Page last updated: 2024-10-28

hydroxyzine and Pain, Postoperative

hydroxyzine has been researched along with Pain, Postoperative in 9 studies

Hydroxyzine: A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
hydroxyzine : A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.

Pain, Postoperative: Pain during the period after surgery.

Research Excerpts

ExcerptRelevanceReference
"A majority of patients experience pruritus, nausea and/or emesis following epidural morphine administration post-cesarean section."9.07Epidural morphine pruritus reduction with hydroxyzine in parturients. ( Ackerman, WE; Bellinger, K; Juneja, MM, 1991)
"A majority of patients experience pruritus, nausea and/or emesis following epidural morphine administration post-cesarean section."5.07Epidural morphine pruritus reduction with hydroxyzine in parturients. ( Ackerman, WE; Bellinger, K; Juneja, MM, 1991)
"Postoperative pain was evaluated with the 10-point Children's and Infants' Postoperative Pain Scale."2.76Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial. ( Köner, O; Menda, F; Mercan, A; Sözübir, S; Türe, H, 2011)
"Chronic postsurgical neuropathic pain was defined as pain in an area of hypesthesia with a positive Douleur Neuropathique 4 questionnaire score."1.42Clinical, histological, and biochemical predictors of postsurgical neuropathic pain. ( Alvarez, JC; Ben Ammar, S; Bouhassira, D; Fletcher, D; Gaudot, F; Martinez, V; Sommer, C; Üçeyler, N, 2015)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19904 (44.44)18.7374
1990's3 (33.33)18.2507
2000's0 (0.00)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Martinez, V1
Üçeyler, N1
Ben Ammar, S1
Alvarez, JC1
Gaudot, F1
Sommer, C1
Bouhassira, D1
Fletcher, D1
Köner, O1
Türe, H1
Mercan, A1
Menda, F1
Sözübir, S1
Famewo, CE1
Hupert, C1
Yacoub, M1
Turgeon, LR1
Lilley, LL1
Guanci, R1
Roux, L1
Rigal-Sastourné, JC1
Bidaux, F1
May, F1
Renard, JP1
Maurin, JF1
Maehara, K1
Nagai, Y1
Ito, T1
Inoue, S1
Juneja, MM1
Ackerman, WE1
Bellinger, K1
Dobkin, AB1
Eamkaow, S1
Zak, S1
Caruso, FK1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Hydroxyzine Dihydrochloride Premedication is a Necessity for Pediatric Patients Undergoing Strabismus Surgery; An Observational Clinical Trial Controlled With Midazolam[NCT03806270]45 participants (Actual)Observational [Patient Registry]2018-10-01Completed
Dyphenhidramine Effect on Prevention of Sevoflurane Induced Post Anesthesia Agitation in Pediatric[NCT02463929]Phase 450 participants (Actual)Interventional2014-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Heart Rate-1

"The lowest heart rate observed from EKG monitorization at the time-out after the anesthesia induction, and just before the surgery starts. Heart rate-1 is a data, not an assessing change, which is recoded during the time-out. The time-out is when the patient's name, the procedure, the surgent name is repeated before the operation starts." (NCT03806270)
Timeframe: "1 minute, at the time out, through study completion an average of 6 months"

Interventionbeats per minute (Mean)
Midazolam114.4
Midazolam&Hydroxyzine dihydrochloride1/2125.8
Midazolam&Hydroxyzine Dihydrochloride122.3

Heart Rate-2

The heart rate observed from EKG monitorization at the time operator warns the investigator just before the traction of the orbital muscle. Heart rate-2 is a data, not an assessing change, which is recorded during the operation at the time operator warns. The heart rate observed from EKG monitorization, before every orbital muscle traction at the time the operator's warning before traction. (NCT03806270)
Timeframe: 1 minute, at the strabismus surgery operation, through study completion an average of 6 months

Interventionbeats per minute (Mean)
Midazolam110.4
Midazolam&Hydroxyzine dihydrochloride1/2125.3
Midazolam&Hydroxyzine Dihydrochloride124.8

Heart Rate-3

The lowest heart rate observed from EKG monitorization, after every orbital muscle traction within 120 seconds. Heart rate-3 is a data, not an assessing change, which is recorded within 120 seconds after traction applied. (NCT03806270)
Timeframe: within 120 seconds after the orbital muscle traction, at the strabismus surgery operation, through study completion an average of 6 months

Interventionbeats per minute (Mean)
Midazolam90.8
Midazolam&Hydroxyzine dihydrochloride1/2113.4
Midazolam&Hydroxyzine Dihydrochloride117.9

Number of Observed Oculocardiac Reflex(OCR)

