hypericin has been researched along with Bladder Cancer in 36 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The optimum combination of dosage of PVP-hypericin and its instillation time was established and will be used to determine sensitivity and specificity of PVP-hypericin cystoscopy in a larger multicenter phase IIB study." | 9.20 | A phase IIA dose-finding study of PVP-hypericin fluorescence cystoscopy for detection of nonmuscle-invasive bladder cancer. ( Abrahamsberg, C; Gschwend, JE; Horn, T; Russ, D; Straub, M, 2015) |
| "Hypericin is a bright red fluorescent compound that can be used in urological medicine as a photodiagnostic to detect non-muscle-invasive bladder cancer lesions." | 7.77 | Human serum albumin as key mediator of the differential accumulation of hypericin in normal urothelial cell spheroids versus urothelial cell carcinoma spheroids. ( de Witte, PA; Lerut, E; Roelants, M; Van Cleynenbreugel, B; Van Poppel, H, 2011) |
| "Photodynamic diagnosis (PDD) using hypericin (HY), a natural photosensitizer, detects bladder cancer significantly better than white light endoscopy." | 7.74 | Effects of N-methyl pyrrolidone on the uptake of hypericin in human bladder carcinoma and co-staining with DAPI investigated by confocal microscopy. ( Fu, CY; Kho, KW; Olivo, M; Saw, CL; Sia Heng, PW; Soo, KC; Wohland, T, 2007) |
| " Given that the photosensitizer hypericin is under consideration for PDT treatment of bladder cancer we used oligonucleotide microarrays in the T24 bladder cancer cell line to identify differentially expressed genes with therapeutic potential." | 7.74 | Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells. ( Agostinis, P; Buytaert, E; Close, P; de Witte, PA; Durinck, S; Kocanova, S; Matroule, JY; Piette, J; Vandenheede, JR, 2008) |
| "In this study we have evaluated the use of hypericin ex vivo urine fluorescence cytology as a non-invasive method for detecting early bladder cancers." | 7.72 | Novel photodynamic diagnosis of bladder cancer: ex vivo fluorescence cytology using hypericin. ( Bhuvaneswari, R; Cheng, C; Lau, W; Manivasager, V; Olivo, M; Soo, KC; Tan, PH; Wei, Z, 2003) |
| "We determined the sensitivity and specificity of detecting flat bladder carcinoma in situ through fluorescent detection after intravesical hypericin instillations." | 7.70 | Fluorescence detection of flat bladder carcinoma in situ after intravesical instillation of hypericin. ( Baert, L; D'Hallewin, MA; De Witte, PA; Merlevede, W; Waelkens, E, 2000) |
| "The optimum combination of dosage of PVP-hypericin and its instillation time was established and will be used to determine sensitivity and specificity of PVP-hypericin cystoscopy in a larger multicenter phase IIB study." | 5.20 | A phase IIA dose-finding study of PVP-hypericin fluorescence cystoscopy for detection of nonmuscle-invasive bladder cancer. ( Abrahamsberg, C; Gschwend, JE; Horn, T; Russ, D; Straub, M, 2015) |
| "Our study has unraveled one of the many factors contributing to the selective uptake of hypericin in bladder cancer." | 3.78 | Altered expression of cell adhesion molecules leads to differential uptake of hypericin in urothelial cancer. ( Kent Mancer, JF; Lau, WK; Lucky, SS; Olivo, M, 2012) |
| "This study shows that PVP-hypericin appears to have great potential as a photodynamic agent against non-muscle-invasive bladder cancers after intravesical administration, with a limited risk of affecting the deeper layers of the bladder." | 3.77 | Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder. ( de Witte, PA; Hettinger, K; Van Cleynenbreugel, B; Van Poppel, H; Vandepitte, J, 2011) |
