hydroxyurea has been researched along with Pyrexia in 34 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is a case presentation of a rarely seen hydroxyurea-induced fever in a patient with cervical adenocarcinoma receiving oral hydroxyurea given concurrently with external beam radiotherapy to the pelvis." | 8.80 | Hydroxyurea-induced fever in cervical carcinoma: case report and review of the literature. ( Browne, B; Capen, C; Cheung, AY, 1999) |
| "A patient with essential thrombocythemia developed a fever 12 hours after beginning hydroxyurea therapy." | 8.79 | Hydroxyurea-induced fever: case report and review of the literature. ( Lossos, IS; Matzner, Y, 1995) |
| "Hydroxyurea (HU) resistance or intolerance occurs in 15 to 24% of patients with polycythemia vera (PV)." | 7.91 | Polycythemia vera and hydroxyurea resistance/intolerance: a monocentric retrospective analysis. ( Delforge, M; Demuynck, T; Devos, T; Vandenberghe, P; Verhoef, G, 2019) |
| "A patient given hydroxyurea for polycythemia suddenly developed severe interstitial pneumonia with fever and hypoxemia." | 7.70 | [Acute interstitial pneumopathy with fever caused by hydroxyurea]. ( Blanc, PL; Hammoud, H; Joasson, JM; Matussière, Y, 2000) |
| "We report on three patients who developed fever after starting treatment with the anti-neoplastic agent, hydroxyurea." | 7.69 | Fever attributed to the use of hydroxyurea. ( Feenstra, J; in 't Veld, BA; Runhaar, EA; Slappendel, AM; Stricker, BH; van Aken, J; Veen, C, 1997) |
| "Hydroxyurea has been rarely implicated as a cause of drug fever." | 7.66 | Fever caused by hydroxyurea. ( Bauernfeind, RA; Bauman, JL; Hartsough, N; Hasegawa, GR; Roden, R; Shulruff, S, 1981) |
| "Drug-induced fever is a frequent (3-5% of all adverse effects) but under recognized adverse effect of several drugs." | 5.30 | [Drug-induced fever caused by hydroxyurea. Apropos of 3 new cases]. ( Allochon, Y; Blanc, M; Evreux, JC; Gallant, C; Monier, JM; Vial, T, 1998) |
| "This is a case presentation of a rarely seen hydroxyurea-induced fever in a patient with cervical adenocarcinoma receiving oral hydroxyurea given concurrently with external beam radiotherapy to the pelvis." | 4.80 | Hydroxyurea-induced fever in cervical carcinoma: case report and review of the literature. ( Browne, B; Capen, C; Cheung, AY, 1999) |
| "A patient with essential thrombocythemia developed a fever 12 hours after beginning hydroxyurea therapy." | 4.79 | Hydroxyurea-induced fever: case report and review of the literature. ( Lossos, IS; Matzner, Y, 1995) |
| "Hydroxyurea (HU) resistance or intolerance occurs in 15 to 24% of patients with polycythemia vera (PV)." | 3.91 | Polycythemia vera and hydroxyurea resistance/intolerance: a monocentric retrospective analysis. ( Delforge, M; Demuynck, T; Devos, T; Vandenberghe, P; Verhoef, G, 2019) |
