hydroxyzine has been researched along with Pruritus in 36 studies
Hydroxyzine: A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
hydroxyzine : A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the effect of gabapentin (GBP) and hydroxyzine (HYDZ) in treating pruritus in patients on dialysis." | 9.34 | Comparison of gabapentin and hydroxyzine in the treatment of pruritus in patients on dialysis. ( Ghorghani, M; Hoseininia, S; Mohammadi Kebar, S; Sharghi, A, 2020) |
| "A 4-week randomized, double-blind safety and efficacy study was conducted to compare the safety and efficacy of cetirizine, doxepine, and hydroxyzine 5 in the treatment of chronic pruritus due to sulfur mustard." | 9.12 | Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial. ( Davoudi, SM; Keshavarz, S; Sadr, B; Shohrati, M; Tajik, A, 2007) |
| "A majority of patients experience pruritus, nausea and/or emesis following epidural morphine administration post-cesarean section." | 9.07 | Epidural morphine pruritus reduction with hydroxyzine in parturients. ( Ackerman, WE; Bellinger, K; Juneja, MM, 1991) |
| "This study evaluates the ability of hydroxyzine and various neuroleptics to suppress histamine-induced pruritus in ten volunteer subjects with the use of a double-blind crossover protocol." | 9.04 | Suppression of histamine-induced pruritus by hydroxyzine and various neuroleptics. ( Ahmed, AR; Arnold, AJ; Jones, HE; Simpson, JG, 1979) |
| "A double-blind crossover study of inhibition of histamine-induced pruritus by three commonly prescribed antihistamines was conducted on 28 normal subjects." | 9.04 | Suppression of histamine-induced pruritus by three antihistaminic drugs. ( Cohan, R; Leifer, KN; Rhoades, RB; Wittig, HJ, 1975) |
| "Uremic pruritus is a common complication in patients with chronic kidney disease." | 6.80 | Comparison of Avena sativa, vinegar, and hydroxyzine for uremic pruritus of hemodialysis patients: a crossover randomized clinical trial. ( Morshedi, J; Nakhaee, S; Nasiri, A; Waghei, Y, 2015) |
| "Loratadine was safe and well tolerated with sedation and dry mouth similar to placebo and significantly less than hydroxyzine." | 6.67 | Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria. ( Bernstein, DI; Cuss, F; Danzig, MR; Fox, RW; Garvin, PR; Grabiec, SV; Honsinger, RW; Kalivas, JT; Katz, HI; Monroe, EW, 1992) |
| "To compare the effect of gabapentin (GBP) and hydroxyzine (HYDZ) in treating pruritus in patients on dialysis." | 5.34 | Comparison of gabapentin and hydroxyzine in the treatment of pruritus in patients on dialysis. ( Ghorghani, M; Hoseininia, S; Mohammadi Kebar, S; Sharghi, A, 2020) |
| "A 4-week randomized, double-blind safety and efficacy study was conducted to compare the safety and efficacy of cetirizine, doxepine, and hydroxyzine 5 in the treatment of chronic pruritus due to sulfur mustard." | 5.12 | Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial. ( Davoudi, SM; Keshavarz, S; Sadr, B; Shohrati, M; Tajik, A, 2007) |
| "A majority of patients experience pruritus, nausea and/or emesis following epidural morphine administration post-cesarean section." | 5.07 | Epidural morphine pruritus reduction with hydroxyzine in parturients. ( Ackerman, WE; Bellinger, K; Juneja, MM, 1991) |
| "This study evaluates the ability of hydroxyzine and various neuroleptics to suppress histamine-induced pruritus in ten volunteer subjects with the use of a double-blind crossover protocol." | 5.04 | Suppression of histamine-induced pruritus by hydroxyzine and various neuroleptics. ( Ahmed, AR; Arnold, AJ; Jones, HE; Simpson, JG, 1979) |
| "A double-blind crossover study of inhibition of histamine-induced pruritus by three commonly prescribed antihistamines was conducted on 28 normal subjects." | 5.04 | Suppression of histamine-induced pruritus by three antihistaminic drugs. ( Cohan, R; Leifer, KN; Rhoades, RB; Wittig, HJ, 1975) |
