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hypericin and Adenocarcinoma

hypericin has been researched along with Adenocarcinoma in 17 studies

Adenocarcinoma: A malignant epithelial tumor with a glandular organization.

Research Excerpts

ExcerptRelevanceReference
" The hypericin and hyperforin effect has been described to understand the signal mechanisms that stimulate or stunt cancer cell sprouting to metastasis on colon adenocarcinoma cells HT-29 and its resistant form HT-29-OxR."7.88The potential of hypericin and hyperforin for antiadhesion therapy to prevent metastasis of parental and oxaliplatin-resistant human adenocarcinoma cells (HT-29). ( Fedoročko, P; Sačková, V; Šemeláková, M, 2018)
" In this study, the combined effect of hypericin (the photodynamically-active pigment from Hypericum perforatum) and selective farnesyltransferase inhibitor manumycin (manumycin A; the selective farnesyltransferase inhibitor from Streptomyces parvulus) on HT-29 adenocarcinoma cells was examined."7.77Enhanced antiproliferative and apoptotic response of HT-29 adenocarcinoma cells to combination of photoactivated hypericin and farnesyltransferase inhibitor manumycin A. ( Fedoročko, P; Kello, M; Kuliková, L; Sačková, V; Uhrinová, I, 2011)
"Colon cancer affects 1."5.51An Electron paramagnetic resonance (EPR) spin labeling study in HT-29 Colon adenocarcinoma cells after Hypericin-mediated photodynamic therapy. ( Kılıç Süloğlu, A; Selmanoğlu, G; Sünnetçioğlu, MM; Yonar, D, 2019)
"Hypericin (HY) has found applications in photodynamic diagnostics solely due to its high specificity for tumour cells and tissues."5.37Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin. ( Fedoročko, P; Hofmanová, J; Hýžďalová, M; Jendželovský, R; Kočí, L; Kovaľ, J; Kozubík, A; Mikeš, J; Vaculová, A, 2011)
"Necrosis was the principal mode of cell death despite different PDT doses and the absence of anti-apoptotic Bcl-2 expression, even if the same condition induced caspase-3 activity at similar toxicity in HeLa cells."5.34Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin. ( Fedorocko, P; Hofmanová, J; Horváth, V; Jamborová, E; Kleban, J; Kozubík, A; Mikes, J; Sacková, V; Vaculová, A, 2007)
"Hypericin was concentrated in the perinucleolar cytoplasmic area mainly on one side of the nucleus--the region rich in endoplasmic reticulum and Golgi."5.31Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines. ( Hjortland, GO; Iani, V; Ma, LW; Moan, J; Steen, HB; Uzdensky, AB, 2001)
" The hypericin and hyperforin effect has been described to understand the signal mechanisms that stimulate or stunt cancer cell sprouting to metastasis on colon adenocarcinoma cells HT-29 and its resistant form HT-29-OxR."3.88The potential of hypericin and hyperforin for antiadhesion therapy to prevent metastasis of parental and oxaliplatin-resistant human adenocarcinoma cells (HT-29). ( Fedoročko, P; Sačková, V; Šemeláková, M, 2018)
"Photoactivated hypericin increased production of reactive oxygen species in human breast adenocarcinoma MCF-7 as well as in MDA-MB-231 cells 1h after photodynamic therapy."3.85Photoactivated hypericin increases the expression of SOD-2 and makes MCF-7 cells resistant to photodynamic therapy. ( Fecková, B; Ilkovičová, L; Kello, M; Kimáková, P; Sačková, V; Solár, P; Solárová, Z, 2017)
" In this study, the combined effect of hypericin (the photodynamically-active pigment from Hypericum perforatum) and selective farnesyltransferase inhibitor manumycin (manumycin A; the selective farnesyltransferase inhibitor from Streptomyces parvulus) on HT-29 adenocarcinoma cells was examined."3.77Enhanced antiproliferative and apoptotic response of HT-29 adenocarcinoma cells to combination of photoactivated hypericin and farnesyltransferase inhibitor manumycin A. ( Fedoročko, P; Kello, M; Kuliková, L; Sačková, V; Uhrinová, I, 2011)
