hydroxyzine has been researched along with Pain, Postoperative in 9 studies
Hydroxyzine: A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
hydroxyzine : A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.
Pain, Postoperative: Pain during the period after surgery.
Excerpt | Relevance | Reference |
---|---|---|
"A majority of patients experience pruritus, nausea and/or emesis following epidural morphine administration post-cesarean section." | 9.07 | Epidural morphine pruritus reduction with hydroxyzine in parturients. ( Ackerman, WE; Bellinger, K; Juneja, MM, 1991) |
"A majority of patients experience pruritus, nausea and/or emesis following epidural morphine administration post-cesarean section." | 5.07 | Epidural morphine pruritus reduction with hydroxyzine in parturients. ( Ackerman, WE; Bellinger, K; Juneja, MM, 1991) |
"Postoperative pain was evaluated with the 10-point Children's and Infants' Postoperative Pain Scale." | 2.76 | Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial. ( Köner, O; Menda, F; Mercan, A; Sözübir, S; Türe, H, 2011) |
"Chronic postsurgical neuropathic pain was defined as pain in an area of hypesthesia with a positive Douleur Neuropathique 4 questionnaire score." | 1.42 | Clinical, histological, and biochemical predictors of postsurgical neuropathic pain. ( Alvarez, JC; Ben Ammar, S; Bouhassira, D; Fletcher, D; Gaudot, F; Martinez, V; Sommer, C; Üçeyler, N, 2015) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (44.44) | 18.7374 |
1990's | 3 (33.33) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (22.22) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Martinez, V | 1 |
Üçeyler, N | 1 |
Ben Ammar, S | 1 |
Alvarez, JC | 1 |
Gaudot, F | 1 |
Sommer, C | 1 |
Bouhassira, D | 1 |
Fletcher, D | 1 |
Köner, O | 1 |
Türe, H | 1 |
Mercan, A | 1 |
Menda, F | 1 |
Sözübir, S | 1 |
Famewo, CE | 1 |
Hupert, C | 1 |
Yacoub, M | 1 |
Turgeon, LR | 1 |
Lilley, LL | 1 |
Guanci, R | 1 |
Roux, L | 1 |
Rigal-Sastourné, JC | 1 |
Bidaux, F | 1 |
May, F | 1 |
Renard, JP | 1 |
Maurin, JF | 1 |
Maehara, K | 1 |
Nagai, Y | 1 |
Ito, T | 1 |
Inoue, S | 1 |
Juneja, MM | 1 |
Ackerman, WE | 1 |
Bellinger, K | 1 |
Dobkin, AB | 1 |
Eamkaow, S | 1 |
Zak, S | 1 |
Caruso, FK | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Hydroxyzine Dihydrochloride Premedication is a Necessity for Pediatric Patients Undergoing Strabismus Surgery; An Observational Clinical Trial Controlled With Midazolam[NCT03806270] | 45 participants (Actual) | Observational [Patient Registry] | 2018-10-01 | Completed | |||
Dyphenhidramine Effect on Prevention of Sevoflurane Induced Post Anesthesia Agitation in Pediatric[NCT02463929] | Phase 4 | 50 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"The lowest heart rate observed from EKG monitorization at the time-out after the anesthesia induction, and just before the surgery starts. Heart rate-1 is a data, not an assessing change, which is recoded during the time-out. The time-out is when the patient's name, the procedure, the surgent name is repeated before the operation starts." (NCT03806270)
Timeframe: "1 minute, at the time out, through study completion an average of 6 months"
Intervention | beats per minute (Mean) |
---|---|
Midazolam | 114.4 |
Midazolam&Hydroxyzine dihydrochloride1/2 | 125.8 |
Midazolam&Hydroxyzine Dihydrochloride | 122.3 |
The heart rate observed from EKG monitorization at the time operator warns the investigator just before the traction of the orbital muscle. Heart rate-2 is a data, not an assessing change, which is recorded during the operation at the time operator warns. The heart rate observed from EKG monitorization, before every orbital muscle traction at the time the operator's warning before traction. (NCT03806270)
Timeframe: 1 minute, at the strabismus surgery operation, through study completion an average of 6 months
Intervention | beats per minute (Mean) |
---|---|
Midazolam | 110.4 |
Midazolam&Hydroxyzine dihydrochloride1/2 | 125.3 |
Midazolam&Hydroxyzine Dihydrochloride | 124.8 |
