hydroxyurea and Uterine Cervical Neoplasms studies

Research Excerpts

Excerpt	Relevance	Reference
"Long-term follow-up data of a randomized trial that compared hydroxyurea and the hypoxic-cell radiosensitizer to misonidazole as adjuncts to standard radiation therapy in locally advanced carcinoma of the cervix are reported."	9.07	Hydroxyurea versus misonidazole with radiation in cervical carcinoma: long-term follow-up of a Gynecologic Oncology Group trial. ( Bundy, BN; Creasman, WT; d'Ablaing, G; Fowler, WC; Keys, HM; Mortel, R; Stehman, FB; Thomas, G, 1993)
"This is a case presentation of a rarely seen hydroxyurea-induced fever in a patient with cervical adenocarcinoma receiving oral hydroxyurea given concurrently with external beam radiotherapy to the pelvis."	8.80	Hydroxyurea-induced fever in cervical carcinoma: case report and review of the literature. ( Browne, B; Capen, C; Cheung, AY, 1999)
"Since 1968, hydroxyurea has been used as a radiosensitizer in combination modality treatments for carcinoma of the cervix."	8.78	Experience with hydroxyurea as a radiosensitizer in carcinoma of the cervix. ( Stehman, FB, 1992)
"Long-term follow-up data of a randomized trial that compared hydroxyurea and the hypoxic-cell radiosensitizer to misonidazole as adjuncts to standard radiation therapy in locally advanced carcinoma of the cervix are reported."	5.07	Hydroxyurea versus misonidazole with radiation in cervical carcinoma: long-term follow-up of a Gynecologic Oncology Group trial. ( Bundy, BN; Creasman, WT; d'Ablaing, G; Fowler, WC; Keys, HM; Mortel, R; Stehman, FB; Thomas, G, 1993)
"Forty-five evaluable patients with stage IIIB carcinoma of the uterine cervix were entered into a prospective, double-blind, randomized study to evaluate the possible radiation-potentiating properties of hydroxyurea."	5.06	Hydroxyurea plus pelvic radiation versus placebo plus pelvic radiation in surgically staged stage IIIB cervical cancer. ( Emrich, LJ; Piver, MS; Vongtama, V, 1987)
"This is a case presentation of a rarely seen hydroxyurea-induced fever in a patient with cervical adenocarcinoma receiving oral hydroxyurea given concurrently with external beam radiotherapy to the pelvis."	4.80	Hydroxyurea-induced fever in cervical carcinoma: case report and review of the literature. ( Browne, B; Capen, C; Cheung, AY, 1999)
"Since 1968, hydroxyurea has been used as a radiosensitizer in combination modality treatments for carcinoma of the cervix."	4.78	Experience with hydroxyurea as a radiosensitizer in carcinoma of the cervix. ( Stehman, FB, 1992)
" This report outlines the results of cell kinetic studies of normal and abnormal squamous epithelium of the female genital tract and presents preliminary results of a regimen utilizing methotrexate, hydroxyurea, and vincristine in patients with far-advanced squamous-cell cancer of the vulva, vagina, and cervix."	3.65	Cell kinetics and programmed chemotherapy for gynecologic cancer. I. Squamous-cell carcinoma. ( Averette, HE; Ford, JH; Girtanner, RE; Hoskins, WJ; Ramos, R; Weinstein, GD, 1976)
