hydroxyzine has been researched along with Substance Withdrawal Syndrome in 22 studies
Hydroxyzine: A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
hydroxyzine : A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To our knowledge, this is the first report of a neonatal withdrawal syndrome associated with maternal usage of 600 mg daily of hydroxyzine hydrochloride throughout pregnancy." | 3.65 | Neonatal withdrawal syndrome associated with hydroxyzine hydrochloride. ( Prenner, BM, 1977) |
| "Pretreatment with palonosetron significantly reduced many signs of experimentally-induced opioid withdrawal." | 2.84 | Palonosetron and hydroxyzine pre-treatment reduces the objective signs of experimentally-induced acute opioid withdrawal in humans: a double-blinded, randomized, placebo-controlled crossover study. ( Chu, LF; Clark, JD; D'Arcy, N; Encisco, EM; Erlendson, MJ; Peltz, G; Rincon-Cruz, L; Yu, JJ, 2017) |
| " Clinicians should consider giving patients with a tendency to abuse drugs nonidentifiable dosage forms." | 2.65 | Effect of patient recognition of tranquilizers on their use in alcohol detoxification. ( Francis, DA; Nelson, AA, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (72.73) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rudolf, G | 1 |
| Walsh, J | 1 |
| Plawman, A | 1 |
| Gianutsos, P | 1 |
| Alto, W | 1 |
| Mancl, L | 1 |
| Rudolf, V | 1 |
| Bock, O | 1 |
| Wenzel, C | 1 |
| Herrmann, J | 1 |
| Dillo, W | 1 |
| Poehnert, D | 1 |
| Bleich, S | 1 |
| Frieling, H | 1 |
| Erlendson, MJ | 1 |
| D'Arcy, N | 1 |
| Encisco, EM | 1 |
| Yu, JJ | 1 |
| Rincon-Cruz, L | 1 |
| Peltz, G | 1 |
| Clark, JD | 1 |
| Chu, LF | 1 |
| Sagduyu, K | 1 |
| Durst, P | 1 |
| Palazzolo, J | 1 |
| Peyrelong, JP | 1 |
| Berger, M | 1 |
| Chalabreysse, M | 1 |
| Billiard, M | 1 |
| Vialle, A | 1 |
| Francis, DA | 1 |
| Nelson, AA | 1 |
| Loeb, P | 1 |
| Adnet, P | 1 |
| Boittiaux, P | 1 |
| Forget, AP | 1 |
| Mille, FX | 1 |
| Coleman, JH | 1 |
| Evans, WE | 1 |
| Runion, HI | 1 |
| Fowler, FN | 1 |
| Dilts, SL | 1 |
| Keleher, DL | 1 |
| Hoge, G | 1 |
| Haglund, B | 1 |
| Prenner, BM | 1 |
| Kaim, SC | 4 |
| McNichol, RW | 1 |
| Cirksena, WJ | 1 |
| Payne, JT | 1 |
| Glasgow, MC | 1 |
| Oge, V | 1 |
| Palestine, ML | 1 |
| Klett, CJ | 2 |
| Rothfeld, B | 1 |
| Schwarz, L | 1 |
| Fjeld, SP | 1 |
| Hollister, LE | 1 |
| Caffey, EM | 1 |
| Malmgren, G | 1 |
| Hudson, FG | 1 |
| McGowan, JM | 1 |
| Renninger, ME | 1 |
| Foster, CA | 1 |
| Knott, DH | 1 |
| Beard, JD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Examination of Palonosetron and Hydroxyzine Pre-treatment as a Possible Method to Reduce the Objective Signs of Experimentally-induced Acute Opioid Withdrawal in Humans: a Double-blind, Randomized, Placebo-controlled Crossover Study[NCT00661674] | 10 participants (Actual) | Interventional | 2008-04-30 | Completed | |||
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The OOWS is a 13-item instrument documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score possible = 13, minimum score possible = 0. T=15 minutes post naloxone administration coordinates with T = 180 (min) for the entire study session.~OOWS scores at T=180 is the primary outcome measure of the study compared with baseline OOWS scores at T=-30 (30 minutes prior to study medication administration). Reported time frames are in relation to time past since administration of study medications.~Mean post-Naloxone OOWS scores (+/- SEM) were determined for pretreatment groups" (NCT00661674)
Timeframe: Change from baseline in OOWS score at 180 minutes (15 minutes post naloxone administration)
| Intervention | units on a scale (OOWS Scale) (Mean) |
|---|---|
| Placebo | 3.5 |
| Palonosetron | 1.0 |
| Palonosetron + Hydroxyzine | 0 |
"The SOWS score is composed of 16 subjective symptoms rated on a scale of 0 to 4 (0=not at all, 4=extremely) based on what subjects were experiencing at the time of testing. 15 minutes post naloxone administration coordinates with T = 180 (min) for the entire study session.~The highest score possible (64) would indicate that the individual was experiencing every symptom of opioid withdrawal to the fullest extent possible while the lowest score (0) would indicate that the individual was not experiencing any symptoms of opioid withdrawal.~Mean post-naloxone SOWS scores (+/- SEM) were computed for pretreatment groups: Placebo, palonosetron, and palonosetron with hydroxyzine" (NCT00661674)
Timeframe: Change from baseline in SOWS score at 180 minutes (15 minutes post naloxone administration)
| Intervention | units on a scale (SOWS Scale) (Mean) |
|---|---|
| Placebo | 6.0 |
| Palonosetron | 4.0 |
| Palonosetron + Hydroxyzine | 3.5 |
9 trials available for hydroxyzine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Palonosetron and hydroxyzine pre-treatment reduces the objective signs of experimentally-induced acute opioid withdrawal in humans: a double-blinded, randomized, placebo-controlled crossover study.