The lowest heart rate observed from EKG monitorization, after every orbital muscle traction within 120 seconds. Heart rate-3 is a data, not an assessing change, which is recorded within 120 seconds after traction applied. (NCT03806270)
Timeframe: within 120 seconds after the orbital muscle traction, at the strabismus surgery operation, through study completion an average of 6 months
Intervention | beats per minute (Mean) |
---|---|
Midazolam | 90.8 |
Midazolam&Hydroxyzine dihydrochloride1/2 | 113.4 |
Midazolam&Hydroxyzine Dihydrochloride | 117.9 |
The OCR is a heartbeat anomaly(bradycardia, any arrhythmia, or cardiac arrest) associated with traction applied to the extraocular muscles during strabismus surgery. The specific criteria were as follows: the lowest heart rate observed within 120 seconds from EKG monitorization, after every orbital muscle traction, was less than 20% of the heart rate observed directly preceding traction of the orbital muscle. Additionally, any kind of arrhythmia or cardiac arrest occurrence within 120 seconds after orbital muscle traction was also defined as an OCR. (NCT03806270)
Timeframe: 2 minutes, at the strabismus surgery operation after recording Heart Rate-3, through study completion an average of 6 months
Intervention | orbital muscles (Count of Units) |
---|---|
Midazolam | 15 |
Midazolam&Hydroxyzine dihydrochloride1/2 | 6 |
Midazolam&Hydroxyzine Dihydrochloride | 1 |
The investigator records every OCR treatment like; pausing surgery, atropin 20mcg/kg intravenous treatment or cardiac resuscitation. (NCT03806270)
Timeframe: within 5 minutes after defining the OCR occurrence, at the strabismus surgery operation, through study completion an average of 6 months
Intervention | number of orbital muscle/s, OCR occured (Number) | ||
---|---|---|---|
pausing surgery | atropin administration | cardiac resuscitation | |
Midazolam | 13 | 2 | 0 |
Midazolam&Hydroxyzine Dihydrochloride | 1 | 0 | 0 |
Midazolam&Hydroxyzine dihydrochloride1/2 | 6 | 0 | 0 |
4 trials available for hydroxyzine and Pain, Postoperative
Article | Year |
---|---|
Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.
Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Inhalation; Ch | 2011 |
Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.
Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Inhalation; Ch | 2011 |
Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.
Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Inhalation; Ch | 2011 |
Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.
Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Inhalation; Ch | 2011 |
[Intracameral lidocaine and phacoemulsification under topical anesthesia. Apropos of 80 operations].
Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Anterior Ch | 1998 |
Epidural morphine pruritus reduction with hydroxyzine in parturients.
Topics: Adult; Analgesia, Epidural; Cesarean Section; Female; Humans; Hydroxyzine; Injections, Epidural; Inj | 1991 |
Butorphanol: a double-blind evaluation in postoperative patients with moderate or severe pain.
Topics: Anesthesia, Inhalation; Atropine; Clinical Trials as Topic; Cyclobutanes; Diazepam; Dose-Response Re | 1974 |
5 other studies available for hydroxyzine and Pain, Postoperative
Article | Year |
---|---|
Clinical, histological, and biochemical predictors of postsurgical neuropathic pain.
Topics: Adolescent; Adult; Female; Follow-Up Studies; Gene Expression; Histamine H1 Antagonists; Humans; Hyd | 2015 |
Management of post-operative pain: current concepts and methods of management.
Topics: Acupuncture Therapy; Analgesics, Opioid; Anesthesia, Inhalation; Biofeedback, Psychology; Humans; Hy | 1983 |
Effect of hydroxyzine on morphine analgesia for the treatment of postoperative pain.
Topics: Adolescent; Adult; Aged; Analgesia; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; | 1980 |
Beware of routine procedures.
Topics: Adult; Analgesics; Drug Combinations; Drug Eruptions; Humans; Hydroxyzine; Hypnotics and Sedatives; | 1995 |
[Effect of acupuncture on postoperative upper abdominal pain].
Topics: Abdomen; Acupuncture Therapy; Adult; Aged; Anesthesia; Female; Humans; Hydroxyzine; Male; Middle Age | 1975 |