| "A patient given hydroxyurea for polycythemia suddenly developed severe interstitial pneumonia with fever and hypoxemia." | 3.70 | [Acute interstitial pneumopathy with fever caused by hydroxyurea]. ( Blanc, PL; Hammoud, H; Joasson, JM; Matussière, Y, 2000) |
| "A patient with idiopathic myelofibrosis is reported who developed a drug fever after treatment with hydroxyurea, a generally effective and well-tolerated drug in chronic myeloproliferative syndromes." | 3.69 | An unwanted side effect of hydroxyurea in a patient with idiopathic myelofibrosis. ( Fickers, MM; Pannebakker, MA; Starmans-Kool, MJ, 1995) |
| "We report on three patients who developed fever after starting treatment with the anti-neoplastic agent, hydroxyurea." | 3.69 | Fever attributed to the use of hydroxyurea. ( Feenstra, J; in 't Veld, BA; Runhaar, EA; Slappendel, AM; Stricker, BH; van Aken, J; Veen, C, 1997) |
| "Hydroxyurea has been rarely implicated as a cause of drug fever." | 3.66 | Fever caused by hydroxyurea. ( Bauernfeind, RA; Bauman, JL; Hartsough, N; Hasegawa, GR; Roden, R; Shulruff, S, 1981) |
| "Clinical complications of sickle cell anemia begin in infancy." | 2.77 | Influence of severity of anemia on clinical findings in infants with sickle cell anemia: analyses from the BABY HUG study. ( Brown, RC; Casella, JF; Howard, TH; Iyer, RV; Lebensburger, JD; Lu, M; Miller, ST; Rogers, ZR; Sarnaik, S; Wang, WC, 2012) |
| "HU induced fever is unusual." | 2.52 | [Hydrocycarbamide induced fever: four cases and literature review]. ( Doutrelon, C; Greib, C; Lazaro, E; Pellegrin, JL; Ribeiro, E; Viallard, JF, 2015) |
| " However, no epidemiologic information about the occurrence of the most clinically significant HU-associated adverse events is yet available." | 1.38 | Hydroxyurea-related toxicity in 3,411 patients with Ph'-negative MPN. ( Antonioli, E; Baccarani, M; Barbui, T; Bertozzi, I; Bosi, A; Cacciola, E; Cacciola, R; Cazzola, M; De Stefano, V; Elli, E; Finazzi, G; Finazzi, M; Guglielmelli, P; Luigia Randi, M; Martinelli, V; Passamonti, F; Pieri, L; Pogliani, E; Rambaldi, A; Rodeghiero, F; Rossi, E; Ruggeri, M; Rumi, E; Vannucchi, AM; Vianelli, N; Za, T, 2012) |
| "Drug-induced fever is a frequent (3-5% of all adverse effects) but under recognized adverse effect of several drugs." | 1.30 | [Drug-induced fever caused by hydroxyurea. Apropos of 3 new cases]. ( Allochon, Y; Blanc, M; Evreux, JC; Gallant, C; Monier, JM; Vial, T, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (14.71) | 18.7374 |
| 1990's | 12 (35.29) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 10 (29.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mvalo, T | 1 |
| Topazian, HM | 1 |
| Kamthunzi, P | 1 |
| Chen, JS | 1 |
| Kambalame, I | 1 |
| Mafunga, P | 1 |
| Mumba, N | 1 |
| Chiume, M | 1 |
| Paseli, K | 1 |
| Tegha, G | 1 |
| Kumwenda, W | 1 |
| Heimlich, JB | 1 |
| Ellis, G | 1 |
| Key, N | 1 |
| Gopal, S | 1 |
| Hoffman, I | 1 |
| Ataga, KI | 1 |
| Westmoreland, KD | 1 |
| Ingerski, LM | 1 |
| Arnold, TL | 1 |