| "Hypericin is a bright red fluorescent compound that can be used in urological medicine as a photodiagnostic to detect non-muscle-invasive bladder cancer lesions." | 3.77 | Human serum albumin as key mediator of the differential accumulation of hypericin in normal urothelial cell spheroids versus urothelial cell carcinoma spheroids. ( de Witte, PA; Lerut, E; Roelants, M; Van Cleynenbreugel, B; Van Poppel, H, 2011) |
| "Photodynamic diagnosis (PDD) using hypericin (HY), a natural photosensitizer, detects bladder cancer significantly better than white light endoscopy." | 3.74 | Effects of N-methyl pyrrolidone on the uptake of hypericin in human bladder carcinoma and co-staining with DAPI investigated by confocal microscopy. ( Fu, CY; Kho, KW; Olivo, M; Saw, CL; Sia Heng, PW; Soo, KC; Wohland, T, 2007) |
| " Given that the photosensitizer hypericin is under consideration for PDT treatment of bladder cancer we used oligonucleotide microarrays in the T24 bladder cancer cell line to identify differentially expressed genes with therapeutic potential." | 3.74 | Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells. ( Agostinis, P; Buytaert, E; Close, P; de Witte, PA; Durinck, S; Kocanova, S; Matroule, JY; Piette, J; Vandenheede, JR, 2008) |
| "To optimise the diagnostic and phototherapeutic efficacy of hypericin in superficial bladder cancer, by developing a bladder instillation fluid that does not depend on the presence of plasma proteins for an appropriate and reliable urothelial uptake of hypericin." | 3.73 | In vivo accumulation of different hypericin ion pairs in the urothelium of the rat bladder. ( de Witte, PA; Huygens, A; Kamuhabwa, AR; Roskams, T; van Cleynenbreugel, B; van Poppel, H, 2005) |
| "We investigated the importance of E-cadherin expression on the selective accumulation of hypericin in superficial bladder cancer after intravesical instillation." | 3.73 | Permeation of hypericin in spheroids composed of different grade transitional cell carcinoma cell lines and normal human urothelial cells. ( de Witte, PA; Huygens, A; Kamuhabwa, AR; Roskams, T; VAN Cleynenbreugel, B; VAN Poppel, H, 2005) |
| "In this study we have evaluated the use of hypericin ex vivo urine fluorescence cytology as a non-invasive method for detecting early bladder cancers." | 3.72 | Novel photodynamic diagnosis of bladder cancer: ex vivo fluorescence cytology using hypericin. ( Bhuvaneswari, R; Cheng, C; Lau, W; Manivasager, V; Olivo, M; Soo, KC; Tan, PH; Wei, Z, 2003) |
| "Hypericin-induced fluorescence has a high sensitivity and specificity for detecting bladder cancer." | 3.71 | Hypericin-based fluorescence diagnosis of bladder carcinoma. ( Baert, L; D'Hallewin, MA; De Witte, PA; Kamuhabwa, AR; Roskams, T, 2002) |
| "We determined the sensitivity and specificity of detecting flat bladder carcinoma in situ through fluorescent detection after intravesical hypericin instillations." | 3.70 | Fluorescence detection of flat bladder carcinoma in situ after intravesical instillation of hypericin. ( Baert, L; D'Hallewin, MA; De Witte, PA; Merlevede, W; Waelkens, E, 2000) |
| "In flat bladder cancer and carcinoma in situ, and in multifocal papillary cancer, some smaller lesions may be overlooked at cystoscopy." | 2.44 | Recent developments in fluorescence cystoscopy: do novel agents bring a benefit? ( Marberger, M; Schmidbauer, J, 2007) |
| "Moreover, we found that a subset of cancer patients of various cancer-types indeed possessed CALRlow or CRTlow-tumours." | 1.42 | Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal. ( Agostinis, P; de Witte, P; Elsen, S; Garg, AD; Krysko, DV; Vandenabeele, P, 2015) |
