hydroxyzine and Pregnancy studies

Hydroxyzine: A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
hydroxyzine : A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

Excerpt	Relevance	Reference
"A majority of patients experience pruritus, nausea and/or emesis following epidural morphine administration post-cesarean section."	9.07	Epidural morphine pruritus reduction with hydroxyzine in parturients. ( Ackerman, WE; Bellinger, K; Juneja, MM, 1991)
"One hundred twenty women were followed after exposure to either hydroxyzine or cetirizine during pregnancy."	7.69	Prospective controlled study of hydroxyzine and cetirizine in pregnancy. ( Bailey, B; Baillie, M; Einarson, A; Jung, G; Koren, G; Spizzirri, D, 1997)
"A majority of patients experience pruritus, nausea and/or emesis following epidural morphine administration post-cesarean section."	5.07	Epidural morphine pruritus reduction with hydroxyzine in parturients. ( Ackerman, WE; Bellinger, K; Juneja, MM, 1991)
" Elevated bile acid levels confirmed a diagnosis of intrahepatic cholestasis of pregnancy, and ursodeoxycholic acid therapy was initiated."	3.77	Primary dermatologic findings with early-onset intrahepatic cholestasis of pregnancy. ( Chao, TT; Sheffield, JS, 2011)
"One hundred twenty women were followed after exposure to either hydroxyzine or cetirizine during pregnancy."	3.69	Prospective controlled study of hydroxyzine and cetirizine in pregnancy. ( Bailey, B; Baillie, M; Einarson, A; Jung, G; Koren, G; Spizzirri, D, 1997)
"To our knowledge, this is the first report of a neonatal withdrawal syndrome associated with maternal usage of 600 mg daily of hydroxyzine hydrochloride throughout pregnancy."	3.65	Neonatal withdrawal syndrome associated with hydroxyzine hydrochloride. ( Prenner, BM, 1977)
"Vomiting was significantly more frequent in the placebo-treated group [0."	2.64	A controlled trial of antiemetics in abortion by PGF2alpha and laminaria. ( Federschneider, JM; Kaul, AF; Stubblefield, PG, 1978)
"Current treatment for toxoplasmosis commonly have high cytotoxic side effects on host and require long durations ranging from one week to more than one year."	2.61	Recent progress on anti-Toxoplasma drugs discovery: Design, synthesis and screening. ( Deng, Y; Li, CH; Wu, T; Zhai, SQ, 2019)
" The objective was to measure the rate of adverse pregnancy outcomes."	2.50	The fetal safety of cetirizine: an observational cohort study and meta-analysis. ( Boskovic, R; Djokanovic, N; Etwel, F; Koren, G; Martinovic, J; Moretti, ME, 2014)

Timeframe	Studies, this research(%)	All Research%
pre-1990	45 (76.27)	18.7374
1990's	3 (5.08)	18.2507
2000's	3 (5.08)	29.6817
2010's	8 (13.56)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Deng, Y	1
Wu, T	1
Zhai, SQ	1
Li, CH	1
Veiga, VF	1
Santos, F	1
Antunes, A	1
Duarte, I	1
Pevtichev, S	1
Dimitrova, V	1
Etwel, F	1
Djokanovic, N	1
Moretti, ME	1
Boskovic, R	1
Martinovic, J	1
Koren, G	2
Fujii, Y	1
Chao, TT	1
Sheffield, JS	1
Othman, M	1
Jones, L	1
Neilson, JP	1
GIANNI, T	1
SAVONA, B	1
PERRICONE, G	1
MAYER, M	1
ESPAGNO, G	1
MULLA, N	1
WOYTON, J	1
CHILDERS, J	1
GORTZ, RV	1
INMON, WB	1
SYLVESTER, WR	1
MARTINS, AD	1
ARANTES, JC	1
CITTERIO, P	1
STEFANINI, U	1
DEJONG, RH	1
GORDON, EM	1
NELSON, HB	1
LUBE, J	1
MUELLENDER, H	1
Jantjes, L	1
Strümpher, J	1
Kotzé, WJ	1
Zarebska, A	1
Datta, S	1
Alper, MH	1
McKenzie, R	1
Wadhwa, RK	2
Uy, NT	1
Phitayakorn, P	1
Tantisira, B	2
Sinchioco, C	1
Taylor, FH	1
Amato, G	1
Corsini, D	1
Pelliccia, E	1
Einarson, A	1
Bailey, B	1
Jung, G	1
Spizzirri, D	1
Baillie, M	1
Michel, M	1
Dompmartin, A	1
Louvet, S	1
Szczurko, C	1
Castel, B	1
Leroy, D	1
Normand, F	1
Armingaud, P	1
Estève, E	1
Petrie, RH	2
Yeh, SY	1
Murata, Y	1
Paul, RH	2
Hon, EH	2
Barron, BA	1
Johnson, RJ	1
Kaul, AF	1
Federschneider, JM	1
Stubblefield, PG	1
