Page last updated: 2024-10-28

hydroxyzine and Hay Fever

hydroxyzine has been researched along with Hay Fever in 22 studies

Hydroxyzine: A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative.
hydroxyzine : A N-alkylpiperazine that is piperzine in which the nitrogens atoms are substituted by 2-(2-hydroxyethoxy)ethyl and (4-chlorophenyl)(phenyl)methyl groups respectively.

Research Excerpts

ExcerptRelevanceReference
"Cetirizine was well tolerated, with sedation being the most common adverse experience, increasing in frequency at higher doses."2.67Double-blind comparison of cetirizine and placebo in the treatment of seasonal rhinitis. ( Altman, R; Brandon, ML; Buchman, E; Connell, JT; Dockhorn, R; Falliers, CJ; Leese, PT; Miller, J; Wasserman, SI; Zeterberg, JM, 1991)
"Cetirizine is a new selective H1-antagonist."2.67Effect of cetirizine in a conjunctival provocation test with allergens. ( Pécoud, AR; Schoeneich, M, 1990)
"Cetirizine was rapidly absorbed with mean peak cetirizine concentrations of 427."2.66Cetirizine: a pharmacokinetic and pharmacodynamic evaluation in children with seasonal allergic rhinitis. ( Chen, XY; Simons, FE; Simons, KJ; Watson, WT, 1989)
"In this review of the current treatment of seasonal allergic rhinitis, the clinical studies that compare these four new second-generation H1-receptor antagonists are discussed."2.38H1-receptor antagonist treatment of seasonal allergic rhinitis. ( Kaiser, HB, 1990)
" To establish dose-response relationships for oral antihistamines in monkeys, we measured the suppression of wheal-and-flare reactions by two such agents, oral cetirizine (CET) 0."1.27A primate model for the evaluation of antihistamines. ( Doyle, W; Fireman, P; Skoner, D; Tanner, E, 1987)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199010 (45.45)18.7374
1990's12 (54.55)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brooks, CD1
Nelson, A1
Parzyck, R1
Maile, MH1
Schaaf, L1
Hendeles, L1
Weinberger, M1
Braunstein, G1
Malaquin, F1
Fajac, I1
Melac, M1
Frossard, N1
Falliers, CJ1
Brandon, ML1
Buchman, E1
Connell, JT1
Dockhorn, R1
Leese, PT1
Miller, J1
Wasserman, SI1
Zeterberg, JM1
Altman, R1
Renton, R2
Fidler, C2
Rosenberg, R1
Backhouse, CI1
Rosenberg, RM1
Schoeneich, M1
Pécoud, AR1
Panayotopoulos, SM1
Panayotopoulou, ES1
Klementsson, H1
Andersson, M1
Pipkorn, U1
Kaiser, HB1
Massey, WA1
Lichtenstein, LM2
Campoli-Richards, DM1
Buckley, MM1
Fitton, A1
Naclerio, RM1
Proud, D1
Kagey-Sobotka, A1
Freidhoff, L1
Norman, PS1
Watson, WT1
Simons, KJ1
Chen, XY1
Simons, FE1
Billardon, M1
von Maur, K1
Fadel, R1
Herpin-Richard, N1
Rihoux, JP1
Henocq, E1
Maddox, DE1
Reed, CE1
Fireman, P1
Skoner, D1
Tanner, E1
Doyle, W1
Atkins, P1
Green, GR1
Zweiman, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Nasal Ocular Reflexes Contribute to Eye Symptoms in Patients With Allergic Rhinitis[NCT00117832]20 participants Interventional2005-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for hydroxyzine and Hay Fever

ArticleYear
H1-receptor antagonist treatment of seasonal allergic rhinitis.
    The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2

    Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Clemastine; Cyprohep

1990
The effects of antihistamines beyond H1 antagonism in allergic inflammation.
    The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2

    Topics: Benzhydryl Compounds; Cetirizine; Cyproheptadine; Dermatitis, Atopic; Histamine H1 Antagonists; Hist

1990
Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria.
    Drugs, 1990, Volume: 40, Issue:5

    Topics: Animals; Asthma; Cetirizine; Chronic Disease; Histamine H1 Antagonists; Humans; Hydroxyzine; Pollen;

1990
Three new non-sedative antihistamines: worth keeping an eye open for.
    Drug and therapeutics bulletin, 1990, May-14, Volume: 28, Issue:10

    Topics: Cetirizine; Cyproheptadine; Histamine H1 Antagonists; Humans; Hydroxyzine; Loratadine; Rhinitis, All

1990

Trials

15 trials available for hydroxyzine and Hay Fever

ArticleYear
Protective effect of hydroxyzine and phenylpropanolamine in the challenged allergic nose.
    Annals of allergy, 1981, Volume: 47, Issue:5 Pt 1

    Topics: Adult; Airway Resistance; Drug Therapy, Combination; Female; Humans; Hydroxyzine; Male; Middle Aged;

1981
Suppression of seasonal allergic rhinitis symptoms with daily hydroxyzine.
    The Journal of allergy and clinical immunology, 1979, Volume: 63, Issue:2

    Topics: Adult; Clinical Trials as Topic; Female; Humans; Hydroxyzine; Immunosuppression Therapy; Male; Rhini