"The overall response rate in the 18 cervical cancer patients was 89% (78% complete, 11% partial)."	2.69	Phase I trial of concomitant chemoradiotherapy for cervical cancer and other advanced pelvic malignancies. ( Fleming, G; Mundt, AJ; Quiet, C; Rotmensch, J; Waggoner, S, 1999)
"Thrombocytosis is a frequent finding among patients with advanced cervical carcinoma and seems to be related to tumor burden."	2.69	The significance of thrombocytosis in patients with locally advanced cervical carcinoma: a Gynecologic Oncology Group study. ( Anderson, LL; Donohue, KA; Heller, PB; Hernandez, E; Stehman, FB, 2000)
"Hydroxyurea was given in a dose of 80 mg/kg each Monday and Thursday during external radiation therapy."	2.66	A randomized trial of hydroxyurea versus misonidazole adjunct to radiation therapy in carcinoma of the cervix. A preliminary report of a Gynecologic Oncology Group study. ( Bundy, BN; Creasman, WT; Currie, JL; Keys, H; Mortel, R; Stehman, FB, 1988)
"Hydroxyurea was evaluated as a possible radiation sensitizer in 130 evaluable women with Stages IIB and IIIB (International Federation of Gynecology and Obstetrics) carcinoma of the uterine cervix."	2.64	Hydroxyurea as a radiation sensitizer in women with carcinoma of the uterine cervix. ( Barlow, JJ; Blumenson, L; Piver, MS; Vongtama, V, 1977)
"In the past, women with early-stage cervical cancer have been treated with radical radiotherapy or radical surgery, and women with locally advanced disease with radical radiotherapy, each offering a good chance of cure."	2.44	Concomitant and neoadjuvant chemotherapy for cervical cancer. ( Symonds, P; Tierney, JF; Vale, C, 2008)
"Zileuton is an FDA-approved drug for treating asthma and an ALOX5 inhibitor."	1.62	Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models. ( Li, L; Wang, S; Xiao, Y; Xu, Z, 2021)
"Cotreatment of bortezomib with eeyarestatin markedly enhanced cell death in cervical cancer cells, allowing reduction of the bortezomib concentration necessary for efficient cell death to as low as 5 ng/ml."	1.39	Eeyarestatin causes cervical cancer cell sensitization to bortezomib treatment by augmenting ER stress and CHOP expression. ( Brem, GJ; Brüning, A; Mylonas, I, 2013)
"To evaluate the outcome of stage IVA cervical cancer treated with radiation and concurrent cisplatin-based chemotherapy."	1.37	Outcome of stage IVA cervical cancer patients with disease limited to the pelvis in the era of chemoradiation: a Gynecologic Oncology Group study. ( Ali, S; Lanciano, R; Rose, PG; Stehman, FB; Whitney, CW, 2011)
"Fifty-five patients with squamous cell carcinoma of the cervix uteri metastatic to high common iliac or periaortic lymph nodes underwent biopsy of the left scalene fat pad as part of a prospective clinical trial."	1.27	Biopsy of the scalene fat pad in carcinoma of the cervix uteri metastatic to the periaortic lymph nodes. ( Abdulhay, G; Bundy, BN; Fowler, WC; Hanjani, P; Stehman, FB; Whitney, CW, 1987)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (41.51)	18.7374