| " The reason for referral was that on the fourth day of treatment with prednisone and hydroxyzine, the patient presented a bilateral highly pruritic palmar erythema that evolved to a generalized morbilliform rash with subsequent complete desquamation." | 3.80 | Cutaneous drug eruption induced by antihistamines. ( Castillo, MJ; Hernández, N; Ibero, M; Viñas, M, 2014) |
| " Elevated bile acid levels confirmed a diagnosis of intrahepatic cholestasis of pregnancy, and ursodeoxycholic acid therapy was initiated." | 3.77 | Primary dermatologic findings with early-onset intrahepatic cholestasis of pregnancy. ( Chao, TT; Sheffield, JS, 2011) |
| "Uremic pruritus is a common complication in patients with chronic kidney disease." | 2.80 | Comparison of Avena sativa, vinegar, and hydroxyzine for uremic pruritus of hemodialysis patients: a crossover randomized clinical trial. ( Morshedi, J; Nakhaee, S; Nasiri, A; Waghei, Y, 2015) |
| "The causes of pruritus are numerous including xerosis, drug and photoeruptions, follicular and papular eruptions as well as infestations and infections by a wide range of organisms." | 2.68 | Pruritus in HIV-1 disease: therapy with drugs which may modulate the pattern of immune dysregulation. ( Lee, RB; Skelton, HG; Smith, KJ; Wagner, KF; Yeager, J, 1997) |
| "Loratadine was safe and well tolerated with sedation and dry mouth similar to placebo and significantly less than hydroxyzine." | 2.67 | Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria. ( Bernstein, DI; Cuss, F; Danzig, MR; Fox, RW; Garvin, PR; Grabiec, SV; Honsinger, RW; Kalivas, JT; Katz, HI; Monroe, EW, 1992) |
| "Hydroxyzine is an effective therapy." | 1.27 | Follicular dermographism. ( Shelley, ED; Shelley, WB, 1983) |
| "Histamine was released into the systemic circulation in both conditions in a similar time course; however, systemic symptoms occurred only after the 41 degree C bath." | 1.26 | Evaluation of a patient with both aquagenic and cholinergic urticaria. ( Bock, SA; Davis, RS; Remigio, LK; Schocket, AL, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (52.78) | 18.7374 |
| 1990's | 6 (16.67) | 18.2507 |
| 2000's | 4 (11.11) | 29.6817 |
| 2010's | 5 (13.89) | 24.3611 |
| 2020's | 2 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Le Gall-Ianotto, C | 1 |
| Verdet, R | 1 |
| Nowak, E | 1 |
| Le Roux, L | 1 |
| Gasse, A | 1 |
| Fiedler, A | 1 |
| Carlhant-Kowalski, D | 1 |
| Marcorelles, P | 1 |
| Misery, L | 1 |
| Ianotto, JC | 1 |
| Mohammadi Kebar, S | 1 |
| Sharghi, A | 1 |
| Ghorghani, M | 1 |
| Hoseininia, S | 1 |
| Veiga, VF | 1 |
| Santos, F | 1 |
| Antunes, A | 1 |
| Duarte, I | 1 |
| Viñas, M | 1 |
| Castillo, MJ | 1 |
| Hernández, N | 1 |
| Ibero, M | 1 |
| Nakhaee, S | 1 |
| Nasiri, A | 1 |
| Waghei, Y | 1 |
| Morshedi, J | 1 |
| do Valle, SO | 1 |
| França, AT | 1 |
| Pires, GV | 1 |
| Guimarães, P | 1 |
| Dias, GA | 1 |
| Levy, SA | 1 |
| Chao, TT | 1 |
| Sheffield, JS | 1 |
| SHANON, J | 1 |
| GANOR, S | 1 |
| NINOMIYA, S | 1 |
| ROYS, HC | 1 |
| Shohrati, M | 1 |
| Davoudi, SM | 1 |
| Keshavarz, S | 1 |
| Sadr, B | 1 |
| Tajik, A | 1 |
| Deutsch, PH | 1 |
| Garafalo, J | 1 |
| Kaplan, AP | 1 |
| Shelley, WB | 1 |
| Shelley, ED | 1 |
| Vasily, DB | 1 |
| Bhatia, SG | 1 |
| Davis, RS | 1 |
| Remigio, LK | 1 |
| Schocket, AL | 1 |
| Bock, SA | 1 |
| Brooks, CD | 1 |
| Nelson, A | 1 |
| Parzyck, R | 1 |
| Maile, MH | 1 |
| Klein, GL | 1 |
| Galant, SP | 1 |
| Baker, BA | 1 |
| Cacchione, JG | 1 |
| Fleischer, AB | 1 |
| Smith, KJ | 1 |
| Skelton, HG | 1 |
| Yeager, J | 1 |
| Lee, RB | 1 |
| Wagner, KF | 1 |
| Normand, F | 1 |
| Armingaud, P | 1 |
| Estève, E | 1 |
| Braun, M | 1 |
| Lowitt, MH | 1 |
| Arnold, AJ | 1 |
| Simpson, JG | 1 |
| Jones, HE | 1 |
| Ahmed, AR | 1 |
| Tindall, JP | 1 |
| Rhoades, RB | 1 |
| Leifer, KN | 1 |
| Cohan, R | 1 |
| Wittig, HJ | 1 |
| Baraf, CS | 1 |
| Monroe, EW | 1 |
| Bernstein, DI | 1 |