The OCR is a heartbeat anomaly(bradycardia, any arrhythmia, or cardiac arrest) associated with traction applied to the extraocular muscles during strabismus surgery. The specific criteria were as follows: the lowest heart rate observed within 120 seconds from EKG monitorization, after every orbital muscle traction, was less than 20% of the heart rate observed directly preceding traction of the orbital muscle. Additionally, any kind of arrhythmia or cardiac arrest occurrence within 120 seconds after orbital muscle traction was also defined as an OCR. (NCT03806270)
Timeframe: 2 minutes, at the strabismus surgery operation after recording Heart Rate-3, through study completion an average of 6 months

Interventionorbital muscles (Count of Units)
Midazolam15
Midazolam&Hydroxyzine dihydrochloride1/26
Midazolam&Hydroxyzine Dihydrochloride1

Number of Orbital Muscles of the Participants With Different Considerations Taken With Respect to the Treatment of OCR

The investigator records every OCR treatment like; pausing surgery, atropin 20mcg/kg intravenous treatment or cardiac resuscitation. (NCT03806270)
Timeframe: within 5 minutes after defining the OCR occurrence, at the strabismus surgery operation, through study completion an average of 6 months

,,
Interventionnumber of orbital muscle/s, OCR occured (Number)
pausing surgeryatropin administrationcardiac resuscitation
Midazolam1320
Midazolam&Hydroxyzine Dihydrochloride100
Midazolam&Hydroxyzine dihydrochloride1/2600

Trials

4 trials available for hydroxyzine and Pain, Postoperative

ArticleYear
Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.
    European journal of anaesthesiology, 2011, Volume: 28, Issue:9

    Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Inhalation; Ch

2011
Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.
    European journal of anaesthesiology, 2011, Volume: 28, Issue:9

    Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Inhalation; Ch

2011
Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.
    European journal of anaesthesiology, 2011, Volume: 28, Issue:9

    Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Inhalation; Ch

2011
Effects of hydroxyzine-midazolam premedication on sevoflurane-induced paediatric emergence agitation: a prospective randomised clinical trial.
    European journal of anaesthesiology, 2011, Volume: 28, Issue:9

    Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthesia, Caudal; Anesthetics, Inhalation; Ch

2011
[Intracameral lidocaine and phacoemulsification under topical anesthesia. Apropos of 80 operations].
    Journal francais d'ophtalmologie, 1998, Volume: 21, Issue:4

    Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Anterior Ch

1998
Epidural morphine pruritus reduction with hydroxyzine in parturients.
    The Journal of the Kentucky Medical Association, 1991, Volume: 89, Issue:7

    Topics: Adult; Analgesia, Epidural; Cesarean Section; Female; Humans; Hydroxyzine; Injections, Epidural; Inj

1991
Butorphanol: a double-blind evaluation in postoperative patients with moderate or severe pain.
    Canadian Anaesthetists' Society journal, 1974, Volume: 21, Issue:6

    Topics: Anesthesia, Inhalation; Atropine; Clinical Trials as Topic; Cyclobutanes; Diazepam; Dose-Response Re

1974

Other Studies

5 other studies available for hydroxyzine and Pain, Postoperative

ArticleYear
Clinical, histological, and biochemical predictors of postsurgical neuropathic pain.
    Pain, 2015, Volume: 156, Issue:11

    Topics: Adolescent; Adult; Female; Follow-Up Studies; Gene Expression; Histamine H1 Antagonists; Humans; Hyd

2015
Management of post-operative pain: current concepts and methods of management.
    African journal of medicine and medical sciences, 1983, Volume: 12, Issue:2

    Topics: Acupuncture Therapy; Analgesics, Opioid; Anesthesia, Inhalation; Biofeedback, Psychology; Humans; Hy

1983
Effect of hydroxyzine on morphine analgesia for the treatment of postoperative pain.
    Anesthesia and analgesia, 1980, Volume: 59, Issue:9

    Topics: Adolescent; Adult; Aged; Analgesia; Double-Blind Method; Drug Synergism; Drug Therapy, Combination;

1980
Beware of routine procedures.
    The American journal of nursing, 1995, Volume: 95, Issue:10

    Topics: Adult; Analgesics; Drug Combinations; Drug Eruptions; Humans; Hydroxyzine; Hypnotics and Sedatives;

1995
[Effect of acupuncture on postoperative upper abdominal pain].
    Masui. The Japanese journal of anesthesiology, 1975, Volume: 24, Issue:2

    Topics: Abdomen; Acupuncture Therapy; Adult; Aged; Anesthesia; Female; Humans; Hydroxyzine; Male; Middle Age

1975