Page last updated: 2024-10-28

hydroxyurea and Thromboembolism

hydroxyurea has been researched along with Thromboembolism in 21 studies

Thromboembolism: Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.

Research Excerpts

ExcerptRelevanceReference
"A total of 114 patients with essential thrombocythemia (77 women and 37 men; median age, 68 years; range, 40 to 85) and a median platelet count of 788,000 per cubic millimeter (range, 533,000 to 1,240,000 per cubic millimeter) were randomly assigned to receive hydroxyurea (56 patients) or no myelosuppressive therapy (58 patients)."9.08Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis. ( Barbui, T; Cortelazzo, S; Finazzi, G; Galli, M; Rodeghiero, F; Ruggeri, M; Vestri, O, 1995)
" We present a unique case of ET causing extensive arterial thromboembolism, despite being on adequate antithrombotic agents including warfarin and aspirin."7.85Medical Management of Extensive Arterial Thromboembolism in a Patient with Essential Thrombocythemia and Warfarin Failure. ( Ahmed, AK; Skeik, N; Youssef, A, 2017)
"A total of 114 patients with essential thrombocythemia (77 women and 37 men; median age, 68 years; range, 40 to 85) and a median platelet count of 788,000 per cubic millimeter (range, 533,000 to 1,240,000 per cubic millimeter) were randomly assigned to receive hydroxyurea (56 patients) or no myelosuppressive therapy (58 patients)."5.08Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis. ( Barbui, T; Cortelazzo, S; Finazzi, G; Galli, M; Rodeghiero, F; Ruggeri, M; Vestri, O, 1995)
" We present a unique case of ET causing extensive arterial thromboembolism, despite being on adequate antithrombotic agents including warfarin and aspirin."3.85Medical Management of Extensive Arterial Thromboembolism in a Patient with Essential Thrombocythemia and Warfarin Failure. ( Ahmed, AK; Skeik, N; Youssef, A, 2017)
" Accordingly, we conclude that clinical trials in SCD designed to increase the bioavailability of NO or association studies in which SCD clinical manifestations are related to plasma hemoglobin via its surrogates should be viewed with caution."2.46Pulmonary hypertension and nitric oxide depletion in sickle cell disease. ( Bunn, HF; Dover, GJ; Hebbel, RP; Nathan, DG; Platt, OS; Rosse, WF; Ware, RE, 2010)
"A case of acute promyelocytic leukemia (APL) treated with all-trans retinoic acid (ATRA) is reported."1.32[All-trans retinoic acid for thromboembolic events in patients with M3 leukemia: a case report]. ( Feng, R; Jiang, ZJ; Liu, XL; Meng, FY; Yin, F; Zheng, WY; Zhou, SY, 2003)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.52)18.7374
1990's3 (14.29)18.2507
2000's8 (38.10)29.6817
2010's7 (33.33)24.3611
2020's1 (4.76)2.80

Authors

AuthorsStudies
Choi, HS1
Hong, J1
Hwang, SM1
Lee, JH1
Ma, Y1
Kim, SA1
Lee, JY1
Lee, JO1
Bang, SM1
Parasuraman, SV1
Shi, N1
Paranagama, DC1
Bonafede, M1
Griesshammer, M1
Kiladjian, JJ1
Besses, C1
Aumiller, J1
Ahmed, AK1
Youssef, A1
Skeik, N1
Ali, FR1
Roberts, LN1
Mistry, H1
Patel, RK1
Edmondson, RA1
Arya, R1
Bunn, HF1
Nathan, DG1
Dover, GJ1
Hebbel, RP1
Platt, OS1
Rosse, WF1
Ware, RE1
Novelli, EM1
Kato, GJ1
Ragni, MV1
Zhang, Y1
Hildesheim, ME1
Nouraie, M1
Barge, S1
Meyer, MP1
Hassett, AC1
Gordeuk, VR1
Gladwin, MT1
Isenberg, JS1
Gemünden, C1
Gerber, B1
Yin, F1
Zheng, WY1
Meng, FY1
Jiang, ZJ1
Liu, XL1
Feng, R1
Zhou, SY1
Gabriel, L1
de Meester, A1
Cazzola, M2
Petrides, PE1
Passamonti, F1
Spry, CJ1
Cortelazzo, S1
Finazzi, G1
Ruggeri, M1
Vestri, O1
Galli, M1
Rodeghiero, F1
Barbui, T1
Rose, C1
Bauters, F1
Galacteros, F1
Lengfelder, E1
Hehlmann, R1
Rezaei Kalantari, H1
Schafer, AI1
Mercadanti, M1
Cavalieri, F1
Ferraccioli, GF1
Ambanelli, U1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Substudy of the CADRE Study: Determination of Clinical Markers in Patients With Extreme Sickle Cell Disease Phenotype[NCT03352986]300 participants (Anticipated)Observational2017-05-15Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for hydroxyurea and Thromboembolism

ArticleYear
Pulmonary hypertension and nitric oxide depletion in sickle cell disease.
    Blood, 2010, Aug-05, Volume: 116, Issue:5

    Topics: Adult; Anemia, Sickle Cell; Animals; Child; Clinical Trials as Topic; Disease Models, Animal; Echoca

2010
Anagrelide: a decade of clinical experience with its use for the treatment of primary thrombocythaemia.
    Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:8

    Topics: Animals; Carcinogens; Clinical Trials as Topic; Drug Therapy, Combination; Heart Diseases; Humans; H