Prenner, BM	1
Wu, R	1
Miller, FC	1
Sacks, DA	1
Sugarman, R	1
Juneja, MM	1
Ackerman, WE	1
Bellinger, K	1
Schuller, DE	1
Turkewitz, D	1
Sadovsky, E	1
Weinstein, D	1
Pfeifer, Y	1
Polishuk, WZ	1
Sulman, FG	1
Clark, RB	1
Reisner, JG	1
King, CT	2
Howell, J	1
Steffek, AJ	1
Derr, JE	1
Standley, K	1
Soule, AB	1
Copans, SA	1
Duchowny, MS	1
Walker, BE	1
Patterson, A	1
Yassemi, N	1
Csapo, AI	1
Kivikoski, A	1
Wiest, WG	1
Simionescu, S	2
Bordeianu, A	2
Stancu, C	2
Daniel, B	2
Pintilescu, V	2
Wingate, MB	1
Wingate, L	1
Iffy, L	1
Freundlich, J	1
Gottsegen, D	1
Mateescu-Cantuniari, A	1
Erez, S	1
Schifrin, BS	1
Dirim, O	1
Dees, HC	1
Spellacy, WN	1
Shattuck, CA	1
Loffer, FD	1
Malkasian, GD	1
Smith, RA	1
Decker, DG	1
Hardesty, WH	1
Withöft, W	1
Saurwein, A	1
Semler, WL	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Intravenous Injection of Diazepam at the Beginning of Active Phase of Labor[NCT02232035]			Phase 2	400 participants (Anticipated)	Interventional	2014-09-30	Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Recent progress on anti-Toxoplasma drugs discovery: Design, synthesis and screening. European journal of medicinal chemistry, 2019, Dec-01, Volume: 183 Topics: Animals; Antiprotozoal Agents; Drug Discovery; Female; Humans; Pregnancy; Toxoplasma; Toxoplasmosis	2019
[Intrahepatic cholestasis of pregnancy]. Akusherstvo i ginekologiia, 2013, Volume: 52, Issue:1 Topics: Anticholesteremic Agents; Bile Ducts; Cholagogues and Choleretics; Cholestasis, Intrahepatic; Choles	2013
The fetal safety of cetirizine: an observational cohort study and meta-analysis. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2014, Volume: 34, Issue:5 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Cetirizine; Female; Histamine H1 Antagoni	2014
Drugs to avoid in pregnant women with allergies. Prescrire international, 2016, Volume: 25, Issue:170 Topics: Abnormalities, Drug-Induced; Arrhythmias, Cardiac; Basal Ganglia Diseases; Female; Histamine H1 Anta	2016
Prevention of nausea and vomiting during termination of pregnancy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2010, Volume: 111, Issue:1 Topics: Abortion, Therapeutic; Antiemetics; Benzimidazoles; Dexamethasone; Dilatation and Curettage; Droperi	2010
Non-opioid drugs for pain management in labour. The Cochrane database of systematic reviews, 2012, Jul-11, Issue:7 Topics: Analgesia, Obstetrical; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-	2012
Anesthesia for cesarean section. Anesthesiology, 1980, Volume: 53, Issue:2 Topics: Anesthesia, Epidural; Anesthesia, General; Anesthesia, Intravenous; Anesthesia, Spinal; Anesthetics;	1980
Adverse effects of antihistamines. Postgraduate medicine, 1986, Feb-01, Volume: 79, Issue:2 Topics: Adolescent; Adult; Aged; Asthma; Brompheniramine; Central Nervous System; Child, Preschool; Chlorphe	1986
Analgesia during labor: effect on the fetus and neonate. Clinical anesthesia, 1974, Volume: 10, Issue:2 Topics: Acidosis; Alphaprodine; Anesthesia, Inhalation; Anesthesia, Obstetrical; Anesthetics; Apgar Score; B	1974

Article	Year
Antiemetic effectiveness of intramuscular hydroxyzine compared with intramuscular droperidol. Anesthesia and analgesia, 1981, Volume: 60, Issue:11 Topics: Abortion, Induced; Antiemetics; Double-Blind Method; Droperidol; Drug Evaluation; Female; Humans; Hy	1981
A controlled trial of antiemetics in abortion by PGF2alpha and laminaria. The Journal of reproductive medicine, 1978, Volume: 20, Issue:4 Topics: Abortion, Induced; Adolescent; Adult; Amnion; Analgesics, Opioid; Antiemetics; Clinical Trials as To	1978
Epidural morphine pruritus reduction with hydroxyzine in parturients. The Journal of the Kentucky Medical Association, 1991, Volume: 89, Issue:7 Topics: Adult; Analgesia, Epidural; Cesarean Section; Female; Humans; Hydroxyzine; Injections, Epidural; Inj	1991