| "Bladder and breast cancer cells and their Pgp-overexpressing MDR subclones (MGHU1, MGHU1/R, MCF-7, MCF-7/R) were given hypericin/MTZ combinations, with/without blue-light illumination." | 1.34 | Photochemical internalisation of chemotherapy potentiates killing of multidrug-resistant breast and bladder cancer cells. ( Adigbli, DK; Farooqui, N; Loizidou, M; Macrobert, AJ; Risley, P; Sousi, E; Taylor, I; Wilson, DG, 2007) |
| "The high mortality rate in bladder cancer can be reduced by early treatment following pre-cancerous screening." | 1.34 | Fluorescence detection of bladder cancer using urine cytology. ( Chin, WW; Fu, CY; Lau, WK; Ng, BK; Olivo, M; Razul, SG; Tan, PH, 2007) |
| "Hypericin (8 microM) was instilled in the bladder for 2-3 h before photodynamic diagnosis of bladder tumors." | 1.33 | Determination of hypericin in human plasma by high-performance liquid chromatography after intravesical administration in patients with transitional cell carcinoma of the bladder. ( Baert, L; D'Hallewin, MA; de Witte, PA; Di Mavungu, JD; Hoogmartens, J; Kamuhabwa, AA, 2005) |
| "Hypericin was introduced intravesically for 2 h before cystoscopy." | 1.33 | Is photodynamic diagnosis using hypericin better than white-light cystoscopy for detecting superficial bladder carcinoma? ( Cheng, CW; Lau, WK; Olivo, M; Sim, HG; Tan, PH, 2005) |
| "The fluorescence of hypericin in the bladder tumors and normal bladder was documented using fluorescence microscopy." | 1.31 | Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy. ( Baert, L; Cosserat-Gerardin, I; D'Hallewin, MA; de Witte, PA; Didelon, J; Guillemin, F; Kamuhabwa, AA; Notter, D; Roskams, T, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 30 (83.33) | 29.6817 |
| 2010's | 6 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Straub, M | 1 |
| Russ, D | 1 |
| Horn, T | 1 |
| Gschwend, JE | 1 |
| Abrahamsberg, C | 1 |
| Garg, AD | 1 |
| Elsen, S | 1 |
| Krysko, DV | 1 |
| Vandenabeele, P | 1 |
| de Witte, P | 2 |
| Agostinis, P | 4 |
| Bhuvaneswari, R | 3 |
| Gan, YY | 1 |
| Lucky, SS | 2 |
| Chin, WW | 3 |
| Ali, SM | 2 |
| Soo, KC | 5 |
| Olivo, M | 10 |
| Vandepitte, J | 1 |
| Van Cleynenbreugel, B | 8 |
| Hettinger, K | 1 |
| Van Poppel, H | 8 |
| de Witte, PA | 17 |
| Kent Mancer, JF | 1 |
| Lau, WK | 3 |
| Roelants, M | 1 |
| Lerut, E | 1 |
| Yuen, GY | 1 |
| Chee, SK | 1 |
| D'Hallewin, MA | 8 |
| Bezdetnaya, L | 1 |
| Guillemin, F | 2 |
| Kamuhabwa, AA | 4 |
| Roskams, T | 9 |
| Baert, L | 8 |
| Lau, W | 2 |
| Manivasager, V | 2 |
| Tan, PH | 4 |
| Cheng, C | 2 |
| Wei, Z | 1 |
| Hao, GY | 1 |
| Zhang, YH | 1 |
| Kamuhabwa, A | 1 |
| Ahmed, B | 1 |
| Landuyt, W | 1 |
| Huygens, A | 6 |
| Kamuhabwa, AR | 7 |
| Di Mavungu, JD | 1 |
| Hoogmartens, J | 1 |
| Van Laethem, A | 1 |
| Sim, HG | 1 |
| Cheng, CW | 1 |
| Jain, S | 1 |
| Kockelbergh, RC | 1 |
| Saw, CL | 2 |
| Heng, PW | 1 |
| Adigbli, DK | 1 |
| Wilson, DG | 1 |
| Farooqui, N | 1 |
| Sousi, E | 1 |
| Risley, P | 1 |
| Taylor, I | 1 |
| Macrobert, AJ | 1 |
| Loizidou, M | 1 |
| Fu, CY | 2 |
| Ng, BK | 1 |
| Razul, SG | 1 |
| Schmidbauer, J | 1 |
| Marberger, M | 1 |
| Crnolatac, I | 2 |
| Maes, J | 1 |
| Wohland, T | 1 |
| Kho, KW | 1 |
| Sia Heng, PW | 1 |
| Buytaert, E | 1 |
| Matroule, JY | 1 |
| Durinck, S | 1 |
| Close, P | 1 |
| Kocanova, S | 1 |
| Vandenheede, JR | 1 |
| Piette, J | 1 |
| Develter, J | 1 |
| Van der Kwast, T | 1 |
| Waelkens, E | 1 |
| Merlevede, W | 1 |
| Zupkó, I | 1 |
| Agostinis, PM | 1 |
| Cosserat-Gerardin, I | 1 |
| Didelon, J | 1 |
| Notter, D | 1 |
| Pytel, A | 1 |
| Schmeller, N | 1 |
5 reviews available for hypericin and Bladder Cancer
| Article | Year |
|---|---|
Fluorescence detection of bladder cancer: a review.
