hymecromone and Tuberculosis--Multidrug-Resistant

hymecromone has been researched along with Tuberculosis--Multidrug-Resistant* in 1 studies

Other Studies

1 other study(ies) available for hymecromone and Tuberculosis--Multidrug-Resistant

Article	Year
Synthesis and antimycobacterial activity of 7-O-substituted-4-methyl-2H-2-chromenone derivatives vs Mycobacterium tuberculosis. Journal of enzyme inhibition and medicinal chemistry, 2005, Volume: 20, Issue:2 A series of 7-O-alkoxy-4-methylumbelliferone derivatives were prepared using a convenient one step synthesis. Additionally the bromo- and azido derivatives 7-O-(4-bromobutoxy)-, 7-O-(6-bromohexyloxy)- and 7-O-(6-azidohexyloxy)-4-methylumbelliferone derivatives were prepared. In vitro evaluation of antimycobacterial activity determined % inhibition and MIC vs M. tuberculosis H37Rv with toxicity (IC50) assessed in VERO cells. The coumarins with longer alkyl chains (nonyl and decyl) showed the optimum inhibitory activity in this series (MIC 3.13 microg/mL) and IC50 > 10 microg/mL. Topics: Animals; Chlorocebus aethiops; Hymecromone; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Mycobacterium tuberculosis; Spectrophotometry; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Tuberculosis, Multidrug-Resistant; Vero Cells	2005

Article

Year

Synthesis and antimycobacterial activity of 7-O-substituted-4-methyl-2H-2-chromenone derivatives vs Mycobacterium tuberculosis.

Journal of enzyme inhibition and medicinal chemistry, 2005, Volume: 20, Issue:2

A series of 7-O-alkoxy-4-methylumbelliferone derivatives were prepared using a convenient one step synthesis. Additionally the bromo- and azido derivatives 7-O-(4-bromobutoxy)-, 7-O-(6-bromohexyloxy)- and 7-O-(6-azidohexyloxy)-4-methylumbelliferone derivatives were prepared. In vitro evaluation of antimycobacterial activity determined % inhibition and MIC vs M. tuberculosis H37Rv with toxicity (IC50) assessed in VERO cells. The coumarins with longer alkyl chains (nonyl and decyl) showed the optimum inhibitory activity in this series (MIC 3.13 microg/mL) and IC50 > 10 microg/mL.

Topics: Animals; Chlorocebus aethiops; Hymecromone; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Mycobacterium tuberculosis; Spectrophotometry; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Tuberculosis, Multidrug-Resistant; Vero Cells

2005