hydroxyzine has been researched along with Torsade de Pointes in 5 studies
Hydroxyzine: A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
hydroxyzine : A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 mg) of hydroxyzine was injected for sedation, and torsade de pointes (Tdp) occurred." | 8.02 | Hydroxyzine-induced Torsade de Pointes in a Patient with Complete Atrioventricular Block. ( Endo, A; Koshino, K; Okazaki, K; Tanabe, K; Watanabe, N, 2021) |
| " In this paper, we will report a case of drug-induced long QT syndrome associated with an H(1)-receptor antagonist, hydroxyzine, in which a mutation was identified in the HERG gene." | 7.74 | Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation. ( Ashihara, T; Ding, WG; Higashi, Y; Horie, M; Ito, M; Itoh, H; Matsuura, H; Nagaoka, I; Oka, Y; Sakaguchi, T; Takeyama, Y; Tsuji, K; Yumoto, Y; Zenda, N, 2008) |
| "Regulatory advisories on hydroxyzine and risk of QT prolongation and Torsade de pointes (TdP) were issued in the UK in April 2015 and Canada in June 2016." | 4.12 | Hydroxyzine Initiation Following Drug Safety Advisories on Cardiac Arrhythmias in the UK and Canada: A Longitudinal Cohort Study. ( Ahmed, B; Bero, L; De Bruin, ML; Dormuth, CR; Gnjidic, D; Hallgreen, CE; Kemp-Casey, A; Kristiansen, SB; Lexchin, J; Lopert, R; Mangin, D; Mintzes, B; Morrow, RL; Pearson, SA; Puil, L; Roughead, EE; Sarpatwari, A; Sketris, I; Souverein, PC, 2022) |
| "5 mg) of hydroxyzine was injected for sedation, and torsade de pointes (Tdp) occurred." | 4.02 | Hydroxyzine-induced Torsade de Pointes in a Patient with Complete Atrioventricular Block. ( Endo, A; Koshino, K; Okazaki, K; Tanabe, K; Watanabe, N, 2021) |
| " In this paper, we will report a case of drug-induced long QT syndrome associated with an H(1)-receptor antagonist, hydroxyzine, in which a mutation was identified in the HERG gene." | 3.74 | Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation. ( Ashihara, T; Ding, WG; Higashi, Y; Horie, M; Ito, M; Itoh, H; Matsuura, H; Nagaoka, I; Oka, Y; Sakaguchi, T; Takeyama, Y; Tsuji, K; Yumoto, Y; Zenda, N, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morrow, RL | 1 |
| Mintzes, B | 1 |
| Souverein, PC | 1 |
| Hallgreen, CE | 1 |
| Ahmed, B | 1 |
| Roughead, EE | 1 |
| De Bruin, ML | 1 |
| Kristiansen, SB | 1 |
| Lexchin, J | 1 |
| Kemp-Casey, A | 1 |
| Sketris, I | 1 |
| Mangin, D | 1 |
| Pearson, SA | 1 |
| Puil, L | 1 |
| Lopert, R | 1 |
| Bero, L | 1 |
| Gnjidic, D | 1 |
| Sarpatwari, A | 1 |
| Dormuth, CR | 1 |
| Koshino, K | 1 |
| Endo, A | 1 |
| Watanabe, N | 1 |
| Okazaki, K | 1 |
| Tanabe, K | 1 |
| Sakaguchi, T | 1 |
| Itoh, H | 1 |
| Ding, WG | 1 |
| Tsuji, K | 1 |
| Nagaoka, I | 1 |
| Oka, Y | 1 |
| Ashihara, T | 1 |
| Ito, M | 1 |
| Yumoto, Y | 1 |
| Zenda, N | 1 |
| Higashi, Y | 1 |
| Takeyama, Y | 1 |
| Matsuura, H | 1 |
| Horie, M | 1 |
| Woosley, RL | 1 |
| Gilbert, JD | 1 |
| Cahill, SA | 1 |
| McCartney, DG | 1 |
| Lukas, A | 1 |
| Gross, GJ | 1 |
1 review available for hydroxyzine and Torsade de Pointes
| Article | Year |
|---|---|
Cardiac actions of antihistamines.
Topics: Animals; Astemizole; Cetirizine; Diphenhydramine; Drug Interactions; Histamine H1 Antagonists; Human | 1996 |
4 other studies available for hydroxyzine and Torsade de Pointes
| Article | Year |
|---|---|
Hydroxyzine Initiation Following Drug Safety Advisories on Cardiac Arrhythmias in the UK and Canada: A Longitudinal Cohort Study.
Topics: Canada; Cohort Studies; DNA-Binding Proteins; Electrocardiography; Humans; Hydroxyzine; Long QT Synd | 2022 |
Hydroxyzine-induced Torsade de Pointes in a Patient with Complete Atrioventricular Block.
Topics: Aged, 80 and over; Atrioventricular Block; Electrocardiography; Female; Humans; Hydroxyzine; Pacemak | 2021 |
Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation.
Topics: Adult; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Female; Gene Expression R | 2008 |
Predictors of torsades de pointes in rabbit ventricles perfused with sedating and nonsedating histamine H1-receptor antagonists.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Astemizole; Cetirizine; Electrocardiography; Heart | 2000 |