1990's	16 (30.19)	18.2507
2000's	11 (20.75)	29.6817
2010's	3 (5.66)	24.3611
2020's	1 (1.89)	2.80

Authors	Studies
Li, L	1
Xiao, Y	1
Xu, Z	1
Wang, S	1
Rose, PG	6
Java, JJ	1
Whitney, CW	3
Stehman, FB	10
Lanciano, R	2
Thomas, GM	1
Tierney, JF	2
Vale, C	1
Symonds, P	2
Mao, J	1
Chen, L	1
Xu, B	1
Wang, L	2
Wang, W	1
Li, M	1
Zheng, M	1
Li, H	1
Guo, J	1
Li, W	1
Jacob, TJ	1
Moore, DH	1
Ali, S	2
Brem, GJ	1
Mylonas, I	1
Brüning, A	1
HOWE, CD	1
SAMUELS, ML	1
Kirwan, J	2
Williams, C	2
Humber, C	1
Tierney, J	1
Green, J	1
Collingwood, M	2
Symonds, RP	1
Humber, CE	1
Green, JA	1
Durdux, C	1
Watkins, E	1
Thigpen, JT	2
Deppe, G	3
Clarke-Pearson, DL	2
Insalaco, S	2
Ghosh, NK	1
Piver, MS	8
Barlow, JJ	3
Vongtama, V	4
Blumenson, L	2
Xynos, FP	1
Benjamin, I	1
Sapiente, R	1
Rana, MW	1
Nalesnik, WJ	1
Fine, BA	1
Hempling, RE	1
Baker, TR	1
McAuley, M	1
Driscoll, D	1
Bundy, BN	6
Thomas, G	1
Keys, HM	1
d'Ablaing, G	1
Fowler, WC	2
Mortel, R	2
Creasman, WT	2
Kucera, PR	1
Reddy, S	1
O'Connor, DM	1
Lindner, H	1
Mundt, AJ	1
Rotmensch, J	1
Waggoner, S	1
Quiet, C	1
Fleming, G	1
Watkins, EB	1
Maiman, MA	1
Monaghan, J	1
Cheung, AY	1
Browne, B	1
Capen, C	1
Haie-Meder, C	2
Fervers, B	1
Chauvergne, J	1
Fondrinier, E	1
Lhommé, C	2
Guastalla, JP	1
Resbeut, M	2
Hernandez, E	1
Donohue, KA	1
Anderson, LL	1
Heller, PB	1
Eifel, PJ	1
de Crevoisier, R	1
Morice, P	1
Ito, H	1
Tsutsui, F	1
Kurihara, S	1
Akabayashi, T	1
Tobe, T	1
Hreshchyshyn, MM	3
Aron, BS	1
Boronow, RC	1
Franklin, EW	1
Shingleton, HM	1
Blessing, JA	1
Brady, LW	1
Averette, HE	1
Weinstein, GD	1
Ford, JH	1
Girtanner, RE	1
Hoskins, WJ	1
Ramos, R	1
Sikic, BI	1
Piver, M	1
Khalil, M	1
Emrich, LJ	3
Kelland, LR	1
Steel, GG	1
Keys, H	1
Currie, JL	1
Bezwoda, WR	1
Nissenbaum, M	1
Derman, DP	1
Hanjani, P	1
Abdulhay, G	1
Krishnamsetty, RM	1
Gelbard, AS	1
Kim, JH	1
Perez, AG	1
Webester, J	1
Smith, JP	1
Rutledge, F	1
Burns, BC	1
Soffar, S	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized Comparison of Radiation vs Radiation Plus Weekly Cisplatin vs Radiation Plus PVI (Protracted Venous Infusion) 5-FU in Patients With Stage II-B, III-B, and IV-A Carcinoma of the Cervix With Negative Paraaortic Nodes[NCT00003078]	Phase 3	870 participants (Anticipated)	Interventional	1997-10-31	Completed
The Efficacy of Chemotherapy Alone in Patients With Poor-differentiated Early-stage Cervical Cancer But Without the Criteria for Adjuvant Radiotherapy According to NCCN Guidelines[NCT05863377]		450 participants (Anticipated)	Observational	2022-01-01	Recruiting
Effect of a Low Residue Diet in Comparison to the Dietary Recommendations From the INCan: A Randomized Clinical Trial to Assess Malnutrition, Gastrointestinal Toxicity and Quality of Life of Advanced Cervical Cancer Patients (IB2-IVA)[NCT03100409]		137 participants (Actual)	Interventional	2017-02-01	Terminated (stopped due to The study was closed prematurely because the interim analysis found that subjects in the experimental group had less gastrointestinal toxicity.)