"We have investigated the photoactivating effect of hypericin on two cancer cell lines: PC-3, a prostatic adenocarcinoma non-responsive to androgen therapy and LNCaP, a lymphonodal metastasis of prostate carcinoma responsive to androgen therapy."3.70Hypericin photosensitization of tumor and metastatic cell lines of human prostate. ( Colasanti, A; Kisslinger, A; Liuzzi, R; Quarto, M; Riccio, P; Roberti, G; Tramontano, D; Villani, F, 2000)
"The tumoricidal properties of photodynamic therapy (PDT) with hypericin (HY) were evaluated in a highly metastatic adenocarcinoma (DA3Hi) and anaplastic squamous cell carcinoma (SQ2) tumors in vivo."3.70Effects of photodynamic therapy with hypericin in mice bearing highly invasive solid tumors. ( Blank, M; Keisari, Y; Lavie, G; Mandel, M, 2000)
"Colon cancer affects 1."1.51An Electron paramagnetic resonance (EPR) spin labeling study in HT-29 Colon adenocarcinoma cells after Hypericin-mediated photodynamic therapy. ( Kılıç Süloğlu, A; Selmanoğlu, G; Sünnetçioğlu, MM; Yonar, D, 2019)
"Hypericin (HY) has found applications in photodynamic diagnostics solely due to its high specificity for tumour cells and tissues."1.37Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin. ( Fedoročko, P; Hofmanová, J; Hýžďalová, M; Jendželovský, R; Kočí, L; Kovaľ, J; Kozubík, A; Mikeš, J; Vaculová, A, 2011)
"Necrosis was the principal mode of cell death despite different PDT doses and the absence of anti-apoptotic Bcl-2 expression, even if the same condition induced caspase-3 activity at similar toxicity in HeLa cells."1.34Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin. ( Fedorocko, P; Hofmanová, J; Horváth, V; Jamborová, E; Kleban, J; Kozubík, A; Mikes, J; Sacková, V; Vaculová, A, 2007)
"Hyperforin is considered to be a primary cause of the inductive effect of St."1.33Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line. ( Koyabu, N; Morimoto, S; Ohtani, H; Sawada, Y; Shoyama, Y; Tian, R, 2005)
"Hypericin is a very promising new photosensitizer for innovative photodynamic therapy of esophageal cancer."1.32Hypericin activated by an incoherent light source has photodynamic effects on esophageal cancer cells. ( Höpfner, M; Kashtan, H; Lenz, M; Maaser, K; Riecken, EO; Scherübl, H; Sutter, AP; Theiss, A; von Lampe, B; Zeitz, M, 2003)
"Hypericin was concentrated in the perinucleolar cytoplasmic area mainly on one side of the nucleus--the region rich in endoplasmic reticulum and Golgi."1.31Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines. ( Hjortland, GO; Iani, V; Ma, LW; Moan, J; Steen, HB; Uzdensky, AB, 2001)
" Chronic use of Saint John's wort (SJW) has been shown to lower the bioavailability for a variety of co-administered drugs including indinavir, cyclosporin, and digoxin."1.31Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure. ( Greenblatt, DJ; Perloff, MD; Shader, RI; Störmer, E; von Moltke, LL, 2001)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's9 (52.94)29.6817
2010's8 (47.06)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Šemeláková, M3
Sačková, V5
Fedoročko, P8
Yonar, D1
Kılıç Süloğlu, A1
Selmanoğlu, G1
Sünnetçioğlu, MM1
Gyurászová, K1
Mikeš, J5
Halaburková, A1
Jendželovský, R5
Kimáková, P1
Solár, P1
Fecková, B1
Solárová, Z1
Ilkovičová, L1
Kello, M3
Koval', J1
Soucek, K1
Procházková, J1
Hofmanová, J3
Kozubík, A3
Hýžďalová, M1
Kočí, L1
Kovaľ, J1
Vaculová, A2
Kuliková, L1
Uhrinová, I1
Höpfner, M1
Maaser, K1
Theiss, A1
Lenz, M1
Sutter, AP1
Kashtan, H1
von Lampe, B1
Riecken, EO1
Zeitz, M1
Scherübl, H1
Tian, R1
Koyabu, N1
Morimoto, S1
Shoyama, Y1
Ohtani, H1
Sawada, Y1
Zhou, Q1
Olivo, M1
Lye, KY1
Moore, S1
Sharma, A1
Chowbay, B1
Kleban, J1
Horváth, V1
Jamborová, E1
Colasanti, A1
Kisslinger, A1
Liuzzi, R1
Quarto, M1
Riccio, P1
Roberti, G1
Tramontano, D1
Villani, F1
Blank, M1
Lavie, G1
Mandel, M1
Keisari, Y1
Uzdensky, AB1
Ma, LW1
Iani, V1
Hjortland, GO1
Steen, HB1
Moan, J1
Perloff, MD1
von Moltke, LL1
Störmer, E1
Shader, RI1
Greenblatt, DJ1