Hydroxyzine for controlling postpartum anxiety: a double-blind study. The Nebraska state medical journal, 1967, Volume: 52, Issue:11 Topics: Anxiety; Clinical Trials as Topic; Female; Humans; Hydroxyzine; Obstetric Labor Complications; Pregn	1967
Double-blind evaluation of hydroxyzine as an antiemetic in pregancy. The Journal of reproductive medicine, 1971, Volume: 7, Issue:1 Topics: Antiemetics; Clinical Trials as Topic; Female; Humans; Hydroxyzine; Hyperemesis Gravidarum; Nausea;	1971
A study of the effect of phenergan and vistaril in combination with demerol on labor and delivery. Journal of the Medical Association of Georgia, 1965, Volume: 54, Issue:9 Topics: Anesthesia, Obstetrical; Clinical Trials as Topic; Female; Georgia; Humans; Hydroxyzine; Meperidine;	1965
A double-blind study of the comparative effects of meperidine with secobarbital, hydroxyzine, or a placebo on labor and delivery. Obstetrics and gynecology, 1966, Volume: 27, Issue:2 Topics: Adult; Anesthesia, Obstetrical; Clinical Trials as Topic; Delivery, Obstetric; Female; Humans; Hydro	1966
Comparison of hydroxyzine-meperidine and promethazine-meperidine for analgesia during labor. Obstetrics and gynecology, 1967, Volume: 30, Issue:4 Topics: Anesthesia, Obstetrical; Blood Pressure; Clinical Trials as Topic; Female; Fetus; Humans; Hydroxyzin	1967

hydroxyzine and Pregnancy

Research Excerpts

Research

Studies (59)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Phemphigoid gestationis. BMJ case reports, 2018, Jun-17, Volume: 2018 Topics: Adult; Antipruritics; Female; Histamine H1 Antagonists; Humans; Hydroxyzine; Pemphigoid Gestationis;	2018
[Pruritic urticarial papules and plaques of pregnancy]. Akusherstvo i ginekologiia, 2008, Volume: 47, Issue:6 Topics: Adult; Anti-Inflammatory Agents; Antipruritics; Betamethasone; Female; Humans; Hydrocortisone; Hydro	2008
Primary dermatologic findings with early-onset intrahepatic cholestasis of pregnancy. Obstetrics and gynecology, 2011, Volume: 117, Issue:2 Pt 2 Topics: Betamethasone; Bile Acids and Salts; Cholagogues and Choleretics; Cholestasis, Intrahepatic; Deliver	2011
[Hydroxyzine hydrochloride (atarax) in the field of obstetrics and gynecology]. Rivista d'ostetricia e ginecologia pratica, 1957, Volume: 39, Issue:11 Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Female; Genital Diseases, Female; Gynecology; Human	1957
[Hydroxyzine in obstetrics; value of the use of a neuroleptic agent in drug therapy of inertia with posterior pituitary extracts]. Minerva ginecologica, 1958, Apr-30, Volume: 10, Issue:8 Topics: Antipsychotic Agents; Dystocia; Female; Humans; Hydroxyzine; Obstetrics; Pituitary Gland; Pituitary	1958
[Hydroxyzine in labor]. La Presse medicale, 1959, May-23, Volume: 67, Issue:25 Topics: Female; Humans; Hydroxyzine; Labor, Obstetric; Pregnancy; Tranquilizing Agents; Work	1959
Clinical evaluation of hydroxyzine hydrochloride in the management of labor. The Journal of the International College of Surgeons, 1961, Volume: 35 Topics: Disease Management; Female; Humans; Hydroxyzine; Labor, Obstetric; Pregnancy; Work	1961
[Attempted therapy of vomiting in pregnancy with atarax]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1959, Jul-06, Volume: 14 Topics: Female; Hydroxyzine; Pregnancy; Pregnancy Complications; Vomiting	1959
Hydroxyzine in labor and delivery. The Journal of the Kentucky Medical Association, 1961, Volume: 59 Topics: Anesthesia; Anesthesia, Obstetrical; Delivery, Obstetric; Female; Humans; Hydroxyzine; Labor, Obstet	1961
[A new therapeutic compound in the treatment of after-pains]. Le Scalpel, 1961, Nov-18, Volume: 114 Topics: Acetanilides; Female; Humans; Hydroxyzine; Labor Pain; Muscle Relaxants, Central; Postpartum Period;	1961