Study on Adaptive Radiotherapy and Multimodal Information of Cervical Cancer Assisted by Artificial Intelligence[NCT04022018]		122 participants (Anticipated)	Interventional	2019-12-18	Recruiting
AVF3963s Neoadjuvant Bevacizumab and Carboplatin Followed by Concurrent Bevacizumab, Carboplatin and Radiotherapy in the Primary Treatment of Cervix Cancer[NCT00600210]	Phase 2	0 participants (Actual)	Interventional	2008-01-31	Withdrawn (stopped due to low patient accrual)
A Prospective Phase II Study of Prophylactic TPO Combined With Bone Marrow-Sparing Intensity-Modulated Radiotherapy to Reduce Platelet Inhibition in Patients With Esophageal Cancer Undergoing Concurrent Chemoradiotherapy[NCT05944809]	Phase 2	27 participants (Anticipated)	Interventional	2023-07-15	Not yet recruiting
A Phase III Randomized Clinical Trial to Study the Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Uterine Cervix.[NCT03256916]	Phase 3	348 participants (Anticipated)	Interventional	2018-01-16	Recruiting
Phase II Trial To Evaluate The Efficiency And Safety Of Neoadjuvant Chemotherapy In Locally Advanced Cancer Cervix[NCT04789941]	Phase 2	50 participants (Anticipated)	Interventional	2021-04-01	Not yet recruiting
Safety and Efficacy of Gemcitabine Based Neoadjuvant Chemotherapy Followed by Chemoradiation in Locally Advanced Cervical Cancer Patients and Association With Human Equilibrative Nucleoside Transporter 1 (hENT1) Expression[NCT02309658]	Phase 2	50 participants (Actual)	Interventional	2013-09-30	Completed
Randomized Phase III Clinical Trial of Weekly Versus Tri-weekly Cisplatin Based Chemoradiation in Locally Advanced Cervical Cancer[NCT01561586]	Phase 3	374 participants (Anticipated)	Interventional	2012-03-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Concomitant and neoadjuvant chemotherapy for cervical cancer. Clinical oncology (Royal College of Radiologists (Great Britain)), 2008, Volume: 20, Issue:6 Topics: Antineoplastic Agents; Female; Humans; Hydroxyurea; Neoadjuvant Therapy; Radiotherapy; Time Factors;	2008
Combined chemotherapy and radiation therapy for cervical cancer. Journal of the National Comprehensive Cancer Network : JNCCN, 2004, Volume: 2, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials, Phase III as Topic; Comb	2004
Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix. The Cochrane database of systematic reviews, 2004, Issue:1 Topics: Antineoplastic Agents; Combined Modality Therapy; Female; Humans; Hydroxyurea; Randomized Controlled	2004
Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix: a systematic review. Cancer treatment reviews, 2004, Volume: 30, Issue:5 Topics: Antineoplastic Agents; Combined Modality Therapy; Female; Humans; Hydroxyurea; Randomized Controlled	2004
[Cisplatin and derivatives with radiation therapy: for what clinical use?]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2004, Volume: 8 Suppl 1 Topics: Animals; Anus Neoplasms; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Clinical Trials, Ph	2004
Locally advanced cervical carcinoma: the role of chemoradiation. Seminars in oncology, 1994, Volume: 21, Issue:1 Topics: Carcinoma; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Female; Fluorouracil; Human	1994
Hydroxyurea-induced fever in cervical carcinoma: case report and review of the literature. Cancer investigation, 1999, Volume: 17, Issue:4 Topics: Adenocarcinoma; Antineoplastic Agents; Combined Modality Therapy; Female; Fever; Humans; Hydroxyurea	1999
[Standards, options and recommendations: concomitant radiochemotherapy for cancer of the cervix: a critical analysis of the literature and update of SOR]. Bulletin du cancer, 1999, Volume: 86, Issue:10 Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic	1999
Chemoradiation for carcinoma of the cervix: advances and opportunities. Radiation research, 2000, Volume: 154, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma, Squamous Cell; Chemotherapy, A	2000
[Concomitant radiochemotherapy in cancer of the cervix uteri: modifications of the standards]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2000, Volume: 4 Suppl 1 Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin;	2000