| Banks, G | 1 |
| Porter, JS | 1 |
| Wang, WC | 2 |
| Bertolini, F | 1 |
| Cassisa, A | 1 |
| Miggiano, MC | 1 |
| Gasparin, P | 1 |
| Demuynck, T | 1 |
| Verhoef, G | 1 |
| Delforge, M | 1 |
| Vandenberghe, P | 1 |
| Devos, T | 1 |
| Thomas, R | 1 |
| Dulman, R | 1 |
| Lewis, A | 1 |
| Notarangelo, B | 1 |
| Yang, E | 1 |
| Doutrelon, C | 1 |
| Lazaro, E | 1 |
| Ribeiro, E | 1 |
| Greib, C | 1 |
| Pellegrin, JL | 1 |
| Viallard, JF | 1 |
| Lizarralde Palacios, E | 1 |
| Gutiérrez Macías, A | 1 |
| Rámiz Martínez, M | 1 |
| Escalante Boleas, M | 1 |
| Geyer, H | 1 |
| Scherber, R | 1 |
| Kosiorek, H | 1 |
| Dueck, AC | 1 |
| Kiladjian, JJ | 1 |
| Xiao, Z | 1 |
| Slot, S | 1 |
| Zweegman, S | 1 |
| Sackmann, F | 1 |
| Fuentes, AK | 1 |
| Hernández-Maraver, D | 1 |
| Döhner, K | 1 |
| Harrison, CN | 1 |
| Radia, D | 1 |
| Muxi, P | 1 |
| Besses, C | 1 |
| Cervantes, F | 1 |
| Johansson, PL | 1 |
| Andreasson, B | 1 |
| Rambaldi, A | 2 |
| Barbui, T | 2 |
| Bonatz, K | 1 |
| Reiter, A | 1 |
| Boyer, F | 1 |
| Etienne, G | 1 |
| Ianotto, JC | 1 |
| Ranta, D | 1 |
| Roy, L | 1 |
| Cahn, JY | 1 |
| Maldonado, N | 1 |
| Barosi, G | 1 |
| Ferrari, ML | 1 |
| Gale, RP | 1 |
| Birgegard, G | 1 |
| Xu, Z | 1 |
| Zhang, Y | 1 |
| Sun, X | 1 |
| Xu, J | 1 |
| Zhang, P | 1 |
| te Boekhorst, PA | 1 |
| Commandeur, S | 1 |
| Schouten, H | 1 |
| Pahl, HL | 1 |
| Griesshammer, M | 1 |
| Stegelmann, F | 1 |
| Lehmann, T | 1 |
| Senyak, Z | 1 |
| Vannucchi, AM | 2 |
| Passamonti, F | 2 |
| Samuelsson, J | 1 |
| Mesa, RA | 1 |
| Lebensburger, JD | 1 |
| Miller, ST | 1 |
| Howard, TH | 1 |
| Casella, JF | 1 |
| Brown, RC | 1 |
| Lu, M | 1 |
| Iyer, RV | 1 |
| Sarnaik, S | 1 |
| Rogers, ZR | 1 |
| Antonioli, E | 1 |
| Guglielmelli, P | 1 |
| Pieri, L | 1 |
| Finazzi, M | 1 |
| Rumi, E | 1 |
| Martinelli, V | 1 |
| Vianelli, N | 1 |
| Luigia Randi, M | 1 |
| Bertozzi, I | 1 |
| De Stefano, V | 1 |
| Za, T | 1 |
| Rossi, E | 1 |
| Ruggeri, M | 1 |
| Elli, E | 1 |
| Cacciola, R | 1 |
| Cacciola, E | 1 |
| Pogliani, E | 1 |
| Rodeghiero, F | 1 |
| Baccarani, M | 1 |
| Finazzi, G | 1 |
| Bosi, A | 1 |
| Cazzola, M | 1 |
| Binder, WD | 1 |
| Brown, DF | 1 |
| Nadel, ES | 1 |
| Ishitsuka, K | 1 |
| Shirahashi, A | 1 |
| Iwao, Y | 1 |
| Shishime, M | 1 |
| Takamatsu, Y | 1 |
| Takatsuka, Y | 1 |
| Utsunomiya, A | 1 |
| Suzumiya, J | 1 |
| Hara, S | 1 |
| Tamura, K | 1 |
| Pavic, M | 1 |
| Sève, P | 1 |
| Le Scanff, J | 1 |
| Gomard, E | 1 |
| Charhon, A | 1 |
| Broussolle, C | 1 |
| Bauman, JL | 1 |
| Shulruff, S | 1 |
| Hasegawa, GR | 1 |
| Roden, R | 1 |
| Hartsough, N | 1 |
| Bauernfeind, RA | 1 |
| Starmans-Kool, MJ | 1 |
| Fickers, MM | 1 |
| Pannebakker, MA | 1 |
| Lossos, IS | 1 |
| Matzner, Y | 1 |
| Nese, M | 1 |
| de Bellis, R | 1 |
| Urtiarte, R | 1 |
| Di Landro, J | 1 |
| Najean, Y | 1 |
| van der Klooster, JM | 1 |
| Sucec, PM | 1 |
| Stiegelis, WF | 1 |
| Hagenbeek, A | 1 |
| in 't Veld, BA | 1 |