A STUDY OF THE EFFECT OF HYDROXYZINE HYDROCHLORIDE ON LABOR AND DELIVERY. American journal of obstetrics and gynecology, 1963, Aug-01, Volume: 86 Topics: Anesthesia; Anesthesia, Obstetrical; Delivery, Obstetric; Female; Humans; Hydroxyzine; Labor, Obstet	1963
NAUSEA AND VOMITING IN PREGNANCY. Southwestern medicine, 1964, Volume: 45 Topics: Female; Humans; Hydroxyzine; Nausea; Pregnancy; Pregnancy Complications; Prochlorperazine; Toxicolog	1964
[RESERPINE IN LABOR]. Hospital (Rio de Janeiro, Brazil), 1964, Volume: 65 Topics: Adjuvants, Anesthesia; Anesthesia; Anesthesia, Obstetrical; Female; Glutethimide; Humans; Hydroxyzin	1964
[EXPERIENCE WITH AN ASSOCIATION OF AN ANALGESIC AND TRANQUILIZING AGENT IN LABOR]. Rivista d'ostetricia e ginecologia pratica, 1964, Volume: 46 Topics: Analgesics; Anesthesia; Anesthesia, Obstetrical; Female; Humans; Hydroxyzine; Hypnotics and Sedative	1964
ARTERIAL CARBON DIOXIDE AND OXYGEN TENSIONS DURING SPINAL BLOCK. JAMA, 1965, Mar-01, Volume: 191 Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthesia, Spinal; Blood Gas Analysis; Carbon Diox	1965
A DOUBLE BLIND STUDY OF THE EFFECT OF TRANQUILIZERS DURING LABOR. American journal of obstetrics and gynecology, 1965, Jun-01, Volume: 92 Topics: Anesthesia; Anesthesia, Obstetrical; Biomedical Research; Double-Blind Method; Drug Therapy; Female;	1965
[Clinical experiences with the problem of the reduction of pain and the shortening of labor with sanaestin, sanaestin/sparcotin, and atarax]. Das Deutsche Gesundheitswesen, 1959, Oct-15, Volume: 14 Topics: Anesthesia; Anesthesia, Obstetrical; Female; Humans; Hydroxyzine; Labor, Obstetric; Pain; Pregnancy	1959
[Atarax in obstetrics]. Praxis, 1962, May-03, Volume: 51 Topics: Female; Humans; Hydroxyzine; Labor, Obstetric; Obstetrics; Pregnancy; Pregnanediones; Work	1962
The experience of childbrith in first-time mothers who received narcotic analgesics during the first stage of labour. Curationis, 2007, Volume: 30, Issue:2 Topics: Adaptation, Psychological; Analgesia, Obstetrical; Analgesics, Opioid; Attitude to Health; Drug Ther	2007
[Effect of hydroxyzine on the spleen of female rats during pregnancy]. Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 1983, Volume: 38 Topics: Alkaline Phosphatase; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Female; Hydroxyz	1983
[Personal experience with a combination of Althesin and Atarax in caesarean section]. Minerva anestesiologica, 1980, Volume: 46, Issue:6 Topics: Alfaxalone Alfadolone Mixture; Anesthesia, Obstetrical; Cesarean Section; Drug Combinations; Female;	1980
Prospective controlled study of hydroxyzine and cetirizine in pregnancy. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 78, Issue:2 Topics: Abortion, Spontaneous; Abortion, Therapeutic; Alcohol Drinking; Anti-Allergic Agents; Birth Rate; Bi	1997
Skin reactions to hydroxyzine. Contact dermatitis, 1997, Volume: 36, Issue:3 Topics: Adult; Aged; Dermatitis, Atopic; Drug Eruptions; Female; Histamine H1 Antagonists; Humans; Hydroxyzi	1997
[Dyshidrosis and acral purpura during polymorphic dermatitis in pregnancy: 2 cases]. Annales de dermatologie et de venereologie, 2001, Volume: 128, Issue:4 Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Antipruritics; Betamethasone; Biopsy; Drug	2001
The effect of drugs on fetal heart rate variability. American journal of obstetrics and gynecology, 1978, Feb-01, Volume: 130, Issue:3 Topics: Analgesics, Opioid; Female; Fetal Heart; Heart Rate; Humans; Hydroxyzine; Labor, Obstetric; Magnesiu	1978
Neonatal withdrawal syndrome associated with hydroxyzine hydrochloride. American journal of diseases of children (1960), 1977, Volume: 131, Issue:5 Topics: Adult; Female; Fetal Blood; Humans; Hydroxyzine; Infant, Newborn; Infant, Newborn, Diseases; Pregnan	1977