Combined modality therapy of gynecologic cancer. Cancer, 1975, Volume: 35, Issue:1 Topics: Adenocarcinoma; Alkylating Agents; Antineoplastic Agents; Evaluation Studies as Topic; Female; Genit	1975
Concurrent chemoradiation in carcinoma of the uterine cervix. Seminars in oncology, 1992, Volume: 19, Issue:4 Suppl 11 Topics: Cisplatin; Combined Modality Therapy; Female; Fluorouracil; Humans; Hydroxyurea; Uterine Cervical Ne	1992
Combined chemotherapy and radiotherapy for advanced-stage carcinomas of the cervix. Frontiers of radiation therapy and oncology, 1992, Volume: 26 Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Humans; Hydroxyur	1992
Experience with hydroxyurea as a radiosensitizer in carcinoma of the cervix. Seminars in oncology, 1992, Volume: 19, Issue:3 Suppl 9 Topics: Animals; Carcinoma; Chemotherapy, Adjuvant; Female; Humans; Hydroxyurea; Radiation-Sensitizing Agent	1992

Article	Year
Long-term follow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: a Gynecologic Oncology Group Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Jul-01, Volume: 25, Issue:19 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combi	2007
Long-term follow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: a Gynecologic Oncology Group Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Jul-01, Volume: 25, Issue:19 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combi	2007
Long-term follow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: a Gynecologic Oncology Group Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Jul-01, Volume: 25, Issue:19 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combi	2007
Long-term follow-up of a randomized trial comparing concurrent single agent cisplatin, cisplatin-based combination chemotherapy, or hydroxyurea during pelvic irradiation for locally advanced cervical cancer: a Gynecologic Oncology Group Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Jul-01, Volume: 25, Issue:19 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combi	2007
Hydroxyurea: a radiation potentiator in carcinoma of the uterine cervix. A randomized double-blind study. American journal of obstetrics and gynecology, 1983, Dec-01, Volume: 147, Issue:7 Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Clinical Trials as Topic; Combined Modality T	1983
Hydroxyurea versus misonidazole with radiation in cervical carcinoma: long-term follow-up of a Gynecologic Oncology Group trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:8 Topics: Adult; Aged; Aged, 80 and over; Carcinoma; Cause of Death; Chemotherapy, Adjuvant; Female; Follow-Up	1993
Carcinoma of the cervix treated with chemotherapy and radiation therapy. Cooperative studies in the Gynecologic Oncology Group. Cancer, 1993, Feb-15, Volume: 71, Issue:4 Suppl Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Protocols; Clinical Trials as Topic; Combin	1993
Hydroxyurea, 5-fluorouracil infusion, and cisplatin adjunct to radiation therapy in cervical carcinoma: a phase I-II trial of the Gynecologic Oncology Group. Gynecologic oncology, 1997, Volume: 66, Issue:2 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcin	1997
Phase I trial of concomitant chemoradiotherapy for cervical cancer and other advanced pelvic malignancies. Gynecologic oncology, 1999, Volume: 72, Issue:1 Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemoth	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. The New England journal of medicine, 1999, Apr-15, Volume: 340, Issue:15 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; C	1999
The significance of thrombocytosis in patients with locally advanced cervical carcinoma: a Gynecologic Oncology Group study. Gynecologic oncology, 2000, Volume: 78, Issue:2 Topics: Adult; Aged; Antineoplastic Agents; Cohort Studies; Combined Modality Therapy; Disease-Free Survival	2000
Hydroxyurea or placebo combined with radiation to treat stages IIIB and IV cervical cancer confined to the pelvis. International journal of radiation oncology, biology, physics, 1979, Volume: 5, Issue:3 Topics: Bone Marrow; Carcinoma, Squamous Cell; Clinical Trials as Topic; Female; Humans; Hydroxyurea; Pelvic	1979