| Slappendel, AM | 1 |
| Feenstra, J | 1 |
| Veen, C | 1 |
| van Aken, J | 1 |
| Runhaar, EA | 1 |
| Stricker, BH | 1 |
| Higashigawa, M | 1 |
| Hori, H | 1 |
| Hirayama, M | 1 |
| Kawasaki, H | 1 |
| Ido, M | 1 |
| Azuma, E | 1 |
| Sakurai, M | 1 |
| Grace, RF | 1 |
| Shenfield, GM | 1 |
| Grant, J | 1 |
| Ravich, R | 1 |
| Westerman, DA | 1 |
| Schwarer, A | 1 |
| Grigg, AP | 1 |
| Cheung, AY | 1 |
| Browne, B | 1 |
| Capen, C | 1 |
| Lannemyr, O | 1 |
| Kutti, J | 1 |
| Blanc, PL | 1 |
| Joasson, JM | 1 |
| Hammoud, H | 1 |
| Matussière, Y | 1 |
| Braester, A | 1 |
| Quitt, M | 1 |
| Tsurumi, H | 1 |
| Goto, H | 1 |
| Hara, T | 1 |
| Moriwaki, H | 1 |
| Rain, JD | 1 |
| Gallant, C | 1 |
| Vial, T | 1 |
| Allochon, Y | 1 |
| Monier, JM | 1 |
| Blanc, M | 1 |
| Evreux, JC | 1 |
| Blonk, MC | 1 |
| Ossenkoppele, GJ | 1 |
| Osterwalder, B | 1 |
| Schmid, L | 1 |
| Jungi, WF | 1 |
| Flury, R | 1 |
| Schmid, U | 1 |
| Staub, P | 1 |
| Senn, HJ | 1 |
| Rice, GC | 1 |
| Gray, JW | 1 |
| Dewey, WC | 1 |
| Stein, KM | 1 |
| Shelley, WB | 1 |
| Weinberg, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG)[NCT00006400] | Phase 3 | 193 participants (Actual) | Interventional | 2000-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
DTPA GFR was originally a co-primary efficacy outcome for the study. Later in May 29, 2009, this measurement was discontinued because of statistical futility (an extremely small chance that the difference between treatment groups would be statistically significant for this outcome) and the small risk posed by the radiation exposure involved with performing the DTPA GFR test. Subjects who had missing data at baseline or 2 years measurement were excluded from the analysis (29 subjects from the hydroxurea, and 31 subjects from the placebo group excluded). (NCT00006400)
Timeframe: Before initiation of treatment and at 2 years
| Intervention | mL/min/1.73m^2 (Mean) |
|---|---|
| Hydroxyurea | 22.56 |
| Placebo | 20.74 |
GFR was calculated using new Schwartz formula: 39.1× [height (cm)/serum creatinine (mg/dL)]0.516 × [1.8/cystatin C]0.294 × [30/blood urea nitrogen]0.169 × [1.099]if male × [height(m)/1.4]0.188. Children with missing baseline or 2 years GFR were excluded from the analysis. (NCT00006400)
Timeframe: Before initiation of treatment and at 2 years
| Intervention | mL/min/1.73m^2 (Mean) |
|---|---|
| Hydroxyurea | 10.57 |
| Placebo | 14.33 |
Schwartz formula used to calculate GFR is: 0.55× height (cm)/serum creatinine (mg/dL). Where height is in cm and serum creatinine is in mg/dL. Children with missing baseline or 2 years GFR were excluded from the analysis. (NCT00006400)
Timeframe: Before initiation of treatment and at 2 years
| Intervention | mL/min/1.73m^2 (Mean) |
|---|---|
| Hydroxyurea | 28.65 |
| Placebo | 33.36 |
5 reviews available for hydroxyurea and Pyrexia
| Article | Year |
|---|---|
[Hydrocycarbamide induced fever: four cases and literature review].