Trials

1 trial available for hypericin and Adenocarcinoma

ArticleYear
Enhancing the therapeutic responsiveness of photodynamic therapy with the antiangiogenic agents SU5416 and SU6668 in murine nasopharyngeal carcinoma models.
    Cancer chemotherapy and pharmacology, 2005, Volume: 56, Issue:6

    Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Anthracenes; Antineoplastic Agents; Chemotherapy,

2005

Other Studies

16 other studies available for hypericin and Adenocarcinoma

ArticleYear
The potential of hypericin and hyperforin for antiadhesion therapy to prevent metastasis of parental and oxaliplatin-resistant human adenocarcinoma cells (HT-29).
    Anti-cancer drugs, 2018, Volume: 29, Issue:10

    Topics: Adenocarcinoma; Anthracenes; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion; Cell Mov

2018
An Electron paramagnetic resonance (EPR) spin labeling study in HT-29 Colon adenocarcinoma cells after Hypericin-mediated photodynamic therapy.
    BMC molecular and cell biology, 2019, 06-20, Volume: 20, Issue:1

    Topics: Adenocarcinoma; Anthracenes; Cell Membrane; Colonic Neoplasms; Computer Simulation; Cyclic N-Oxides;

2019
YM155, a small molecule inhibitor of survivin expression, sensitizes cancer cells to hypericin-mediated photodynamic therapy.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2016, 06-08, Volume: 15, Issue:6

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Anthracenes; Antineoplastic Agents; Autophagy; Caspase 3; Ce

2016
Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 81

    Topics: Adenocarcinoma; Anthracenes; Blotting, Western; Cell Line, Tumor; Colonic Neoplasms; Cytochrome P-45

2016
Photoactivated hypericin increases the expression of SOD-2 and makes MCF-7 cells resistant to photodynamic therapy.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 85

    Topics: 2-Methoxyestradiol; Adenocarcinoma; Anthracenes; Breast Neoplasms; Cell Line, Tumor; Estradiol; Fema

2017
Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2009, Volume: 8, Issue:12

    Topics: Adenocarcinoma; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Ca

2009
Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2011, Volume: 10, Issue:4

    Topics: Adenocarcinoma; Anthracenes; Cell Line; Colon; Colonic Neoplasms; Epithelial Cells; Fetus; Humans; M

2011
Enhanced antiproliferative and apoptotic response of HT-29 adenocarcinoma cells to combination of photoactivated hypericin and farnesyltransferase inhibitor manumycin A.
    International journal of molecular sciences, 2011, Volume: 12, Issue:12

    Topics: Adenocarcinoma; Anthracenes; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3

2011
The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells.
    Journal of photochemistry and photobiology. B, Biology, 2012, Dec-05, Volume: 117

    Topics: Adenocarcinoma; Anthracenes; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Ce

2012
Hypericin activated by an incoherent light source has photodynamic effects on esophageal cancer cells.
    International journal of colorectal disease, 2003, Volume: 18, Issue:3

    Topics: Adenocarcinoma; Aminolevulinic Acid; Anthracenes; Antineoplastic Agents; Apoptosis; Carcinoma, Squam

2003
Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.
    Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:4

    Topics: Adenocarcinoma; Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biolo

2005
Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2007, Volume: 6, Issue:7

    Topics: Adenocarcinoma; Anthracenes; Caspase 3; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Dose-Resp

2007
Hypericin photosensitization of tumor and metastatic cell lines of human prostate.
    Journal of photochemistry and photobiology. B, Biology, 2000, Volume: 54, Issue:2-3

    Topics: Adenocarcinoma; Anthracenes; Antineoplastic Agents; Humans; Male; Neoplasm Metastasis; Perylene; Pho

2000
Effects of photodynamic therapy with hypericin in mice bearing highly invasive solid tumors.
    Oncology research, 2000, Volume: 12, Issue:9-10

    Topics: Adenocarcinoma; Animals; Anthracenes; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Squamous C

2000
Intracellular localisation of hypericin in human glioblastoma and carcinoma cell lines.
    Lasers in medical science, 2001, Volume: 16, Issue:4

    Topics: Adenocarcinoma; Anthracenes; Carcinoma in Situ; Colonic Neoplasms; Female; Glioblastoma; Humans; Per

2001
Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure.
    British journal of pharmacology, 2001, Volume: 134, Issue:8

    Topics: Adenocarcinoma; Anthracenes; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, M

2001