hydroxyurea has been researched along with Neuroblastoma in 15 studies
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We tested whether it is possible to encourage neuroblastoma tumor cells to enter the senescence pathway by low concentrations of the micronuclei-inducing drug hydroxyurea (HU)." | 7.74 | Induction of senescence in MYCN amplified neuroblastoma cell lines by hydroxyurea. ( Ambros, IM; Ambros, PF; Boukamp, P; Bozsaky, E; Kowalska, A; Narath, R, 2007) |
| "Long-term results are presented of 28 patients who were diagnosed with neuroblastoma at more than 12 months of age and who received melphalan 180 mg/m2 (n = 6) or 240 mg/m2 (n = 22) to consolidate remissions of Stage IV disease or to control refractory disease." | 7.68 | High-dose melphalan with 6-hydroxydopamine-purged autologous bone marrow transplantation for poor-risk neuroblastoma. ( Cheung, NK; Exelby, PR; Gulati, SC; Kushner, BH; Kwon, JH; O'Reilly, RJ, 1991) |
| "Because the antitumor drug caracemide causes neuropsychiatric effects in patients, we investigated its effects on the neurochemistry of cultured neuroblastoma cells (murine clone N1E-115)." | 7.67 | Effect of the antitumor drug caracemide on the neurochemistry of murine neuroblastoma cells (clone N1E-115). ( McKinney, M; Pfenning, M; Richelson, E, 1986) |
| " In this study, IGI was investigated by exposing human SH-SY5Y neuroblastoma cells to hydroxyurea and zeocin, two chemicals mimicking different DNA-damaging effects of ionizing radiation." | 4.12 | Genomic instability induced by radiation-mimicking chemicals is not associated with persistent mitochondrial degeneration. ( Höytö, A; Juutilainen, J; Luukkonen, J; Naarala, J; Sokka, M; Syväoja, J, 2022) |
| "Long-term results are presented of 28 patients who were diagnosed with neuroblastoma at more than 12 months of age and who received melphalan 180 mg/m2 (n = 6) or 240 mg/m2 (n = 22) to consolidate remissions of Stage IV disease or to control refractory disease." | 3.68 | High-dose melphalan with 6-hydroxydopamine-purged autologous bone marrow transplantation for poor-risk neuroblastoma. ( Cheung, NK; Exelby, PR; Gulati, SC; Kushner, BH; Kwon, JH; O'Reilly, RJ, 1991) |
| "Because the antitumor drug caracemide causes neuropsychiatric effects in patients, we investigated its effects on the neurochemistry of cultured neuroblastoma cells (murine clone N1E-115)." | 3.67 | Effect of the antitumor drug caracemide on the neurochemistry of murine neuroblastoma cells (clone N1E-115). ( McKinney, M; Pfenning, M; Richelson, E, 1986) |
| "A rationally devised induction regimen of vincristine, Adriamycin (Adria Laboratories, Columbus, OH), and sequentially-escalated cyclophosphamide (CPM), followed by S-phase-specific agents (5-fluorouracil [5-FU]/cytosine arabinoside [ara-C]/hydroxyurea), was used in 100 patients with neuroblastoma." | 3.67 | Coordinated use of sequentially escalated cyclophosphamide and cell-cycle-specific chemotherapy (N4SE protocol) for advanced neuroblastoma: experience with 100 patients. ( Helson, L; Kushner, BH, 1987) |
| "Neuroblastoma is the second most common solid malignancy of childhood." | 1.31 | Inhibition of N-myc expression and induction of apoptosis by iron chelation in human neuroblastoma cells. ( Berg, PE; Eskenazi, AE; Fan, L; Frantz, CN; Frick, KK; Ikegaki, N; Iyer, J; Kennett, RH; Wada, RK; Zhu, S, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Luukkonen, J | 1 |
| Höytö, A | 1 |
| Sokka, M | 1 |
| Syväoja, J | 1 |
| Juutilainen, J | 1 |
| Naarala, J | 1 |
| Prochazka, P | 1 |
| Hrabeta, J | 1 |
| Vícha, A | 1 |
| Eckschlager, T | 1 |
| ORIGENES, ML | 1 |
| BEATTY, EC | 1 |
| BRUBAKER, C | 1 |
| HAMMOND, D | 1 |
| HARTMANN, JR | 1 |
| SHORE, N | 1 |
| WILLIAMS, KO | 1 |
| FERNBACH, DJ | 1 |
| BLOEDOW, CE | 1 |
| Martin, FL | 1 |
| Williamson, SJ | 1 |
| Paleologou, KE | 1 |
| Hewitt, R | 1 |
| El-Agnaf, OM | 1 |
| Allsop, D | 1 |
| Liao, YF | 1 |
| Wang, BJ | 1 |
| Hsu, WM | 1 |
| Lee, H | 1 |
| Liao, CY | 1 |
| Wu, SY | 1 |
| Cheng, HT | 1 |
