hypericin has been researched along with Benign Neoplasms, Brain in 17 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypericin is a potent inhibitor of glioma growth in vitro." | 9.15 | A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. ( Appley, AJ; Cabana, BE; Chen, TC; Couldwell, WT; Forsyth, PA; Hinton, DR; Spence, AM; Stillerman, CB; Surnock, AA; Tobia, AJ, 2011) |
| "In a syngeneic subcutaneous glioma mouse model we investigated the time dependent hypericin (HYP) uptake in malignant tumor tissue by microendoscopically fluorescence measurements." | 7.79 | Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model. ( Ehrhardt, A; Feigl, GC; Göbel, W; Mayer, D; Naumann, U; Noell, S; Ritz, R; Serifi, D, 2013) |
| "In five patients with a recurrence of a malignant glioma a newly developed water soluble formulation of hypericin was given intravenously (0." | 7.78 | Hypericin for visualization of high grade gliomas: first clinical experience. ( Bornemann, A; Daniels, R; Dietz, K; Feigl, GC; Mayer, D; Noell, S; Ramina, K; Ritz, R; Schmidt, V; Strauss, WS; Tatagiba, M, 2012) |
| " Hypericin (HY) exhibit high phototoxicity to malignant cells and accumulates to a higher extent in glioblastoma cells as compared to neurons." | 7.74 | Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines. ( Dietz, K; Ritz, R; Roser, F; Schenk, M; Strauss, WS; Tatagiba, M; Wein, HT, 2007) |
| "The effect of hypericin, an antiviral drug and a potent protein kinase C (PKC) inhibitor, on glioma cell invasion was investigated in vitro." | 7.69 | Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor. ( Couldwell, WT; Hinton, DR; Law, RE; Zhang, W, 1997) |
| "Malignant gliomas are diffuse infiltrative growing tumors with a poor prognosis despite treatment with a combination of surgery, radiotherapy and chemotherapy." | 5.37 | Selective enrichment of hypericin in malignant glioma: pioneering in vivo results. ( Mayer, D; Noell, S; Ritz, R; Strauss, WS; Tatagiba, MS, 2011) |
| "Three patients suffered from an anaplastic astrocytoma, WHO grade III, nine had a glioblastoma, WHO grade IV." | 5.35 | Hypericin uptake: a prognostic marker for survival in high-grade glioma. ( Bornemann, A; Dietz, K; Duffner, F; Müller, M; Ritz, R; Roser, F; Tatagiba, M, 2008) |
| "When hypericin was combined with diazepam, photocytotoxicity was increased in U-87 MG cells and primary cultures unlike U373 MG cells." | 5.33 | Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells. ( Gajdos, M; Kocanová, S; Lavicka, J; Mirossay, A; Mirossay, L; Miskovsky, P; Mojzis, J; Sarissky, M; Sulla, I, 2005) |
| "Tamoxifen and hypericin were able to greatly increase the growth-inhibitory and apoptosis-stimulatory potency of temozolomide via the downregulation of critical cell cycle-regulatory and prosurvival components." | 5.33 | Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin. ( Chen, TC; Gupta, V; Hofman, FM; Kardosh, A; Liebes, LF; Schönthal, AH; Su, YS; Wang, W, 2006) |
| "Hypericin is a potent inhibitor of glioma growth in vitro." | 5.15 | A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. ( Appley, AJ; Cabana, BE; Chen, TC; Couldwell, WT; Forsyth, PA; Hinton, DR; Spence, AM; Stillerman, CB; Surnock, AA; Tobia, AJ, 2011) |
| "In a syngeneic subcutaneous glioma mouse model we investigated the time dependent hypericin (HYP) uptake in malignant tumor tissue by microendoscopically fluorescence measurements." | 3.79 | Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model. ( Ehrhardt, A; Feigl, GC; Göbel, W; Mayer, D; Naumann, U; Noell, S; Ritz, R; Serifi, D, 2013) |