Hydroxyurea as a radiation sensitizer in women with carcinoma of the uterine cervix. American journal of obstetrics and gynecology, 1977, Oct-15, Volume: 129, Issue:4 Topics: Clinical Trials as Topic; Double-Blind Method; Female; Hematopoiesis; Humans; Hydroxyurea; Lymphatic	1977
Gynecologic Oncology Group Reports I and II. Gynecologic oncology, 1975, Volume: 3, Issue:3 Topics: Carcinoma, Squamous Cell; Female; Genital Neoplasms, Female; Humans; Hydroxyurea; Interprofessional	1975
Standard administration of hydroxyurea recommended. American journal of obstetrics and gynecology, 1989, Volume: 161, Issue:5 Topics: Clinical Trials as Topic; Combined Modality Therapy; Drug Administration Schedule; Female; Humans; H	1989
Hydroxyurea plus pelvic irradiation versus placebo plus pelvic irradiation in nonsurgically staged stage IIIB cervical cancer. Journal of surgical oncology, 1989, Volume: 42, Issue:2 Topics: Adult; Aged; Carcinoma; Carcinoma, Squamous Cell; Combined Modality Therapy; Double-Blind Method; Fe	1989
Hydroxyurea plus pelvic radiation versus placebo plus pelvic radiation in surgically staged stage IIIB cervical cancer. Journal of surgical oncology, 1987, Volume: 35, Issue:2 Topics: Adult; Aged; Carcinoma; Combined Modality Therapy; Female; Humans; Hydroxyurea; Lymphatic Metastasis	1987
A randomized trial of hydroxyurea versus misonidazole adjunct to radiation therapy in carcinoma of the cervix. A preliminary report of a Gynecologic Oncology Group study. American journal of obstetrics and gynecology, 1988, Volume: 159, Issue:1 Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Clinical Trials as Topic; Combined Modality T	1988
Treatment of metastatic and recurrent cervix cancer with chemotherapy: a randomised trial comparing hydroxyurea with cisdiamminedichloro-platinum plus methotrexate. Medical and pediatric oncology, 1986, Volume: 14, Issue:1 Topics: Actuarial Analysis; Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trial	1986
Hydroxyurea and radiation therapy in advanced cervical cancer. American journal of obstetrics and gynecology, 1974, Dec-01, Volume: 120, Issue:7 Topics: Anemia, Aplastic; Clinical Trials as Topic; Drug Eruptions; Drug Evaluation; Evaluation Studies as T	1974
Hydroxyurea (NSC-32065) with irradiation for cervical carcinoma--preliminary report. Cancer chemotherapy reports, 1968, Volume: 52, Issue:5 Topics: Carcinoma, Squamous Cell; Clinical Trials as Topic; Female; Humans; Hydroxyurea; Uterine Cervical Ne	1968

hydroxyurea and Uterine Cervical Neoplasms

Research Excerpts

Research

Studies (53)

Authors

Clinical Trials (10)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Zileuton inhibits arachidonate-5-lipoxygenase to exert antitumor effects in preclinical cervical cancer models. Cancer chemotherapy and pharmacology, 2021, Volume: 88, Issue:6 Topics: Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Cell Proliferation; Disease Models, Animal; Female;	2021
Locally advanced adenocarcinoma and adenosquamous carcinomas of the cervix compared to squamous cell carcinomas of the cervix in gynecologic oncology group trials of cisplatin-based chemoradiation. Gynecologic oncology, 2014, Volume: 135, Issue:2 Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Adenosquamous; Car	2014
Volume-activated chloride channels contribute to cell-cycle-dependent regulation of HeLa cell migration. Biochemical pharmacology, 2009, Jan-15, Volume: 77, Issue:2 Topics: Cell Cycle; Cell Division; Cell Membrane; Cell Movement; Chloride Channels; Demecolcine; Electrophys	2009
Outcome of stage IVA cervical cancer patients with disease limited to the pelvis in the era of chemoradiation: a Gynecologic Oncology Group study. Gynecologic oncology, 2011, Jun-01, Volume: 121, Issue:3 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Cisplatin; Combined Modality Th	2011
Eeyarestatin causes cervical cancer cell sensitization to bortezomib treatment by augmenting ER stress and CHOP expression. Gynecologic oncology, 2013, Volume: 128, Issue:2 Topics: Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Drug Synergism; Endoplasm	2013
