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Diazepam; Drug Interact | 2005 |
Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin.
Topics: Animals; Anthracenes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combi | 2006 |
Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Glioblastoma; Glioma; Humans; Light; | 2007 |
Hypericin uptake: a prognostic marker for survival in high-grade glioma.
Topics: Adult; Aged; Anthracenes; Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Diseas | 2008 |
Hypericin: a potential antiglioma therapy.
Topics: Anthracenes; Apoptosis; Brain Neoplasms; Cell Division; Cell Line; Cell Survival; DNA Damage; Dose-R | 1994 |
Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report.
Topics: Adult; Anthracenes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Brain Neoplasms; Cell Di | 1996 |
Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor.
Topics: Anthracenes; Antineoplastic Agents; Brain Neoplasms; Cell Movement; Cells, Cultured; Enzyme Inhibito | 1997 |