hypaconitine and Drug-Related-Side-Effects-and-Adverse-Reactions

hypaconitine has been researched along with Drug-Related-Side-Effects-and-Adverse-Reactions* in 1 studies

Other Studies

1 other study(ies) available for hypaconitine and Drug-Related-Side-Effects-and-Adverse-Reactions

Article	Year
[Changes of DDAs content affected by different processing time and its relationship with safety of processed Fuzi]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:9 To study the correlation between content changes of Diester diterpenoid alkaloids (DDAs) content and safety of the processed Fuzi.. Sequential and Bliss methods were used to evaluate the safety of 7 kinds of Fuzi processed with different processing time. The relationship between ED50, TD50, TI and content changes of DDAs of those processed Fuzi was studied, the correlation between the content changes and effect of different processed Fuzi was analyzed, and the toxicity of those processed Fuzi with multiple linear regression was tested.. Fuzi with good efficiency and safety contains proper hypaconitine (HA) and mesaconitine (MA). Aconitine (AC) interfered efficacy of Fuzi (negative correlation), HA showed positive correlation with toxicity and efficacy of Fuzi.. HA and MA kept in determinate proportion are very important for the safety and effectivity of processed Fuzi. Topics: Aconitine; Alkaloids; Animals; Diterpenes; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Magnoliopsida; Male; Rats; Time Factors	2009

Article

Year

[Changes of DDAs content affected by different processing time and its relationship with safety of processed Fuzi].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:9

To study the correlation between content changes of Diester diterpenoid alkaloids (DDAs) content and safety of the processed Fuzi.. Sequential and Bliss methods were used to evaluate the safety of 7 kinds of Fuzi processed with different processing time. The relationship between ED50, TD50, TI and content changes of DDAs of those processed Fuzi was studied, the correlation between the content changes and effect of different processed Fuzi was analyzed, and the toxicity of those processed Fuzi with multiple linear regression was tested.. Fuzi with good efficiency and safety contains proper hypaconitine (HA) and mesaconitine (MA). Aconitine (AC) interfered efficacy of Fuzi (negative correlation), HA showed positive correlation with toxicity and efficacy of Fuzi.. HA and MA kept in determinate proportion are very important for the safety and effectivity of processed Fuzi.

Topics: Aconitine; Alkaloids; Animals; Diterpenes; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Magnoliopsida; Male; Rats; Time Factors

2009