1979
Inhibition of histamine-induced nasal obstruction by cetirizine in allergic rhinitis.
    British journal of clinical pharmacology, 1992, Volume: 33, Issue:4

    Topics: Adult; Airway Resistance; Cetirizine; Female; Histamine; Histamine H1 Antagonists; Humans; Hydroxyzi

1992
Double-blind comparison of cetirizine and placebo in the treatment of seasonal rhinitis.
    Annals of allergy, 1991, Volume: 66, Issue:3

    Topics: Adult; Cetirizine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antag

1991
Multicenter, crossover study of the efficacy and tolerability of terfenadine, 120 mg, versus cetirizine, 10 mg, in perennial allergic rhinitis.
    Annals of allergy, 1991, Volume: 67, Issue:4

    Topics: Adult; Cetirizine; Dose-Response Relationship, Drug; Female; Histamine H1 Antagonists; Humans; Hydro

1991
Multicentre, double-blind comparison of terfenadine and cetirizine in patients with seasonal allergic rhinitis.
    The British journal of clinical practice, 1990, Volume: 44, Issue:3

    Topics: Adult; Benzhydryl Compounds; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; Humans; Hydr

1990
Effect of cetirizine in a conjunctival provocation test with allergens.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1990, Volume: 20, Issue:2

    Topics: Adolescent; Adult; Allergens; Cetirizine; Clinical Trials as Topic; Conjunctivitis, Allergic; Double

1990
Efficacy of cetirizine in the treatment of seasonal allergic rhinoconjunctivitis.
    Annals of allergy, 1990, Volume: 65, Issue:2

    Topics: Adult; Cetirizine; Clinical Trials as Topic; Conjunctivitis, Allergic; Double-Blind Method; Histamin

1990
Allergen-induced increase in nonspecific nasal reactivity is blocked by antihistamines without a clear-cut relationship to eosinophil influx.
    The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:4 Pt 1

    Topics: Allergens; Benzhydryl Compounds; Cetirizine; Double-Blind Method; Eosinophils; Histamine H1 Antagoni

1990
The effects of antihistamines beyond H1 antagonism in allergic inflammation.
    The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2

    Topics: Benzhydryl Compounds; Cetirizine; Cyproheptadine; Dermatitis, Atopic; Histamine H1 Antagonists; Hist

1990
The effect of cetirizine on early allergic response.
    The Laryngoscope, 1989, Volume: 99, Issue:6 Pt 1

    Topics: Albumins; Antigens; Cetirizine; Clinical Trials as Topic; Double-Blind Method; Histamine; Histamine

1989
Cetirizine: a pharmacokinetic and pharmacodynamic evaluation in children with seasonal allergic rhinitis.
    The Journal of allergy and clinical immunology, 1989, Volume: 84, Issue:4 Pt 1

    Topics: Cetirizine; Child; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Histamin

1989
[Importance of Zyrtec in the treatment of chronic urticaria and allergic rhinopathies apropos of 1168 cases seen by hospital practitioners].
    Allergie et immunologie, 1989, Volume: 21, Issue:8

    Topics: Adolescent; Adult; Cetirizine; Chronic Disease; Female; Histamine H1 Antagonists; Humans; Hydroxyzin

1989
Antihistamine selection in patients with allergic rhinitis.
    Annals of allergy, 1985, Volume: 55, Issue:3

    Topics: Chlorpheniramine; Clinical Trials as Topic; Diphenhydramine; Histamine H1 Antagonists; Humans; Hydro

1985
Inhibitory effect of cetirizine 2HCl on eosinophil migration in vivo.
    Clinical allergy, 1987, Volume: 17, Issue:4

    Topics: Adult; Cell Movement; Cetirizine; Eosinophils; Female; Histamine; Histamine H1 Antagonists; Humans;

1987

Other Studies

4 other studies available for hydroxyzine and Hay Fever

ArticleYear
[Cetirizine in allergic symptoms. General practice relevance and a profile of effects. Resume of current studies].
    Fortschritte der Medizin. Supplement : die Kongressinformation fur die Praxis, 1990, Volume: 89

    Topics: Asthma; Cetirizine; Eosinophils; Histamine H1 Antagonists; Humans; Hydroxyzine; Rhinitis, Allergic,

1990
Clinical pharmacodynamics of antihistamines.
    Annals of allergy, 1987, Volume: 59, Issue:6 Pt 2

    Topics: Animals; Asthma; Brain; Bronchial Provocation Tests; Cetirizine; Drug Evaluation; Electroencephalogr

1987
A primate model for the evaluation of antihistamines.
    Annals of allergy, 1987, Volume: 59, Issue:6 Pt 2

    Topics: Administration, Oral; Airway Resistance; Animals; Bronchial Provocation Tests; Cetirizine; Chlorphen

1987
Histologic studies of human skin test responses to ragweed, compound 48-80, and histamine.
    The Journal of allergy and clinical immunology, 1973, Volume: 51, Issue:5

    Topics: Adult; Biopsy; Eosinophils; Histamine; Humans; Hydroxyzine; Male; Mast Cells; p-Methoxy-N-methylphen

1973