hydroxyzine has been researched along with Long QT Syndrome in 5 studies
Hydroxyzine: A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
hydroxyzine : A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this paper, we will report a case of drug-induced long QT syndrome associated with an H(1)-receptor antagonist, hydroxyzine, in which a mutation was identified in the HERG gene." | 7.74 | Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation. ( Ashihara, T; Ding, WG; Higashi, Y; Horie, M; Ito, M; Itoh, H; Matsuura, H; Nagaoka, I; Oka, Y; Sakaguchi, T; Takeyama, Y; Tsuji, K; Yumoto, Y; Zenda, N, 2008) |
| "Regulatory advisories on hydroxyzine and risk of QT prolongation and Torsade de pointes (TdP) were issued in the UK in April 2015 and Canada in June 2016." | 4.12 | Hydroxyzine Initiation Following Drug Safety Advisories on Cardiac Arrhythmias in the UK and Canada: A Longitudinal Cohort Study. ( Ahmed, B; Bero, L; De Bruin, ML; Dormuth, CR; Gnjidic, D; Hallgreen, CE; Kemp-Casey, A; Kristiansen, SB; Lexchin, J; Lopert, R; Mangin, D; Mintzes, B; Morrow, RL; Pearson, SA; Puil, L; Roughead, EE; Sarpatwari, A; Sketris, I; Souverein, PC, 2022) |
| " In this paper, we will report a case of drug-induced long QT syndrome associated with an H(1)-receptor antagonist, hydroxyzine, in which a mutation was identified in the HERG gene." | 3.74 | Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation. ( Ashihara, T; Ding, WG; Higashi, Y; Horie, M; Ito, M; Itoh, H; Matsuura, H; Nagaoka, I; Oka, Y; Sakaguchi, T; Takeyama, Y; Tsuji, K; Yumoto, Y; Zenda, N, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morrow, RL | 1 |
| Mintzes, B | 1 |
| Souverein, PC | 1 |
| Hallgreen, CE | 1 |
| Ahmed, B | 1 |
| Roughead, EE | 1 |
| De Bruin, ML | 1 |
| Kristiansen, SB | 1 |
| Lexchin, J | 1 |
| Kemp-Casey, A | 1 |
| Sketris, I | 1 |
| Mangin, D | 1 |
| Pearson, SA | 1 |
| Puil, L | 1 |
| Lopert, R | 1 |
| Bero, L | 1 |
| Gnjidic, D | 1 |
| Sarpatwari, A | 1 |
| Dormuth, CR | 1 |
| Kobayashi, K | 1 |
| Omuro, N | 1 |
| Takahara, A | 1 |
| Vigne, J | 1 |
| Alexandre, J | 1 |
| Fobe, F | 1 |
| Milliez, P | 1 |
| Loilier, M | 1 |
| Fedrizzi, S | 1 |
| Coquerel, A | 1 |
| Mistraletti, G | 1 |
| Iapichino, G | 1 |
| Sakaguchi, T | 1 |
| Itoh, H | 1 |
| Ding, WG | 1 |
| Tsuji, K | 1 |
| Nagaoka, I | 1 |
| Oka, Y | 1 |
| Ashihara, T | 1 |
| Ito, M | 1 |
| Yumoto, Y | 1 |
| Zenda, N | 1 |
| Higashi, Y | 1 |
| Takeyama, Y | 1 |
| Matsuura, H | 1 |
| Horie, M | 1 |
5 other studies available for hydroxyzine and Long QT Syndrome
| Article | Year |
|---|---|
Hydroxyzine Initiation Following Drug Safety Advisories on Cardiac Arrhythmias in the UK and Canada: A Longitudinal Cohort Study.
Topics: Canada; Cohort Studies; DNA-Binding Proteins; Electrocardiography; Humans; Hydroxyzine; Long QT Synd | 2022 |
The conventional antihistamine drug cyproheptadine lacks QT-interval-prolonging action in halothane-anesthetized guinea pigs: comparison with hydroxyzine.
Topics: Action Potentials; Anesthesia; Animals; Cyproheptadine; Dose-Response Relationship, Drug; Electrocar | 2014 |
QT prolongation induced by hydroxyzine: a pharmacovigilance case report.
Topics: Aged; Histamine H1 Antagonists; Humans; Hydroxyzine; Long QT Syndrome; Male; Pharmacovigilance | 2015 |
Hydroxyzine and QTc interval: drugs without sin cast the first stone!
Topics: Critical Care; Humans; Hydroxyzine; Long QT Syndrome; Pharmacovigilance; Premedication | 2016 |
Hydroxyzine, a first generation H(1)-receptor antagonist, inhibits human ether-a-go-go-related gene (HERG) current and causes syncope in a patient with the HERG mutation.
Topics: Adult; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Female; Gene Expression R | 2008 |