| Fox, RW | 1 |
| Grabiec, SV | 1 |
| Honsinger, RW | 1 |
| Kalivas, JT | 1 |
| Katz, HI | 1 |
| Cuss, F | 1 |
| Danzig, MR | 1 |
| Garvin, PR | 1 |
| Healy, B | 1 |
| Juneja, MM | 1 |
| Ackerman, WE | 1 |
| Bellinger, K | 1 |
| Coulie, P | 1 |
| Wery, M | 1 |
| Ghys, L | 1 |
| Rihoux, JP | 1 |
| Youngchaiyud, U | 1 |
| Berger, RS | 1 |
| Grolnick, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aprepitant Versus Hydroxyzine in Association With Cytoreductive Treatments for Patients With Myeloproliferative Neoplasia Suffering From Persistent Aquagenic Pruritus.[NCT03808805] | Phase 3 | 80 participants (Anticipated) | Interventional | 2019-04-16 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for hydroxyzine and Pruritus
| Article | Year |
|---|---|
Pruritus.
Topics: Acupuncture; Administration, Topical; Anti-Inflammatory Agents; Antipruritics; Combined Modality The | 2001 |
15 trials available for hydroxyzine and Pruritus
| Article | Year |
|---|---|
Rationale and design of the multicentric, double-blind, double-placebo, randomized trial APrepitant versus HYdroxyzine in association with cytoreductive treatments for patients with myeloproliferative neoplasia suffering from Persistent Aquagenic Pruritus
Topics: Aprepitant; Cytoreduction Surgical Procedures; Humans; Hydroxyzine; Neoplasms; Pruritus; Quality of | 2021 |
Comparison of gabapentin and hydroxyzine in the treatment of pruritus in patients on dialysis.
Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Antipruritics; Case-Control Studies; Cross-Over St | 2020 |
Comparison of Avena sativa, vinegar, and hydroxyzine for uremic pruritus of hemodialysis patients: a crossover randomized clinical trial.
Topics: Acetic Acid; Adult; Aged; Avena; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydroxyzin | 2015 |
Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial.
Topics: Administration, Oral; Adult; Antipruritics; Cetirizine; Chemical Warfare Agents; Chronic Disease; Do | 2007 |
Atarax (hydroxyzine) for itching.
Topics: Clinical Trials as Topic; Humans; Hydroxyzine; Pruritus; Urticaria | 1980 |
Protective effect of hydroxyzine and phenylpropanolamine in the challenged allergic nose.
Topics: Adult; Airway Resistance; Drug Therapy, Combination; Female; Humans; Hydroxyzine; Male; Middle Aged; | 1981 |
A comparison of the antipruritic efficacy of hydroxyzine and cyproheptadine in children with atopic dermatitis.
Topics: Adolescent; Antipruritics; Child; Child, Preschool; Cyproheptadine; Dermatitis, Atopic; Dermatologic | 1980 |
Pruritus in HIV-1 disease: therapy with drugs which may modulate the pattern of immune dysregulation.
Topics: Administration, Cutaneous; Administration, Topical; Anti-Inflammatory Agents; Antipruritics; Cycloox | 1997 |
Suppression of histamine-induced pruritus by hydroxyzine and various neuroleptics.
Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Double-Blind Method; Histamine; Humans; Hydro | 1979 |
Suppression of histamine-induced pruritus by three antihistaminic drugs.
Topics: Adolescent; Adult; Clinical Trials as Topic; Cyproheptadine; Differential Threshold; Diphenhydramine | 1975 |
Treatment of pruritus in allergic dermatoses: an evaluation of the relative efficacy of cyproheptadine and hydroxyzine.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Cyproheptadine; Dermatitis, Atopic; Dermatitis, C | 1976 |
Relative efficacy and safety of loratadine, hydroxyzine, and placebo in chronic idiopathic urticaria.
Topics: Adolescent; Adult; Aged; Chronic Disease; Double-Blind Method; Humans; Hydroxyzine; Loratadine; Midd | 1992 |
Epidural morphine pruritus reduction with hydroxyzine in parturients.
Topics: Adult; Analgesia, Epidural; Cesarean Section; Female; Humans; Hydroxyzine; Injections, Epidural; Inj | 1991 |
Pharmacologic modulation by cetirizine-2 HCl of cutaneous reactions and pruritus in man after experimental mosquito bites.
