Page last updated: 2024-10-28

hydroxyurea and Sterility, Male

hydroxyurea has been researched along with Sterility, Male in 8 studies

Research Excerpts

ExcerptRelevanceReference
"Two experiments were conducted to determine: 1) whether the adult male transgenic sickle cell mouse (Tg58 x Tg98; TSCM), exhibits the patterns of reproductive endpoints (hypogonadism) characteristic of men with sickle cell disease (SCD) and 2) whether hydroxyurea (HU) exacerbates this condition."3.75Adverse effects of a clinically relevant dose of hydroxyurea used for the treatment of sickle cell disease on male fertility endpoints. ( Aguinaga, MP; Archibong, AE; Bourne, P; Brooks, CM; Bruce, D; Hills, ER; Jones, KM; Niaz, MS; Rice, VM; Roberson, SI, 2009)
"Treatment with hydroxyurea is usually considered for patients with recurrent vaso-occlusive events, but additional indications for treatment may include laboratory markers of disease severity and evidence of chronic organ dysfunction."2.45Advances in the use of hydroxyurea. ( Aygun, B; Ware, RE, 2009)
"Recent progress in the treatment of sickle cell disease, in particular the use of hydroxyurea, has considerably modified the prognosis of this disease."1.35Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males. ( Ancel, PY; Bachir, D; Berthaut, I; de Larouziere, V; Galactéros, F; Girot, R; Guignedoux, G; Jouannet, P; Kirsch-Noir, F; Kunstmann, JM; Levy, L; Mandelbaum, J; Ravel, C, 2008)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's3 (37.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Joseph, L1
Jean, C1
Manceau, S1
Chalas, C1
Arnaud, C1
Kamdem, A1
Pondarré, C1
Habibi, A1
Bernaudin, F1
Allali, S1
de Montalembert, M1
Boutonnat-Faucher, B1
Arlet, JB1
Koehl, B1
Cavazzana, M1
Ribeil, JA1
Lionnet, F1
Berthaut, I2
Brousse, V1
Tohamy, HG1
Gad El-Karim, DR1
El-Sayed, YS1
DeBaun, MR1
Smith-Whitley, K1
Guignedoux, G1
Kirsch-Noir, F1
de Larouziere, V1
Ravel, C1
Bachir, D1
Galactéros, F1
Ancel, PY1
Kunstmann, JM1
Levy, L1
Jouannet, P1
Girot, R1
Mandelbaum, J1
Lukusa, AK1
Vermylen, C1
Jones, KM1
Niaz, MS1
Brooks, CM1
Roberson, SI1
Aguinaga, MP1
Hills, ER1
Rice, VM1
Bourne, P1
Bruce, D1
Archibong, AE1
Ware, RE1
Aygun, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Sickle Cell Liver Disease[NCT01950429]42 participants (Actual)Observational2013-10-16Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for hydroxyurea and Sterility, Male

ArticleYear
Hydroxyurea therapy contributes to infertility in adult men with sickle cell disease: a review.
    Expert review of hematology, 2014, Volume: 7, Issue:6

    Topics: Anemia, Sickle Cell; Animals; Antisickling Agents; Humans; Hydroxyurea; Hypogonadism; Infertility, M

2014
Reproductive issues in sickle cell disease.
    Blood, 2014, Dec-04, Volume: 124, Issue:24

    Topics: Anemia, Sickle Cell; Antisickling Agents; Female; Fertility; Humans; Hydroxyurea; Infertility, Femal

2014
Advances in the use of hydroxyurea.
    Hematology. American Society of Hematology. Education Program, 2009

    Topics: Adult; Anemia, Sickle Cell; Animals; Arterial Occlusive Diseases; Bone Marrow Diseases; Child; Clini

2009

Other Studies

5 other studies available for hydroxyurea and Sterility, Male

ArticleYear
Effect of hydroxyurea exposure before puberty on sperm parameters in males with sickle cell disease.
    Blood, 2021, 02-11, Volume: 137, Issue:6

    Topics: Acute Chest Syndrome; Adolescent; Age Factors; Anemia, Sickle Cell; Antisickling Agents; Arterial Oc

2021
Attenuation potentials of royal jelly against hydroxyurea-induced infertility through inhibiting oxidation and release of pro-inflammatory cytokines in male rats.
    Environmental science and pollution research international, 2019, Volume: 26, Issue:21

    Topics: Animals; Antioxidants; Catalase; Cytokines; Fatty Acids; Hydroxyurea; Infertility, Male; Male; Oxida

2019
Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males.
    Haematologica, 2008, Volume: 93, Issue:7

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Fertility; Heterozygote; Homozygote; Humans; Hydroxyurea; In

2008
Use of hydroxyurea from childhood to adult age in sickle cell disease: semen analysis.
    Haematologica, 2008, Volume: 93, Issue:11

    Topics: Adolescent; Adult; Anemia, Sickle Cell; Child; Fertility; Humans; Hydroxyurea; Infertility, Male; Ma

2008
Adverse effects of a clinically relevant dose of hydroxyurea used for the treatment of sickle cell disease on male fertility endpoints.
    International journal of environmental research and public health, 2009, Volume: 6, Issue:3

    Topics: Anemia, Sickle Cell; Animals; Antisickling Agents; Disease Models, Animal; Hydroxyurea; Hypogonadism

2009
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