| "In five patients with a recurrence of a malignant glioma a newly developed water soluble formulation of hypericin was given intravenously (0." | 3.78 | Hypericin for visualization of high grade gliomas: first clinical experience. ( Bornemann, A; Daniels, R; Dietz, K; Feigl, GC; Mayer, D; Noell, S; Ramina, K; Ritz, R; Schmidt, V; Strauss, WS; Tatagiba, M, 2012) |
| " Hypericin (HY) exhibit high phototoxicity to malignant cells and accumulates to a higher extent in glioblastoma cells as compared to neurons." | 3.74 | Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines. ( Dietz, K; Ritz, R; Roser, F; Schenk, M; Strauss, WS; Tatagiba, M; Wein, HT, 2007) |
| "The effect of hypericin, an antiviral drug and a potent protein kinase C (PKC) inhibitor, on glioma cell invasion was investigated in vitro." | 3.69 | Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor. ( Couldwell, WT; Hinton, DR; Law, RE; Zhang, W, 1997) |
| "Malignant gliomas are diffuse infiltrative growing tumors with a poor prognosis despite treatment with a combination of surgery, radiotherapy and chemotherapy." | 1.37 | Selective enrichment of hypericin in malignant glioma: pioneering in vivo results. ( Mayer, D; Noell, S; Ritz, R; Strauss, WS; Tatagiba, MS, 2011) |
| "Three patients suffered from an anaplastic astrocytoma, WHO grade III, nine had a glioblastoma, WHO grade IV." | 1.35 | Hypericin uptake: a prognostic marker for survival in high-grade glioma. ( Bornemann, A; Dietz, K; Duffner, F; Müller, M; Ritz, R; Roser, F; Tatagiba, M, 2008) |
| "When hypericin was combined with diazepam, photocytotoxicity was increased in U-87 MG cells and primary cultures unlike U373 MG cells." | 1.33 | Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells. ( Gajdos, M; Kocanová, S; Lavicka, J; Mirossay, A; Mirossay, L; Miskovsky, P; Mojzis, J; Sarissky, M; Sulla, I, 2005) |
| "Tamoxifen and hypericin were able to greatly increase the growth-inhibitory and apoptosis-stimulatory potency of temozolomide via the downregulation of critical cell cycle-regulatory and prosurvival components." | 1.33 | Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin. ( Chen, TC; Gupta, V; Hofman, FM; Kardosh, A; Liebes, LF; Schönthal, AH; Su, YS; Wang, W, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Bassler, MC | 1 |
| Rammler, T | 1 |
| Wackenhut, F | 1 |
| Zur Oven-Krockhaus, S | 1 |
| Secic, I | 1 |
| Ritz, R | 6 |
| Meixner, AJ | 1 |
| Brecht, M | 1 |
| Chong, K | 1 |
| Ku, T | 1 |
| Saw, PE | 1 |
| Jon, S | 1 |
| Park, JH | 1 |
| Choi, C | 1 |
| Noell, S | 3 |
| Feigl, GC | 2 |
| Serifi, D | 1 |
| Mayer, D | 3 |
| Naumann, U | 1 |
| Göbel, W | 1 |
| Ehrhardt, A | 1 |
| Garg, AD | 1 |
| Vandenberk, L | 1 |
| Koks, C | 1 |
| Verschuere, T | 1 |
| Boon, L | 1 |
| Van Gool, SW | 1 |
| Agostinis, P | 1 |
| Misuth, M | 1 |
| Joniova, J | 1 |
| Horvath, D | 1 |
| Dzurova, L | 1 |
| Nichtova, Z | 1 |
| Novotova, M | 1 |
| Miskovsky, P | 2 |
| Stroffekova, K | 1 |
| Huntosova, V | 1 |
| Shibata, Y | 1 |
| Strauss, WS | 3 |
| Tatagiba, MS | 1 |
| Couldwell, WT | 4 |
| Surnock, AA | 2 |
| Tobia, AJ | 1 |
| Cabana, BE | 1 |
| Stillerman, CB | 1 |
| Forsyth, PA | 1 |
| Appley, AJ | 1 |
| Spence, AM | 1 |
| Hinton, DR | 4 |
| Chen, TC | 3 |
| Daniels, R | 1 |
| Schmidt, V | 1 |
| Bornemann, A | 2 |
| Ramina, K | 1 |
| Dietz, K | 3 |
| Tatagiba, M | 3 |
| Su, S | 1 |
| Fry, D | 1 |
| Liebes, L | 1 |
| Sarissky, M | 1 |
| Lavicka, J | 1 |
| Kocanová, S | 1 |
| Sulla, I | 1 |
| Mirossay, A | 1 |
| Gajdos, M | 1 |
| Mojzis, J | 1 |
| Mirossay, L | 1 |
| Gupta, V | 1 |
| Su, YS | 1 |
| Wang, W | 1 |
| Kardosh, A | 1 |
| Liebes, LF | 1 |
| Hofman, FM | 1 |