Topics: Animals; Cetirizine; Culicidae; Double-Blind Method; Histamine H1 Antagonists; Humans; Hydroxyzine; | 1989 |
Comparison of the efficacy of four antihistamines in chronic urticaria.
Topics: Adolescent; Adult; Chlorpheniramine; Chronic Disease; Cimetidine; Clemastine; Double-Blind Method; D | 1988 |
20 other studies available for hydroxyzine and Pruritus
| Article | Year |
|---|---|
Phemphigoid gestationis.
Topics: Adult; Antipruritics; Female; Histamine H1 Antagonists; Humans; Hydroxyzine; Pemphigoid Gestationis; | 2018 |
Cutaneous drug eruption induced by antihistamines.
Topics: Aged; Drug Eruptions; Erythema; Female; Hand Dermatoses; Histamine H1 Antagonists; Humans; Hydroxyzi | 2014 |
[Pruritic urticarial papules and plaques of pregnancy].
Topics: Adult; Anti-Inflammatory Agents; Antipruritics; Betamethasone; Female; Humans; Hydrocortisone; Hydro | 2008 |
Dapsone hypersensitivity syndrome during delayed pressure urticaria treatment.
Topics: Adult; Dapsone; Dengue; Diagnosis, Differential; Drug Hypersensitivity; Erythema; Female; Fever; His | 2010 |
Primary dermatologic findings with early-onset intrahepatic cholestasis of pregnancy.
Topics: Betamethasone; Bile Acids and Salts; Cholagogues and Choleretics; Cholestasis, Intrahepatic; Deliver | 2011 |
[The therapeutic effect of hydroxyzine in skin diseases associated with pruritus. (Double-blind study)].
Topics: Dermatology; Double-Blind Method; Humans; Hydroxyzine; Pruritus; Skin Diseases | 1962 |
[Cases of pruritic skin diseases, particularly chronic urticaria, cured with Atarax].
Topics: Chronic Disease; Humans; Hydroxyzine; Pruritus; Skin; Urticaria | 1963 |
Hydroxyzine in control of ruritus of dermatoses.
Topics: Humans; Hydroxyzine; Pruritus; Skin Diseases | 1962 |
Dermatographism treated with hydroxyzine and cimetidine and ranitidine.
Topics: Adult; Cimetidine; Dermatitis, Atopic; Drug Therapy, Combination; Humans; Hydroxyzine; Male; Pruritu | 1984 |
Histamine release and therapy of severe dermatographism.
Topics: Adolescent; Animals; Cyproheptadine; Diphenhydramine; Female; Histamine; Histamine Release; Humans; | 1981 |
Follicular dermographism.
Topics: Adolescent; Adult; Female; Humans; Hydroxyzine; Male; Middle Aged; Physical Stimulation; Pruritus; U | 1983 |
Lichen striatus.
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Fluocinonide; Humans; Hydroxyzine; Nail Diseases | 1981 |
Evaluation of a patient with both aquagenic and cholinergic urticaria.
Topics: Anxiety; Child; Cholinergic Fibers; Female; Heart Rate; Histamine; Hot Temperature; Humans; Hydroxyz | 1981 |
Dermatologic cross-sensitivity between diltiazem and amlodipine.
Topics: Amlodipine; Diltiazem; Diphenhydramine; Drug Eruptions; Humans; Hydroxyzine; Male; Methylprednisolon | 1994 |
Pruritus in the elderly: management by senior dermatologists.
Topics: Administration, Oral; Administration, Topical; Aged; Aging; Anti-Inflammatory Agents; Attitude of He | 1993 |
[Dyshidrosis and acral purpura during polymorphic dermatitis in pregnancy: 2 cases].
Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Antipruritics; Betamethasone; Biopsy; Drug | 2001 |
Relieving localized and generalized pruritus.
Topics: Aged; Bandages; Chlorpromazine; Cyproheptadine; Dermatitis; Dermatitis, Seborrheic; Female; Humans; | 1975 |
Nurses talk about their experiences with drug addiction.
Topics: Benzodiazepines; Buspirone; Female; Humans; Hydroxyzine; Nurses; Professional Impairment; Pruritus; | 1992 |
The unremarkable brown recluse spider bite.
Topics: Adult; California; Erythema; Female; Humans; Hydroxyzine; Lymphocyte Activation; Missouri; Pruritus; | 1973 |
An investigative and clinical evaluation of dermographism.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Dermatitis, Atopic; Edema; Erythema; | 1970 |