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: UROLOGIC AND GYNECOLOGIC NEOPLASMS. Cancer chemotherapy reports, 1964, Volume: 40 Topics: Adenocarcinoma; Anemia; Anemia, Aplastic; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Ther	1964
Drug-induced biochemical markers of cancer in cervical carcinoma cells. Clinical biochemistry, 1982, Volume: 15, Issue:1 Topics: Alkaline Phosphatase; Butyrates; Butyric Acid; Carcinoembryonic Antigen; Chorionic Gonadotropin; Cho	1982
Adriamycin and hydroxyurea as radiopotentiators in the treatment of squamous cell carcinoma of the cervix implanted in nude mice: a preliminary report. Gynecologic oncology, 1980, Volume: 9, Issue:2 Topics: Animals; Carcinoma, Squamous Cell; Doxorubicin; Female; Humans; Hydroxyurea; Mice; Mice, Nude; Neopl	1980
Severe radiation morbidity in carcinoma of the cervix: impact of pretherapy surgical staging and previous surgery. International journal of radiation oncology, biology, physics, 1995, Feb-15, Volume: 31, Issue:4 Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Adenosquamous; Carcinoma, Squamous Cell; Female; Humans; Hyd	1995
[How toxic and effective is simultaneous radiochemotherapy with hydroxyurea, 5-FU and cisplatin in cervix carcinoma?]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1998, Volume: 174, Issue:11 Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chem	1998
Time to add chemotherapy to radiotherapy for cervical cancer. Lancet (London, England), 1999, Apr-17, Volume: 353, Issue:9161 Topics: Antineoplastic Combined Chemotherapy Protocols; Brachytherapy; Cisplatin; Clinical Trials, Phase III	1999
Chemotherapy plus radiation improves survival in patients with cervical cancer. Oncology (Williston Park, N.Y.), 1999, Volume: 13, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Female; Fluoro	1999
Treatment of high-risk cervical cancer. The New England journal of medicine, 1999, Aug-26, Volume: 341, Issue:9 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality	1999
Chemoradiotherapy: the new standard care for invasive cervical cancer. Drugs, 2000, Volume: 60, Issue:6 Topics: Antineoplastic Agents; Cisplatin; Combined Modality Therapy; Female; Fluorouracil; Humans; Hydroxyur	2000
Serum antibodies to herpesvirus early antigens in patients with cervical carcinoma determined by anticomplement immunofluorescence technique. International journal of cancer, 1976, Nov-15, Volume: 18, Issue:5 Topics: Antibodies, Viral; Antigens, Viral; Cells, Cultured; Complement Fixation Tests; Culture Media; Cyclo	1976
Cell kinetics and programmed chemotherapy for gynecologic cancer. I. Squamous-cell carcinoma. American journal of obstetrics and gynecology, 1976, Apr-15, Volume: 124, Issue:8 Topics: Carcinoma, Squamous Cell; Cell Division; DNA, Neoplasm; Female; Genital Neoplasms, Female; Humans; H	1976
Modification of radiation dose-rate sparing effects in a human carcinoma of the cervix cell line by inhibitors of DNA repair. International journal of radiation biology, 1988, Volume: 54, Issue:2 Topics: Aphidicolin; Benzamides; Caffeine; Cell Line; Cobalt Radioisotopes; Diterpenes; DNA Repair; Female;	1988
Biopsy of the scalene fat pad in carcinoma of the cervix uteri metastatic to the periaortic lymph nodes. Surgery, gynecology & obstetrics, 1987, Volume: 165, Issue:6 Topics: Adipose Tissue; Adult; Aged; Aorta, Abdominal; Biopsy, Needle; Carcinoma, Squamous Cell; Cisplatin;	1987
Survival of nonsurgically staged patients with negative lymphangiograms who had Stage IIB carcinoma of the cervix treated by pelvic radiation plus hydroxyurea. American journal of obstetrics and gynecology, 1985, Apr-15, Volume: 151, Issue:8 Topics: Adult; Aged; Cesium Radioisotopes; Combined Modality Therapy; Female; Humans; Hydroxyurea; Lymphatic	1985
Fluctuations in deoxycytidine monophosphate deaminase activity during the cell cycle in synchronous populations of HeLa cells. Biochimica et biophysica acta, 1969, Jun-17, Volume: 182, Issue:2 Topics: Aminohydrolases; Autoradiography; Carbon Isotopes; Cell Line; Cycloheximide; Cytosine Nucleotides; D	1969
Systemic chemotherapy for carcinoma of the cervix. American journal of obstetrics and gynecology, 1967, Mar-15, Volume: 97, Issue:6 Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Cyclophosphamide; Fema	1967