The effect of drugs on uterine activity. Obstetrics and gynecology, 1976, Volume: 48, Issue:4 Topics: Adolescent; Adult; Alphaprodine; Female; Humans; Hydroxyzine; Labor, Obstetric; Magnesium Sulfate; M	1976
Prevention of serotonin abortion by serotonin antagonists in rats. Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 205, Issue:2 Topics: Abortion, Induced; Animals; Atropine; Benzocycloheptenes; Dimethylamines; Ergolines; Female; Gestati	1973
Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. American journal of obstetrics and gynecology, 1966, May-01, Volume: 95, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Antiemetics; Female; Histamine H1 Antagonists; Hydroxyzine; Mi	1966
The comparative pathogenesis of experimentally induced cleft palate. Journal of oral therapeutics and pharmacology, 1966, Volume: 3, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Hydroxyzine; Maxillofacial Development;	1966
Letter: Preabortion medication. JAMA, 1974, Feb-04, Volume: 227, Issue:5 Topics: Abortion, Therapeutic; Anesthesia, General; Diazepam; Female; Humans; Hydroxyzine; Nausea; Pregnancy	1974
Local-regional anesthesia during childbirth: effect on newborn behaviors. Science (New York, N.Y.), 1974, Nov-15, Volume: 186, Issue:4164 Topics: Anesthesia, Conduction; Anesthesia, Local; Anesthesia, Obstetrical; Apgar Score; Birth Weight; Bupiv	1974
Induction of cleft palate in mice by tranquilizers and barbiturates. Teratology, 1974, Volume: 10, Issue:2 Topics: Animals; Barbiturates; Chlordiazepoxide; Chlorpromazine; Cleft Palate; Diazepam; Female; Hydroxyzine	1974
Use of atarax with ketamine anaesthesia in obstetrics. Middle East journal of anaesthesiology, 1974, Volume: 4, Issue:2 Topics: Anesthesia, Inhalation; Anesthesia, Obstetrical; Atropine; Cesarean Section; Female; Humans; Hydroxy	1974
Massive initial prostaglandin impact in postconceptional therapy. Prostaglandins, 1972, Volume: 2, Issue:2 Topics: Abortion, Induced; Adult; Amniotic Fluid; Estradiol; Female; Humans; Hydroxyzine; Injections; Meperi	1972
[Studies of the influence of the non-specific pharmacodynamic action of hydroxyzine on the sex function equilibration mechanism]. Revue roumaine de physiologie, 1973, Volume: 10, Issue:4 Topics: Animals; Estrus; Female; Genitalia, Female; Hydroxyzine; Ovary; Pregnancy; Rats; Uterus	1973
The effect of epidural analgesia upon fetal and neonatal status. American journal of obstetrics and gynecology, 1974, Aug-15, Volume: 119, Issue:8 Topics: Analgesia; Analgesics; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthetics; Apgar Score; Bloo	1974
[The nonspecific pharmacodynamic action of certain psychotropic drugs of different structure and classification on the equilibrium of sexual function]. Revue roumaine de physiologie, 1974, Volume: 11, Issue:3 Topics: Animals; Antidepressive Agents; Chlordiazepoxide; Estrus; Female; Hydroxyzine; Meprobamate; Ovary; P	1974
Inadvertent intra-arterial injection. JAMA, 1970, Aug-03, Volume: 213, Issue:5 Topics: Adult; Female; Humans; Hydroxyzine; Injections, Intra-Arterial; Injections, Intravenous; Pregnancy;	1970
[Panel discussion: re-evaluation of premedication]. Masui. The Japanese journal of anesthesiology, 1967, Volume: 16, Issue:10 Topics: Adjuvants, Anesthesia; Anesthesia, Obstetrical; Atropine; Female; Haloperidol; Humans; Hydroxyzine;	1967
[Effect of hydroxizine on labor pains and delivery course. Contribution to medicinal labor control]. Therapie der Gegenwart, 1968, Volume: 107, Issue:10 Topics: Female; Humans; Hydroxyzine; Labor, Obstetric; Pregnancy	1968
Use of Hydroxyzine in management of labor. Wisconsin medical journal, 1965, Volume: 64, Issue:10 Topics: Adolescent; Adult; Anesthesia, Obstetrical; Female; Humans; Hydroxyzine; Meperidine; Pregnancy	1965