Topics: Administration, Intravesical; Aminolevulinic Acid; Anthracenes; Carcinoma in Situ; Cystoscopy; Dihem | 2002 |
[Fluorescence technique on diagnosis of urinary bladder carcinoma].
Topics: Aminolevulinic Acid; Anthracenes; Fluorescence; Humans; Perylene; Urinary Bladder Neoplasms | 2003 |
Hypericin as a potential phototherapeutic agent in superficial transitional cell carcinoma of the bladder.
Topics: Animals; Anthracenes; Carcinoma, Transitional Cell; Humans; Perylene; Photosensitizing Agents; Photo | 2004 |
The role of photodynamic diagnosis in the contemporary management of superficial bladder cancer.
Topics: Aminolevulinic Acid; Anthracenes; Antineoplastic Agents; Carcinoma, Transitional Cell; Cystoscopy; D | 2005 |
Recent developments in fluorescence cystoscopy: do novel agents bring a benefit?
Topics: Aminolevulinic Acid; Anthracenes; Carcinoma in Situ; Cystoscopy; Fluorescence; Fluorescent Dyes; Hum | 2007 |
1 trial available for hypericin and Bladder Cancer
| Article | Year |
|---|---|
A phase IIA dose-finding study of PVP-hypericin fluorescence cystoscopy for detection of nonmuscle-invasive bladder cancer.
Topics: Adult; Aged; Aged, 80 and over; Anthracenes; Cystoscopy; Dose-Response Relationship, Drug; Female; F | 2015 |
30 other studies available for hypericin and Bladder Cancer
| Article | Year |
|---|---|
Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Calreticulin; Cancer Vacc | 2015 |
Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy.
Topics: Angiogenic Proteins; Animals; Anthracenes; Blotting, Western; Cell Line, Tumor; Endoscopy; Fluoresce | 2008 |
Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder.
Topics: Aminolevulinic Acid; Animals; Anthracenes; Antineoplastic Agents; Female; Fluorescence; Perylene; Ph | 2011 |
Altered expression of cell adhesion molecules leads to differential uptake of hypericin in urothelial cancer.
Topics: Aged; Aged, 80 and over; alpha Catenin; Anthracenes; beta Catenin; Cadherins; Cell Adhesion Molecule | 2012 |
Human serum albumin as key mediator of the differential accumulation of hypericin in normal urothelial cell spheroids versus urothelial cell carcinoma spheroids.
Topics: Anthracenes; Carcinoma; Cells, Cultured; Humans; Perylene; Photochemotherapy; Photosensitizing Agent | 2011 |
Antiangiogenesis agents avastin and erbitux enhance the efficacy of photodynamic therapy in a murine bladder tumor model.
Topics: Angiogenesis Inhibitors; Animals; Anthracenes; Antibodies, Monoclonal; Antibodies, Monoclonal, Human | 2011 |
Bio-distribution and subcellular localization of Hypericin and its role in PDT induced apoptosis in cancer cells.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Colonic Neoplasms; Cytochrome c Group; Humans; Intrac | 2002 |
Microscopic quantification of hypercin fluorescence in an orthotopic rat bladder tumor model after intravesical instillation.
Topics: Animals; Anthracenes; Cell Line, Tumor; Dose-Response Relationship, Drug; Female; Kinetics; Microsco | 2003 |
Macro-microscopic fluorescence of human bladder cancer using hypericin fluorescence cystoscopy and laser confocal microscopy.
Topics: Anthracenes; Carcinoma, Transitional Cell; Enzyme Inhibitors; Fluorescent Dyes; Humans; Image Proces | 2003 |
Whole bladder wall photodynamic therapy of transitional cell carcinoma rat bladder tumors using intravesically administered hypericin.
Topics: Administration, Intravesical; Animals; Anthracenes; Carcinoma, Transitional Cell; Female; Perylene; | 2003 |
Novel photodynamic diagnosis of bladder cancer: ex vivo fluorescence cytology using hypericin.
Topics: Anthracenes; Carcinoma, Transitional Cell; Diagnostic Imaging; Fluorescence; Humans; Microscopy, Con | 2003 |
In vivo accumulation of different hypericin ion pairs in the urothelium of the rat bladder.