Topics: Aged; Antimetabolites, Antineoplastic; Cross-Sectional Studies; Female; Fever; Humans; Hydroxyurea; | 2015 |
[Fever induced by hydroxycarbamide].
Topics: Aged; Fever; Humans; Hydroxyurea; Male; Myalgia; Recurrence; Thrombocythemia, Essential | 2015 |
Hydroxyurea-induced fever: case report and review of the literature.
Topics: Fever; Humans; Hydroxyurea; Male; Middle Aged; Thrombocytosis | 1995 |
Fever caused by hydroxyurea: a report of three cases and review of the literature.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Female; Fever; Humans; Hydroxyurea; Male; Middle Age | 1997 |
Hydroxyurea-induced fever in cervical carcinoma: case report and review of the literature.
Topics: Adenocarcinoma; Antineoplastic Agents; Combined Modality Therapy; Female; Fever; Humans; Hydroxyurea | 1999 |
2 trials available for hydroxyurea and Pyrexia
| Article | Year |
|---|---|
Influence of severity of anemia on clinical findings in infants with sickle cell anemia: analyses from the BABY HUG study.
Topics: Acute Disease; Anemia, Sickle Cell; Antisickling Agents; Double-Blind Method; Fever; Hemoglobins; Hu | 2012 |
[Treatment of chronic myeloid leukemia using alpha-interferon and hydroxyurea. Study of 30 cases].
Topics: Adolescent; Adult; Aged; Combined Modality Therapy; Female; Fever; Humans; Hydroxyurea; Immunologic | 1994 |
27 other studies available for hydroxyurea and Pyrexia
| Article | Year |
|---|---|
Real-world experience using hydroxyurea in children with sickle cell disease in Lilongwe, Malawi.
Topics: Absenteeism; Adolescent; Anemia, Sickle Cell; Blood Transfusion; Child; Child, Preschool; Combined M | 2019 |
Clinic Attendance of Youth With Sickle Cell Disease on Hydroxyurea Treatment.
Topics: Adolescent; Ambulatory Care; Anemia, Sickle Cell; Child; Child, Preschool; Family Characteristics; F | 2017 |
Skin nodules in onset of acute myeloid leukemia, a myelomonocytic variant case.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Cytarabine; Daunorubicin; Delayed Diagnosis; | 2017 |
Polycythemia vera and hydroxyurea resistance/intolerance: a monocentric retrospective analysis.
Topics: Adult; Aged; Aged, 80 and over; Drug Resistance; Female; Fever; Follow-Up Studies; Humans; Hydroxyur | 2019 |
Prospective longitudinal follow-up of children with sickle cell disease treated with hydroxyurea since infancy.
Topics: Anemia, Sickle Cell; Blood Transfusion; Child; Child, Preschool; Female; Fetal Hemoglobin; Fever; Fo | 2019 |
Symptomatic Profiles of Patients With Polycythemia Vera: Implications of Inadequately Controlled Disease.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Fatigue; Female; Fever; Humans; Hydroxyurea; | 2016 |
Hydroxyurea-related toxicity in 3,411 patients with Ph'-negative MPN.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Carcinoma, Squamous Cell; Drug Eruptions; Female; F | 2012 |
Blurred vision, epistaxis, and fever in a young man.
Topics: Acute Disease; Adult; Allopurinol; Antimetabolites; Antineoplastic Agents; Epistaxis; Fever; Fluid T | 2002 |
Bone marrow necrosis in a patient with acute promyelocytic leukemia during re-induction therapy with arsenic trioxide.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Bone Marrow; Bone Marr | 2004 |
[An uncommon case of hydroxyurea-induced fever].