2004
The hypereosinophilic syndrome: clinical features, laboratory findings and treatment.
    Allergy, 1982, Volume: 37, Issue:8

    Topics: Anticoagulants; Bone Marrow; Central Nervous System Diseases; Endomyocardial Fibrosis; Eosinophilia;

1982
[Polycythemia vera: current status of therapy].
    Deutsche medizinische Wochenschrift (1946), 2000, Oct-13, Volume: 125, Issue:41

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bloodletting; Clinical Trials

2000
[How I treat ... sickle cell anemia: current therapies].
    Revue medicale de Liege, 2001, Volume: 56, Issue:10

    Topics: Anemia, Sickle Cell; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antisickling Agents; A

2001
Essential thrombocythemia.
    Progress in hemostasis and thrombosis, 1991, Volume: 10

    Topics: Abortion, Habitual; Age Factors; Blood Platelets; Combined Modality Therapy; Diagnosis, Differential

1991

Trials

2 trials available for hydroxyurea and Thromboembolism

ArticleYear
Thromboembolic events in polycythemia vera.
    Annals of hematology, 2019, Volume: 98, Issue:5

    Topics: Age Factors; Anticoagulants; Aspirin; Humans; Hydroxyurea; Interferons; Nitriles; Phlebotomy; Polycy

2019
Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis.
    The New England journal of medicine, 1995, Apr-27, Volume: 332, Issue:17

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Female; Follow-Up Studies; Hemorrhage; Humans; Hydroxyurea;

1995

Other Studies

13 other studies available for hydroxyurea and Thromboembolism

ArticleYear
Evaluation of the need for cytoreduction and its potential carcinogenicity in children and young adults with myeloproliferative neoplasms.
    Annals of hematology, 2021, Volume: 100, Issue:10

    Topics: Adolescent; Adult; Antineoplastic Agents; Aspirin; Child; Female; Fibrinolytic Agents; Follow-Up Stu

2021
Health Care Costs and Thromboembolic Events in Hydroxyurea-Treated Patients with Polycythemia Vera.
    Journal of managed care & specialty pharmacy, 2018, Volume: 24, Issue:1

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Cross-Sectional Studies; Drug Resistance, Neoplasm;

2018
[Polycythemia vera: the disadvantages of overproduction].
    MMW Fortschritte der Medizin, 2015, Apr-30, Volume: 157, Issue:8

    Topics: Aged; Aspirin; Bloodletting; Diagnosis, Differential; Female; Hematocrit; Humans; Hydroxyurea; Inter

2015
Medical Management of Extensive Arterial Thromboembolism in a Patient with Essential Thrombocythemia and Warfarin Failure.
    Annals of vascular surgery, 2017, Volume: 42

    Topics: Anticoagulants; Arterial Occlusive Diseases; Blood Coagulation; Blood Coagulation Tests; Computed To

2017
Recurrent refractory arterial thromboembolism associated with the Janus kinase 2 V617F mutation.
    Journal of vascular surgery, 2009, Volume: 49, Issue:1

    Topics: Anticoagulants; Arterial Occlusive Diseases; Humans; Hydroxyurea; Janus Kinase 2; Male; Middle Aged;

2009
Plasma thrombospondin-1 is increased during acute sickle cell vaso-occlusive events and associated with acute chest syndrome, hydroxyurea therapy, and lower hemolytic rates.
    American journal of hematology, 2012, Volume: 87, Issue:3

    Topics: Acute Chest Syndrome; Adult; Anemia, Sickle Cell; Antisickling Agents; Biomarkers; Cohort Studies; F

2012
[Polycythemia vera].
    Praxis, 2012, May-09, Volume: 101, Issue:10

    Topics: Aged; Algorithms; Alleles; Bone Marrow Examination; Diagnosis, Differential; Erythropoietin; Female;

2012
[All-trans retinoic acid for thromboembolic events in patients with M3 leukemia: a case report].
    Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 2003, Volume: 23, Issue:2

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Fatal Outcome; Humans; Hydroxyurea; Leukemia,

2003
Myocardial infarction and primary thrombocytosis in a young man.
    Acta cardiologica, 2003, Volume: 58, Issue:1

    Topics: Adult; Antineoplastic Agents; Coronary Angiography; Electrocardiography; Fibrinolytic Agents; Humans

2003
Towards a rational treatment of essential thrombocythemia, despite limited evidence and old prejudices.
    Haematologica, 2004, Volume: 89, Issue:2

    Topics: Adult; Cohort Studies; Disease Progression; Evidence-Based Medicine; Expert Testimony; Female; Hemor

2004
Cytoreductive therapy for patients with essential thrombocythemia at high risk of thromboembolic complications. The difficult choice of the optimal drug.
    Haematologica, 2004, Volume: 89, Issue:11

    Topics: Adult; Humans; Hydroxyurea; Middle Aged; Pipobroman; Platelet Aggregation Inhibitors; Prognosis; Ris

2004
Hydroxyurea therapy in highly unstable hemoglobin carriers.
    Blood, 1996, Oct-01, Volume: 88, Issue:7

    Topics: Adult; Anemia, Hemolytic; Combined Modality Therapy; Female; Fetal Hemoglobin; Gene Expression Regul

1996
[Idiopathic hypereosinophilic syndrome. Current clinico-therapeutic state].
    Minerva medica, 1985, Oct-13, Volume: 76, Issue:39

    Topics: Adrenal Cortex Hormones; Adult; Antibody Formation; Anticoagulants; Blood Proteins; Cardiomyopathies

1985