| Hu, MK | 1 |
| Narath, R | 1 |
| Ambros, IM | 1 |
| Kowalska, A | 1 |
| Bozsaky, E | 1 |
| Boukamp, P | 1 |
| Ambros, PF | 1 |
| Steinherz, PG | 1 |
| Rosen, G | 1 |
| Ghavimi, F | 1 |
| Wollner, N | 1 |
| Wang, Y | 1 |
| Miller, DR | 1 |
| Matsui, T | 1 |
| Taketo, A | 1 |
| Fan, L | 1 |
| Iyer, J | 1 |
| Zhu, S | 1 |
| Frick, KK | 1 |
| Wada, RK | 1 |
| Eskenazi, AE | 1 |
| Berg, PE | 1 |
| Ikegaki, N | 1 |
| Kennett, RH | 1 |
| Frantz, CN | 1 |
| Kushner, BH | 2 |
| Gulati, SC | 1 |
| Kwon, JH | 1 |
| O'Reilly, RJ | 1 |
| Exelby, PR | 1 |
| Cheung, NK | 1 |
| Tonin, PN | 1 |
| Yeger, H | 1 |
| Stallings, RL | 1 |
| Srinivasan, PR | 1 |
| Lewis, WH | 1 |
| McKinney, M | 1 |
| Pfenning, M | 1 |
| Richelson, E | 1 |
| Helson, L | 1 |
15 other studies available for hydroxyurea and Neuroblastoma
| Article | Year |
|---|---|
Genomic instability induced by radiation-mimicking chemicals is not associated with persistent mitochondrial degeneration.
Topics: Cell Line, Tumor; Genomic Instability; Humans; Hydroxyurea; Mitochondria; Neuroblastoma; Reactive Ox | 2022 |
Expulsion of amplified MYCN from homogenously staining chromosomal regions in neuroblastoma cell lines after cultivation with cisplatin, doxorubicin, hydroxyurea, and vincristine.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line, Tumor; Cisplatin; Doxorubicin | 2010 |
TRIAL OF HYDROXYUREA (NSC-32065) IN CANCER IN CHILDREN.
Topics: Antineoplastic Agents; Busulfan; Child; Cyclophosphamide; Dactinomycin; Humans; Hydroxyurea; Leukemi | 1964 |
PEDIATRIC CLINICAL TRIALS WITH HYDROXYUREA (NSC-32065).
Topics: Adolescent; Antineoplastic Agents; Child; Drug Therapy; Hodgkin Disease; Hydroxyurea; Leukemia; Neop | 1964 |
PHASE II STUDIES OF HYDROXYUREA (NSC-32065) IN ADULTS: MISCELLANEOUS TUMORS.
Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Carcinom | 1964 |
Fe(II)-induced DNA damage in alpha-synuclein-transfected human dopaminergic BE(2)-M17 neuroblastoma cells: detection by the Comet assay.
Topics: alpha-Synuclein; Amino Acid Substitution; Cell Line, Tumor; Comet Assay; Cytarabine; DNA; DNA Damage | 2003 |
Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells.
Topics: Amino Acids; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Antineoplastic Agents; Cel | 2007 |
Induction of senescence in MYCN amplified neuroblastoma cell lines by hydroxyurea.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cellular Senescence; Gene Amplification; Humans; Hydroxyure | 2007 |
Higher leukocyte nadirs with lithium carbonate after chemotherapy.
Topics: Adolescent; Adult; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Female; Humans; Hydroxyure | 1980 |
Induction of catecholamine synthesis in human neuroblastoma cells by replication inhibitors and sodium butyrate.
Topics: Amanitins; Antineoplastic Agents; Butyrates; Cyclic AMP; Cycloheximide; Dactinomycin; DNA Replicatio | 1999 |
Inhibition of N-myc expression and induction of apoptosis by iron chelation in human neuroblastoma cells.
Topics: Aphidicolin; Apoptosis; Deferoxamine; Gene Expression; Gene Expression Regulation, Neoplastic; Genes | 2001 |
High-dose melphalan with 6-hydroxydopamine-purged autologous bone marrow transplantation for poor-risk neuroblastoma.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Bone Marrow Transp | 1991 |
Amplification of N-myc and ornithine decarboxylase genes in human neuroblastoma and hydroxyurea-resistant hamster cell lines.
Topics: Adolescent; Animals; Cell Line; Child; Child, Preschool; Cricetinae; DNA; Drug Resistance; Gene Ampl | 1989 |
Effect of the antitumor drug caracemide on the neurochemistry of murine neuroblastoma cells (clone N1E-115).
Topics: Adenylyl Cyclase Inhibitors; Alprostadil; Animals; Antineoplastic Agents; Catechols; Cell Line; Chol | 1986 |
Coordinated use of sequentially escalated cyclophosphamide and cell-cycle-specific chemotherapy (N4SE protocol) for advanced neuroblastoma: experience with 100 patients.
Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cell Cycle | 1987 |