hydroxyurea has been researched along with Subarachnoid Hemorrhage in 3 studies
Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Zileuton is a 5-lipoxygenase inhibitor that reduces the levels of downstream pro-inflammatory cytokines." | 1.72 | Zileuton, a 5-Lipoxygenase Inhibitor, Attenuates Haemolysate-Induced BV-2 Cell Activation by Suppressing the MyD88/NF-κB Pathway. ( Lin, CL; Su, HY; Tsai, HP; Tsai, YC, 2022) |
| "Zileuton and LY294002 were used to inhibit expression of 5-LOX and Akt, respectively." | 1.62 | 5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats. ( Chen, H; Deng, Y; Guo, Z; He, Z; Liang, Y; Liu, L; Sun, X; Zhang, P; Zhang, Z, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Su, HY | 1 |
| Tsai, YC | 1 |
| Tsai, HP | 1 |
| Lin, CL | 1 |
| Liu, L | 1 |
| Zhang, P | 1 |
| Zhang, Z | 1 |
| Liang, Y | 1 |
| Chen, H | 1 |
| He, Z | 1 |
| Sun, X | 1 |
| Guo, Z | 1 |
| Deng, Y | 1 |
| Barbosa, MD | 1 |
| Arthur, AS | 1 |
| Louis, RH | 1 |
| MacDonald, T | 1 |
| Polin, RS | 1 |
| Gazak, C | 1 |
| Kassell, NF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cerebral Aneurysms: a Retrospective Study on the Experience in Our Hospital With a Comparative Analysis Between the Different Techniques Used in Its Treatment[NCT04792944] | 247 participants (Actual) | Observational | 2007-01-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for hydroxyurea and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Zileuton, a 5-Lipoxygenase Inhibitor, Attenuates Haemolysate-Induced BV-2 Cell Activation by Suppressing the MyD88/NF-κB Pathway.
Topics: Animals; Hydroxyurea; Lipopolysaccharides; Lipoxygenase Inhibitors; Microglia; Myeloid Differentiati | 2022 |
5-Lipoxygenase inhibition reduces inflammation and neuronal apoptosis via AKT signaling after subarachnoid hemorrhage in rats.
Topics: Administration, Oral; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Brain Injuries; Chromones; Di | 2021 |
The novel 5-lipoxygenase inhibitor ABT-761 attenuates cerebral vasospasm in a rabbit model of subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Disease Models, Animal; Enzyme Inhibitors; Hydroxyurea; Lipoxygenase Inhibi | 2001 |