Topics: Aged; Enzyme Inhibitors; Female; Fever; Humans; Hydroxyurea | 2004 |
Fever caused by hydroxyurea.
Topics: Aspirin; Female; Fever; Humans; Hydroxyurea; Middle Aged; Psoriasis; Recurrence | 1981 |
An unwanted side effect of hydroxyurea in a patient with idiopathic myelofibrosis.
Topics: Aged; Fever; Humans; Hydroxyurea; Male; Primary Myelofibrosis | 1995 |
Unwanted side effect of hydroxyurea.
Topics: Female; Fever; Humans; Hydroxyurea; Middle Aged; Thrombocythemia, Essential | 1996 |
Fever attributed to the use of hydroxyurea.
Topics: Aged; Antineoplastic Agents; Female; Fever; Humans; Hydroxyurea; Male; Recurrence; Thrombocytosis | 1997 |
Salvage therapy for relapsed or refractory childhood acute lymphocytic leukemia by alternative administration a lymphoid- and myeloid-directed chemotherapeutic regimen consisting of dual modulation of ara-C, hydroxyurea, and etoposide.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Transplantation; Child; Co | 1997 |
Recurrent pyrexia, cough and dyspnoea with hydroxyurea.
Topics: Cough; Dyspnea; Fever; Humans; Hydroxyurea; Male; Middle Aged; Polycythemia Vera; Recurrence | 1998 |
Hydroxyurea-induced fever and hepatitis.
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Fever; Humans; Hydroxyurea; Male; Middle Aged; | 1998 |
Hydroxyurea as a cause of drug fever in essential thrombocythaemia.
Topics: Aged; Aged, 80 and over; Antisickling Agents; Female; Fever; Humans; Hydroxyurea; Thrombocytosis | 1999 |
[Acute interstitial pneumopathy with fever caused by hydroxyurea].
Topics: Aged; Aged, 80 and over; Female; Fever; Follow-Up Studies; Humans; Hydroxyurea; Lung Diseases, Inter | 2000 |
Hydroxyurea as a cause of drug fever.
Topics: Female; Fever; Humans; Hydroxyurea; Middle Aged; Thrombocythemia, Essential | 2000 |
Hydroxyurea-induced fever in a patient with chronic myelogenous leukemia.
Topics: Antineoplastic Agents; Fever; Humans; Hydroxyurea; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; | 2000 |
[Hydroxyurea--is it a harmless drug in Vaquez disease?]].
Topics: Aged; Alopecia; Combined Modality Therapy; Cystitis; Erectile Dysfunction; Female; Fever; Follow-Up | 2001 |
[Drug-induced fever caused by hydroxyurea. Apropos of 3 new cases].
Topics: Aged; Antineoplastic Agents; Enzyme Inhibitors; Female; Fever; Humans; Hydroxyurea; Male; Middle Age | 1998 |
Hydroxyurea as a cause of drug fever in chronic myeloid leukaemia.
Topics: Drug Hypersensitivity; Fever; Humans; Hydroxyurea; Leukemia, Myeloid; Male; Middle Aged | 1988 |
[Myeloproliferative syndrome and acute febrile neutrophilic dermatosis (Sweet's syndrome)--a rare association].
Topics: Acute Disease; Adrenal Cortex Hormones; Aged; Fever; Humans; Hydroxyurea; Male; Myeloproliferative D | 1987 |
FACS analysis of a hyperthermia-induced alteration in Hoechst 33342 permeability and direct measurement of its relationship to cell survival.
Topics: Animals; Benzimidazoles; Cell Line; Cell Membrane Permeability; Cell Separation; Cell Survival; Cric | 1985 |
Hydroxyurea in the treatment of pustular psoriasis.
Topics: Administration, Oral; Adolescent; Female; Fever; Humans; Hydroxyurea; Leukocyte Count; Leukocytosis; | 1971 |