Topics: Cross-Over Studies; Double-Blind Method; Drug Synergism; Healthy Volunteers; Humans; Hydroxyzine; Is | 2017 |
Effect of patient recognition of tranquilizers on their use in alcohol detoxification.
Topics: Adult; Aged; Alcoholism; Anti-Anxiety Agents; Anxiety; Diazepam; Humans; Hydroxyzine; Male; Middle A | 1984 |
A double blind study of chlordiazepoxide and hydroxyzine HC1 therapy in acute alcohol withdrawal utilizing chronic electromyography for tremor assessment.
Topics: Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Double-Blind Method; Electromyography; Human | 1978 |
Prevention of delirium tremens: use of phenothiazines versus drugs cross-dependent with alcohol.
Topics: Antipsychotic Agents; Biogenic Amines; Brain Chemistry; Chlordiazepoxide; Chlorpromazine; Drug Toler | 1974 |
Drug treatment of the alcohol withdrawal syndrome and delirium tremens. A comparison of haloperidol with mesoridazine and hydroxyzine.
Topics: Adult; Aged; Alcoholism; Clinical Trials as Topic; Female; Haloperidol; Humans; Hydroxyzine; Injecti | 1973 |
Treatment of the acute alcohol withdrawal state: a comparison of four drugs.
Topics: Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Humans; Hydroxyzine; Middle Aged; Placeb | 1969 |
Hydroxyzine in the treatment of alcoholic withdrawal syndrome.
Topics: Adult; Alcoholism; Clinical Trials as Topic; Humans; Hydroxyzine; Male; Middle Aged; Placebos; Subst | 1969 |
Evaluating changes in symptoms during acute alcohol withdrawal.
Topics: Affect; Alcoholism; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Female; Humans; Hydr | 1971 |
Comparative investigation of the effects of dixyrazine, placebo and chlordiazepoxide on alcoholics during hospital care.
Topics: Adult; Aged; Alcoholism; Chemical Phenomena; Chemistry; Chlordiazepoxide; Chronic Disease; Clinical | 1967 |
13 other studies available for hydroxyzine and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
A novel non-opioid protocol for medically supervised opioid withdrawal and transition to antagonist treatment.
Topics: Adult; Amines; Analgesics, Opioid; Buprenorphine; Clonidine; Counseling; Cyclohexanecarboxylic Acids | 2018 |
Brief psychotic disorder after abrupt withdrawal of hydroxyzine hydrochloride.
Topics: Adult; Female; Humans; Hydroxyzine; Psychotic Disorders; Substance Withdrawal Syndrome | 2014 |
Hydroxyzine for generalized anxiety disorder.
Topics: Anxiety Disorders; Benzodiazepines; Histamine H1 Antagonists; Humans; Hydroxyzine; Randomized Contro | 2003 |
[Methadone and sleep apnea syndrome].
Topics: Adult; Brain; Clonidine; Cocaine-Related Disorders; Dose-Response Relationship, Drug; Drug Administr | 2005 |
[Benzodiazepine withdrawal presenting as pseudo-surgical abdominal pain].
Topics: Abdomen, Acute; Adult; Alprazolam; Anti-Anxiety Agents; Bromazepam; Diagnosis, Differential; Headach | 1997 |
Pharmacotherapy of the acute alcohol withdrawal syndrome.
Topics: Alcoholism; Anti-Anxiety Agents; Barbiturates; Chemical and Drug Induced Liver Injury; Chloral Hydra | 1975 |
Hydroxyzine in the treatment of alcohol withdrawal.
Topics: Alcoholic Intoxication; Humans; Hydroxyzine; Substance Withdrawal Syndrome | 1977 |
Neonatal withdrawal syndrome associated with hydroxyzine hydrochloride.
Topics: Adult; Female; Fetal Blood; Humans; Hydroxyzine; Infant, Newborn; Infant, Newborn, Diseases; Pregnan | 1977 |
Management of withdrawal from alcohol (including delirium tremens).
Topics: Adrenocorticotropic Hormone; Alcoholism; Anti-Bacterial Agents; Chlorpromazine; Humans; Hydrocortiso | 1967 |
Drug therapy in alcoholism. It is especially important in the prevention of such complications as seizures, DT's, Wernicke's encephalopathy, or polyneuritis.
Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Chlorpromazine; Diazepam; Disulfiram; Humans; Hydroxy | 1971 |
Grand-mal seizures in two patients in acute alcohol withdrawal after treatment with hydroxyzine.
Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Epilepsy, Tonic-Clonic; Humans; Hydroxyzine; Injectio | 1967 |
Diagnosis and therapy of acute withdrawal from alcohol.
Topics: Acute Disease; Adult; Alcoholism; Anti-Bacterial Agents; Anticonvulsants; Carbohydrate Metabolism; C | 1970 |
Optimal therapy of the alcohol withdrawal state.
Topics: Adult; Chlordiazepoxide; Chlorpromazine; Electrolytes; Female; Humans; Hydroxyzine; Male; Paraldehyd | 1970 |