Topics: Administration, Intravesical; Animals; Anthracenes; Drug Carriers; Female; Ions; Microscopy, Fluores | 2005 |
Determination of hypericin in human plasma by high-performance liquid chromatography after intravesical administration in patients with transitional cell carcinoma of the bladder.
Topics: Administration, Intravesical; Anthracenes; Carcinoma, Transitional Cell; Chromatography, High Pressu | 2005 |
Enhancing the photodynamic effect of hypericin in tumour spheroids by fractionated light delivery in combination with hyperoxygenation.
Topics: Anthracenes; Apoptosis; Carcinoma, Transitional Cell; Cell Line, Tumor; Fluorescence; Humans; Light; | 2005 |
Is photodynamic diagnosis using hypericin better than white-light cystoscopy for detecting superficial bladder carcinoma?
Topics: Aged; Aged, 80 and over; Anthracenes; Cystoscopy; Early Diagnosis; Female; Humans; Male; Middle Aged | 2005 |
Permeation of hypericin in spheroids composed of different grade transitional cell carcinoma cell lines and normal human urothelial cells.
Topics: Anthracenes; Carcinoma, Transitional Cell; Cell Line, Tumor; Humans; Perylene; Radiation-Sensitizing | 2005 |
Enhancing the photodynamic effect of hypericin in human bladder transitional cell carcinoma spheroids by the use of the oxygen carrier, perfluorodecalin.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell | 2006 |
Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Survival; Chick Embryo; Chorioallantoic Membrane; Cysto | 2007 |
Photochemical internalisation of chemotherapy potentiates killing of multidrug-resistant breast and bladder cancer cells.
Topics: Absorption; Anthracenes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Deat | 2007 |
Fluorescence detection of bladder cancer using urine cytology.
Topics: Anthracenes; Automation; Humans; Image Processing, Computer-Assisted; Microscopy, Confocal; Microsco | 2007 |
Influence of the glycosaminoglycan layer on the permeation of hypericin in rat bladders in vivo.
Topics: Analysis of Variance; Animals; Anthracenes; Antineoplastic Agents; Carcinoma, Transitional Cell; Fem | 2007 |
Effects of N-methyl pyrrolidone on the uptake of hypericin in human bladder carcinoma and co-staining with DAPI investigated by confocal microscopy.
Topics: Anthracenes; Antineoplastic Agents; Biological Availability; Carcinoma; Diagnostic Imaging; Dose-Res | 2007 |
Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells.
Topics: Anthracenes; Apoptosis; Biomarkers, Tumor; Cell Death; Cell Line, Tumor; Cell Movement; Cell Prolife | 2008 |
Differential accumulation of hypericin in spheroids composed of T-24 transitional cell carcinoma cells expressing different levels of E-cadherin.
Topics: Anthracenes; Antineoplastic Agents; Cadherins; Carcinoma, Transitional Cell; Cell Line, Tumor; Clone | 2008 |
Fluorescence detection of flat bladder carcinoma in situ after intravesical instillation of hypericin.
Topics: Administration, Intravesical; Anthracenes; Carcinoma in Situ; Carcinoma, Transitional Cell; Fluoresc | 2000 |
In vivo photodynamic activity of hypericin in transitional cell carcinoma bladder tumors.
Topics: Animals; Anthracenes; Antineoplastic Agents; Carcinoma, Transitional Cell; Female; Injections, Intra | 2001 |
Cellular photodestruction induced by hypericin in AY-27 rat bladder carcinoma cells.
Topics: Animals; Anthracenes; Antineoplastic Agents; Antioxidants; Cell Death; Cell Division; Humans; Peryle | 2001 |
Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy.
Topics: Animals; Anthracenes; Antineoplastic Agents; Carcinoma, Transitional Cell; Female; Models, Animal; P | 2002 |
New aspect of photodynamic diagnosis of bladder tumors: fluorescence cytology.
Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Anthracenes; Carcinoma in Situ; Cystitis; Cytophotomet | 2002 |
Hypericin-based fluorescence diagnosis of bladder carcinoma.
Topics: Anthracenes; Carcinoma in Situ; Carcinoma, Papillary; Cystoscopy; Humans; Microscopy, Fluorescence; | 2002 |