hypaconitine and Wounds-and-Injuries

Regeneratory activities of Baikal aconite alkaloids were studied on the excision skin wound model. Manifest wound healing effects of songorine, napelline, and hypaconitine were detected. The therapeutic efficiency was based on activation of residual mesenchymal progenitor elements. The development of this phenomenon was explained by the direct effects of alkaloids on precursors and by higher production of growth factors by the skin stromal cells. Songorine exhibited the most pronounced specific activity due to more significant stimulation of progenitor cell differentiation associated with maximum activation of the secretory function of the microenvironment cells.

Topics: Aconitine; Aconitum; Alkaloids; Animals; Animals, Outbred Strains; Cell Differentiation; Cellular Microenvironment; Diterpenes; Intercellular Signaling Peptides and Proteins; Male; Mesenchymal Stem Cells; Mice; Regeneration; Skin; Stromal Cells; Wound Healing; Wounds and Injuries