hymecromone and Biliary-Tract-Diseases

The survey of its own and literature data describes the clinical "masks" of the primary and second functional disorders of the biliary tract, describes the mechanisms of their formation, which include the plural disturbances of the organs interactions, psycho - emotional and vegetative disturbances, development ofbiliar and pancreatic insufficiency. It is shown that Hymecromone (Odeston) can be successfully used, as the base means, with the treatment of patients with primary and second functional disorders of the biliary tract with different clinical "masks" of this pathology.

Topics: Biliary Tract; Biliary Tract Diseases; Humans; Hymecromone; Indicators and Reagents; Pancreas; Pancreatic Diseases

Topics: Biliary Tract Diseases; Cholagogues and Choleretics; Chronic Disease; Clinical Trials as Topic; Humans; Hymecromone; Liver Diseases; Parasympatholytics

Topics: Administration, Oral; Aged; Biliary Tract Diseases; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Hymecromone; Placebos; Psychotropic Drugs; Umbelliferones

To test the hypotheses that: 1) postprandial gallbladder emptying might be abnormal in patients with acalculous biliary colic; and 2) that hymecromone, a drug that increases bile flow and relaxes biliary muscle might improve symptoms.. Twenty-four women were studied. Twelve patients presented recurrent biliary type of pain in the absence of gallstones, and persistence of contrast in the gallbladder, 24 hours after an oral cholecystogram, suggesting cholesterolosis. Twelve healthy volunteers used as controls had no symptoms and the gallbladder was not visible the day after an oral cholecystogram. Gallbladder emptying induced by an oral meal was studied with ultrasound in both groups before and after the administration of hymecromone.. Gallbladder volumes were similar in both groups (23 +/- 10 ml vs. 31 +/- 11 ml; NS). Gallbladder emptying in the control group was simple exponential (R2 = 0.948 +/- 0.059) with a rate of 32 +/- 16 minutes. Gallbladder emptying was bimodal in patients. Gallbladder volume increased to 120% in the first 10 minutes, to empty exponentially thereafter (R2 = 0.964 +/- 0.040. Rate: 29 +/- 22 minutes). This resulted in a marked reduction in gallbladder volume emptied at 40 minutes when compared to controls (30% +/- 27% vs. 54% +/- 14%; p = 0.012). Pretreatment of controls with hymecromone induced an emptying pattern similar to that of patients. In patients, emptying after hymecromone did not change but symptoms were improved.. An abnormal emptying pattern of the gallbladder was identified in patients with acalculous biliary colic, and hymecromone was partly effective to reduce pain, despite a minor effect on gallbladder emptying pattern.

Topics: Biliary Tract Diseases; Cholagogues and Choleretics; Colic; Female; Gallbladder Emptying; Humans; Hymecromone; Middle Aged

Topics: Adolescent; Adult; Aged; Biliary Tract Diseases; Cholangiopancreatography, Endoscopic Retrograde; Contrast Media; Female; Humans; Hymecromone; Male; Middle Aged; Parasympatholytics; Umbelliferones

The immediate effect of 400 mg mendiaxon was studied in 8 patients with various hepatobiliary diseases. The drug was administered via a duodenal tube in a duodenal drainage tubing according to a minute schedule during the phase of pure bile C secretion. An increased volume was found in all cases. The maximum choleresis exceeds the basal one from 3 to 8 times. The rate of bile flow, in the majority of the patients, was between 2 and 3.3. ml/min. The treatment was carried out on 25 patients in the course of 10 days with a daily dose of 1200 mg (400 mg three times). A good pain-killing effect was obtained. Adverse effects and allergic reactions were not observed. The results from our studies provided grounds to recommend mendiaxon use in the clinical practice.

Topics: Adult; Aged; Biliary Tract Diseases; Cholagogues and Choleretics; Cholecystectomy; Cholecystitis; Cholelithiasis; Female; Humans; Hymecromone; Liver Cirrhosis; Male; Middle Aged; Parasympatholytics; Postoperative Complications; Syndrome; Umbelliferones

Topics: Ampulla of Vater; Biliary Dyskinesia; Biliary Tract Diseases; Cholecystectomy; Cholelithiasis; Drug Evaluation; Humans; Hymecromone; Injections, Intravenous; Postoperative Complications; Sphincter of Oddi; Umbelliferones

Topics: Adult; Aged; Biliary Tract Diseases; Cholecystectomy; Female; Humans; Hymecromone; Male; Middle Aged; Postoperative Care; Umbelliferones