hymecromone and Atrophy

hymecromone has been researched along with Atrophy* in 1 studies

Other Studies

1 other study(ies) available for hymecromone and Atrophy

ArticleYear
Inhibition of putative hyalurosome platform in keratinocytes as a mechanism for corticosteroid-induced epidermal atrophy.
    The Journal of investigative dermatology, 2013, Volume: 133, Issue:4

    The main limitation of using topical corticosteroids in dermatology is their atrophic effects on the skin. We have previously proposed a molecular platform composed of CD44, EGFR, and hyaluronate synthase (HAS) that is functionally defective in dermatoporosis, a chronic cutaneous insufficiency/fragility syndrome. In this study, we explored the molecular mechanisms of the skin atrophy induced by corticosteroids. We observed an important skin atrophy and a significant decrease of hyaluronic acid (HA), its main cell surface receptor CD44, and F-actin in mouse skin treated with topical clobetasol propionate (CP). Human keratinocytes exposed to CP showed an impaired HA secretion and diminished expression of CD44 and HAS3. CP also abolished filopodia of keratinocytes exposed to CP together with a redistribution of CD44 and F-actin depolymerization. We also show that HA fragments of intermediary size (HAFi) induced keratinocyte filopodia and protected them against CP. Topical HAFi induced hyperplasia in mouse epidermis and prevented CP-induced atrophy. Our results suggest that a CD44/EGFR/HAS platform associated with F-actin and filopodia of keratinocytes is the target of corticosteroids for their atrophogenic effects. These observations may lead to the development of new treatment and prevention strategies for corticosteroid-induced skin atrophy.

    Topics: Animals; Atrophy; Cell Line, Transformed; Clobetasol; Dermatologic Agents; Drug Interactions; Epidermis; Glucocorticoids; Glucuronosyltransferase; Homeostasis; Hyaluronan Receptors; Hyaluronan Synthases; Hyaluronic Acid; Hymecromone; Keratinocytes; Mice; Mice, Hairless; Molecular Weight; Peptide Fragments; Pseudopodia; Skin Cream; Viscosupplements

2013