| Schönthal, AH | 1 |
| Wein, HT | 1 |
| Schenk, M | 1 |
| Roser, F | 2 |
| Müller, M | 1 |
| Duffner, F | 1 |
| Gopalakrishna, R | 1 |
| He, S | 1 |
| Weiss, MH | 1 |
| Law, RE | 3 |
| Apuzzo, ML | 1 |
| Zhang, W | 2 |
1 trial available for hypericin and Benign Neoplasms, Brain
| Article | Year |
|---|---|
A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anthracenes; Antineoplastic Agents; Brain Neoplasms; | 2011 |
16 other studies available for hypericin and Benign Neoplasms, Brain
| Article | Year |
|---|---|
Accumulation and penetration behavior of hypericin in glioma tumor spheroids studied by fluorescence microscopy and confocal fluorescence lifetime imaging microscopy.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Glioma; Humans; Microscopy, Fluorescence; Perylene; | 2022 |
Enhancement of the photocytotoxic efficiency of sub-12 nm therapeutic polymeric micelles with increased co-localisation in mitochondria.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Humans; Light; Micelles; Mitochondria | 2013 |
Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model.
Topics: Animals; Anthracenes; Brain Neoplasms; Cell Line, Tumor; Disease Models, Animal; Endoscopy; Glioma; | 2013 |
Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma.
Topics: Adaptive Immunity; Animals; Anthracenes; Apoptosis; Brain Neoplasms; Cancer Vaccines; CD8-Positive T | 2016 |
The flashlights on a distinct role of protein kinase C δ: Phosphorylation of regulatory and catalytic domain upon oxidative stress in glioma cells.
Topics: Algorithms; Anthracenes; Apoptosis; Brain Neoplasms; Catalytic Domain; Cell Line, Tumor; Glioma; Hum | 2017 |
Comment on "Hypericin uptake: a prognostic marker for survival in high-grade glioma".
Topics: Anthracenes; Brain Neoplasms; Glioma; Humans; Perylene | 2009 |
Selective enrichment of hypericin in malignant glioma: pioneering in vivo results.
Topics: Animals; Anthracenes; Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Glioma; Male; Neopla | 2011 |
Hypericin for visualization of high grade gliomas: first clinical experience.
Topics: Aged; Anthracenes; Brain Neoplasms; Female; Fluorescence; Glioma; Humans; Injections, Intravenous; M | 2012 |
Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apop | 2003 |
Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells.
Topics: Adult; Aged; Anthracenes; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Diazepam; Drug Interact | 2005 |
Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin.
Topics: Animals; Anthracenes; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combi | 2006 |
Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell lines.
Topics: Anthracenes; Brain Neoplasms; Cell Line, Tumor; Cell Membrane; Glioblastoma; Glioma; Humans; Light; | 2007 |
Hypericin uptake: a prognostic marker for survival in high-grade glioma.
Topics: Adult; Aged; Anthracenes; Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Diseas | 2008 |
Hypericin: a potential antiglioma therapy.
Topics: Anthracenes; Apoptosis; Brain Neoplasms; Cell Division; Cell Line; Cell Survival; DNA Damage; Dose-R | 1994 |
Malignant glioma sensitivity to radiotherapy, high-dose tamoxifen, and hypericin: corroborating clinical response in vitro: case report.
Topics: Adult; Anthracenes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Brain Neoplasms; Cell Di | 1996 |
Inhibition of human malignant glioma cell motility and invasion in vitro by hypericin, a potent protein kinase C inhibitor.
Topics: Anthracenes; Antineoplastic Agents; Brain Neoplasms; Cell Movement; Cells, Cultured; Enzyme Inhibito | 1997 |